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6555826 |
Apparatus for illuminating a specimen and confocal fluorescence scanning microscope
An apparatus for illuminating a specimen ( 1 ), preferably in confocal fluorescence scanning microscopy is disclosed. Two illumination beam paths ( 2, 4 ) are combined with a beam splitter ( 6 ) in...
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6552787 |
Rapid non-destructive screening methods for polymeric coatings and materials
This invention provides a method for the rapid determination of the light-induced degradation of polymeric materials and coatings. In a preferred embodiment of this method, samples are exposed to...
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6545276 |
Near field optical microscope
A light illumination portion illuminates light to a sample surface. A probe has a tip which is smaller than the wavelength of light illuminated by the light illumination portion, the tip is...
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6545264 |
Systems and methods for high performance scanning
The present invention provides a scanning confocal microscope image detection system having a simple and inexpensive objective lens and a high acceleration/high speed voice coil driven translation...
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6545758 |
Microarray detector and synthesizer
The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention...
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6542691 |
Glass capillary array for fluorescence analysis and manufacturing method thereof
A glass capillary array for fluorescence analysis is provided which is capable of preventing reduction of the transmittance of a laser beam through the glass capillaries during electrophoretic DNA...
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6537829 |
Up-converting reporters for biological and other assays using laser excitation techniques
The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with...
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6534774 |
Method and apparatus for evaluating the quality of a semiconductor substrate
A first chopper between a laser device and a semiconductor substrate chops an excitation light at a specific frequency, and a second chopper between the first chopper and the semiconductor...
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6528318 |
Scatter controlled emission for optical taggants and chemical sensors
Sensors and/or taggants feature high optical gain materials which are disposed in a high scattering environment. These materials, when adequately excited, emit intense and spectrally narrow light...
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6528802 |
Method for optical excitation of fluorophore marked DNA and RNA
A method for optical excitation of fluorophore-labeled DNA and fluorophore-labeled RNA, particularly of specific localizations of DNA and RNA labeled by fluorescence in situ hybridization (FISH)....
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6529271 |
Method of finding, recording and evaluating object structures
A method of finding, recording and optionally evaluating object structures, especially on slides, preferably of fluorescent object structures such as gene spots. A microscope with a CCD camera, a...
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6521899 |
Arrangement for the adjustment of laser power and/or pulse length of a short pulse laser in a microscope
An arrangement for the adjustment of laser power and/or pulse length in a microscope, wherein a specimen is excited to nonlinear fluorescence, preferably two-photon fluorescence, by radiation by...
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6521050 |
Methods for evaluating advanced wafer drying techniques
Methods for evaluating advanced wafer drying techniques are provided. An exemplary method includes applying a solution containing an analytically detectable compound to a substrate prior to a...
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6515743 |
Scanner-type fluorescence detection apparatus using small sized excitation light source
A fluorescence detection apparatus comprising: a sample holder for fixing and holding sample vessels on a circular arc; a partition plate being joined to drive means for rotation on the center of...
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6509960 |
Method and apparatus employing external light source for endpoint detection
A method and apparatus for endpoint detection for the stripping of a particular material, such as photo-resist material, from a substrate surface. A beam of light is projected onto the substrate...
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6503711 |
Nucleic acid biosensor diagnostics
A biosensor for direct analysis of nucleic acid hybridazation by use of an optical fiber functionalized with nucleic acid molecules and fluorescence transduction is disclosed. Nucleic acid probes...
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6491871 |
System for determining receptor-ligand binding affinity
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6492646 |
Method of and apparatus for obtaining fluorescence image
Exciting light is projected onto a specimen such as an organic body, and an intensity in at least one wavelength range of fluorescence emitted from the specimen upon excitation by the exciting...
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6486949 |
Method and apparatus for evaluating the quality of an optical crystal
A method for evaluating the quality of an optical material includes obtaining a fluorescence spectrum of the optical material, obtaining a fluorescence spectrum of a reference material having...
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6481886 |
Apparatus for measuring pedestal and substrate temperature in a semiconductor wafer processing system
Apparatus for measuring wafer support assembly temperature in a semiconductor wafer processing system. The apparatus is a modular plug that is mounted to the support assembly. The plug contains a...
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6483582 |
Apparatus and methods for time-resolved spectroscopic measurements
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
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6471916 |
Apparatus and method for calibration of a microarray scanning system
A microarray scanning system for conducting microarray experiments on a planar substrate includes an excitation radiation source, a detection system, and a computational device, the planar...
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6469305 |
Radiation image sensor
A radiation image sensor has a scintillator panel and an imaging device, and the scintillator panel comprises a radiation-transparent substrate, a deliquescent scintillator formed on the substrate,...
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6464852 |
Multicapillary bundle for electrophoresis and detection for DNA
A multichannel electrophoretic cassette structure is disclosed comprising distinct regions for loading and detection with different spacing between channels. A method and an apparatus are further...
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6466316 |
Apparatus and methods for spectroscopic measurements
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
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6462345 |
Process and arrangement for confocal microscopy
A process for confocal microscopy is disclosed in which laser light is coupled into a microscope beam path, directed successively with respect to time onto different locations of a specimen, and an...
