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7616304 |
System and method for providing a tunable optical parametric oscillator laser system that provides dual frequency output for non-linear vibrational spectroscopy and microscopy
A system is disclosed for providing a first electromagnetic field and a second electromagnetic field to vibrational analysis equipment that is responsive to a difference between first and second...
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7609378 |
Structure for supporting sample to be subjected to surface enhanced vibrational spectroscopic analysis and method of manufacturing the same
A structure for supporting a sample to be subjected to a surface enhanced vibrational spectroscopic analysis includes a substrate, a ground film formed on the substrate, and a base formed on the...
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7609377 |
Surface enhanced raman spectroscopy with periodically deformed SERS-active structure
An apparatus and related methods for facilitating surface-enhanced Raman spectroscopy (SERS) is described. A SERS-active structure near which a plurality of analyte molecules is disposed is...
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7609376 |
Method and apparatus for pixel display and SERS analysis
Irradiation devices and methods of amplification and irradiation are disclosed for displaying pixels and Surface Enhanced Raman Spectroscopy (SERS) analysis. The devices include an optical...
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7609370 |
Single detector based dual excitation wavelength spectra display
A single detector based spectroscopy system using FAST (fiber array spectral translator) fibers and two excitation sources in conjunction with a holographic spectrum analyzer (HSA) to obtain...
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7605916 |
Online analyte detection by surface enhanced Raman scattering (SERS)
Devices and methods for separating and detecting analytes in a sample. The separation can be accomplished utilizing capillary electrophoresis (CE) or high-performance liquid chromatography (HPLC)....
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7602488 |
High-speed, rugged, time-resolved, raman spectrometer for sensing multiple components of a sample
A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. The system additionally is compact, environmentally rugged, low cost...
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7599732 |
Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
According to one embodiment of the invention, a method for biomedical imaging includes directing time-varying excitation light at a surface area of a light scattering material, the material...
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7599066 |
Localized plasmon resonance sensor
A localized plasmon resonance sensor for detecting a change in optical constant uses a structure including metal. In a response spectrum with respect to light incident on the structure, there are...
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7599057 |
Method and apparatus for detection of biological organisms using Raman scattering
A system for the detection of compounds, including a target biological organism or component from a sample, using one or more reactant that will bind to the biological organism or compound forming...
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7599056 |
Method, structure, and apparatus for Raman spectroscopy
Disclosed herein are a Raman spectroscopy structure comprising a porous material substrate, and a method of performing Raman spectroscopy of a sample disposed adjacent to the structure comprising...
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7595882 |
Hollow-core waveguide-based raman systems and methods
Embodiments of the invention include a system for sensing homonuclear diatomic molecules, such as, for example, nitrogen. Other embodiments include a method for sensing homonuclear diatomic...
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7595877 |
Low profile spectrometer and raman analyzer utilizing the same
A spectrometer comprising a collimating element for receiving input light and collimating the same, a dispersive optical element for receiving light from the collimating element and dispersing the...
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7595873 |
Rapid spatial averaging over an extended sample in a Raman spectrometer
An optical method and apparatus is utilized to provide rapid spatial averaging over a large sample area in a Raman spectrometer, without defocusing of the optical source or the collection optics....
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7595872 |
Analyzer for nanostructured substrate for surface enhanced Raman scattering
A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of...
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7588827 |
Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof
Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among...
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7586603 |
Method and apparatus for improved signal to noise ratio in Raman signal detection for MEMS based spectrometers
A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to...
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7586602 |
Method and apparatus for improved signal to noise ratio in Raman signal detection for MEMS based spectrometers
A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to...
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7586601 |
Applications of laser-processed substrate for molecular diagnostics
Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and...
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7583379 |
Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a virus, bacterium, or other infectious agent, are provided. A spectroscopic assay...
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7583378 |
Spectrograph calibration using known light source and Raman scattering
A method is provided for calibrating a spectrometer device used for Raman scattering analysis. A predetermined dispersion curve for a diffraction grating or spectrograph of the spectrometer device...
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7582473 |
Apparatus and method for analyzing bacteria
An apparatus for analyzing bacteria is described that includes an analyte sample preparing section for preparing an analyte sample from a specimen; a detector for detecting optical information from...
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7580126 |
Method and apparatus for producing a streaming Raman image of nucleation, aggregation, and chemical interaction
The present disclosure describes methods and apparatus to produce a streaming image of a sample during a time period when an attribute of the sample is changing. The streaming image can be viewed...
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7576854 |
Arrays of nano structures for surface-enhanced raman scattering
Disclosed herein is a SERS sensing surface device comprising a substrate supporting a plurality of nano structures, an exposed sensing surface upon the nano structures, wherein said surface...
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7573577 |
Spatial heterodyne wide-field Coherent Anti-Stokes Raman spectromicroscopy
Methods for chemically-resolved optical microscopy are presented. The methods can provide a wide-field, spatial interference imaging using multiple nonlinear scattering channels to produce...
