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6970246 Method and apparatus for detecting fluorescence of a sample  
The present invention relates to an apparatus and a method for detecting the fluorescence of a sample, wherein the apparatus comprises excitation light source located on the same side of the sample...
6963398 Laser scanning microscope  
The laser scanning microscope comprises an objective focusing a laser beam on a sample, and takes fluorescence or reflected light from the sample, optical scanning means for scanning the laser beam...
6958813 Plume detector  
Provided is a photodetector that detects missile launches from an above-flying surveillance platform through clouds. The plume detector includes a passive electro-optical sensor which detects the...
6956647 Method for operating a laser scanning confocal microscope system and a system thereof  
A method for operating a confocal microscope system includes deflecting a light beam on a specimen with at least one beam deflection device. The position of the light beam is stepped with at least...
6952008 Fluorescence detection with increased dynamic range  
The light detection system includes at least two light detection elements. Each element is responsive to a selected light color in a first mode, and each element has a different sensitivity and is...
6952259 Method of detecting the presence of a liquid in a mix  
The invention relates to a method of detecting the presence of a liquid introduced into a mix of constituents. The method comprises the following steps: excitation of the mix by a light signal in...
6947134 Method and instrumentation for measuring fluorescence spectra of individual airborne particles sampled from ambient air  
A Fluorescence Particle Spectrometer (FPS) performs real-time measurement of the fluorescence spectra of aerosol particles in the size range 1-10 μm diameter. The FPS has a sufficiently high ...
6924138 Single-and multi-mode configurations for fiber-optic-coupler biosensors  
Single-mode and multi-mode fibers to achieve modal splitting and greater sensitivity in an optical fiber coupler for evanescent-wave biosensor applications. A source of light having multiple modes...
6921908 Methods for fluorescence detection that minimizes undesirable background fluorescence  
The present invention provides a method for the excitation of a fluorescent sample and the measurement of the fluorescent emission. The method of the present invention has the advantage of...
6914668 Personal identification verification and controlled substance detection and identification system  
A personal identification and security system including a personal identification verification system, a controlled substance detection and identification system and an alarm indicator responsive...
6914720 Time resolved fluorescence microscope  
A time-resolved fluorescence microscope having high spatial and time resolution. Fluorescence from a sample 26 mounted on a confocal inverted optical microscope 19 and excitation laser light are...
6911344 Composite waveguide for solid phase binding assays  
A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one...
6909505 Method and apparatus for molten material analysis by laser induced breakdown spectroscopy  
An apparatus and a method are disclosed for use with Laser Induced Breakdown Spectroscopy (LIBS) systems that can be applied to the real time analysis of molten materials or liquid. Since it is...
6907149 Compact optical measurement probe  
A remote optical measurement suitable for Raman and fluorescence detection uses one or more dielectric components and an optical configuration which affords significant miniaturization, in some...
6906797 Side light activated microfluid channels  
Devices are provided comprising reflecting channels for directing horizontally a vertical light beam through a multiplicity of streams. The devices provide particular applications in microfluidics,...
6903817 Method for optically detecting chemical species contained in condensed media  
A method for detecting chemical species present in a condensed medium including determining characteristic wavelengths and intensity values of back-scattered electromagnetic emission signals due to...
6903816 Mirror driving mechanism, and spectroscope and scanning laser microscope comprising mirror which is driven by mirror driving mechanism  
A mirror driving mechanism comprises a driver configured to drive at least one mirror which reflects a light flux while adjusting a wavelength width and a wavelength band of the light flux...
6900891 Optical sensors for the detection of nitric oxide  
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or...
6900889 Submersible light-directing member for material excitation in microfluidic devices  
A system for material excitation in microfluidic devices is described. Aspects of the invention resemble a submerged periscope when in use. They allow for light to be redirected along a more...
6884624 Method for measuring the rate of cell reproduction by analysis of nanoliter cell samples  
A method of detecting cancer using a laser biocavity having a semiconductor laser including a microchannel through which cells in fluid traverse, comprising determining the laser wavelength of the...
6879394 Multi-photon imaging installation  
An installation is provided for multi-dimensional non-linear imaging of a material comprising intrinsic chromophores, using laser scanning. This installation comprises i) at least one source (115)...
6870627 System for directed molecular interaction in surface plasmon resonance analysis  
Disclosed is apparatus and method for controlled surface plasmon resonance analysis having a surface plasmon resonance sensor (200) with a derivatized surface plasmon layer (116) in optical...
6864975 Method of and system for analyzing a sample containing a plurality of fluorescent substances  
The present invention proposes a method of and system for analyzing samples (particularly, bio-samples), wherein the continuous spectrum white light pulse generated from an ultra-short optical...
6850323 Locally enhanced raman spectroscopy with an atomic force microscope  
An atomic force microscope (AFM) tip is used to selectively produce surface enhanced Raman scattering (SERS) for localized Raman spectroscopy. Spectra of thin films, undetectable with a Raman...
6847446 Chemical analysis and detection by selective adsorbent sampling and laser induced breakdown spectroscopy  
The present invention describes an apparatus capable of specific detection of environmental chemicals in water and air. The apparatus combines a specific chemical sampler, encompassing selectively...
