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5469251 |
Apparatus for detecting fluorescence of particles in a fluid and analyzing the particles
An apparatus for analyzing particles at high precision capable of obtaining informations in real time such as morphological informations and fluorescence image of cells (particles) contained in a...
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5459325 |
High-speed fluorescence scanner
A high-speed fluorescence scanner for scanning a sample at equal angles is disclosed. The scanner has most of its optical components, including a light beam source, a detector, and various filters,...
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5444527 |
Imaging flow cytometer for imaging and analyzing particle components in a liquid sample
An imaging flow cytometer for capturing images and, analyzing particle components in a liquid sample containing particle components such as blood and urine, or microparticles such as organic high...
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5422726 |
Solid state spectrofluorimeter and method of using the same
The spectrofluorimeter according to the present invention advantageously uses a triggered xenon flash tube powered with a capacitor store and controlled by program instructions from a...
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5412465 |
Method for verification of constituents of a process stream just as they go through an inlet of a reaction vessel
A method for validating a process stream for the presence or absence of a substance of interest such as a chemical warfare agent; that is, for verifying that a chemical warfare agent is present in...
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5383023 |
Method and apparatus for performing dual-beam dual-wavelength fluorescence spectrophotometric evaluation of a biological specimen
A quantitative fluorescence technique is presented as "differential real-time fluorescence spectroscopy" (DRFS), pursuant to which one can simultaneously make time-resolved measurement of...
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5367474 |
Flow cytometer
A flow cytometer includes a plurality of detectors for providing voltage pulse signals over a four decade range as particles pass through an illuminated detection station. Each voltage pulse signal...
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5362653 |
Examination of objects of macromolecular size
In a method and apparatus for examining samples comprising individual objects (28) of macromolecular or similar size, or smaller, an instrument element (14) comprises a substrate (16) overlaid with...
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5355215 |
Method and apparatus for quantitative fluorescence measurements
Measurement of the fluorescence of a layer of cells, disposed in a well, with supernatant liquid thereabove, is greatly enhanced in sensitivity by illuminating the cell layer with a beam of light...
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5353790 |
Method and apparatus for optical measurement of bilirubin in tissue
A method and apparatus for the determination of bilirubin concentration in tissue such as skin, particularly neonatal skin. Light reflected from the skin under test is analyzed to determine...
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5341805 |
Glucose fluorescence monitor and method
A glucose monitor, and related method, determines the concentration of glucose in a sample by monitoring fluorescent light produced directly by any glucose present in the sample. The glucose...
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5327225 |
Surface plasmon resonance sensor
An optical fiber surface plasmon resonance (SPR) sensor includes both a metal layer and an overlay or underlay material on its surface. Existing fiber based SPR devices are inherently incapable of...
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5322798 |
Method for carrying out surface plasmon resonance measurement and sensor for use in the method
In a method for carrying out a surface plasmon resonance (SPR) measurement a beam of electromagnetic radiation is directed through a part transparent to it onto a surface of a material layer having...
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5317162 |
Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses
A flow cytometer measures phase fluorescence lifetimes by the phase shift of a reference signal and an emission from a particle or cell in a flow chamber. An acoustic optic modulator modulates...
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5306385 |
Method for generating photoluminescence emission lines from transition element doped CAF2 thin films over a Si-based substrate
A method and apparatus for producing photoluminescence emissions (68) from thin CaF 2 films grown on either silicon or silicon/aluminum substrate shows narrow emission linewidth and high emission...
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5306144 |
Device for detecting dental caries
A device for detecting dental caries has an illumination device which emits radiation of a pre-determined wavelength towards a tooth. A filter accepts radiation returned by the tooth in a...
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5302349 |
Transient-state luminescence assay apparatus
Light, pulsed or continuous at a particular wavelength (e.g. 780 nm), fluoresces a specimen. The specimen may be combinations of an antigen (e.g. rubella) labelled with a fluorescent dye, unlabeled...
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5300423 |
Specific binding assay involving separation of light emissions
This invention uses the evanescent wave detection of particles to distinguish bound from free in an analyte-binding assay. Illumination below the critical angle is employed, and a beveled window is...
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5280333 |
Apparatus and a method for testing documents
In an apparatus for testing documents, the optical illuminating unit comprises at least one light guide provided with fluorescent substance for directing at least two light fractions of different...
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5268304 |
Method of determining the concentration of a chemical of interest in a solution
A method determines the concentration of a chemical of interest in a solution. A permeable membrane is placed in the solution and a ligand is exuded through the membrane to continually renew the...
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5260029 |
Fluorescence detection of DNA bases
To assure detection of fluorescence produced from continuously supplied fine particles such as DNA bases with accuracy and excellent efficiency, fine particles supplied from a flow cell are...
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5257202 |
Method and means for parallel frequency acquisition in frequency domain fluorometry
A digital frequency domain fluorometer utilizing a computer-controlled digital data acquisition system is use for the study of fluorescence and phosphorescence phenomena in the bio-chemical,...
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5256880 |
Process for the qualitative analysis of plastic particles
A process and apparatus for the qualitative analysis of particles of various kinds of plastic which comprises passing said particles serially in a predetermined path, irradiating each particle with...
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5212099 |
Method and apparatus for optically measuring concentration of an analyte
Apparatus and method in which a beam of radiant energy (16) is passed into a medium at a wavelength selected to cause a response of an analyte in the medium or of a sensor (10,14) exposed to the...
