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6693709 |
Photometric device
The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test...
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6692974 |
Analytical apparatus
A surface plasmon resonance apparatus for detecting a soluble analyte (e.g. a protein) or a particulate analyte (e.g. a cell), the apparatus comprising: (a) a sensor block adapted to receive a...
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6674058 |
Apparatus and method for focusing a laser scanning cytometer
The invention relates to a method and system for focusing a laser scanning cytometer. In the illustrative embodiment, during one cytometric measurement process, a single laser is used for focusing...
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6665061 |
Method and device for detecting variations of optical properties in a sample in and analysis process
The invention concerns a method which consists in performing for a time interval ranging between 1 ms and 10 ms a first turbidimetric measurement using a first light pulse originating from a first...
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6661511 |
Method and apparatus for enhanced laser-induced plasma spectroscopy using mixed-wavelength laser pulses
A sample of heterogeneous material is analyzed by directing a mixed-wavelength laser pulse at the sample to produce a plasma. The mixed wavelength pulse contains both shorter and longer wavelength...
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6661510 |
Device for detection of fluorescent species
A device for detection of one or several fluorescent species, said species being contained in a medium, said medium being contained in a conduit, said device comprising a means of exciting the...
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6657721 |
Method for quantitative analysis of atomic components of materials by LIBS spectroscopy measurements
A method based on the LIBS technique is described, which allows to determine, without calibration of the measurement system, the concentration of atomic components in solid, liquid and aerial...
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6657720 |
Spectrometer attachments and phosphorescence decay measurement
A spectrometry instrument, e.g., for time-resolved spectroscopy, has quick-change exchangeable accessories ( 48, 50, 52 ) which are manually attached via rotation of a camming means to engage and...
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6654119 |
Scanning spectrophotometer for high throughput fluroescence detection
A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a...
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6653152 |
Sensor disk having radial grooves and optical assaying method using same
An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes...
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6649361 |
Surface plasmon resonance enzyme sensor
A surface plasmon resonance enzyme sensor including a sensing part 6 having an optically transparent base 1 , a thin metal film 2 made of gold or silver, and a film 4 provided on the metal...
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6650411 |
System, method, and product for pixel clocking in scanning of biological materials
Systems and methods are described that may be applied to scanning biological materials in or on probe arrays. For example, a system is described that includes a scanner that has one or more...
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6643015 |
System, method, and product for symmetrical filtering in scanning of biological materials
An apparatus is described that includes an emission signal detector and an emission signal filter. An excitation beam scans an array of biological materials, and the emission signal detector...
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6636304 |
Laser induced fluorescence capillary interface
An optical scheme that substantially eliminates spherical aberration and coma, thereby substantially improving fluorescence excitation and collection efficiency. The optical scheme utilizes a laser...
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6629464 |
Laser shock peening quality assurance by acoustic analysis
A method for quality control monitoring of laser shock peening a surface of a production workpiece during which laser beam pulses form a plurality of corresponding plasmas. An acoustic signal of...
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6624887 |
Methods for determining the physiological state of a plant
The present invention provides methods for measuring a photosynthetic parameter. The methods of the invention include the steps of: (a) illuminating a plant leaf until steady-state photosynthesis...
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6621575 |
Method and device for analyzing molecular reaction products in biological cells
A large number of cells can be evaluated in terms of their reaction state with molecular reactants under near-field optical conditions in a measuring and evaluation procedure of the invention....
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6614525 |
Laser scanning microscope with single wavelength excitation
A laser scanning microscope, preferably a confocal laser scanning microscope, having a laser light source for illuminating a specimen and a detector for detecting the light returning from the...
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6603547 |
Method for determination of the radiation stability of crystals
The method for determining radiation stability of a crystal to radiation of a working wavelength to be employed in a subsequent application includes taking a first absorption spectrum (A) of a...
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6573107 |
Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy
The biosensor involves a specially designed surface which can be optically coupled to a Surface Plasmon Resonance spectrometer. The key components of the biosensor are a bimetallic layer, a self...
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6571118 |
Combined fluorescence and reflectance spectroscopy
Methods and apparatus for performing fluorescence and spatially resolved reflectance spectroscopy on a sample. A sample is irradiated with a fluorescence excitation fiber and radiation is collected...
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6567164 |
Entangled-photon microscope and confocal microscope
The invention discloses an entangled-photon microscope ( 1 ) having a light source ( 3 ) and an objective ( 31 ). The entangled-photon microscope ( 1 ) has a microstructured optical element ( 11 ),...
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6551451 |
Method for determining liquid content in chemical pulps using ramen spectrometry
A rapid method is provided for the on-line spectroscopic determination of lignin content and/or kappa number in wood pulps. Unlike currently available commercial instrumentation, the method enables...
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6545240 |
Metal scrap sorting system
A system for sorting randomly positioned, irregularly shaped scrap metal particles on a moving conveyor employs laser-induced breakdown spectroscopy (LIBS), and includes an image detector for...
