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6380547 |
Tagging compositions and methods
A process for marking an article in a manner which is optically invisible and difficult to detect. The process is carried out by selecting a laser luminophore which fluoresces in a predetermined...
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6377346 |
Sample imaging device
An imaging device for biochemical or medical samples, the pulse mode light source of which incorporates flash lamps and a rotating mirror in an inclined position, the said mirror reflecting the...
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6377842 |
Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
A fiber optic based probe has been designed to sample the fluorescence or phosphorescence signal from animal or human tissues, such that the light intensity is not multiply scattered. This type of...
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6373069 |
Method for evaluating an epitaxial wafer for a light emitting device, recording medium readable by a computer and epitaxial wafer for a light emitting device
An evaluating method capable of quickly measuring the essential lifetime in an epitaxial wafer for a light emitting device independently from the excited carrier density without breaking the...
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6369894 |
Modular fluorometer
Described and claimed is a modular fluorometer and a method of using same to control an industrial water system, wherein said modular fluorometer comprises: one or more units with each unit...
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6365904 |
System and method of heat signature verification/authentication of an object
The validity or authenticity of a latent illuminance material is established by heating or cooling the material to a predetermined temperature and then determining its decay time constant at that...
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6366354 |
Diode laser based measurement apparatus
The instant diagnostic system includes a measurement device including a laser diode and communicatable with a computer. The diagnostic system further includes a memory medium readable by the...
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6361956 |
Biospecific, two photon excitation, fluorescence detection and device
A method for measuring the end point and for monitoring the real time kinetics of a bioaffinity reaction in biological fluids and suspensions, employing microparticles as bioaffinity binding solid...
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6362487 |
Method and device for nondestructive detection of crystal defects
The nondestructive detection and characterization of crystal defects in monocrystalline semiconductor material is by a combination of photoluminescence heterodyne spectroscopy, photothermal...
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6352672 |
Apparatus for measuring the luminescence emitted in a luminescent assay
The present invention relates to an apparatus for measuring the luminescence emitted in a luminescent assay, which makes it possible to correct certain perturbations due to the measuring medium.
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6351306 |
Optical measurement probe calibration configurations
Methods and apparatus are disclosed for calibrating remote optical probe configurations of the type wherein a spectrum emitted by a sample is delivered to a spectrograph for analysis using...
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6344653 |
Multi-photon laser microscopy
A laser scanning microscope produces molecular excitation in a target material by simultaneous absorption of three or more photons to thereby provide intrinsic three-dimensional resolution....
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6342701 |
Time correlated photon counting
A system for time-correlated photon counting. The system uses one or more photon detectors to produce electrical pulses corresponding to photons read from a target. The system uses a discriminator...
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6342397 |
Homogeneous biospecific assay using a solid phase, two-photon excitation and confocal fluorescence detection
A homogeneous biospecific assay method for an analyte in solution or in a biological suspension, in which a biospecific reagent competitively binding an analyte and a ligand labeled with a...
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6335531 |
Modification of resist and/or resist processing with fluorescence detection
The detectability of photoresist is enhanced through the addition of materials to enhance the fluorescence of photoresist such that residual photoresist that either does not fluoresce or fluoresces...
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6333507 |
System for measuring concentration of chemical composition of fluid
A system is designed to measure the concentration of a specific chemical composition of a fluid and is formed of a light generating device, a fluorescent light receiver, and a display. The light...
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6329660 |
Method of deriving sunlight induced fluorescence from radiance measurements and devices for executing the method
To derive sunlight induced fluorescence from radiance measurements, a first radiance measurement is taken inside an atmospheric absorption band, and an additional radiance measurement is taken...
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6323495 |
Method and apparatus for the determination of phase delay in a lifetime fluorometer without the use of lifetime standards
A method for measuring the fluorescent lifetime of an unknown fluorescent sample, such as a biological liquid, without the requirement of manual intervention or a separate reference standard. An...
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6320660 |
Sieving apparatus for a bio-chip
The invention is directed to a sieving apparatus for a bio-chip, which has a light source, a HOE unit, a splitter, an objective lens, a filter, and an optical signal sensor. The HOE unit is coupled...
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6321111 |
Optical imaging using time gated scattered light
The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of...
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6320196 |
Multichannel high dynamic range scanner
A method and apparatus for reducing the crosstalk between two or more dye channels in a multiple frequency laser induced fluorescence scanner in which two laser beams and associated optics are...
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6317207 |
Frequency-domain light detection device
Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting...
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6316774 |
Optical system for a scanning fluorometer
A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells...
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6313471 |
Scanning fluorometer
A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells...
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6310354 |
Method and a device for monitoring nucleic acid amplification reactions
A method for quantitatively measuring nucleic acid amplification reactions, especially the polymerase chain reaction, employing microparticles as hybridization solid phase, a probe sequence labeled...
