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6369894 |
Modular fluorometer
Described and claimed is a modular fluorometer and a method of using same to control an industrial water system, wherein said modular fluorometer comprises: one or more units with each unit...
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6366354 |
Diode laser based measurement apparatus
The instant diagnostic system includes a measurement device including a laser diode and communicatable with a computer. The diagnostic system further includes a memory medium readable by the...
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6366353 |
Method to determine the identity of a material in an object
A method and apparatus for determining an identity of at least one constituent on a soot that is deposited on a substrate is disclosed. The method includes the steps of sending a pulse of energy...
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6361956 |
Biospecific, two photon excitation, fluorescence detection and device
A method for measuring the end point and for monitoring the real time kinetics of a bioaffinity reaction in biological fluids and suspensions, employing microparticles as bioaffinity binding solid...
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6359687 |
Aerosol beam-focus laser-induced plasma spectrometer device
An apparatus for detecting elements in an aerosol includes an aerosol beam focuser for concentrating aerosol into an aerosol beam; a laser for directing a laser beam into the aerosol beam to form a...
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6351306 |
Optical measurement probe calibration configurations
Methods and apparatus are disclosed for calibrating remote optical probe configurations of the type wherein a spectrum emitted by a sample is delivered to a spectrograph for analysis using...
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6342397 |
Homogeneous biospecific assay using a solid phase, two-photon excitation and confocal fluorescence detection
A homogeneous biospecific assay method for an analyte in solution or in a biological suspension, in which a biospecific reagent competitively binding an analyte and a ligand labeled with a...
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6335984 |
Image processing method and apparatus for multiple spectrum image data
There are formed three kinds of virtual spectrum aperture images in which a weight is added to each spectrum channel image of multiple spectrum data, three kinds of characteristic virtual spectrum...
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6333499 |
Method of detecting a scanning start point, scanner, method of reading out image information, and image information reader
An image information reader capable of accurately performing reading in going and returning directions so that there is no pixel difference between image information read out in the going direction...
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6327493 |
Light scanning devices of a water-tight structure to be inserted into a body cavity to obtain optical information on inside of a biological tissue
A light scanning device has a tip structure which includes a light scanning part connected to a light source, and which is insertable into a body cavity and is formed so as to be water-tight. A...
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6320660 |
Sieving apparatus for a bio-chip
The invention is directed to a sieving apparatus for a bio-chip, which has a light source, a HOE unit, a splitter, an objective lens, a filter, and an optical signal sensor. The HOE unit is coupled...
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6317207 |
Frequency-domain light detection device
Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting...
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6312961 |
Optical sensor using an immunological reaction and a fluorescent marker
A biosensor comprises a waveguide into which light is coupled by a diffraction grating. The sample to be analyzed is placed on a reaction region in which a component of the immunological reaction...
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6304771 |
Systems and methods for imaging fluorophores
The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse...
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6290912 |
Read head for luminometer
The read head for luminometer includes a housing that encloses a cylindrical core. The housing has a through opening that aligns with a central passageway of the cylindrical core to define a...
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6280960 |
Optical detection and analysis of sub-micron particles
Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises and optically transparent substrate coated with a thin film of metal...
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6277651 |
Diode laser electrochemical sensor for detecting chemical and biological analytes
The present sensor allows the user of any diode laser structure to be employed to provide sensitive chemical and biological detector. A diode laser electrochemical sensor is described in U.S. Pat....
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6277653 |
Optical assaying method and system having movable sensor with multiple sensing regions
An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes...
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6278521 |
Method of and apparatus for bispectral fluorescence colorimetry
A novel modular bench-top bispectral fluorescence colorimeter and technique embodying in self-contained housing excitation and emission monochromator, preferably with fiber light guide...
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6278518 |
Centrifuging process for sample characterization
A process for characterizing at least one sample comprising at least one substance (S i ), in which at least one substance (S i ) in the sample is identified and in which at least one quantity (G...
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6243163 |
Wavelength detector
The present invention can accurately detect a wavelength of a light to be detected, which is output from a source of light to be detected, without an error even if there is a change in the...
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6232125 |
Method and apparatus for differentiating and enumerating leukocytes
A method and apparatus for differentiating and enumerating the five major sub-populations of leukocytes in a blood sample (i.e., lymphocytes, monocytes, eosinophils, neutrophils and basophils) uses...
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6229635 |
Light sensing device
The present invention relates to a light scanning device for exciting and detecting an emission of secondary light, especially fluorescent light, of a sample, comprising a light generating device...
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6222619 |
Diagnostic device and method
A method and apparatus of diagnosing a cardiac disease state in as little as two minutes involving the utilization of an evanescent wave assay system in conjunction with a data acquisition and...
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6194223 |
Method for the simultaneous determination of biomolecular interactions by means of plasmon resonance and fluoresence detection
A method for the detection of an analyte is described which is characterized in that the binding of the analyte to a solid phase is determined by the independent analysis of the signals from a...
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6190919 |
System for controlling deglycerolization of red blood cells
A system for controlling the deglycerolization of red blood cells includes a cell sorter having multiple fluid channels each having a unique cross-sectional area for directing a fluid mixture...
