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6519025 |
Method and apparatus for direct spectrophotometric measurements in unaltered whole blood
A method and apparatus that allows accurate spectrophotometric determination of the concentrations of various hemoglobin species in whole undiluted blood. The invention employs 1) an optical...
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6510330 |
Method and device for measuring blood parameters
Methods are disclosed for analysing the concentration of red blood cells in a flow of blood including flowing the blood through a cuvette, directing a light through the flow of blood, measuring...
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6507391 |
Measuring the velocity of small moving objects such as cells
Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so...
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6493069 |
Method and instrument for measuring blood sugar level
A blood sugar measuring instrument for measuring the blood sugar level of blood on the basis of change in the color of the reagent having reacted with the blood. The instrument irradiates light...
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6448067 |
Method for determining the glucose content of a blood sample
The invention relates to a method and apparatus for determining a chemical component from a sample, where the sample is measured on a test strip with the help of a color reaction. The method...
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6441890 |
Method and apparatus for timing intermittent illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube-imaging system
Centrifuged material layer volumes are measured and quantified during centrifugation of the material layers contained in a sample tube in a centrifuge assembly, which sample tube is disposed on a...
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6437856 |
Imaging of superficial biological tissue layers using polarized light
A imaging device includes a light source, a detector, and an optical polarization system for video imaging of superficial biological tissue layers. The device relies on taking a set of measurements...
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6430513 |
Monitoring constituents of an animal organ using statistical correlation
Constituents such as oxy- and deoxy-hemoglobin are monitored non-invasively in an animal organ such as a brain with a spectrometric instrument by passing radiation through the organ. Concentrations...
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6424730 |
Medical image enhancement method for hardcopy prints
A method for the enhancement of medical images for hardcopy prints comprising the steps of: obtaining a medical image in digital format; conducting a plurality of operations for Human Visual System...
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6420709 |
Methods of minimizing scattering and improving tissue sampling in non-invasive testing and imaging
An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection...
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6419822 |
Systems and methods for sensing red blood cell hematocrit
Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection...
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6411373 |
Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis
The invention provides a design process that is used in the determination of the pattern of detector and illumination optical fibers at the sampling area of a subject. Information about the system,...
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6388752 |
Optical measurement system for determination of transmitted and scattered radiation
An optical measurement system for determining transmitted radiation and scattered radiation in a liquid sample contained in a capillary tube and subject to measurement radiation, is provided with a...
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6384914 |
Method for optical detection of analyte molecules in a natural biological medium
In order to carry out optical detection and identification of individual tumor markers in undiluted blood plasma, said tumor markers are marked with fluorescent dyes which are characterized by...
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6379976 |
Determination of polymerization/coagulation in a fluid
An analytical method of qualitative and optionally quantitative determination of the occurrence of polymerization/coagulation in a fluid containing polymerizable/coagulable components is described....
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6359683 |
Method for determining the volume of particles suspended in liquids
The present invention relates to the field of quantitative microspectroscopy, and in particular to a method for determining the volume of particles that are suspended in liquids.
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6350613 |
Determination of white blood cell differential and reticulocyte counts
Target nucleated cells, and target cells containing remnant ribosomal material, which are present in a quiescent anticoagulated whole blood sample are optically detected, enumerated, and analyzed...
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6330058 |
Spectrophotometric method and apparatus for blood typing
A method and apparatus for characterizing the type of a blood sample are provided wherein an optical density spectrum of the sample is collected over a predetermined wavelength range. A reference...
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6317511 |
Method and apparatus for particle image analysis using flow cell
A sample is flowed through a flow cell, the passage of particles is detected by a laser light beam, a flash lamp is turned on in response to the detection, still images of the particles are picked...
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6312607 |
Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the...
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6309884 |
Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose
A method is provided for calibrating a noninvasive glucose monitor for prospective noninvasive glucose determination. Spectroscopic transflectance readings are measured on the patient's skin using...
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6304767 |
Non-invasive optical measurement of blood hematocrit
The invention provides an optical method and apparatus for non-invasively determining blood hematocrit. The method includes the step of first irradiating blood with optical radiation. Radiation...
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6288778 |
Handling of blood in bags by means of rotating discs
An apparatus for handling blood in bags includes a housing having disposed therein a plurality of generally circular discs arranged one above another, spaced from each other, parallel with each...
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6285448 |
Clinical analyte determination by infrared spectroscopy
The present invention comprises methods for minimally invasive and noninvasive analyte determination using infrared spectroscopy. A minimally invasive in vitro method comprises obtaining a volume...
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6268910 |
Method and apparatus for screening plasma for interferents in plasma from donor blood bags
An apparatus and a method whereby plasma integrity of plasma contained in a blood bag is rapidly and accurately assessed without compromising the sterility of the plasma, or destroying any of its...
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6263227 |
Apparatus for imaging microvascular blood flow
An apparatus for measuring and imaging blood perfusion in tissue comprises a monochromatic laser light source, means for shaping the laser light beam, means for irradiating a section of the surface...
