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5162654 |
Detection apparatus for electrophoretic gels
An apparatus is disclosed to optically determine which of four fluorophores is attached to a band of DNA molecules on an electrophoresis gel. The apparatus includes four separate band pass...
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5141609 |
Method and device employing time-delayed integration for detecting sample components after separation
This invention relates to a detection method and apparatus useful in capillary electrophoresis and capillary chromatography that employs an array of solid state detector such as a charge-coupled...
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5114551 |
Multi-point detection method for electrophoresis and chromatography in capillaries
Multiple electropherograms or chromatograms representing successive stages of an electrophoretic or chromatographic separation in a capillary are obtained by training a recorder on a succession of...
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5108179 |
System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands
The use of continuous wave (CW) laser excitation to measure small differences in the fluorescence of bands of fluorophore stained nucleic acid fragments present in gels is described.
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5104511 |
Electrophoresis system
In an electrophoresis system, a specimen is analyzed on the basis of a division image obtained by applying the specimen on a substrate and causing an electrophoresis phenomenon to occur. The...
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5104508 |
Analysis of carbohydrates
A carbohydrate structure, possibly in the form of or derived from a glycoprotein or glycolipide, is analyzed by decomposing the structure into various constituent fragments, separating the...
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5100529 |
Fluorescence detection type gel electrophoresis apparatus
With respect to a gel which is mounted on a gel electrophoresis apparatus, a calibration process is provided before starting of measurement to obtain calibration data for bringing a portion of the...
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5098536 |
Method of improving signal-to-noise in electropherogram
A method and apparatus for improving signal to noise in an electropherogram acquired by electrophoresis. The migration time is remapped by binning the data with respect to migration time to improve...
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5061067 |
Electrophoresis pattern analyzer for genetic material
An electrophoresis pattern analyzer for genetic material of this invention comprises: an image data generating means for optically reading an electrophoresis specimen and outputting datum image...
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5037207 |
Laser imaging system
A laser imaging system is disclosed which provides the versatility of wide field digital imaging with enhanced spatial resolution and light gathering efficiency. The system will scan targets of any...
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5035863 |
Surface plasmon resonance sensors
A surface plasmon resonance (SPR) sensor is adapted for biochemical and similar testing on large area samples such as the gel of an electrophoresis apparatus. The gel is sandwiched between a pair...
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4940333 |
Method and apparatus for detecting universally and selectively concentration gradients, and for deflecting a light beam in a controlled fashion
Concentration gradients in samples to be evaluated are detected by measuring the deflection of a probe light beam passed through the sample using the principals of Schlieren optics. Specific...
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4938593 |
Photothermal densitometer for reading electrophoresis gels
A densitometer apparatus for evaluating electrophoresis gel samples based on photothermal techniques. In accordance with this invention, electrophoresis gels are characterized by passing a heating...
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4930893 |
Electrophoresis imaging system
A method and system for imaging unstained smaple material constituents on a gel electrophoresis unit. The system includes a gel electrophoresis unit, preferably having a pH gradient gel thereon,...
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4908112 |
Silicon semiconductor wafer for analyzing micronic biological samples
An analytical separation device in which a capillary sized conduit is formed by a channel in a semiconductor device and the channel is closed by a glass plate. Electrodes are positioned in the...
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4881812 |
Apparatus for determining base sequence
An apparatus for determining a base sequence comprising an assembly for making an exciting beam incident on a slab of electrophoretic gel in a direction normal to the plane thereof, the gel...
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4832815 |
Wavelength dispersion electrophoresis apparatus
In a wavelength dispersion electrophoresis apparatus which detects fluorescences of unequal wavelengths emitted from the samples of DNA, RNA or the like labeled with a plurality of fluorophores, a...
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4801366 |
Apparatuses and methods for analyzing macro-ions at electrophoretic steady state
A stable, unchanging concentration gradient of macro-ions dissolved in aqueous or other polar solvents is established adjacent to a semipermeable membrane by the opposing forces of a directed...
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4784494 |
Method and apparatus for detecting universal and selectively concentration gradients, and for deflecting a light beam in a controlled fashion
Concentration gradients in samples to be evaluated are detected by measuring the deflection of a probe light beam passed through the sample using the principals of Shlieren optics. Specific...
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4726681 |
Monitoring deflocculated particles in a suspension
A method of monitoring the deflocculation of particles in a suspension, which particles, when deflocculated, are such that they can become aligned in an applied field, comprises applying a beam of...
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4675095 |
Fluorescence detection type electrophoretic apparatus
An electrophoretic apparatus according to this invention comprises electrophoretic paths along which sample fragments labeled with phosphor migrate; electrodes disposed at both the ends of said...
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4675300 |
Laser-excitation fluorescence detection electrokinetic separation
An electrokinetic process and apparatus employing coherent radiation-excited fluorescence for detection is disclosed. In a preferred embodiment, the support liquid is a chiral liquid and the...
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4653914 |
Monitoring deflocculated particles in a suspension
A method of monitoring the deflocculation of particles in a suspension, which particles, when deflocculated, are such that they can become aligned in an applied field, comprises applying a beam of...
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4648715 |
Electrophoretic light scattering with plural reference beams, apparatus and method
Multichannel electrophoresis apparatus employing electrophoretic light scattering as a means for characterizing the particles under study. The apparatus is characterized by the ability to measure...
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4627727 |
Monitoring deflocculated particles in a suspension
A method of monitoring the deflocculation of particles in a suspension, which particles, when deflocculated, are such that they can become aligned in an applied field, by applying a beam of...
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4591272 |
Photothermal deflection densitometer for thin layer chromatography
A photothermal deflection detector for thin layer chromatography includes a translation means for holding and moving a thin layer chromatographic plate; a first impinging laser beam (e.g., 20 mW...
