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7606403 |
Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy....
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7602954 |
Method for quantitative video-microscopy and associated system and computer software program product
A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being...
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7599893 |
Methods and systems for feature selection in machine learning based on feature contribution and model fitness
Methods and systems are provided for feature selection in machine learning, in which the features selected for inclusion in a prediction rule are selected based on statistical metric(s) of feature...
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7599090 |
Method and apparatus for automatically segmenting a microarray image
A microarray image is segmented into discreet segments for respective spots in the microarray image based on locating microarray image rows and columns by maximizing scores associated with vertical...
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7593560 |
Systems and methods for monitoring the amplification and dissociation behavior of DNA molecules
The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
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7567695 |
Method and apparatus for reading reporter labeled beads
Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed...
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7551762 |
Method and system for automatic vision inspection and classification of microarray slides
The present invention provides a unique low cost vision inspection and classification system and methods for automatic inspection and classification of a microarray slide without manual...
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7536045 |
Method for the analysis of array images and device
A method of image analysis applicable to the analysis of arrays, such as DNA or protein microarrays. In the method the luminous spots of the array are filtered and isolated without any intervention...
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7507579 |
Apparatus and methods for simultaneous operation of miniaturized reactors
The present invention provides a variety of microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing...
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7474777 |
Device and method for optical measurement of chemical and/or biological samples
An optical measurement device for measurement of chemical and/or biological samples comprises an illumination means ( 16 ) for illuminating the sample ( 20 ) to be measured. Further, an optics...
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7457481 |
Apparatus and method for labeling rows and columns in an irregular array
The apparatus and method of the invention provide for assigning coordinates to samples in an array. The method is based on a hierarchical pattern matching to a local lattice structure that is used...
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7457449 |
Figure moving method
A method of moving figures whereby a number of aligned figures can be efficiently moved while maintaining the alignment. The method includes a figure group generating step of generating a plurality...
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7433504 |
User interactive method for indicating a region of interest
A method for defining a volume of interest (VOI) in a medical image is presented. A user interface is used to select a point on an initial linear border segment of a volume of interest. The user...
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7398171 |
Automated quality control method and system for genetic analysis
Aspects of the present invention describe a method and apparatus for automating quality control for gene expression data. A computer based device receives gene expression data associated with a...
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7383134 |
Method and/or system for analyzing biological samples using a computer system
A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.
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7374945 |
Method for enhancing the association rates of polynucleotides
The present invention features a method and associated kit for increasing the association rate between polynucleotides having complementary, single-stranded regions, where the method includes...
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7369696 |
Classification of cells into subpopulations using cell classifying data
A method of classifying cells into subpopulations using cell classifying data is described. The method comprises receiving and analyzing image data to identify object areas in the image data to...
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7359537 |
DNA microarray image analysis system
In a microarray image analysis system, when one of a plurality of statuses is set for a spot of a microarray by the user, the status of a similar spot is automatically determined. In a microarray...
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7324677 |
Feature quantitation methods and system
Methods, systems and recordable media for accurately reading and identifying high quality signals from a microarray feature. Signals may be identified and used regardless of their...
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7308123 |
System and method for collecting DNA and fingerprints
A system and method is provided that simultaneously or consecutively collects DNA samples and ridge and valley signatures from the same subject during the same collection window that adds value to...
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7285384 |
Parallel genotyping of multiple patient samples
The present invention relates to parallel genotyping (or other sample analysis) of multiple patients by direct sample immobilization onto microspheres of an array. The patient beads can then be...
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7274809 |
Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer
Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of...
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7241572 |
Method for isolating and purifying nucleic acids
A method for isolating and purifying nucleic acids with an improved recovery yield is provided. A mixed solution containing the nucleic acids, salts, and an organic solvent is contacted with an...
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7221785 |
Method and system for measuring a molecular array background signal from a continuous background region of specified size
A method and system for estimating the background signal over an arbitrarily-sized region of a scanned image of a molecular array, including a background region surrounding the ROI corresponding to...
