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7428046 Trace chemical optical probe  
New and improved applications of Raman Scattering are disclosed. These applications may be implemented with or without using an enhanced nano-structured surface that is trademarked as the...
7428045 Raman spectral analysis of pathogens  
Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using...
7426322 Plasmon photocatalysis  
Plasmons on a waveguide may deliver energy to photocatalyze a reaction. The waveguide or other energy carrier may be configured to carry electromagnetic energy and generate plasmon energy at one or...
7426025 Nanostructures, systems, and methods including nanolasers for enhanced Raman spectroscopy  
Nanostructures configured to enhance the intensity of Raman scattered radiation scattered by an analyte include a substantially planar substrate, a plurality of nanoparticles disposed on a surface...
7420679 Method and apparatus for extended hyperspectral imaging  
The disclosure relates to method and apparatus for obtaining a multimodal hyperspectral image of a sample for widefield spectral analysis. An apparatus according to one embodiment may include a...
7420672 Method and apparatus for conducting Raman spectroscopy  
Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light...
7417095 Method and apparatus for monitoring polyolefin production  
The present technique provides for the use of spectroscopic probes, such as Raman probes, within the conduits of a polyolefin production system. The Raman probe or other spectroscopic probes may be...
7414717 System and method for detection and identification of optical spectra  
A spectral correlator comprises a specimen and an optical device configured to collect light from the specimen and to optically determine a similarity of a received first spectra of the light...
7411672 Method and apparatus for chemical imaging in a microfluidic circuit  
The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which...
7411671 Technique for analyzing biological compounds in a non-destructive mode  
A medium is analyzed for the search for an odorous biological molecule characteristic of a specific substance in an environment to be studied comprising the steps of: exposing a component...
7411670 Collection probe for use in a Raman spectrometer system and methods of making and using the same  
A photonic crystal based collection probe is provided. The probe includes a photonic crystal configured to guide and condition a beam of Raman scattered photons. Further, the device includes a...
7408636 Method and apparatus for dark field chemical imaging  
The disclosure is generally directed to a method and apparatus for providing an image of a sample. The apparatus includes an illuminating source for transmitting photons to a sample. The...
7408635 Optical measurement method and device  
An optical measurement of a crystalline sample to be measured. The sample is irradiated with an exciting light from the polarization direction in which the Raman scattering is prohibited by the...
7406217 Plasmon photocatalysis  
Plasmons on a waveguide may deliver energy to photocatalyze a reaction. The waveguide or other energy carrier may be configured to carry electromagnetic energy and generate plasmon energy at one or...
7405822 Systems and methods for detection of Raman scattered photons  
Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having...
7403282 Coherently controlled nonlinear Raman spectroscopy and microscopy  
A method and system are presented for producing an output coherent anti-stokes Raman scattering (CARS) signal of a medium. The method comprises generation of a unitary optical excitation pulse that...
7403281 Raman spectrometer  
A system, method and apparatus for taking a Raman spectrum of a sample is disclosed. In one embodiment, for example, an integrated Raman spectrometer is provided. In another embodiment, a portable...
7403273 System and method for the deposition, detection and identification of threat agents using a phase mask  
A system method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is illuminated via an illumination source along an optical path with a plurality of photons...
7400941 Method and apparatus for monitoring polyolefin production  
The present technique provides for the use of spectroscopic probes, such as Raman probes, within the conduits of a polyolefin production system. The Raman probe or other spectroscopic probes may be...
7400395 Metal coated nanocrystalline silicon as an active surface enhanced raman spectroscopy (SERS) substrate  
The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute...
7398119 Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals  
A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the...
7397559 Surface plasmon enhanced Raman spectroscopy  
An apparatus and related methods for spectroscopic analysis of analyte molecules is described. The analyte molecules are disposed near a metallic film that is positioned between a first medium on a...
7397558 Ordered array of nanoparticles for efficient nanoenhanced Raman scattering detection and methods of forming the same  
Methods of forming NERS-active structures are disclosed that include ordered arrays of nanoparticles. Nanoparticles covered with an outer shell may be arranged in an ordered array on a substrate...
7394542 Method and apparatus for chemical imaging in a microfluidic circuit  
The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which...
7391511 Raman signal-enhancing structures and Raman spectroscopy systems including such structures  
A Raman signal-enhancing structure includes a substrate and a plurality of protrusions located at predetermined positions relative to a surface of the substrate. Each protrusion includes a Raman...