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4572671 |
Densitometer for an electrophoresis apparatus
A densitometer comprises a first carrier supporter for supporting a carrier formed of a cellulose acetate film for carrying a blood serum specimen after an electrophoresis process is completed and...
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4571081 |
Light scattering apparatus and method
A light scattering interfacial tension spectrometer has a laser source of light directed, as an incident beam I i , through a focusing lens and a diffraction grating. The grating divides the...
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4547071 |
Method and apparatus for measuring density gradient
The present invention related to a method and a device for use in measuring the gradient of density in a fluid. The device is comprised of a laser for providing a columnar light beam and a...
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4534647 |
Apparatus for photometrically scanning gels
An apparatus for photometrically scanning gels comprises a monochromator from which the light beam passes through a stop aperture and a gel placed in a cell, which are installed one after the other...
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4429996 |
Process of fractionating electrophoretogram signals
To facilitate fractionation of an electrophoretogram, the disclosed process differentiates signals representing the electrophoretogram so as to obtain the differential of the first order and to...
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4427294 |
Apparatus for densitometric measurement of proteic fractions separated by electrophoresis
An indexing fixture with many seats can be rotated in such a way as to present in each succeeding time interval a different seat at a reader. An electronic processing unit can control, under the...
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4420383 |
Fractionating method in electrophoreses
A fractionating method in electrophoresis wherein, in order to make it possible to automatically and accurately fractionate a pattern obtained by the electrophoresis of a sample to be measured,...
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4332472 |
Automatic cataphoresis apparatus
An apparatus for automatic cataphoresis comprises means for feeding a blood serum bearing film; a cutter for cutting the film to a given length; means for supplying a buffer solution for wetting...
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4285594 |
Optical system for densitometer
An optical system is disclosed for a densitometer which scans an electrophoretically separated sample and provides an output signal for graphical display indicative of the optical density of the...
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4244803 |
Quantitative protein analysis by immunodiffusion
Methods and apparatus are described by which immunochemical procedures such as immunodiffusion and immunoelectrophoresis can be used to provide quantitative measurement of the concentration of...
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4242194 |
Apparatus for spectroscopic measurement of the velocity of particles in a fluid
In electrophoretic apparatus measuring the velocity of particles in a fluid, a reference beam and a scattered beam scattered by the particles in the fluid at various scattering angles must be...
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4130824 |
Recording analyzer for electrophoretic samples
A recorder pen is mounted on the sample scanning stage of an electrophoretic sample analyzer. Movement of the stage scans the sample optically while, at the same time, the recorder pen produces an...
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4116565 |
Electrophoretic analyzer with automatic reference circuit
An analyzer for electrophoretic samples has a sample stage movable linearly with respect to a source and a detector of analysis energy. During a first scan of the sample, a voltage is produced...
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4113596 |
Method of measuring the mobility of colloids in an electrical field
The invention relates to a method for the measurement of the movement of colloidal particles in suspensions or solutions. The apparatus used in this method comprises an electrophoresis tank...
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4101220 |
Laser Doppler spectroscopy with smoothened spectra line shapes
Changes in electrophoretic mobility distribution of particles in an electric field, as determined by Doppler shifts of laser light scattered by the particles while undergoing oscillation, may be...
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4070263 |
Apparatus for the measurement of the mobility of colloids in an electric field
The invention relates to an improved method and apparatus for the measurement of the movement of colloidal particles in suspensions or solutions, wherein an electrophoresis tank is equipped with...
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4021200 |
Electronic digital radial and electro immunodiffusion calibrating viewer
A viewer, with electronic digital read out display, and calibrated to measure either a radial immunodiffusion or an electrophoresis rocket type protrusion.
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4011044 |
Use of laser speckle patterns for measurement of electrophoretic mobilities
Reduction in electrophoretic mobility of antigen-coated microscopic polystyrene spheres due to an antigen-antibody reaction is detected by observing changes in oscillation amplitude of speckle...
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3936272 |
Method of separating and scanning organic cells and molecules
A method of separating and immobilizing constituent cells of heterogenuous intact organic cells and the molecular components of organic cells into bands in quartz tubes and scanning the bands with...
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3870612 |
ANALYSIS FOR POLYMER MIXTURES IN SOLUTION UTILIZING ELECTROPHORETIC LIGHT SCATTERING APPARATUS
An electrophoretic scattering apparatus for determining the electrophoretic mobility and diffusion coefficient of a macromolecular polymer in solution is disclosed. More particularly, the charged...
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3826575 |
HIGH PERFORMANCE RING LASER GYROSCOPE WITH MAGNETO-OPTICAL BIAS
A ring laser gyroscope capable of producing an output signal at low rates angular rotation. A differential magneto-optical bias system eliminates the requirement of extreme stability in the bias...
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3732014 |
ELECTROMAGNETIC RADIATION APPARATUS FOR ANALYZING SMALL PARTICLES
Method and apparatus for measuring static and dynamic properties of small particles are disclosed. A beam of energy is split into signal and reference beams. The signal beam is focused into a...
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3663395 |
CROSS-SECTION ILLUMINATOR FOR A CONTINUOUS PARTICLE ELECTROPHORESIS CELL
In a continuous particle electrophoresis cell, the present invention comprises means for illuminating a section of the electrolyte curtain with a narrow blade of light rather than with a broad beam...
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3623812 |
METHOD FOR THE AUTOMATED ELECTRONIC DENSITOMETRIC EVALUATION OF SEPARATED MATERIAL MIXTURES, USING CARRIERLESS ELECTROPHORESIS
The present invention relates to a method for the automated electronic detometric evaluation of separated material mixtures, using carrierless electrophoresis, in which the distribution pattern of...
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