Matches 101 - 150 out of 249 < 1 2 3 4 5 >
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5897760 Method and apparatus for the removal of non-uniformities in an electrophoresis apparatus  
A method and apparatus for correcting non-uniformities in the source and the lens assembly of an electrophoresis apparatus is provided. Assuming a detector with a uniform responsivity, correcting...
5892581 Absorptivity detecting apparatus, chromatographic apparatus, method of detecting absorptivity and method of chromatography  
In order to suppress base line drift due to change in a light source and to start analysis with a short waiting time so as to improve quantitative accuracy of analysis, a detected signal in a...
5891314 Method and apparatus for correcting lens non-uniformities in an electrophoresis apparatus  
A method and apparatus for correcting non-uniformities in the lens assembly of an electrophoresis apparatus is provided. Assuming a detector with a uniform responsivity as well as a uniform...
5867266 Multiple optical channels for chemical analysis  
Apparatus for optical analysis of a sample material includes a channel block incorporating microfabricated channels and an integral gel material. Illuminating optics direct light to the sample...
5861124 Method and apparatus for detecting denaturation of nucleic acid  
An apparatus for detecting denaturation of a nucleic acid, including: denaturation condition controlling means for controlling condition of denaturation under which a double-stranded nucleic acid...
5856866 Image producing apparatus  
An image producing apparatus includes at least one light emitting diode stimulating ray source, a filter for cutting a stimulating ray emitted from the at least one light emitting diode stimulating...
5852495 Fourier detection of species migrating in a microchannel  
The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology...
5846702 Reagent including an osmium-containing redox mediator  
A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the...
5840877 Electrophoresis gels of enhanced selectivity  
Electrophoresis gels of enhanced selectivity are produced by adding a preformed polymer to a polymerization solution containing at least one monomer and at least one cross-linker. The polymer must...
5835231 Broad band intra-cavity total reflection chemical sensor  
A broadband, ultrahigh-sensitivity chemical sensor is provided that allows etection through utilization of a small, extremely low-loss, monolithic optical cavity. The cavity is fabricated from...
5784157 Method and apparatus for identifying fluorophores  
The present invention is a unique method for identifying the presence, and preferably the identity, of a fluorophore by optically stimulating one or more fluorophores with an optical signal which...
5784154 Electrophoresis separation in a capillary passage  
The separations resulting from capillary electrophoresis performed in a microbore capillary tube are detected on-line by focusing a light beam in the form of a line or sheet of light on the...
5784152 Tunable excitation and/or tunable detection microplate reader  
A method and apparatus of analyzing samples contained in a microplate is provided. The instrument is capable of measuring fluorescence, luminescence, and/or absorption within multiple locations...
5783397 Screening natural samples for new therapeutic compounds using capillary electrophoresis  
A method in which natural sample components are simultaneously fractionated and screened for compounds that bind tightly to specific molecules of interest is disclosed. Such newly isolated ligands...
5776767 Virtual DNA sequencer  
A virtual DNA sequencer combines a plurality of individual DNA sequencers. Samples of DNA or other nucleic acid from subjects are prepared and allocated in real time to particular lanes or sets of...
5774214 Multi-mode imaging apparatus for radiation-emitting or absorbing samples  
A multi-mode apparatus for capturing light patterns emitted or absorbed by a planar sample, such as an electropheresis gel, is made possible by a unique tray and sample holder system which...
5763277 Fiber optic axial view fluorescence detector and method of use  
The present invention system includes an axially oriented end of a fiber optic present in an axially oriented system component bore in which, during use, sample analyte fluorescence is caused to...
5759374 DNA detector and DNA detection method  
An electrophoresis apparatus includes a plurality of first capillaries containing a separation medium, such as a gel, and an optical cell in which one end of each of the first capillaries is...
5754291 Micro-imaging system  
The present invention features two flat-field, telecentric, infinite conjugate, achromatic objectives each of which has an external pupil lying in a common plane located equidistant from the two...
5712476 Electrophoresis and fluorescence detection apparatus  
An improved electrophoresis and fluorescence detection apparatus has an electromagnetic radiation sensor juxtaposed with a sensing region. The output signal from the electromagnetic radiation...
5710628 Automated electrophoresis and fluorescence detection apparatus and method  
Improved detection methods and apparatus which may be used individually or in various combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in...
5699157 Fourier detection of species migrating in a microchannel  
The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology...
5694215 Optical array and processing electronics and method therefor for use in spectroscopy  
A sample cell assembly employs optics for focusing light though a sample cell, such as one used in electrophoresis. The optical array includes a first cylindrical lens having a central longitudinal...
5667656 DNA detector and DNA detection method  
An electrophoresis apparatus for detecting samples migrating in migration portions includes a plurality of gel separation portions separate from one another and having respective ends disposed...
5663790 Method and apparatus for determination of refractive index  
In a method of determining the refractive index of a gaseous, liquid or solid sample, preferably a gaseous or liquid sample, there is used a waveguide resonator (1) which includes an open waveguide...
