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6361956 |
Biospecific, two photon excitation, fluorescence detection and device
A method for measuring the end point and for monitoring the real time kinetics of a bioaffinity reaction in biological fluids and suspensions, employing microparticles as bioaffinity binding solid...
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6342397 |
Homogeneous biospecific assay using a solid phase, two-photon excitation and confocal fluorescence detection
A homogeneous biospecific assay method for an analyte in solution or in a biological suspension, in which a biospecific reagent competitively binding an analyte and a ligand labeled with a...
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6320660 |
Sieving apparatus for a bio-chip
The invention is directed to a sieving apparatus for a bio-chip, which has a light source, a HOE unit, a splitter, an objective lens, a filter, and an optical signal sensor. The HOE unit is coupled...
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6317207 |
Frequency-domain light detection device
Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting...
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6315955 |
Method and apparatus for quantitative particle determination in fluids
The present invention includes a method and an apparatus for the quantitative determination of particles in fluid. The apparatus of the invention includes an emitters set of one or more light...
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6312961 |
Optical sensor using an immunological reaction and a fluorescent marker
A biosensor comprises a waveguide into which light is coupled by a diffraction grating. The sample to be analyzed is placed on a reaction region in which a component of the immunological reaction...
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6310687 |
Light detection device with means for tracking sample sites
Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio. These apparatus and methods may involve among others moving an sample substrate (108) while...
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6300639 |
Process and arrangement for the device configuration of confocal microscopes
A process for the device configuration of confocal microscopes, preferably of laser scanning microscopes is disclosed, in which laser light with one or more spectral lines is generated and directed...
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6290912 |
Read head for luminometer
The read head for luminometer includes a housing that encloses a cylindrical core. The housing has a through opening that aligns with a central passageway of the cylindrical core to define a...
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6280960 |
Optical detection and analysis of sub-micron particles
Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises and optically transparent substrate coated with a thin film of metal...
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6277653 |
Optical assaying method and system having movable sensor with multiple sensing regions
An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes...
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6245508 |
Method for fingerprinting utilizing an electronically addressable array
A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out...
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6232125 |
Method and apparatus for differentiating and enumerating leukocytes
A method and apparatus for differentiating and enumerating the five major sub-populations of leukocytes in a blood sample (i.e., lymphocytes, monocytes, eosinophils, neutrophils and basophils) uses...
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6222619 |
Diagnostic device and method
A method and apparatus of diagnosing a cardiac disease state in as little as two minutes involving the utilization of an evanescent wave assay system in conjunction with a data acquisition and...
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6221602 |
Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities....
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6219144 |
Apparatus and method for measuring the refractive index and optical path length effects of air using multiple-pass interferometry
Apparatus and methods particularly suitable for use in electro-optical metrology and other applications to measure and monitor the refractive index of a gas in at least one measurement path and/or...
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6219566 |
Method of measuring concentration of luminescent materials in turbid media
The present invention provides a method for measurement of concentration of fluorophores in turbid media. The method uses a fluorescence plus reflectance technique to measure quantitatively the in...
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6211989 |
Light-scanning device
A light scanning device for exciting and detecting secondary light, especially fluorescent light, on a sample, comprising a light emission device for emitting exciting light with a wavelength...
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6211954 |
Integrated optical luminescence sensor
An integrated-optical luminescence sensor having an excitation light beam with a first optical axis (k ein ), a planar waveguide (1), a sample interacting with the evanescent field thereof, and a...
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6207392 |
Semiconductor nanocrystal probes for biological applications and process for making and using such probes
A semiconductor nanocrystal compound is described which is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in...
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6198869 |
Measuring device and its use
A device comprising a planar optical waveguide, consisting of a transparent carrier (40) and a wave-guiding layer (41), wherein the waveguide at least has a diffractive element (42) for coupling...
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6191847 |
Fixed optic sensor system and distributed sensor network
A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various...
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6190919 |
System for controlling deglycerolization of red blood cells
A system for controlling the deglycerolization of red blood cells includes a cell sorter having multiple fluid channels each having a unique cross-sectional area for directing a fluid mixture...
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6177990 |
Optical substrate for enhanced detectability of fluorescence
A sample substrate for use in a fluorescence imaging system includes a rigid base with a specularly reflective surface, typically metal, on which is deposited a transparent coating layer. The...
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6160617 |
High resolution imaging microscope (HIRIM) and uses thereof
The invention pertains to a high resolution imaging microscope, and more specifically, to a digital imaging spectrophotometer (DIS) configured to enable the direct determination of the ground state...
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6157442 |
Micro optical fiber sensor device
A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip...
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6154282 |
Semiconductor based excitation illuminator for fluorescence and phosphorescence microscopy
Apparatus for exciting a fluorescent or phosphorescent molecule applied to a specimen in a microscope, the molecule having a known excitation wavelength, comprises a semiconductor light source...