7391000 EMCCD detector, as well as a spectrometer and a microscope having an EMCCD detector  
An EMCCD detector includes a first gain register and a photoactive area divided into at least a two detection regions. At least one of the detection regions is assigned to the first gain register.
7388668 Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy  
A system is disclosed for detecting a non-linear coherent field induced in a sample volume. The system includes a first source for generating a first electromagnetic field at a first frequency, a...
7388661 Nanoscale structures, systems, and methods for use in nano-enhanced raman spectroscopy (NERS)  
NERS-active structures for use in Raman spectroscopy include protrusions extending from a surface of a substrate. A Raman signal-enhancing material is disposed on at least one surface of a first...
7385692 Method and system for fiber optic determination of gas concentrations in liquid receptacles  
A system for determining gas compositions includes a probe, inserted into a source of gaseous material, the probe having a gas permeable sensor tip and being capable of sending and receiving light...
7385691 Integrated modular system and method for enhanced Raman spectroscopy  
Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source...
7379179 Raman spectroscopic methods for component particle analysis  
The invention relates to methods of assessing one or more geometric properties of a particle of a substance using a Raman spectroscopic property of the substance. The method is useful, for example,...
7372562 Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing  
A system for performing nanostructure-enhanced Raman spectroscopy (NERS) includes a radiation source, a radiation detector configured to detect Raman scattered radiation scattered by an analyte,...
7365839 Process and compositions for synthetic calibration of bio-photonic scanners  
A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The...
7362431 Non-invasive identification of fluorescent dyes in historic textiles by matrix transfer-surface enhanced Raman scattering  
A new process is presented to non-invasively identify organic dyes in historic textiles and other works of art. A small gel bead loaded with a SERS substrate is used to gently extract microscopic...
7362430 Raman spectrometry apparatus  
The invention concerns a Raman spectrometry apparatus containing a source of excitation ( 14 ), optical means ( 16 ) of excitation directing a beam of excitation ( 15 ) derived from that source on...
7362426 Raman and photoluminescence spectroscopy  
Systems and techniques for contemporaneous Raman and photoluminescence spectroscopy. Light that has interacted with a sample is dispersed to separate wavelength components, including Raman and...
7359585 Plasmon photocatalysis  
Plasmons on a waveguide may deliver energy to photocatalyze a reaction. The waveguide or other energy carrier may be configured to carry electromagnetic energy and generate plasmon energy at one or...
7359048 Raman signal-enhancing structures and devices  
Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing...
7359040 Simultaneous capture of fluorescence signature and raman signature for spectroscopy analysis  
A system and method are provided for analyzing a substance using spectroscopy techniques. Raman scattered energy and fluorescence scattered energy are simultaneously excited in the substance from a...
7356446 Method and apparatus for analyzing multi-channel chromatogram  
A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First,...
7355704 Chemical and biological sensing using metallic particles in amplifying and absorbing media  
A film for surface enhanced raman scattering may be utilized for chemical and biological sensing. The film includes a polymeric layer, and a metallic nanoparticle having a cross-section, the...
7355703 Raman-active lateral flow device and methods of detection and making  
A lateral flow device is disclosed. The lateral flow device includes a substrate having a flow path and a detection zone disposed along the flow path. The detection zone includes an immobilized...
7355702 Confocal observation system  
A confocal observation system, comprising, an image acquisition unit for acquiring optical cross sectional images of a three-dimensional specimen, a three-dimensional image construction unit for...
7352469 Quantum resonance analytical instrument  
Quantum resonance fluorescent microscope systems for detecting component substances in a specimen are described. The systems are based on exciting the sample containing the material with a...
7352458 System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses  
A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first...
7351588 Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS  
An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are...
7342656 Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing  
A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle....
7339666 Light-amplifying structures and methods for surface-enhanced Raman spectroscopy  
Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface...
7336351 Laser remote sensing of backscattered light from a target sample  
A laser remote sensing apparatus comprises a laser to provide collimated excitation light at a wavelength; a sensing optic, comprising at least one optical element having a front receiving surface...
7333190 Raman interrogation of threat aerosols  
A system and method are provided for detecting non-fluorescing aerosol particles of biological origin within ambient background aerosol particles using Raman spectroscopy.