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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7605922 |
Method and gas sensor for performing quartz-enhanced photoacoustic spectroscopy
A method for performing quartz-enhanced photoacoustic spectroscopy of a gas, includes providing a light source configured to introduce a laser beam having at least one wavelength into the gas such...
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7602494 |
Method of imaging fluorescence and fluorescence imaging apparatus
A method of imaging fluorescence, in which an inverted fluorescence imaging apparatus provided with an immersion objective is used to image an observation phosphor for a constant term, includes an...
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7602479 |
Light emission measuring apparatus and light emission measuring method
A light fluctuation measuring apparatus, comprising a parameter setting unit 2 which sets parameters of a microscopic image obtaining unit and/or parameters of a light emission measuring unit...
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7601539 |
Standard material for particle analyzer
A standard material that is used for judging an abnormal portion in a particle analyzer is described. The standard material comprises first standard particles to be fluorescence-stained by a...
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7599732 |
Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
According to one embodiment of the invention, a method for biomedical imaging includes directing time-varying excitation light at a surface area of a light scattering material, the material...
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7599060 |
Optical scanning configurations, systems, and methods involving at least one actuator for scanning a scan head
An optical system includes a sample substrate having a surface, the surface defining a 2-dimensional sample plane. The system includes an excitation source configured to provide excitation light to...
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7599059 |
Monitoring molecular interactions using photon arrival-time interval distribution analysis
A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more...
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7599058 |
Methods for plasma diagnostics and the measurement of thin films
Methods for obtaining and analyzing data from a spectral source is provided. The method includes identifying an environment that is capable of generating spectral information, and obtaining the...
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7583380 |
Spectroscopic analysis apparatus and method with excitation system and focus monitoring system
The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method....
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7582882 |
Solid state multi frequency fluorometric measurements system and method
A method of spectrographic measurement is disclosed. The method generates light energy using a solid state low capacitance excitation source, the light energy being caused to fall on a sample to be...
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7576862 |
Measuring time dependent fluorescence
Methods and apparatus, including computer program products, implementing and using techniques for collecting optical data pertaining to one or more characteristics of a sample. A light beam of a...
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7573571 |
Airborne particulate discriminator
A method and apparatus for rapid and accurate detection and discrimination of biological, radiological, and chemical particles in air. A suspect aerosol of the target particulates is treated with a...
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7573570 |
Compact Raman or fluorescence excitation system
A compact Raman and fluorescence spectroscopy system that uses a microprism or micromirror based optical structure to accomplish the introduction of excitation radiation with compactness and...
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7570988 |
Method for extraction of optical properties from diffuse reflectance spectra
An iterative process calculates the absorption and scattering coefficients of tissue from a set of diffuse reflectance measurements made with an optical spectrometer operating in the UV-VIS...
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7564621 |
Examination apparatus and focusing method of examination apparatus
A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe...
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7564550 |
Fluorescence polarization imaging devices and methods
The present invention is directed to a novel multi-spectral exogenous fluorescence polarization imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a...
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7557916 |
Spectroscopic system with multiple probes
The present invention provides a spectroscopic system for non invasive spectral analysis of substances or biological structures ( 114, 116 ) that are located in a plurality of various volumes of...
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7547508 |
Use of nanosecond scale, time-resolved, imaging to differentiate contemporaneous fluorescence responses from multiple substances
Time-dependent differences in fluorescence responses of normal surfaces of the fruit or vegetable as opposed to surfaces which are contaminated with feces, may be used for improved detection of...
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7545495 |
Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
The present invention relates to optical methods of observing, distinguishing and/or visualizing grown or nascent crystals of biological material within a biological sample.
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7545494 |
Analytical system and method for analyzing nonlinear optical signals
A method for the ultrasensitive simultaneous measurement of nonlinear optical emission signals in one or two local dimensions wherein excitation light is irradiated in modulated form from at least...
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7539115 |
Creating a permanent structure with high spatial resolution
In a method of creating a permanent structure with high spatial resolution, a substance which may be modified by an optical signal is provided in a writing area. The optical signal is applied to...
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7538941 |
Method and arrangement for positioning a structure to be imaged
The invention is directed to a method and a device for imaging structures either in the focal plane of the objective of a microscope or in the pupil of the objective or in the respective conjugate...
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7536213 |
Reduction in scattering from a turbid medium by photo-bleaching
A method is proposed whereby photo-bleaching is used not only to change the absorption and fluorescence of a sample but is also employed to change its scattering characteristics. When the compounds...
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7532326 |
Multiple-label fluorescence imaging using excitation-emission matrices
Methods and devices are disclosed which apply an excitation-emission matrix (EEM) to a heterogeneous, two-dimensional sample, allowing a considerably larger number of emitting, e.g. fluorescent,...