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6455861 |
Fluorescence polarization assay system and method
An instrument is disclosed for fluorescence assays which is capable of reading many independent samples at the same time. This instrument provides enhanced throughput relative to single-sample...
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6449039 |
Laser scanning fluorescence microscopy with compensation for spatial dispersion of fast laser pulses
In laser scanning microscope systems using short pulsed laser sources incorporating an acousto-optical deflector, compensation is provided for spatial dispersion introduced by the deflector....
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6444992 |
High throughput microscopy
An apparatus for high resolution, high throughput, three-dimensional fluorescence microscopy with a rotatable circular disc for mounting samples to be viewed and multiple CCDs and beam splitters as...
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6441379 |
Imaging system for an optical scanner
An imaging system comprises a radiation device for providing excitation radiation of at least two different wavelengths, an objective lens for focusing the excitation wavelengths onto a sample to...
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6441380 |
Coding and authentication by phase measurement modulation response and spectral emission
A method of coding and authentication includes the steps of irradiating a sample with a harmonically modulated radiation and detecting a component of an emission of the sample in response where the...
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6441892 |
Compact spectrofluorometer
Spectrofluorometer employing a pair of linear variable spectral filters to produce a three dimensional data output is disclosed. A collimated white light source is used that first passes through a...
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6437345 |
Sensing unit provided with separated detection light guiding
An optical sensing unit is provided which comprises at least one sample measurement cell, at least one excitation light source acting upon the or each measurement cell to provide one or more sensor...
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6433345 |
Fluorescence observing apparatus
A fluorescence observing apparatus including a light source for emitting excitation light, an excitation light irradiation section for irradiating the excitation light to a sample, and a...
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6429936 |
Synchronous multiwavelength fluorescence system
A multichannel system for synchronizing independently driven filter wheels. The system is comprised of a means for controlling operation of the system by providing appropriate instructions. A clock...
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6429968 |
Apparatus for photoluminescence microscopy and spectroscopy
In accordance with the teachings of the present invention, it has been discovered that an optical analysis that is uniquely based on geometrical rather than diffraction considerations, for the...
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6426505 |
Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier
A low cost apparatus and method for measuring nanosecond luminescence lifetimes with a modulated LED light source that is driven by a lock-in amplifier. The lock-in amplifier provides both a DC...
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6424421 |
Method and devices for measuring distances between object structures
The invention concerns a method and devices for far field microscopy and flow fluorometry for geometric distance measurements between object structures, i.e. measurement structures, marked with...
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6420183 |
Masking background fluorescence and luminescence in optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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6407395 |
Portable biochip scanner device
A portable biochip scanner device used to detect and acquire fluorescence signal data from biological microchips (biochips) is provided. The portable biochip scanner device employs a laser for...
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6407383 |
Method and device for determining the oil concentration in liquids by means of fluorescence excitation with an excimer lamp
The present invention relates to a method and a device for fluorescence measurement of oil residues in water. The core of the invention is to use a powerful, narrow-band excimer lamp to excite...
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6403957 |
Nucleic acid reading and analysis system
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6403970 |
Matrix biochip sensing system
The matrix biochip sensing system of this invention uses a low-cost LED (light emit diode) matrix as the light source for the sensing system. The matrix biochip sensing system comprises an LED...
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6391354 |
Apparatus and method for selecting and separating out sprouted kernel
An apparatus of the present invention for selecting and separating out sprouted kernel comprises: a light source for emitting light in a predetermined wavelength region to an object kernel; an...
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6392248 |
Method and apparatus for color radiography, and color light emission sheet therefor
A color radiography system comprises a color light emission sheet having a phosphor layer that contains a phosphor emitting in a plurality of colors to radiation and emits light under irradiation...
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6388746 |
Method, apparatus and flow cell for high-sensitivity detection of fluorescent molecules
Method and apparatus for high-sensitivity fluorescence detection wherein (I) a sample comprising fluorescent molecules is made to flow through a channel structure ( 1 ) comprising a constricted...
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6384914 |
Method for optical detection of analyte molecules in a natural biological medium
In order to carry out optical detection and identification of individual tumor markers in undiluted blood plasma, said tumor markers are marked with fluorescent dyes which are characterized by...
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6384409 |
Optical tracking system
An optical system for the tracking or verification of items, having an energy source (e.g., an illumination source), selectively producing a specific wavelength (or small set of wavelengths, such...
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6384912 |
Measuring device and the use thereof
A device has a planar optical waveguide, including a transparent carrier ( 40 ) and a wave-guiding layer ( 41 ), wherein the waveguide at least has a diffractive element ( 42 ) for coupling...
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6378976 |
Use of an essentially colorless marker to allow evaluation of nozzle health for printing colorless “fixer” agents in multi-part ink-jet images
A method and apparatus for a test pattern used in the alignment of an ink-jet pen which deposits fixer fluid, or other clear ink precursor fluid, or even colored ink fluid, on print media...
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