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6538735 |
Method and apparatus for producing and measuring light and for determining the amounts of analytes in microplate wells
An apparatus for measuring light in samples using a high intensity light source, is presented. The system utilizes bifurcated fiber bundles to transmit light at the excitation and emission...
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6532068 |
Method and apparatus for depth profile analysis by laser induced plasma spectros copy
In a method of spectrochemical depth-profile analysis of heterogeneous materials, a first burst of ablation laser pulses in a first beam is directed at a sample to form an ablation crater. A second...
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6532067 |
Aerosol fluorescence spectrum analyzer for rapid measurement of single airborne particles
A method for fluorescence probing of particles flowing in a fluid includes defining a trigger volume in the fluid by intersecting a plurality of substantially orthogonally aimed trigger laser...
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6525812 |
Optical arrangement for a laser scanning microscope
An optical arrangement in the beam path of a laser scanning microscope, with at least one adjustable spectrally selective element ( 2 ) adjustable to the wavelength of the excitation light from a...
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6515743 |
Scanner-type fluorescence detection apparatus using small sized excitation light source
A fluorescence detection apparatus comprising: a sample holder for fixing and holding sample vessels on a circular arc; a partition plate being joined to drive means for rotation on the center of...
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6511854 |
Regenerable biosensor using total internal reflection fluorescence with electrochemical control
An improved electrochemical method for disassociating a biological binding partner from a corresponding second biological binding partner associated with a waveguide surface, the electrochemical...
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6504607 |
Light source power modulation for use with chemical and biochemical analysis
Systems and methods for analyzing a sample are disclosed. The system may include a light source operable to transmit light onto the sample, a detector operable to detect intensity of the light...
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6496267 |
Scanning microscope
A scanning microscope allowing fluorescence observation and morphological observation to be simultaneously performed on the same region of interest and permitting both a fluorescence observation...
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6486949 |
Method and apparatus for evaluating the quality of an optical crystal
A method for evaluating the quality of an optical material includes obtaining a fluorescence spectrum of the optical material, obtaining a fluorescence spectrum of a reference material having...
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6483582 |
Apparatus and methods for time-resolved spectroscopic measurements
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
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6466309 |
Method and apparatus for chemical and topographical microanalysis
A scanning probe microscope is combined with a laser induced breakdown spectrometer to provide spatially resolved chemical analysis of the surface correlated with the surface topography....
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6466316 |
Apparatus and methods for spectroscopic measurements
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
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6462345 |
Process and arrangement for confocal microscopy
A process for confocal microscopy is disclosed in which laser light is coupled into a microscope beam path, directed successively with respect to time onto different locations of a specimen, and an...
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6459484 |
Scanning optical apparatus
A scanning optical apparatus includes a light source unit, an objective lens, a scanning device, an imaging optical system, a confocal aperture, a plurality of photodetectors, a spectrum...
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6455861 |
Fluorescence polarization assay system and method
An instrument is disclosed for fluorescence assays which is capable of reading many independent samples at the same time. This instrument provides enhanced throughput relative to single-sample...
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6449039 |
Laser scanning fluorescence microscopy with compensation for spatial dispersion of fast laser pulses
In laser scanning microscope systems using short pulsed laser sources incorporating an acousto-optical deflector, compensation is provided for spatial dispersion introduced by the deflector....
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6436651 |
Optical diffraction biosensor
The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed...
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6433862 |
Method and device for treating samples
A method for analyzing a sample of a steel melt taken from a metallurgical vessel includes taking a sample in a measuring probe, inserting the measuring probe into a holder, and severing the...
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6426505 |
Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier
A low cost apparatus and method for measuring nanosecond luminescence lifetimes with a modulated LED light source that is driven by a lock-in amplifier. The lock-in amplifier provides both a DC...
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6420183 |
Masking background fluorescence and luminescence in optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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6400396 |
Displaced-beam confocal-reflection streak lindae apparatus with strip-shaped photocathode, for imaging very small volumes and objects therein
An imaging system for detecting the contents of a turbid medium which is at least partially transmissive of light. The system includes a light source for producing a series of discrete pulse beams...
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6399295 |
Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as...
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6388746 |
Method, apparatus and flow cell for high-sensitivity detection of fluorescent molecules
Method and apparatus for high-sensitivity fluorescence detection wherein (I) a sample comprising fluorescent molecules is made to flow through a channel structure ( 1 ) comprising a constricted...
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6384914 |
Method for optical detection of analyte molecules in a natural biological medium
In order to carry out optical detection and identification of individual tumor markers in undiluted blood plasma, said tumor markers are marked with fluorescent dyes which are characterized by...
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6379976 |
Determination of polymerization/coagulation in a fluid
An analytical method of qualitative and optionally quantitative determination of the occurrence of polymerization/coagulation in a fluid containing polymerizable/coagulable components is described....
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6377344 |
Adjustable coupling in and/or detection of one or more wavelengths in a microscope
A device for the adjustable coupling of wavelengths or wavelength regions into the illumination beam path of a microscope, preferably in the beam path of a confocal microscope, comprising at least...
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