6844963 Double-resonance-absorption microscope  
The present invention provides various embodiments of a double-resonance-absorption microscope which realizes a super-resolution by using double resonance absorption. In particular, a...
6833916 High efficiency, large field scanning microscope  
A fluorescent optical imaging system (10) produces two separate spots (S1 and S2) on a sample (12) by a pair of excitation laser beams (B1 and B2) that are generated by first and second lasers (L1...
6833915 Optical diagnosis system for small animal imaging  
Optical diagnosis system for small animal imaging, in which the animal which has been arranged on a bearing plate and treated with an activatable optical contrast medium is irradiated by an...
6825924 Dual peak wavelength tube, illuminator for inspection, inspecting apparatus, and method thereof  
The invention provides methods and apparatus for substrate inspection and other lighting applications. It includes an lighting apparatus 10 which comprises: an illuminator 12 including a light...
6816257 Method and apparatus for detecting microparticles in fluid samples  
A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle...
6809811 Protective shield for an instrument probe  
A shield is disclosed that is particularly useful for protecting exposed optical elements at the end of optical probes used in the analysis of hazardous emissions in and around an industrial...
6809814 System and method for epi-detected coherent anti-stokes raman scattering microscopy  
Systems and methods are disclosed for detecting a coherent anti-Stokes Raman scattering (CARS) signal from a microscopic sample in an epi-direction. In an embodiment, the system includes at least...
6809813 Spectroscopic probe  
A spectroscopic probe includes a monolithic block (10) of transparent material and GRIN lenses (20, 22, 24). Light for illuminating a sample is delivered by an optical fiber (31), and light...
6809816 Measurement of fluorescence decay times  
Laser pulses from laser head 12 pass through objective lens 16 to a focal spot in sample spot 17. If a pulse hits a fluorophore molecule in the focal spot a fluorescence photon is emitted which is...
6806955 Method and apparatus for measuring fiber properties  
The invention relates to a fluorescence microscopy technique for measuring physical and chemical properties of individual fiber-like particles. Fluorescence intensity per unit length is shown to be...
6804000 Beam-steering of multi-chromatic light using acousto-optical deflectors and dispersion-compensatory optics  
Method and apparatus for steering a beam of light. The method and apparatus are based on the discovery that the spectral dispersion of multi-chromatic light pulses by an acousto-optical deflector...
6801595 X-ray fluorescence combined with laser induced photon spectroscopy  
A device and method for identifying the composition of a target sample. The target sample may be a matrix such as a metal alloy, a soil sample, or a work of art. The device includes an x-ray...
6798502 Microwave regime surface spectroscopy  
The nonlinear system includes a fixed visible input and tunable visible input that are directed to a location on a surface to be interrogated. The fixed visible input and the tunable visible inputs...
6795189 Universal microplate analyzer  
A universal microplate analyzer capable of carrying out measurements on samples contained in the wells of microplates by fluorescence, absorbance, luminescence employs at least two light sources...
6795179 Metal scrap sorting system  
A system for sorting randomly positioned, irregularly shaped scrap metal particles on a moving conveyor employs laser-induced breakdown spectroscopy (LIBS), and includes an image detector for...
6794670 Method and apparatus for spectrometric analysis of turbid, pharmaceutical samples  
The present invention relates to a method and an apparatus for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a...
6788407 Laser interrogation of surface agents  
An apparatus for laser interrogation of surface agents moving relative to the apparatus. A receiver telescope includes a secondary reflector that may compensate for variations in distance from a...
6785302 Optical system in the ray path of a confocal fluorescence microscope  
The invention relates to an optical system in the ray path of a confocal fluorescence microscope, comprising at least one laser light source (1, 2), a device positioned in the...
6771368 Laser-induced ionisation spectroscopy, particularly for coal  
An apparatus for analyzing material, such as coal, comprises subjecting the coal (14) to laser light. The laser light is used to vaporize and ionize a small amount of the coal to produce spectral...
6770488 Practical method and apparatus for analyte detection with colloidal particles  
A colloidal system for detection of a variety of analytes involves techniques which permit reconstitution of a desiccated substance such as for surface enhanced Raman spectroscopic analysis and...
6766184 Methods and apparatus for diagnostic multispectral digital imaging  
Methods and apparatus for generating multispectral images of tissue. The multispectral images may be used as a diagnostic tool for conditions such as cervical cancer detection and diagnosis....
6762415 Vacuum chamber with recessed viewing tube and imaging device situated therein  
A vacuum chamber includes chamber walls separating a chamber interior and a chamber exterior, with one or more access ports defined in the chamber walls. A viewing tube extends from the chamber...
6762835 Fiber optic laser-induced breakdown spectroscopy sensor for molten material analysis  
A fiber optic laser-induced breakdown spectroscopy (LIBS) sensor, including a laser light source, a harmonic separator for directing the laser light, a dichroic mirror for reflecting the laser...
6762836 Portable laser plasma spectroscopy apparatus and method for in situ identification of deposits  
A portable Laser Plasma Spectroscopy (LPS) system and process is provided for performing in situ, near-real time, remote elemental analysis and identification of deposits or other foreign material...
6760105 Method and apparatus for inspecting DNA and method for detecting fluorescence  
A DNA sample added with a plurality of fluorescent marks is irradiated with excitation lights having a plurality of wavelengths and when fluorescence intensities are detected separately, the...