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6144448 |
Fluorescence detecting apparatus
A fluorescence detecting apparatus which allows highly precise measurement of fluorescence even with minute sample amounts, which has a strong responsiveness to temperature variations, which allows...
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6139831 |
Apparatus and method for immobilizing molecules onto a substrate
Apparatus and method for immobilizing molecules, particularly biomolecules such as DNA, RNA, proteins, lipids, carbohydrates, or hormones onto a substrate such as glass or silica; patterns of...
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6124928 |
Methods and apparatus for obtaining a selectively polarized induced emission
In an optical measurement system of the type wherein a source of excitation radiation is directed along an excitation path to stimulate an optical emission from a sample along a collection path,...
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6111248 |
Self-contained optical sensor system
A self-contained optical sensor (5) with a device platform (7) and an encapsulating light transmissive housing (9) formed therein is disclosed in conjunction with several sensor configurations...
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6111641 |
Nonlinear spectrophotometer
The purpose of the nonlinear spectrophotometer is to provide a simple instrument that can be used on a routine basis to accurately measure the two-photon absorption (TPA) coefficient and...
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6110749 |
System for simultaneously conducting multiple ligand binding assays
A system for simultaneously conducting multiple ligand assays on a sample potentially containing target analytes uses as a detector a waveguide having a planar surface with a plurality of probes of...
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6107101 |
Method for assaying photosensitizing drug in tissue
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength is determined by the steps of drawing...
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6097485 |
Microchip optical transport technology for use in a personal flow cytometer
An ultra-miniature personal flow cytometer (pFCM) for the measurement of laser-induced fluorescence. The pFCM is approximately the size of a fluorescent microscope and includes a miniature optical...
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6094300 |
Laser scanning microscope
A laser scanning microscope having a first scanning optical system that causes coherent light projected from a first laser light source to scan a specimen, and a second scanning optical system that...
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6071748 |
Light detection device
A high-throughput light detection instrument and method are described. Confocal optics structure enables exclusive light detection from a sensed volume in a composition.
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6066245 |
Method and apparatus for scanning fluorescently labeled particles
A system and method for illuminating an optically active sample and collecting scattered light emitted by the sample. Preferably, the sample is a fluorescently labeled and fluoresces light. The...
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6067156 |
Wavelength calibration and tracking methods and apparatus
Calibration wavelengths are injected into an optical detection system preferably at a point after laser rejection filtration, enabling the known spectral content of the calibration radiation to...
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6049380 |
Single molecule identification using selected fluorescence characteristics
Single fluorescent molecules in a flowing sample stream are distinguished and identified using only a single laser excitation wavelength. A sample stream is formed containing a dilute mixture of...
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6034768 |
Induced breakdown spectroscopy detector system with controllable delay time
The invention relates to high power, spark induced breakdown spectroscopy (SIBS) detectors with controllable delay time and to spark induced breakdown spectroscopy plasma generators with dual...
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6030828 |
Microsensor and use of such microsensor
The invention relates to a microsensor for determining the concentration of a primary substrate by measuring the concentration of a secondary substrate. The microsensor comprises a transducer (1)...
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6008894 |
Remote adjustable focus Raman spectroscopy probe
A remote adjustable focus Raman spectroscopy probe allows for analyzing Raman scattered light from a point of interest external probe. An environmental barrier including at least one window...
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5994150 |
Optical assaying method and system having rotatable sensor disk with multiple sensing regions
An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes...
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5981958 |
Method and apparatus for detecting pathological and physiological change in plants
An imaging fluorometer is described comprising a source of electromagnetic radiation, optical components to direct the radiation, excitation and emission filters, and an imaging device. The...
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5973330 |
Fluorescence detection apparatus
A fluorescence detection apparatus is provided which has a partial reflection mirror 8 for transmitting a part of fluorescence light emitted from a fluorescent substance by projecting excitation...
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5951838 |
Method and apparatus for correcting illumination non-uniformities
A method and apparatus for achieving uniform illumination in an electrophoresis apparatus is provided. Uniform illumination allows quantitative measurements of an electrophoresis gel to be made,...
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5933232 |
Fluorimeter
A fluorimeter has a flash lamp, a measurement station with a receiver for microtitration plates, at least one measurement head disposed at the receiver and an evaluation station having a detector....
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5925884 |
Fluorescence station for biological sample testing machine
A sample card transport station moves a test sample card from an incubation station for the card to a transmittance and fluorescence optical station in a sample testing machine. The sample card...
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5919710 |
Optical method for quantitating dissolved oxygen in fuel
A method for the quantitative determination of dissolved oxygen in a liquid fuel includes the steps of doping a sample of the fuel with a preselected concentration of a probe material including a...
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