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7256393 |
Non-linear signal amplifiers and uses thereof in a mass spectrometer device
Signal amplifiers having a non-linear transfer function. A high speed (high bandwidth) circuit with a non-linear transfer function over a limited range of input signal is provided. By appropriate...
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7256397 |
Mass analyzer and mass analyzing method
A mass analyzer includes: an ion trap device including an ion trapping space surrounded by a plurality of electrodes; a time-of-flight mass analyzer for determining a mass to charge ratio of ions...
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7250600 |
Mass spectrometer with an ion trap
In the mass spectrometer of the present invention, the controller controls the time of changing the voltage applied to the electrode or electrodes of the ion trap from the ion trapping voltage to...
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7247846 |
Electric sector time-of-flight mass spectrometer with adjustable ion optical elements
The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric...
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7244931 |
Ion mobility spectrometer with parallel running drift gas and ion carrier gas flows
An ion mobility spectrometer is provided including at least one ionization chamber ( 1 ), which can be passed through by analyte-containing gas and at least one radiation source ( 2 ), from which...
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7241989 |
Systems for differential ion mobility analysis
Disclosed herein are systems, methods and apparatus, for detection and identification of analytes in a volatilized or volatilizable sample, using the mobility-based signature that is produced when...
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7242008 |
Bipolar ion detector
The present invention is directed to a bipolar ion detector capable of detecting both positive and negative ions in a single configuration. The invention uses either a single microchannel plates or...
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7230234 |
Orthogonal acceleration time-of-flight mass spectrometer
An orthogonal acceleration time-of-flight (oa-TOF) mass spectrometer has an ion source producing ions, a first region of a low degree of vacuum, an ion reservoir, and a second region of a high...
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7230238 |
Method and apparatus for control of mobility-based ion species identification
System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification, based on control of electrical and environmental...
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7230237 |
Mass spectrometer
A mass spectrometer adopting a differential pumping system includes an ionization chamber with substantially atmospheric pressure, two intermediate vacuum chambers, and a mass analyzing chamber...
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7227132 |
Apparatus and method for adjustment of ion separation resolution in FAIMS
An apparatus for controllably varying specificity of a FAIMS-based ion separation includes a first electrode surface portion defining an ion inlet within a portion thereof and a second electrode...
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7227131 |
Time of flight mass spectrometer
A time of flight type mass spectrometer (TOF-MS) of the present invention includes: a flight space containing a loop orbit on which ions fly once or more than once; a flight controller for making...
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7227136 |
Method and arrangement for detecting harmful substances
A method and an arrangement detect harmful substances while eliminating or minimizing the drawbacks of an ion-mobility spectrometer (IMS). The sample gas flow is mixed with a reference gas...
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7223969 |
Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions
Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions...
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7223966 |
Time-of-flight mass spectrometers with orthogonal ion injection
The invention relates to time-of-flight mass spectrometers, equipped with ion reflector and ion detector, with orthogonal ion injection and outpulsing of a segment of the ion beam perpendicular to...
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7220383 |
Method and instrument for automated analysis of fluid-based processing systems
An analytical apparatus to monitor fluid systems has at least one extraction module having a raw-sample reservoir connected by input fluid conduit to individual ones of said fluid systems, to...
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7220970 |
Process and device for measuring ions
The invention relates to a method and a device for the measurement of ions by coupling different measurement methods/techniques, a first detector being a collector ( 17 ) and a second detector...
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7217921 |
Method and apparatus for FAIMS for in-line analysis of multiple samples
A method of separating ions includes providing a FAIMS analyzer region including an ion inlet orifice for providing ions thereto, and providing a sample holder along a side of the ion inlet orifice...
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7217920 |
Pancake spectrometer
Method and apparatus for identification of chemical compounds in a sample based on differences in ion mobility, wherein the filter and detector electrodes are formed radially spaced on facing...
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7211788 |
Mass spectrometer and mass filters therefor
A mass filter apparatus for filtering a beam of ions is described. The apparatus comprises an ion beam source and first and second mass filter stages in series to receive the ion beam. A vacuum...
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7208726 |
Ion trap mass spectrometer with scanning delay ion extraction
An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector...
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7205537 |
Ion guides with movable RF multiple segments
The invention relates to an ion guide consisting of RF multipole segments to transfer ions from an ion source into a mass analyzer. The invention consists in having movable RF multipole segments in...
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7199362 |
Cross-flow ion mobility analyzer
A cross-flow ion mobility analyzer (CIMA) that includes a component of gas flow that opposes an electric field that is established within a channel, wherein ions are carried through the channel,...