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7218764 |
Ploidy classification method
Image analysis methods and apparatus are used for determination of the ploidy of cells. The methods may involve segmenting an image to identify one or more discrete regions occupied by cells or...
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7209579 |
Anatomic and functional imaging of tagged molecules in animals
A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them...
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7206439 |
Feature locations in array reading
Feature locations are determined in an array image obtained from reading a chemical array comprising multiple features arranged in a polygon and which array optionally includes sub-arrays within...
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7200254 |
Probe reactive chip, sample analysis apparatus, and method thereof
Technology is disclosed for highly accurate automated execution of processing for alignment of a detection area to a DNA microarray image file and processing for quantitative determination of...
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7160680 |
Mutation analysis by mass spectrometry using photolytically cleavable primers
The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer...
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7155041 |
Anomalous shadow detection system
An improved anomalous shadow detection system enables more reliable and efficient image diagnosis of an image of a suspected anomalous shadow etc. outputted by image output means. The image output...
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7146062 |
Apparatus and method for labeling rows and columns in an irregular array
The apparatus and method of the invention provide for assigning coordinates to samples in an array. The method is based on a hierarchical pattern matching to a local lattice structure that is used...
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7144699 |
Iterative resequencing
The invention provides iterative methods of analyzing a target nucleic acid that represents a variant of a reference nucleic acid. An array of probes is designed to be complementary to an estimated...
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7136517 |
Image analysis process for measuring the signal on biochips
The invention relates to an image analysis process for measuring the signal on biochips organized into one or several blocks each comprising a large number of spots each composed of at least one...
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7133547 |
Method for quantitative video-microscopy and associated system and computer software program product
A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being...
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7133546 |
Digital medical image analysis
A medical image is analyzed using an algorithm requiring input parameters. Values of the input parameters are derived from metadata, indicating properties of the medical image. For example, the...
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7115229 |
Apparatus and method for monitoring molecular species within a medium
Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing....
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7110586 |
Apparatus for remote control of a microscope
An apparatus and method acquires and stores multiple resolution images from a specimen on a support and provides to the user a low magnification, reconstructed macro image of the entire specimen,...
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7110585 |
Nanoparticle imaging system and method
An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate...
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7099502 |
System and method for automatically processing microarrays
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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7094531 |
Nucleic acid sequencing
Provided is a method for sequencing DNA, which comprises: (a) obtaining a target DNA population comprising one or more single-stranded DNAs to be sequenced, each of which is present in a unique...
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7085404 |
Image analysis system and method of biochip
Disclosed is a biochip image analysis system which comprises an image storage unit for storing images including an original image of a biochip comprising a set of specific genes expressed in...
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7076115 |
Analysis of chemical data from images
Computer programs and computer-implemented methods implement techniques for evaluating experimental data from a library of materials. The techniques receive a plurality of images of a library of...
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7068830 |
Method and system for providing a probe array chip design database
Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information...
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7068829 |
Method and apparatus for imaging samples
A method for analysis of DNA data. A DNA source image is generated based on the DNA data. A digital bit-map is created from the DNA source image plotting image intensity data against a...
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7068828 |
Biochip image analysis system and method thereof
A biochip image analysis system comprises an image storage unit storing image information including an original image of the biochip including genes extracted from experimental and control groups'...
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7060436 |
Nucleic acid accessible hybridization sites
The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and...
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7050620 |
Method of assaying shape and structural features in cells
The method for repetitively determining a profile of quantitative features for different cells in a sample by collecting and analyzing information on the mass distribution in cells or portions of...
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7031844 |
Cluster analysis of genetic microarray images
A method for determining relative incidence of a binding substance within two biological samples is provided. The two samples are labeled with luminescent materials having different chromatic...
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7013033 |
System for the automatic analysis of images such as DNA microarray images
The system can be used for the automatic analysis of images, including a matrix of spots, such as images of DNA microarrays after hybridization. The system can be associated—and preferably...
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7001721 |
Nucleic acid sequence identification
Disclosed are methods for determining the presence or absence of a target nucleic acid (e.g. DNA) sequence in a sample nucleic acid, the method comprising: (a) exposing the sample to a detection...
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