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6262799 |
Method and apparatus for rapid measurement of cell layers
Centrifuged material layer volumes are measured and quantified during centrifugation of the material layers. The material layers are differentially highlighted by means of one or more supravital...
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6254784 |
Optical interface detection system for centrifugal blood processing
A centrifuge for continuously separating the various constituents of blood or other biological fluids includes a rotating bowl having high-G and low-G walls. An inwardly directed ramped surface on...
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6246786 |
Particle analyzer
A particle analyzer includes a detection section to detect a parameter representative of characteristics of particles in a sample, a processing section to process the detected parameter, and an...
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6232125 |
Method and apparatus for differentiating and enumerating leukocytes
A method and apparatus for differentiating and enumerating the five major sub-populations of leukocytes in a blood sample (i.e., lymphocytes, monocytes, eosinophils, neutrophils and basophils) uses...
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6228652 |
Method and apparatus for analyzing cells in a whole blood sample
A blood analyzing instrument includes a single transducer for simultaneously measuring the DC volume, RF conductivity, light scattering and fluorescence characteristics of blood cells passing...
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6222189 |
Methods of enhancing optical signals by mechanical manipulation in non-invasive testing
The invention relates to the enhancement of the signal-to-background ratio of a non-invasive measurement of the concentration of a blood constituent at a measurement site by applying an external...
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6222619 |
Diagnostic device and method
A method and apparatus of diagnosing a cardiac disease state in as little as two minutes involving the utilization of an evanescent wave assay system in conjunction with a data acquisition and...
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6219132 |
Method and apparatus for performing spectroscopic analysis with applicability to samples with turbidity and absorption
A method of performing analysis of samples having turbidity and/or high absorbance is disclosed. The analysis utilizes information from multiple factors, which affect transmittance or absorbance....
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6215554 |
Laser diagnostic unit for detecting carcinosis
A laser diagnostic unit for detection of carcinosis and method of detecting carcinosis in a patient by examining a specimen taken from the patient. The laser diagnostic unit includes a specimen...
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6207459 |
Method for the analysis of medical samples containing haemoglobin
The invention concerns a method for the determination of an analyte in a sample containing free haemoglobin in which the determination is carried out by an optical measurement and the value...
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6201607 |
Blood fluid characteristics analysis instrument
An apparatus for enhancing the analysis of light reflected from a blood exposed reagent is described. Light from sources, such as LED's, is used to detect the levels of glucose and fructosamine in...
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6201606 |
Method and apparatus for processing spectrum in spectral measurement
The apparatus for processing a spectrum in spectral measurement includes: a measurement section 10 for measuring an energy spectrum of light for measurement from an object to be measured; an...
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6197593 |
Method for enumerating blood cells
A method for enumerating and distinguishing between blood cell populations in a biological sample includes the steps of contacting a biological sample with a cell membrane-permeant, red-excited,...
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6195158 |
Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer
A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and...
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6191847 |
Fixed optic sensor system and distributed sensor network
A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various...
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6190919 |
System for controlling deglycerolization of red blood cells
A system for controlling the deglycerolization of red blood cells includes a cell sorter having multiple fluid channels each having a unique cross-sectional area for directing a fluid mixture...
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6188470 |
Bioenergetic data collection apparatus
A Bioenergetic Data Collection Apparatus utilizing a modified oximeter (1) to collect signals characteristic of blood flow in terminal tissue, such as a finger tip (12). A processing means (7) in...
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6177984 |
Video imaging of superficial biological tissue layers using polarized light
A video imaging device includes a light source, a detector, and an optical polarization system for video imaging of superficial biological tissue layers. The device relies on taking a set of...
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6174447 |
Process and devices for fluid separation of whole blood as a mixture of liquids into individual, differently-colored blood constituents, in particular for separation of concentrated thrombocytes from buffy coat
The invention relates to a method for fluid separation of whole blood as a mixture of liquids into individual, differently-colored blood constituents, which blood is packed in flexible containers,...
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6175420 |
Optical sensors for cell processing systems
An optical sensor is disclosed for use in an interactive cell processing system that includes a plurality of sensors arranged for monitoring and providing sensor data to a control module that...
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6172743 |
Technique for measuring a blood analyte by non-invasive spectrometry in living tissue
A device for non-invasively measuring an analyte within the body uses a source of light to illuminate a tissue component, then detects and measures the light during more than one selected time...
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6165795 |
Methods for performing fibrinogen assays using dry chemical reagents containing ecarin and magnetic particles
A method of performing a fibrinogen assay is provided using an assay reagent containing ecarin to give an assay that is insensitive to the presence of heparin and insensitive to hematocrit, while...
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6157442 |
Micro optical fiber sensor device
A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip...
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6151107 |
Method of non-invasive determination of oxygen saturation in tissue in which blood is circulating
In a method for the non-invasive determination of the oxygen saturation in tissue supplied with blood, the tissue is irradiated with red and infrared light and the DC and AC components of the...
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