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7622712 |
Method for operating an ion trap mass spectrometer system
A method of operating a mass spectrometer system having an ion trap is provided. The method comprises encoding a selected characteristic in at least one of the first group of precursor ions and the...
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7615743 |
Overcoming space charge effects in ion cyclotron resonance mass spectrometers
In an ion cyclotron resonance mass spectrometer in which ions are trapped axially by applying electrical potentials to a pattern of electrode elements to produce an inhomogeneous alternating...
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7615742 |
Measurement of light fragment ions with ion traps
The invention relates to methods for the measurement of fragment ion spectra in ion trap mass spectrometers in which fragment ions below a cut-off mass cannot normally be measured. The invention...
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7595485 |
Data analysis to provide a revised data set for use in peptide sequencing determination
In one aspect of the present invention, the less “useful” spectral data is disregarded from the spectral data resulting from the fragmentation by ETD and candidate charge states for the...
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7586089 |
Feedback fragmentation in ion trap mass spectrometers
In an RF ion trap mass spectrometer, selected parent ions are fragmented by collisions or electrons and a spectrum of the ion fragments is measured. The measured fragment ion spectrum is then...
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7582862 |
Ion source for electron transfer dissociation and deprotonation
In mass spectrometric analysis equipment, highly charged analyte fragment ions are obtained by electron transfer dissociation of highly charged analyte ions by radical anions and the dissociation...
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7582864 |
Linear ion trap with an imbalanced radio frequency field
An imbalanced radio frequency (RF) field creates a retarding barrier near the exit aperture of a multipole ion guide, in combination with the extracting DC field such that the barrier provides an...
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7579589 |
Ultra compact ion mobility based analyzer apparatus, method, and system
An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and,...
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7573029 |
Ion trap with longitudinal permanent magnet and mass spectrometer using same
A vacuum magnetic ion trap includes an assembly forming a permanent magnet including at least two magnetized structures ( 30, 32 ) in the form of hollow cylinders, one convergent radial structure,...
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7569811 |
Concentrating mass spectrometer ion guide, spectrometer and method
An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field...
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7569835 |
Gating grid and method of manufacture
The present invention relates generally to grids for gating a stream of charged particles and methods for manufacturing the same. In one embodiment, the present invention relates to a...
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7557344 |
Confining ions with fast-oscillating electric fields
The applicants' teachings provide methods, systems, and apparatus useful in operating mass spectrometers and other devices incorporating multipole rod sets or other multi-electrode devices to...
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7550717 |
Quadrupole FAIMS apparatus
A combined rf-only/FAIMS analyzer is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of flat-plate electrodes arranged around a...
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7547891 |
Ion sampling apparatuses in fast polarity-switching ion sources
The present invention provides ion sampling apparatuses that can be used in a fast polarity-switching electric field. In some embodiments, the ion sampling apparatus comprises a capillary made with...
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7544934 |
System and method for implementing balanced RF fields in an ion trap device
A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential...
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7541579 |
Linear quadrupoles with added hexapole fields and method of building and operating same
A mass spectrometer and a method of operating and building same is provided in which a hexapole component is deliberately added to a substantially quadrupole field. This can result in unwanted...
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7534998 |
System and method for implementing balanced RF fields in an ion trap device
A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential...
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7514674 |
Octapole ion trap mass spectrometers and related methods
A mass spectrometer according to one embodiment can include first and second endcap electrodes, first and second outer ring electrodes, and a central ring electrode. The first outer ring electrode...
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7498571 |
RF power supply for a mass spectrometer
The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. Such...
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7491930 |
Hooked differential mobility spectrometry apparatus and method therefore
Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially...
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7479629 |
Multichannel rapid sampling of chromatographic peaks by tandem mass spectrometer
Systems and methods for optimizing the analysis of co-eluting compounds during a cycle of a tandem mass spectrometer system are provided. The tandem mass spectrometer system switches fast from...
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7476854 |
High speed, multiple mass spectrometry for ion sequencing
A detector system for detecting trace molecules. The detector includes an ion trap that is coupled to an ionizer and a detector. The system also includes a controller that can generate voltage...
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7468511 |
FAIMS electrodes with lateral ion focusing
A FAIMS cell including one of side-to-side cylindrical geometry electrodes and stacked-plate electrodes is adapted with a medial surface feature for focusing ions along a lateral direction within...