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7573570 |
Compact Raman or fluorescence excitation system
A compact Raman and fluorescence spectroscopy system that uses a microprism or micromirror based optical structure to accomplish the introduction of excitation radiation with compactness and...
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7570358 |
Angularly resolved scatterometer, inspection method, lithographic apparatus, lithographic processing cell device manufacturing method and alignment sensor
An angularly resolved scatterometer uses a broadband radiation source and an acousto-optical tunable filter to select one or more narrowband components from the broadband beam emitted by the source...
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7570356 |
System and method for classifying cells and the pharmaceutical treatment of such cells using Raman spectroscopy
A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman...
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7570355 |
Nanowire heterostructures and methods of forming the same
A NERS-active structure is disclosed that includes at least one heterostructure nanowire. The at least one heterostructure nanowire may include alternating segments of an NERS-inactive material and...
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7570349 |
Cars/absorption dual mode electro-optic sensor
A target gas sensing system includes a single source at a first location for generating two light beams having first and second frequencies wherein the difference between the first and second...
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7564549 |
Carbon nanotube nanometrology system
The present invention provides systems and methods for quantifying, purifying and separating fullerenes, such as single wall carbon nanotubes (SWNTs). The purification/separation combination...
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7564548 |
Low pixel count tunable laser raman spectroscopy system and method
A Raman system uses a semiconductor tunable laser subsystem to generate a tunable signal that is tuned over a scan band of greater than 50 nanometers. A probe system transmits the tunable signal to...
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7564547 |
Spectroscopy system
Systems and techniques for improved spectroscopy. In some embodiments, mechanical and/or optical zoom mechanisms may be provided for monochromator systems. For example, movable detector systems...
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7564546 |
Dynamic imaging of biological cells and other subjects
The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic...
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7564541 |
System for obtaining images in bright field and crossed polarization modes and chemical images in raman, luminescence and absorption modes
An integrated system including one or more light sources, at least one processor, an optical lens, a two-dimensional tunable filter, one or more two-dimensional array of detection elements and...
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7561264 |
System and method for the coincident deposition, detection and identification of threat agents
A system and method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is identified substantially coincident in time with the depositing of the sample of the...
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7560285 |
Micelle-controlled nanoparticle synthesis for SERS
The methods and apparatus disclosed herein concern nanoparticle layers uniformly distributed on a surface or substrate. In certain embodiments of the invention, the nanoparticle layers are of use...
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7557915 |
Automated acquisition of spectral data and image data
A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching...
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7549338 |
Nanostructure sensor of presence and concentration of a target molecule
Method and system (i) to determine when a selected target molecule is present or absent in a fluid, (2) to estimate concentration of the target molecule in the fluid and (3) estimate possible...
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7548311 |
Method and apparatus for conducting Raman spectroscopy
A Raman probe assembly comprises: a light source for generating laser excitation light; a camera for capturing an image; a light analyzer for analyzing a Raman signature; and a light path for (i)...
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7548310 |
Method and apparatus for compact spectrometer for multipoint sampling of an object
The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or...
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7545495 |
Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
The present invention relates to optical methods of observing, distinguishing and/or visualizing grown or nascent crystals of biological material within a biological sample.
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7545493 |
Raman spectroscopic apparatus utilizing internal grating stabilized semiconductor laser with high spectral brightness
A Raman spectroscopic apparatus utilizing a broad stripe semiconductor laser as the excitation light source is provided. The output spectrum of the semiconductor laser is narrowed and stabilized by...
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7542138 |
Sample container and system for a handheld spectrometer and method for using therefor
A container for holding a sample and a system and method for a handheld spectrometer using the container is disclosed. In one embodiment, the container includes a vial with an optical window at the...
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7542137 |
Pathogen detection using coherent anti-stokes Raman scattering microscopy
The invention provides a system and method for automatic real-time monitoring for the presence of a pathogen in water using coherent anti-stokes Raman scattering (CARS) microscopy. Water sample...
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7542132 |
Raman spectroscopy as integrated chemical metrology
A method for measuring the concentration of the metal solution and reducing agent solution within the electroless plating solution is disclosed. Raman spectroscopy is used to measure the...
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7541600 |
Lithographic and measurement techniques using the optical properties of biaxial crystals
A method and apparatus for accurately retrieving the position of an optical feature. The method uses the optical properties of biaxial crystals to conically refract the optical feature and...
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7538869 |
Multipoint method for identifying hazardous agents
The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman...
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7533000 |
Method and apparatus for analysing a dataset of spectra
A method of analyzing a dataset of spectra is provided in which each spectrum has a count value for each of a number of parameter values within a parameter range. The method is for identifying one...
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7532321 |
Compositions and methods for the detection of water treatment polymers
Compositions and methods utilizing Raman Spectroscopy to detect and determine, directly or indirectly, the concentration of water treatment polymers in water or methods for measuring or quantifying...
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