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7532325 |
Method and apparatus for the separation of fluoroscence and elastic scattering produced by broadband illumination using polarization discrimination techniques
An apparatus for separating fluorescent light from light elastically scattered/reflected from a material illuminated with a broadband illumination source includes a polarization discriminator,...
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7532323 |
Spatial light modulator apparatus and method
A device for discriminately illuminating a sample ( 22 ) to be viewed with excitation light ( 70 ). For example, an image taken with a CCD ( 10 ) provides feedback which is used to modulate the...
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7528949 |
Aerial-supported procedure for exploration of hydrocarbon deposits
The present invention refers to an aerial-supported procedure for the exploration of hydrocarbon deposits, especially crude oil and gas deposits, using fluorescence procedures, including...
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7528947 |
Nanoparticles functionalized probes and methods for preparing such probes
The present invention provides probes functionalized with nanoparticles, methods for binding nanoparticles to the probes and the use of such probes in nanometer scale imaging techniques. More...
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7525653 |
Spectroscopic chemical analysis methods and apparatus
Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor...
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7522271 |
Microarray detector and synthesizer
The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention...
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7515261 |
Capillary based optical measurement system
Provided is a system for characterizing biological/chemical test specimens. In particular, a container such as a tube or capillary for containing a test specimen is interconnected at one end to a...
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7511812 |
Aberration correction for spectroscopic analysis
A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of...
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7511811 |
Pulsed-multiline excitation for color-blind fluorescence detection
The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput...
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7508505 |
Apparatus and method for all-solid-state fluorescence lifetime imaging
Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique increasingly used in the life sciences during the past decades. An all-solid-state fluorescence-lifetime-imaging microscope (...
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7505131 |
Methods and systems for dynamic range expansion
Methods and systems for expanding the dynamic range of a system are provided. One method includes splitting fluorescent light emitted by a particle into multiple light paths having different...
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7502115 |
System and method for high sensitivity optical detection of gases
A method and apparatus architecture for detecting gases, particularly hazardous gases which should be detected in miniscule amounts. High sensitivity detection of chemical warfare agents (CWAs) is...
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7502113 |
Automated seed sampler and methods of sampling, testing and bulking seeds
An automated seed sampler includes a sampling station; a sampler for removing material from a seed in the sampling station; a seed conveyer for conveying the seed from the sampling station to a...
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7502107 |
Apparatus and method for transport of microscopic object(s)
A system and the method for transport of microscopic objects/particles involving the use of laser source operatively connected to a microscope objective which is adapted to generate optical focal...
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7499161 |
Depth-resolved spectroscopy method and apparatus
Methods and apparatus for depth-resolved spectroscopy. A ball lens may be used to redirect light from a fiber-optic probe so that the light intersects the detection region of a collection probe in...
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7499154 |
Readhead for optical inspection apparatus
A readhead for illuminating a sample carrier and receiving light from the sample carrier, including a housing for receiving a sample carrier, an array of light sources mounted within the housing in...
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7485875 |
Resolution-enhanced luminescence microscopy
A resolution-enhanced luminescence microscopy method, wherein a sample is excited so as to luminesce, and thus to emit a given luminescence radiation, by irradiation of exciting radiation and an...
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7480046 |
Scanning microscope with evanescent wave illumination
A scanning microscope includes a light source for evanescently illuminating a sample disposed on a slide. A point detector receives detection light emanating from a scanning point of the sample. A...
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7477380 |
Scanning microscope comprising a confocal slit scanner for imaging an object
A scanning microscope for imaging an object includes a light source and a spectrally selective detection device. An illumination beam path extends from the light source to the object. A detection...
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7474400 |
Multi-wavelength fluorometric system and probe for monitoring of bioprocesses
A fluorometric system for on-line monitoring of biological processes uses a plurality of light sources, each with a different spectral width, to illuminate a sample, the light sources selected to...
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7474399 |
Dual illumination system for an imaging apparatus and method
A dual illumination system is disclosed for use with an imaging apparatus. The imaging apparatus defines a light-tight imaging compartment with an interior wall having a view port extending into...
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7474398 |
Illumination system for an imaging apparatus with low profile output device
A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination...
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7466418 |
Fluorescence illumination assembly for an imaging apparatus and method
A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a...
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7466408 |
Measurement system
A measurement system that optically measures in turn a plurality of samples arranged in an array via an objective lens and an imaging lens is disclosed, which is characterized by comprising an...
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7463353 |
Modular, micro-scale, optical array and biodetection system
A modular, micro-scale, optical array and biodetection device for quantifying fluorescence intensities of a plurality of substantially separated, and dimensionally uniform elements of a bioarray...
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