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6187592 |
Method for determining properties of red blood cells
A method for quantifying the concentration of hemoglobin in a cell, and indicia of anemia, comprises determining the wavelength of the longitudinal mode of a liquid in a laser microcavity;...
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6184990 |
Miniature multiple wavelength excitation and emission optical system and method for laser-induced fluorescence detectors in capillary electrophoresis
An optical apparatus for and method of improving collection efficiency and signal strength of optical instruments used in capillary electrophoresis, such as laser-induced fluorescence detectors are...
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6181413 |
Displacing volume in field of view
A method and assay system for the displacement of background from the area surrounding target material allows more sensitive detection. The invention is for use with a system in which specific...
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6177990 |
Optical substrate for enhanced detectability of fluorescence
A sample substrate for use in a fluorescence imaging system includes a rigid base with a specularly reflective surface, typically metal, on which is deposited a transparent coating layer. The...
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6172750 |
Method for determining spectral interference
There is provided a method or system that utilizes fluorescence in a sample that would otherwise yield inaccurate results due to spectrally interfering components. The system quantifies spectral...
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6166804 |
Method and apparatus for obtaining fluorescence data
In an exemplary embodiment, the apparatus includes an electromagnetic radiation source, an optical analyzer, and a fiber optic bundle. The fiber optic bundle has an excitation fiber in optical...
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6160618 |
Hyperspectral slide reader
An apparatus and method for analyzing samples on a slide comprising a slide mover positioned to hold a slide, a imaging spectrometer positioned in the path of light from the slide to split the...
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6154708 |
Method of processing and correcting spectral data in two-dimensional representation
The present method of processing spectral data calculates the first to fourth derivative spectra of an original spectrum with respect to the wavenumber and creates a two-dimensional representation...
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6154282 |
Semiconductor based excitation illuminator for fluorescence and phosphorescence microscopy
Apparatus for exciting a fluorescent or phosphorescent molecule applied to a specimen in a microscope, the molecule having a known excitation wavelength, comprises a semiconductor light source...
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6147754 |
Laser induced breakdown spectroscopy soil contamination probe
A LIBS cone penetrometer comprises a decoupling mirror to separate an excitation signal and a response signal, an optical fiber arranged with the decoupling mirror for receiving the excitation...
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6134002 |
Apparatus and method for the rapid spectral resolution of confocal images
A confocal scanning microscope apparatus and method is used to rapidly acquire spectrally resolved images. The confocal scanning microscope apparatus includes optics used to simultaneously acquire...
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6134001 |
Fluid diagnostic technique
A non-obstructive fluid diagnostic technique is described which enables the measurement of different parameters in a fluid. The diagnostic technique includes the steps of focusing a laser (10) in a...
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6124926 |
Defect detecting method and device
A defect detecting method and a defect detecting device are provided. An image is formed by scattered light and emitted light from a specimen when a laser beam enters the specimen, and the image is...
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6124928 |
Methods and apparatus for obtaining a selectively polarized induced emission
In an optical measurement system of the type wherein a source of excitation radiation is directed along an excitation path to stimulate an optical emission from a sample along a collection path,...
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6111641 |
Nonlinear spectrophotometer
The purpose of the nonlinear spectrophotometer is to provide a simple instrument that can be used on a routine basis to accurately measure the two-photon absorption (TPA) coefficient and...
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6110749 |
System for simultaneously conducting multiple ligand binding assays
A system for simultaneously conducting multiple ligand assays on a sample potentially containing target analytes uses as a detector a waveguide having a planar surface with a plurality of probes of...
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6111644 |
Interferometer for detecting and analyzing coherent radiation
Incoming optical radiation is divided into two focused beams with a relatively large amount of delay and shift introduced between the beams. Through the focusing of each of the beams to a different...
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6107101 |
Method for assaying photosensitizing drug in tissue
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength is determined by the steps of drawing...
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6094300 |
Laser scanning microscope
A laser scanning microscope having a first scanning optical system that causes coherent light projected from a first laser light source to scan a specimen, and a second scanning optical system that...
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6091843 |
Method of calibration and real-time analysis of particulates
A method of analyzing particles for chemical or biological species. Spectral images of the particles are acquired. Targets are identified in the images and are classified according to morphology...
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6088097 |
Point-scanning luminescent microscope
A point-scanning luminescent microscope, especially for studying biological objects, has at least one collimated light source for producing an excitation light beam, an optical arrangement which...
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6084669 |
Fluorescent light measuring device and an apparatus wherein such a device is used
A device for simultaneously and/or group-wise random measuring fluorescent light emitted by sample-reagent mixtures contained in a plurality of reaction vessels. In order to measure fluorescence...
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6078390 |
Scanning system and method of operation for automatically setting detection sensitivity
An optical scanning system uses a low-resolution scanning operation, to automatically adjust the sensitivity of the system. The system performs a low-resolution scanning operation by scanning a...
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6075593 |
Method for monitoring and controlling laser shock peening using temporal light spectrum analysis
A method for quality assurance of a laser shock peening process of workpieces includes measuring and recording or temporal light intensity data over a short period during the duration of a plasma...
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