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5914779 |
Portable flash lamp reflectance analyzer system and method
The system and method allow spectroscopic analysis of vegetation or the like without effects from changing sun and cloud conditions, undesired portions of the area of interest or atmospheric...
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5910661 |
Flourescence sensing device
A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of an optical filter, which is positioned on a photodetector...
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5905570 |
Remote electro-optical sensor system for water quality monitoring
An improved water quality monitoring system and method. The system utilizes reflectance radiometers to provide multiple wavelength measurement of downwelling irradiance and/or upwelling radiance....
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5895764 |
Controlled sheath flow injection cytometry
A flow cytometry method and system to regulate both the sheath and sample streams during the period of sample injection. The period of turbulence between the streams is reduced to approximately 100...
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5894347 |
Fluorimeter and detection method
A method and fluorimeter for flashing a target at several different levels for detection of fluorescence by a PMT without blinding the PMT at the highest level. Two lamps are provided each of which...
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5891658 |
Single-step, solid-state competitive immunoassay
Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit...
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5885840 |
Multiple assays of cell specimens
A method for increasing the accuracy and the types of data measurements of laser scanned dye stained cells, in a single sample, by means of multiple assays, utilizing cell positions as a factor in...
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5883711 |
Method and device for selecting low-pressure mercury discharge lamps
The invention relates to a method of selecting low-pressure mercury discharge lamps each provided with a discharge vessel which supports a luminescent layer on an inner surface, by which method the...
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5882940 |
Method for assaying photosensitizing drug in plasma
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength, is determined by the steps of...
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5880474 |
Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
A multi-laser flow-cytometry system provides for inter-location emissions crosstalk cancellation, through either pulse subtraction or gating, to avoid false triggering based on shadow (pre- and...
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5876672 |
Transient state luminescene assay apparatus
Light, pulsed or continuous at a wavelength (e.g. 780 nm), fluoresceces a specimen. The specimens may be combinations of a dye (preferably labelled), an antigen (e.g. rubella) and an antibody...
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5865754 |
Fluorescence imaging system and method
A system and method non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique consists of a modulated light source (120) coupled to tissue (100) of a...
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5863790 |
Biological sterility indicator
A system is used for determining efficacy of a sterilization cycle. A biological sterility indicator exhibits fluorescence in response to biological activity which is indicative of bacterial growth...
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5858799 |
Surface plasmon resonance chemical electrode
This disclosure describes new methods and devices for sensing redox-active analytes in solution. The invention combines a surface plasmon resonance (SPR) sensor and a chemical electrode sensor. A...
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5858800 |
Optical measurement method and apparatus thereof
An exciting light 2 is introduced within a slab-type optical waveguide 1, an evanescent wave due to the exciting light 2 excites fluorescent light, and among the fluorescent light, a fluorescent...
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5854063 |
Method and apparatus for spectrophotometric observation of plants
An instrument is described for making both fluorometric and spectrophotometric images of plants. The instrument includes two sources of electromagnetic radiation, optical components to direct the...
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5851835 |
Multiparameter hematology apparatus and method
A multi-parameter hematology analyzer and method are provided for in vitro determination of blood parameters. The analyzer apparatus includes a laser for transmitting light through a specimen...
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5846834 |
Method for assaying photosensitizing drug in whole blood
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength, is determined by the steps of...
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5840582 |
Method for determining the hydrogen-to-carbon ratio in a liquid hydrocarbon fraction and use thereof
In a first embodiment of the invention, a method for determining the hydrogen-to-carbon ratio of a liquid hydrocarbon fraction is presented. A sample of the liquid fraction is subjected to an...
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5830766 |
Enhanced signal-to-noise ratio and sensitivity optical immunoassay
A method of assaying for a ligand in a sample involves incubating the sample in contact with a specific binding partner for the ligand carried on one surface of an optical structure, irradiating...
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5822060 |
Method of detecting sample substances and fluorescence spectrometer using the method
A method of detecting sample substances separated by an analytical separation technique, for example liquid chromatography or capillary electrophoresis, using electromagnetic radiation, and a...
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5811312 |
Optical measurement apparatus and method therefor
An optical measurement apparatus includes a reaction vessel 2 which is formed in one body with a slab-type optical waveguide 1, and the apparatus adds fine-grains or water soluble dye for absorbing...
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5787888 |
Absorption tomography system and method using direct reconstruction of scattered radiation
A method for the direct reconstruction of an object from measurements of the transmitted intensity of diffusively scattered radiation effected by irradiating the object with a source of continuous...
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5770454 |
Method and aparatus for determining an analyte in a biological sample
A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two...
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5757013 |
Fluorescence decay measurement by calculation of inner product
An apparatus and its accompanying method measures fluorescence decay, fluorescence amplitude and fluorescence polarization. The instrument includes a light emitting diode or laser diode light...
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5757014 |
Optical detection device for analytical measurement of chemical substances
In the optical detection device (1), the excitation light guide (11) and the emission light guide (12) form a structural unit having the end face (14) facing the fluorescence changer (4). The end...