5650846 Microcolumnar analytical system with optical fiber sensor  
An analytical system for analyzing a fluid sample is disclosed. The analytical system includes a microcolumn for conducting the fluid sample, a light source for delivering light through the...
5627643 Method and detector for separation processes  
The present invention comprises a method Of detecting and quantifying components separated by capillary electrophoresis or other techniques using thin capillaries in the separation. The method of...
5600444 Detecting analyte light absorption utilizing degenerate four wave mixing  
A method and apparatus using either two or three input laser beams in a nonlinear degenerate four-wave mixing arrangement for ultrasensative analytical measurements of an analyte. In accordance...
5600433 Optical fiber waist refractometer  
The present invention relates to a refractive index detector for a dynamic liquid sample having a fiber optic filament of a predetermined diameter with an unclad sensor region, wherein the sensor...
5599503 Detector cell  
A miniaturized detector cell (4) having a measuring chamber volume of 25 fl-1 μl is described. In spite of its miniaturized construction, the detector cell has an optical path length of about...
5584982 Multiple capillary biochemical analyzer  
A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being...
5578460 Electrophoretic method for the isolation and separation of microorganisms and cell populations  
The present invention sorts microorganism populations from a mixture which contains more than one microorganism population. Microorganisms of different types vary in size, shape, and surface charge...
5556790 Method for Automated DNA sequencing  
An automated DNA sequencing apparatus and method is disclosed in which a laser beam having a predetermined wavelength is sequentially focused on a plurality of lanes of DNA fragments migrating in a...
5556529 DNA base sequencer  
The improved DNA base sequencer has a flat plate type gel electrophoretic unit that has multiple tracks for electrophoresing DNA fragments and which is held in a vertical position, a light exciting...
5552322 DNA base sequencer  
The improved DNA base sequencer comprises a flat plate type gel electrophoretic means that has a multiple of tracks for electrophoresing DNA fragments and which is held in a vertical position, a...
5549805 Digital DNA typing  
To sequence DNA automatically, fluorescently marked DNA are electrophoresed in a plurality of channels through a gel electrophoresis slab; wherein the DNA samples are resolved in accordance with...
5545901 Automated optical alignment using a galvometric scanner  
An apparatus and method are set for determining the centers of capillaries in a multicapillary electrophoresis array for subsequent rapid and efficient laser induced fluorescence interrogation. A...
5543018 Method and apparatus for automated electrophoresis using light polarization detector  
Changes in polarized light incident on a detection zone within a separation matrix are used to detect optically active molecules within the separation matrix. The separation and detection of...
5540825 Noise suppressing capillary separation system  
A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through...
5538613 Electrophoresis analyzer  
An apparatus for detecting fluorescently-labeled molecules moving in an electrophoretic separation medium. The apparatus utilizes a scanning detection system in which multiple fluorophores are...
5534703 Electrophoresis analyzer with wavelength selective detection  
An electrophoresis analyzer includes a light detector for detecting images of a linear fluorescence emitting region, the linear fluorescence emitting region including a plurality of fluorescence...
5529679 DNA detector and DNA detection method  
An electrophoresis apparatus includes a plurality of first capillaries containing a separation medium, such as a gel, and an optical cell in which one end of each of the first capillaries is...
5528366 Precision determination for molecular weights  
This invention describes a method by which the precision of the reported molecular weights and radii of chromatographically separated molecules may be estimated. By suitably analyzing both the...
5527680 Method for extracting solutes from gel plugs  
A flow-through receptacle is disclosed, one end of which is designed to hold multiple plugs of gel material, containing solutes such as macromolecules, excised from electrophoretic separations, and...
5515169 Spectral wavelength discrimination system and method for using  
A spectral wavelength discrimination system and method for using are provided which allows the wavelength of a beam of radiation to be accurately determined using compact inexpensive optics and...
5503994 System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities  
In many separation techniques, such as field flow fractionation, liquid chromatography and electro-phoresis, chemical species form bands that migrate at different velocities. If the...
5498324 Multiplexed fluorescence detector system for capillary electrophoresis  
A fluorescence detection system for capillary electrophoresis is provided wherein the detection system can simultaneously excite fluorescence and substantially simultaneously monitor separations in...
5483075 Rotary scanning apparatus  
A rotary scanning apparatus for scanning a plurality of separation lanes where the separation lanes are disposed in a nonplanar array. The scanning apparatus includes an optical detection system...
5482608 Capillary electrophoresis flow control system  
A system for controlling the bulk flow rate in capillary electrophoresis employs pressure to increase velocity without unacceptably increasing plate height. Thus, the system controls bulk flow over...
5459325 High-speed fluorescence scanner  
A high-speed fluorescence scanner for scanning a sample at equal angles is disclosed. The scanner has most of its optical components, including a light beam source, a detector, and various filters,...
Matches 101 - 150 out of 249 < 1 2 3 4 5 >