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6989277 |
Method for immunoassays based on infrared reflection absorption spectroscopy
This invention relates to a method for immunoassays based on infrared reflection absorption spectroscopy that utilizes proteins such as antigen and antibody that have specific absorptions in...
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6989234 |
Method and apparatus for non-contact electrostatic actuation of droplets
An apparatus for actuating a droplet comprises a first conductive layer, a second conductive layer, a conductive elongate element, and a voltage source. The first conductive layer comprises a first...
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6989237 |
Capillary array and related methods
The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each...
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6979543 |
Method for detecting biological agents
A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate...
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6979424 |
Integrated sample analysis device
An analysis device comprises a body having a reaction chamber for chemically reacting a sample, a separation region for separating components of the sample, and a transition region connecting the...
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6979425 |
High capacity microarray dispensing
A high capacity microarrayer for spotting solution onto slides in an automated microarray dispensing device. A microplate indexing device automatically moves, in sequence, a plurality of...
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6979569 |
Apparatus and method for mixing fluids for analysis
In an apparatus for fluid analysis, a plurality of reagent-mixture components are each injected by a respective pump through a valve matrix and into a flow-injection unit. The flow-injection unit...
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6977041 |
Apparatus for manufacturing deionized water and using method thereof
An apparatus and method for manufacturing deionized water is provided. Water is supplied to a first conduit. A plurality of reverse osmotic pressure vessels are connected to the first conduit. A...
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6977149 |
Biochemical reaction detection apparatus
A biochemical reaction detection chip capable of controlling the temperature for biochemical reactions including hybridizations and its substrate. The function of the chip is performed by...
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6969489 |
Micro array for high throughout screening
Array based fluid is stored in through holes that extend through a substrate. Combined capillary and hydrophyllic forces are used to retain the fluid and also transfer it to other substrates of...
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6969615 |
Methods, devices, arrays and kits for detecting and analyzing biomolecules
The present disclosure is directed to devices, arrays, kits and methods for detecting biomolecules in a tissue section (such as a fresh or archival sample, tissue microarray, or cells harvested by...
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6967105 |
Surface-modified wick for diagnostic test strip
A wicking material is disclosed that exhibits a horizontal wicking velocity of at least about 1.0 millimeter per second when contacted with a physiological fluid such as blood, lymph or cellular...
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6965832 |
Investigating different physical and/or chemical forms of materials
Apparatus and a method are described for investigating polymorphs of a material, isomers of a material which allow different isomeric forms to be resolved, different hydrates/solvates and/or...
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6962782 |
Method for producing addressed ligands matrixes on a support
A method for fabricating matrices of addressed ligands on a carrier. In the method, an element is used such as a reservoir filled with ligand and containing an electrode to deposit and...
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6962674 |
Dissolution test apparatus
A dissolution test apparatus comprises a spindle head assembly interconnected between first and second lateral support members. The lateral support members are translatable along a first axis, and...
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6960170 |
Image processing system for predicting ovulation
An image processing system for predicting ovulation using a test channel for collecting saliva sample and a miniature camera for capturing the image of the saliva at dried state for analyzing the...
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6960477 |
Closed heat-decomposing appliance, pretreatment method of sample using it, analytical method and device therefor
Disclosed are a closed heat-decomposing appliance comprising a heating section with one side closed and other side having common ground portion, screw portion or O-ring-mounted portion and a closed...
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6960467 |
Biochannel assay for hybridization with biomaterial
The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads...
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6958216 |
DNA-bridged carbon nanotube arrays
A class of biological sensing devices that include a substrate comprising an array of carbon nanotubes (CNTs) to which are chemically attached biological molecules is disclosed. The attached...
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6957565 |
Method and apparatus for characterizing materials by using a mechanical resonator
A method for measuring properties of a fluid that includes oscillating a tuning fork resonator in a fluid. The invention is particularly suitable for in-line monitoring of various physical and...
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6958131 |
Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance
The optical sensor contains an optical waveguide ( 1 ) with a substrate ( 104 ), waveguiding material ( 105 ), a cover medium ( 106 ) and a waveguide grating structure ( 101-103 ). By means of a...
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6955881 |
Method and apparatus for producing biochips
A method and apparatus for mass producing biochips quickly and easily, wherein a plurality of DNA molecules are amplified using a PCR (polymerase chain reaction) method and transcribing the...
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6955923 |
Device and method for investigating the flowability of a physiological fluid sample
To investigate the flowability of a physiological fluid sample, an uptake passage ( 12 ) for the fluid sample ( 16 ), an actuator device ( 18 ) for the cyclic change in orientation of measuring...