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5745231 |
Method of fluorescence analysis comprising evanescent wave excitation and out-of-plane photodetection
Fluorescence measuring methods and apparatus use planar optical waveguides to excite fluorescence in the evanescent field of the waveguides and photodetectors to sense the fluorescence produced....
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5741714 |
Detection of bound analyte by magnetic partitioning and masking
A method and apparatus for determining qualitatively or quantitatively the presence of analyte bound to a separation media without doing a bound/free separation. In the method, the bound fraction...
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5738997 |
Method of assay of enzymatic activity and apparatus therefor
Method of assay of enzymatic activity, comprising projecting excitation light to a sample containing an enzyme, a substrate which forms a product by action of the enzyme, and a reference substance...
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5737077 |
Apparatus and method for time resolved spectroscopy
A time resolved spectroscopy system and method are provided using digital processing techniques of a low power, continuous wave signal generated by a continuous wave light source, such as a cw...
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5724151 |
Waveguide sensing element for use in a sample medium and method of rear-firing electromagnetic radiation
A waveguide sensing element has a substrate having an input opening adapted to house an input optical fiber and an output opening adapted to house an output optical fiber. The input optical fiber...
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5719666 |
Particle analyzer classifying particles of various biological types using a correlation of measurements
A particle analyzer includes a flow cell including first and second cells for containing an electrolyte with various types of biological particles floating therein. The first and second cells are...
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5716850 |
Monitoring the colour and bitterness of beer
A method of determining one or both of the colour and bitterness of beer by illuminating the beer with light of a pre-determined wavelength, typically 400±30 nm, to cause iso-α-acids in the beer...
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5713364 |
Spectral volume microprobe analysis of materials
An optical probe collects light responses from a specimen that selectively and preferentially emanates from a localized volume element within the sample, with illumination irradiance and collection...
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5689110 |
Calibration method and apparatus for optical scanner
A calibration method and device for a fluorescence spectrometer which uses fluorescence from a homogeneous solid state standard as the source of calibration fluorescence and wherein the solid state...
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5631170 |
Method for improving measurement precision in evanescent wave optical biosensor assays
A method for improving measurement precision in an optical biosensor assay for a ligand in a sample is described. The method involves referencing the assay with an artificially raised background...
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5596414 |
Solid state spectroflourimeter and method of using the same
The spectrofluorimeter according to the present invention advantageously uses a triggered xenon flash tube powered with a capacitor store and controlled by program instructions from a...
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5578499 |
Homogeneous immunoassay system employing fourier transform infrared spectroscopy
The present invention relates to an homogeneous immunoassay system for the determination of an antibody or an antigen in a sample which consists of an interferometric signal emitted from an...
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5561069 |
Surface plasmon resonance detector having collector for eluted ligate
An improved surface plasmon resonance detector, capable of recovering a desired eluted ligate, permits the isolation and characterization of novel ligates and ligands.
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5559037 |
Method for rapid and simultaneous analysis of nucleated red blood cells
A method and a device for the simultaneous and quantitative, flow cytometric analysis of nucleated red blood cells (NRBC) and white blood cells (WBC) in a whole blood sample. The method includes...
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5537207 |
Process for determining carbon black concentration and distribution in rubber compounds and other carbon black containing materials and device to carry out the process
To determine the carbon black distribution two measurements of spectral intensities of separately produced plasmas are carried out with different time delays relative to a particular laser pulse,...
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5528045 |
Particle analyzer with spatially split wavelength filter
A fluorescence particle analyzer includes a flow tube through which particles marked with different fluorochromes pass from a first location to a second location. Emissions from the first and...
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5515161 |
Calibration device for fluorescence photometers
A calibration device is disclosed for use with fluorescence photometers of the type which direct an excitation radiation at a sample to be tested, and then read the fluorescent emission from the...
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5512490 |
Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
The present invention is an optical detection and identification system and provides an optic sensor, an optic sensing apparatus and methodology for detecting and evaluating one or more analytes or...
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5498875 |
Signal processing for chemical analysis of samples
A method and apparatus determines the analyte content of a sample by generating first and second input signals and directing the input signals to the sample. The input signals differ in wavelength...
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5492840 |
Surface plasmon resonance sensor unit and its use in biosensor systems
Methods for functionalizing sensing surfaces to be used in systems for measuring simultaneously several properties of one biomolecule as well as for simultaneously measuring the concentrations of a...
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5488473 |
Method of and apparatus for increasing measurement sensitivity of fluorescence and luminescence
A technique and apparatus for increased sensitivity fluorescence and luminescence emission measurements in which the emission volume is enclosed in a closely fitting cavity having highly reflecting...
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5480775 |
Method for measuring a specimen by the use of fluorescent light
A method of and an apparatus for measuring a specimen by the use of fluorescence light which has the step of dyeing the specimen with a fluorescence dye, the step of applying light to the dyed...
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5478755 |
Long range surface plasma resonance immunoassay
A method of assaying for a ligand in a sample involves incubating the sample in contact with a specific binding partner for the ligand carried on one surface of an optical structure, irradiating...
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5476511 |
Subconjunctival implants for ocular drug delivery
A system for providing controlled release of an active agent in an eye includes a device with a shape thereof for enabling placement of the device under a conjunctiva of an eye and additionally...
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