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6310687 |
Light detection device with means for tracking sample sites
Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio. These apparatus and methods may involve among others moving an sample substrate (108) while...
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6304771 |
Systems and methods for imaging fluorophores
The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse...
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6300639 |
Process and arrangement for the device configuration of confocal microscopes
A process for the device configuration of confocal microscopes, preferably of laser scanning microscopes is disclosed, in which laser light with one or more spectral lines is generated and directed...
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6300638 |
Modular probe for total internal reflection fluorescence spectroscopy
An instrument for total internal reflection fluorescence spectroscopy having modular probe that inexpensively monitors vapors and liquid-phase analytes under field conditions is described. The...
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6296749 |
System and method for chromatography and electrophoresis using circular optical scanning
A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of...
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6297509 |
Device and method for detecting fluorescent and phosphorescent light
The apparatus has an illuminating device for illuminating sheet material with clocked excitation light. Both during the light phase of clocked excitation light and during the dark phase of clocked...
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6295123 |
Multiple photon absorption for high resolution lithography
Conventional optical lithography has a lower limit of about 180 nm because the projection system is opaque to radiation of wavelength shorter than this. This limitation has been overcome by using,...
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6284546 |
Method and device for photodetection
The present invention provides methods and apparatus for mixing two or more liquids and detecting light emitted by the mixture. The method comprises forming a liquid droplet containing two or more...
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6274872 |
Process and device for carrying out quantitative, fluorescence affinity tests
A process and device are disclosed for carrying out in particular quantitative fluorescence immunity tests by means of evanescent field excitation, possibly on the basis of various known...
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6274873 |
Spectrum analyzer for reading authentication marks
A spectrum analyzer determines the light emission characteristics of an authentication mark that is invisible when illuminated with visible light but is visible when illuminated with IR light. The...
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6271042 |
Biochip detection system
A biochip detection system detects and locates samples that are labeled with multiple fluorescent tags and are located on a biochip. This biochip detection system includes a charge coupled device...
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6262423 |
Scanning microscope in which a sample is simultaneously and optically excited at various points
An optical apparatus, especially a scanning microscope (1), wherein an expanded laser beam (2) is divided into several partial beams (4) by micro lenses (5) arranged next to one another. Each...
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6259104 |
Superresolution in optical microscopy and microlithography
In scanned optical systems such as confocal laser microscopes wherein a beam of light is focused to a spot in a specimen to excite a fluorescent species or other excitable species in the spot, the...
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6254831 |
Optical sensors with reflective materials
Provided is an optical sensor including a support and a detection layer, wherein the detection layer includes: (a) a luminescent material wherein the luminescence intensity of the luminescent...
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6255659 |
Method and apparatus for passive optical dosimeter comprising caged dye molecules
A new class of ultraviolet dosimeters is made possible by exposing caged dye molecules, which generate a dye molecule on exposure to ultraviolet radiation, to an exterior environment. Applications...
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6252235 |
Apparatus for imaging fluorescent particles
An apparatus for imaging fluorescent particles comprises an imaging vessel having a lower section defining an interior space for containing fluorescent particles, the lower section having a side...
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6252236 |
Method and apparatus for imaging a sample on a device
A method and apparatus for imaging a sample are provided. An electromagnetic radiation source generates excitation radiation which is sized by excitation optics to a line. The line is directed at a...
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6246061 |
Counterfeit-resistant materials and a method and apparatus for authenticating materials
Fluorescent dichroic fibers randomly incorporated within a media provide an improved method for authentication and counterfeiting protection. The dichroism is provided by an alignment of...
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6235535 |
Fluorescent energy transfer ligand interaction assay on a lipid film
This invention relates to a fluorescence-based immunoassay method for the detection of an analyte, or for the measurement of its concentration in a biological sample. The method is based on the...
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6232608 |
Optimization systems in a scanning fluorometer
A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells...
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6225625 |
Signal detection methods and apparatus
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6225635 |
System and method for optically locating microchannel positions
A system and method is disclosed for optically locating a microchannel position. A laser source generates a primary laser beam which is directed at a microchannel plate. The microchannel plates...
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6225636 |
Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
Techniques for acquiring and analyzing M-FISH images in a manner that allows for proper image registration; and techniques for combining a plurality of registered images to provide labeled images....
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6211953 |
Vessel for imaging fluorescent particles
A vessel for imaging fluorescent particles comprises a tubular body having an upper section, and a lower section defining an interior space for containing fluorescent particles. The lower section...
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6211954 |
Integrated optical luminescence sensor
An integrated-optical luminescence sensor having an excitation light beam with a first optical axis (k ein ), a planar waveguide (1), a sample interacting with the evanescent field thereof, and a...
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