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6955788 |
Apparatus and method for aligning microarray printing head
An alignment apparatus and method are described for accurately and reliably depositing biological materials on a microscope slide or other substrate. A preferred implementation includes a first...
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6955787 |
Integrated biological and chemical sensors
An array of piezoelectric resonators used in a sensor device in order to identify chemical and biological agents. The resonators can operate as bulk acoustic wave (BAW), surface acoustic wave...
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6955914 |
Method for making a molecularly smooth surface
A method is provided for making a molecularly smooth surface, preferably on an electrode of an assay chip. This is desirable because it allows molecules, preferably oligonucloetides, to attach to...
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6955878 |
Apparatus for analyzing samples using linear probe array
There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of...
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6953676 |
Mesoscale polynucleotide amplification device and method
Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymerization reaction. The devices comprise a substrate microfabricated to define a...
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6953550 |
Affinity binding-based system for detecting particulates in a fluid
This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based,...
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6951936 |
Probe for detecting a highly ordered structural site of a single stranded nucleic acid of a gene, and a method and a device for detecting the same
The invention provides a probe for detecting a highly ordered structural site of a nucleic acid of a gene by specifically binding with the structural site to generate an electrochemical response....
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6951631 |
Test kits and devices
A test kit for determining qualitatively or quantitatively the presence of one or more analytes in a fluid sample, comprising an assay device together with a reading device which engages with the...
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6951632 |
Microfluidic devices for introducing and dispensing fluids from microfluidic systems
The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the...
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6949377 |
Chemiluminescence-based microfluidic biochip
The disclosure describes how to use luminescence detection mechanism, move microfluid, and control multiple-step biochemical reactions in closed confined microfluidic biochip platform. More...
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6943036 |
Error detection in chemical array fabrication
A method, apparatus, and computer program product, for forming an addressable array of chemical moieties on a substrate. The method may include, for each of multiple locations on the substrate,...
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6942836 |
System for filling substrate chambers with liquid
The present invention is directed to a system for filling sample chambers with liquid. The system includes a substrate defining the sample chambers and having a fill port, and a network of...
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6939451 |
Microfluidic chip having integrated electrodes
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities,...
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6936225 |
Pressure-variation fluid transport, in particular for body-fluid analysis
A fluid movement system for moving a sample fluid is preferably included in a cartridge to be inserted into a reading device. The fluid movement system includes a pressure variation means for...
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6936474 |
Method and apparatus for manufacturing biochip
A method and apparatus for manufacturing biochips. The apparatus includes a conveying device and a series of dispensers positioned at a series of dispensing positions above the conveying device. At...
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6933379 |
Method for linking nucleic acids and/or glycosaminoglycans to polar/hydrophilic materials
The invention relates to a method for linking nucleic acid and/or glycosaminoglycan or glycosaminoglycan mimetics to a polar/hydrophilic material, characterized by contacting a nucleic acid and/or...
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6933112 |
Device for mass transport assisted optical assays
An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the...
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6929953 |
Apparatus for analyzing biologic fluids
An apparatus for analyzing a sample of biologic fluid quiescently residing within a chamber is provided. The apparatus includes a light source, a positioner, a mechanism for determining the volume...
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6929943 |
Device for analyzing immunoassays
A device for analyzing immunoassays with a liquid assay medium includes a vessel for holding the assay medium. The vessel has a base comprised of a solid body having a first side wall and a top...
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6927570 |
Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
An apparatus is provided for quantitatively measuring samples whose amount or other characteristic quality is to be determined. The samples are arranged in a predefined pattern and are excited in a...
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6926864 |
Microfluidics apparatus and methods for use thereof
A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing...
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6924152 |
Handling method of body fluid sample and analysis apparatus using the same
Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle,...
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6921637 |
Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
A liquid composition comprising a colloidal suspension of a biomolecule-binding matrix material (preferably nitrocellulose) dispersed in a liquid, with particles of the matrix material being of a...
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6919046 |
Microfluidic analytical devices and methods
Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure,...
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6914220 |
Microelectromechanical heating apparatus and fluid preconcentrator device utilizing same
A microelectromechanical heating apparatus and fluid preconcentrator device utilizing same wherein heating elements of the apparatus are sized and spaced to substantially uniformly heat a heating...
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6913933 |
Fluid dispensing algorithm for a variable speed pump driven metering system
A method for improving the fluid dispense rate in a metering system utilizing speed includes the steps of modifying the fluid flow rate profile during a portion thereof so as substantially increase...
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6911182 |
Device for placement of effluent
A device for placement of effluent comprises a substrate positioner, a deposition conduit, and a conduit positioner. The substrate positioner supports and positions a substrate on which effluent...
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