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5212386 |
High speed cross-correlation frequency domain fluorometry-phosphorimetry
Apparatus for cross-correlation frequency domain fluorometry and/or phosphorimetry in which means are provided for sequentially performing runs of the cross correlation frequency domain fluorometry...
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5203923 |
Apparatus for painting highway markings
A method and apparatus for painting traffic marking lines over old paint markings on road pavement is disclosed. The apparatus, normally installed on a marking vehicle having a paint gun and a...
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5200064 |
Fuel contamination detector
A fuel contamination detection system for use in testing the contamination level of a fuel sample, wherein the system is selectively operable in a first mode as a particulate detector and in a...
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5152962 |
Immunoassay apparatus
An assay apparatus employing total internal reflection of excitation radiation at the interface between a replaceable optically conductive assay device and a surrounding liquid phase containing the...
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5151869 |
Frequency domain fluorometry using coherent sampling
Apparatus and methods for measuring response of a chemical composition to light, as by frequency domain, phase angle, or modulation fluorometry and/or phosphorimetry. Pulsed light having a known...
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5148031 |
Device for obtaining spatial and time characteristics of a weak optical radiation from an object
A device for obtaining spatial and time characteristics of a weak optical radiation from an object comprises an optical pulsed radiator for irradiating the test object, a photoelectronic multiplier...
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5127729 |
Method and apparatus for guiding and collecting light in photometry or the like
A method and an apparatus for guiding and collecting light which issues from a light source and which is passed in the form of an incident primary beam to a specimen or like material to be measured...
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5128102 |
Probe for measuring oxygen concentration
A probe for measuring oxygen concentration including an immobilized polypyridine metal complex, which can be used for measurement of oxygen concentration even in a case where the exciting ray to be...
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5128019 |
Device for measuring chemical and physical parameters of a liquid or gaseous medium
In order to reduce the measuring volume in a device for measuring chemical and physical parameters of liquid or gaseous media by means of optical sensor elements whose optodes may be replaced...
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5118608 |
Optical assay technique
An assay technique for qualitative and quantitative detection of a chemical, biochemical or biological detection of a chemical, biochemical or biological species in sample. The technique comprises:...
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5108932 |
Process for the quantitative determination of at least one parameter of a liquid or gaseous sample
For the simultaneous measurement of two parameters of a liquid or gaseous sample, in a fluorescence measuring device in which the influence of the aging processes of the indicator substance and the...
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5095213 |
Method of using an opaque plastic microscope slide for epi-fluorescent microscopy
Disclosed is a novel microscope slide. The slide of this invention is a plastic microscope slide which is optically opaque and substantially non-fluorescent. The slide of this invention has...
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5037763 |
Article coated with cured material and methods of making
An article such as a drawn optical fiber (21) or an array of optical fibers is provided with a curable coating material. The array of optical fibers may be held together with a curable matrix...
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5026991 |
Gaseous species absorption monitor
A wavelength-locked laser gaseous species monitor including a variable wavelength laser with a laser output actively stabilized to a wavelength at or near an absorption wavelength of the species...
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5018865 |
Photon scanning tunneling microscopy
A method and apparatus for photon scanning tunneling microscopy for examining a sample in a sample area on a surface at a subwavelength resolution is disclosed. The method comprises generating a...
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RE33581 |
Immunoassay using optical interference detection
Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of...
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4937457 |
Picosecond multi-harmonic fourier fluorometer
A frequency domain spectrofluorometer employing extrinsically modulated DC light sources or intrinsically modulated laser pulse trains, containing multiple, harmonically related, phase-locked...
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4907883 |
High-temperature laser induced spectroscopy in nuclear steam generators
An apparatus and method for conducting optical spectroscopy in a hostile environment comprises a light source, e.g., a laser or an incandescent light connected to a multiplexer for supplying high...
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4893259 |
Standardization of spectral lines
A method and apparatus for standardizing spectral line intensities in a spectral monochromator separate an input beam into a sample spectral line characteristic of a sample element, a reference...
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4892640 |
Sensor for the determination of electrolyte concentrations
An ion-selective electrode for determining an electrolyte concentration in an aqueous solution includes an ion-selective layer and a potential-sensitive fluorescent indicator in the ion-selective...
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4882288 |
Assay technique and equipment
An assay technique for the qualitative and/or quantitative detection of a chemical, biochemical or biological species in a sample comprising (a) coating at least a predetermined part of a...
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4880752 |
Dielectric waveguide sensors and their use in immunoassays
The present invention relates to novel dielectric waveguide (i.e., fiber optic) sensors for use in spectrophotometric assays of analytes in fluids. More particularly, the use of these sensors in...
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4865424 |
Optical device with adjusting means
Apparatus is provided to sense and measure solar-induced luminescence, as well as reflectance, within the field of view of a target window for receiving a composite ray of light from the target. A...
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4840485 |
Frequency domain cross-correlation fluorometry with phase-locked loop frequency synthesizers
Frequency domain cross-correlation fluorometers may be improved over present designs by providing a coherent signal at one frequency to means for detecting luminescence from a sample, which is...
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4834945 |
High resolution cinephotographics system pressure vessel
A propellant sample combustion apparatus employing a multiply optical ported pressure vessel for sample illumination, sample viewing, and sample burn face elevation is described. High-speed motion...
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4822167 |
Laser fluorometric detector for microcolumn chromatography
A laser fluorometric detector for microcolumn chromatography includes the following optically connected components: a laser, a cylindrical telescope, an adjustable diaphragm which has the shape of...
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