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8182767 |
Needle-septum interface for a fluidic analyzer
Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a...
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8182765 |
Fluid transfer mechanism
A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the...
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8178057 |
Apparatus for filling a sample volume defining device
An apparatus for filling a sample volume defining device for separating at least one small defined volume of a liquid sample from a relatively larger undefined volume of said sample, said device...
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8168443 |
Instrument for cassette for sample preparation
A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor...
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8168140 |
Microfluidic apparatuses with nanochannels
In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be...
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8168139 |
Recirculating fluidic network and methods for using the same
The present invention provides a variety of microfluidic devices and methods for conducting assays and syntheses. The devices include a solid substrate layer having a surface that is capable of...
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8163254 |
Micromanifold assembly
A micromanifold for connecting external capillaries to the inlet and/or outlet ports of a microfluidic device can employ a ferrule/capillary assembly that includes: (a) a ferrule comprising an...
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8158082 |
Micro-fluidic device
Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes...
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8158083 |
Precision liquid dispensing system
A system for dispensing microdrops of reagent in small, precisely metered quantities maintains the fluid reagent to be dispensed in a reservoir under a controlled pressure. The reagent is dispensed...
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8147775 |
Self-cleaning and mixing microfluidic elements
Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of...
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8147770 |
Microfluidic device including a dissolvable structure for flow control
A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be...
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8137641 |
Microfluidic module including an adhesiveless self-bonding rebondable polyimide
A method of making a microfluidic module is disclosed that includes forming a fluid flow channel in a self-bonding rebondable polyimide film to provide a channel sheet, the self-bonding rebondable...
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8137624 |
Method and apparatus for attaching a fluid cell to a planar substrate
Provided is a method and apparatus for attaching a fluid cell to a planar substrate. The planar substrate may have on it sensors or devices for detecting components within the fluid, and/or be...
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8137617 |
Thin film heater and analytical instrument
The present invention relates to a thin film heater (2) including a thin film heat-producing resistor, and a first and a second thin film electrodes (22, 24) electrically connected to the thin film...
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8133456 |
Microreactor and method of liquid feeding making use of the same
A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and...
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8133455 |
Micro-fabricated stamp array for depositing biologic diagnostic testing samples on bio-bindable surface
The present invention discloses micro-stamp array supported on a substrate comprising a plurality of micro-stamp sticks. Each of the micro-stamp sticks includes a micro-stamp-stick head having a...
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8129176 |
Integrated active flux microfluidic devices and methods
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
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8128795 |
Biosensor
The present invention is directed to a biosensor being provided with a suction cavity which sucks a certain amount of sample by means of capillary phenomenon, the biosensor including a flow channel...
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8128893 |
Thermal transfer methods and structures for microfluidic systems
Processing devices that include one or more process arrays with thermal transfer structures that can be used alone or in conjunction with gravity/rotation to transport fluids within a microfluidic...
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8124031 |
Discharge volume control method, discharge pressure control method, and microbody forming method
A second valve is opened to combine an injection-pressure generating pressure with a maintaining pressure into an injection pressure. After the injection pressure is applied to a capillary to cause...
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8119079 |
Microfluidic apparatus having fluid container
A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the...
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8110158 |
Heat-reduction methods and systems related to microfluidic devices
A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. In one example, current is supplied to a...
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8105551 |
Microfluidic device and method of fabricating the same
A microfluidic device and a method of fabricating the microfluidic device are provided. The microfluidic device includes: a platform including an upper substrate and a lower substrate that are...
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8105553 |
Crystal forming devices and systems and methods for using the same
The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions...
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8105554 |
Nanoliter array loading
An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of...
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8101428 |
Microfluidic systems and control methods
The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for...
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8101137 |
Analysis instrument
An analysis instrument for processing a microfluidic device, having sample storage means, a microfluidic device holder, sample loading means for loading sample into a microfluidic device disposed...
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8100293 |
Microfluidic dispensing assembly
A microfluidic dispensing system may include diaphragm pumps that may be used for aspirating in corresponding ingredients via a nozzle or a tip from supply sources. Tips may be placed in contact...
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8097466 |
Optical reagent format for small sample volumes
An optical waveguiding optical format enables consistent optical analysis of small sample volumes with minimal variation in light path length among optical formats. The optical format is comprised...
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8096322 |
Microfluidic device with variable volume material
The invention relates to a microfluidic device comprising a first plate forming the substrate and including at least one perforation and, on either side of said first plate, at several locations, a...
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8088282 |
Sieving media from planar arrays of nanoscale grooves, method of making and method of using the same
Disclosed herein are an apparatus and a method for separating molecules on the basis of size and or structure, and to a method of making the apparatus. Generally, the separation method includes...
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8088578 |
Method of detecting an analyte
The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one...
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8084270 |
Device for analyzing fluids
It is an object of the invention to provide for an alternative for analyzing fluids. To this end a device for analyzing fluids comprising magnetic particles is provided, the device comprising...
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8080220 |
Thermal bend actuated microfluidic peristaltic pump
A peristaltic microfluidic pump. The pump comprises a pumping chamber positioned between an inlet and an outlet; a plurality of moveable fingers positioned in a wall of the pumping chamber, the...
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8080202 |
Component separating device and chemical analysis device using the same
A vibrator has a large strength of a standing wave even with a low driving voltage, thereby improving the accuracy of component separation. A device according to the present invention includes a...
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8075852 |
System and method for bubble removal
In one aspect of the invention, systems, methods, and devices are provided for handling liquid. In some embodiments, such systems, methods, and devices are used to combine fluids while removing...
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8075855 |
MEMS integrated circuit comprising peristaltic microfluidic pump
A MEMS integrated circuit comprising a peristaltic microfluidic pump and control circuitry for the pump. The pump comprises a pumping chamber positioned between an inlet and an outlet; a plurality...
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8075851 |
Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and...
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8071035 |
Microfluidic radiosynthesis system for positron emission tomography biomarkers
Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In...
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8071054 |
Microfluidic magnetophoretic device and methods for using the same
A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally...
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8062612 |
MEMS integrated circuit comprising microfluidic diaphragm valve
A MEMS integrated circuit comprising one or more microfluidic diaphragm valves and control circuitry for the valves. Each valve comprises: an inlet port; an outlet port; a weir positioned between...
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8062904 |
Method and device for dosing and mixing small amounts of liquid
A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir (3) connected to a reaction reservoir (1) via at least one joining structure...
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8062609 |
Flow cytometer and fluidic line assembly with multiple injection needles
A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer...
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8057758 |
Variable valve apparatus and methods
Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located...
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8055034 |
Methods and systems for image processing of microfluidic devices
A method of processing data associated with fluorescent emissions from a microfluidic device. The method includes performing an auto-focus process associated with a first image of the microfluidic...
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8053239 |
Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the...
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8050516 |
Methods and systems for determining a baseline during image processing
A method of determining a plurality of positions associated with a plurality of reaction chambers of a microfluidic device includes a) providing a baseline image; b) providing a template image of a...
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8048387 |
Centrifugal microfluidic device having sample distribution structure and centrifugal microfluidic system including the centrifugal microfluidic device
Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal...
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8043581 |
Microfluidic devices having a reduced number of input and output connections
A system and method for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. In one example, a...
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8034305 |
Container segment assembly
A container segment assembly suitable for use with a carousel of an analytical instrument, including (a) a container rack having the shape of a rectangular parallelepiped, the container rack...
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