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7456397 |
Ion fragmentation by electron transfer in ion traps
The invention relates to a method and instrument for the fragmentation of large molecular analyte ions, preferably biopolymer ions, by reactions between multiply charged positive analyte ions and...
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7449687 |
Methods and compositions for combining ions and charged particles
The invention provides an apparatus for combining ions and charged particles. In general, the apparatus contains: a) a multipole device having an ion exit end; b) a mass analyzer; and c) a source...
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7442921 |
Protein profiles with atmospheric pressure ionization
The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to...
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7420161 |
Branched radio frequency multipole
Systems and methods of the invention include a branched radio frequency multipole configured to act, for example, as an ion guide. The branched radio frequency multipole comprises multiple ion...
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7417225 |
Apparatus and method for adjustment of ion separation resolution in FAIMS
An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is...
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7405399 |
Field conditions for ion excitation in linear ion processing apparatus
Methods for applying an RF field in a two-dimensional electrode structure include applying RF voltages to main electrodes and to compensation electrodes. The voltages on the compensation electrodes...
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7405400 |
Adjusting field conditions in linear ion processing apparatus for different modes of operation
Methods for applying an RF field in a two-dimensional electrode structure include applying RF voltages to one or more main electrodes and compensation electrodes. The voltages on the one or more...
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7399959 |
Method and apparatus for enhanced ion based sample filtering and detection
The invention provides, in various embodiments, systems and methods relating to enhancing the filtering and detection capability of ion mobility based systems by various techniques to counteract a...
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7397029 |
Method and apparatus for ion fragmentation in mass spectrometry
An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate...
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7388197 |
Multiplex data acquisition modes for ion mobility-mass spectrometry
A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate...
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7388195 |
Apparatus and systems for processing samples for analysis via ion mobility spectrometry
The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological...
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7388196 |
Hyperbolic horn helical mass spectrometer
An improved rotating electric field ion mass spectrometer (REFIMS) provides for a smooth transition of the input ion beam from zero rotation to the desired level of field rotation. The REFIMS grid...
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7378648 |
High-resolution ion isolation utilizing broadband waveform signals
A desired ion is isolated in an ion trapping volume by applying an ion isolation signal to a plurality of ions in the ion trapping volume, including the desired ion to be retained in the ion...
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7378651 |
High field asymmetric waveform ion mobility spectrometer FAIMS
Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and...
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7368711 |
Measuring cell for ion cyclotron resonance mass spectrometer
The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF...
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7355172 |
Liquid cheromatography/mass spectrometry apparatus
A liquid chromatography/mass spectrometry apparatus combines a chromatograph having a liquid delivery part for delivering mixed multiple solvents, and a mass spectrometer having an ionization part...
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7351955 |
Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions
A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of...
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7339164 |
Systems and methods for ion mobility control
The invention provides, in various embodiments, systems and methods relating to controlling ion behavior in an ion-based analysis system.
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7339165 |
Dual outlet pyrolyzer for biological agent detection system
A chemical biological detection system detects the presence of biological agents in the air. The system includes a pyrolyzer having an inlet through which air is drawn into the pyrolyzer and a...
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7326924 |
Method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser
A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance...
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7312444 |
Atmosperic pressure quadrupole analyzer
The present invention relates to an apparatus and method for focusing, separating, and detecting gas-phase ions using the principles of electrohydrodynamic quadrupole fields at high pressures, at...
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7282708 |
Method of selecting ions in an ion storage device
The method of the present invention is to select ions having a predetermined mass to charge ratio by applying an ion selecting electric field in an ion storage space of an ion storage device. The...
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7259379 |
On-axis electron impact ion source
An electron impact ion source includes an ionization chamber in which a first rf multipole field can be generated and an ion guide positioned downstream from the ionization chamber in which a...
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7247847 |
Mass spectrometers and methods of ion separation and detection
A mass spectrometer comprises an ion source which provides a beam of ions; a mass filter comprising a pair of electrodes and a drive circuit, the drive circuit operable to apply a time varying...
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7244931 |
Ion mobility spectrometer with parallel running drift gas and ion carrier gas flows
An ion mobility spectrometer is provided including at least one ionization chamber ( 1 ), which can be passed through by analyte-containing gas and at least one radiation source ( 2 ), from which...
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7230238 |
Method and apparatus for control of mobility-based ion species identification
System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification, based on control of electrical and environmental...
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7227137 |
Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap
In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion...
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