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7189966 |
Apparatus for ion desolvation in FAIMS
Ion separation in a FAIMS analyzer is affected by the presence of neutral species and solvent vapor. A diffuser element, which is fabricated from a porous material, is disposed within a curtain gas...
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7189963 |
Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and...
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7189965 |
Storage device for molecular detector
The invention relates to ion storage devices for a molecular detector which determines the presence and quantity of a predetermined ion species out of a large number of stored ions. The invention...
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7186973 |
Ion trap/time-of-flight mass analyzing apparatus and mass analyzing method
An “ion trap-TOF/MS” capable of calibrating the observed mass for each of an ion trap and a TOF. In the ion trap-TOF/MS, sample ions having known mass numbers and ionized by an ion source are...
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7186517 |
Compositions and methods for monitoring breast cancer treatment
The present invention provides compositions and a method for monitoring breast cancer treatment.
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7186972 |
Time of flight mass analyzer having improved mass resolution and method of operating same
A time-of-flight mass analyzer having improved mass resolution without mandating a corresponding increase in instrument size is disclosed. The analyzer includes an ionizer that generates the ions...
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7183541 |
Mass spectrometer
A mass spectrometer has an ionizing portion for ionizing a sample, a mass spectrometric portion for subjecting a sample ion to mass separation and detecting the sample ion and a control portion for...
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7183543 |
Compensating for a measured variation in length of a flight tube of a mass spectrometer
A mass spectrometer system comprises a flight tube having an operational length, a measurement device for measuring a variation in the longitudinal length of the flight tube, means for compensating...
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7183542 |
Time of flight ion trap tandem mass spectrometer system
Apparatus for delivering ions to a mass analyzer. The apparatus includes a time of flight ion guide, a pulsing device for receiving a continuous ion stream containing ions of different atomic mass...
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7180060 |
E×B ion detector for high efficiency time-of-flight mass spectrometers
An ion detector having a planar electrically conducting entrance plate, a converter assembly including a planar electrically conducting converter plate and a converter member for providing free...
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7180418 |
Active threat detection and elimination while in transit
A method of active detection of at least one threat to the homeland security. Each such threat is either hidden inside at least one cargo container before transit, or is placed inside at least one...
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7176452 |
Microfabricated beam modulation device
A beam modulation device gate is constructed from a silicon material, such as a silicon layer on an silicon on insulator wafer. The device further comprises a set of electrical contacts on the...
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7176454 |
Ion sources for mass spectrometry
Provided are ion sources, methods of forming ions and mass analyzer systems. In various embodiments, the present teachings provide ion sources, methods for focusing ions from an ion source, and...
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7170053 |
Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)
Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is...
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7170052 |
MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection
An ion mobility/mass spectrometry method and instrument using aerosolized samples and dual positive and negative mode detection is described. Sample preparation methods are also described.
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7164123 |
Method for filtering spurious resonances from an NMR dataset
A method for filtering spurious resonances from an NMR dataset comprises the steps of:
(a) creating a first, non-oscillating magnetic field of a predetermined field strength across a sample,...
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7164122 |
Ion mobility spectrometer
The present invention relates to an improved ion mobility spectrometer and method for the analysis of chemical samples. The improvements are realized in the optimization of resolution and...
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7161141 |
Ion trap/time-of-flight mass spectrometer and method of measuring ion accurate mass
An ion trap/time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS/MS and MS n has an ion source for ionizing a sample, an ion trap capable of...
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7161143 |
Method and apparatus to increase the resolution and widen the range of differential mobility analyzers (DMAs)
A differential mobility analyzer (DMA) for separating charged particles or ions suspended in a gas and a method of using the DMA for separating such particles. The invention includes various means...
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7157701 |
Compact time-of-flight mass spectrometer
The invention provides a method of design for a time-of-flight mass spectrometer that is compact and has high mass resolution over a broad range of ion masses. This method of design, for the...
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7155812 |
Method for producing a tube
A method is described for producing tubular substrates having parallel spaced concentric rings of electrical conductors that can be used as the drift tube of an Ion Mobility Spectrometer (IMS). The...
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7154087 |
Method and apparatus for carrying out Ion mobility spectrometry analyses
A method and apparatus for carrying out analyses of a gas comprising one or more species by using an ion mobility spectrometer which includes a plurality of electrodes arranged in a chamber divided...
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7154086 |
Conductive tube for use as a reflectron lens
A reflectron lens and method are provided. The reflectron lens comprises a tube having a continuous conductive surface along the length of the tube for providing an electric field interior to the...
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7148472 |
Aerosol mass spectrometer for operation in a high-duty mode and method of mass-spectrometry
An aerosol TOF MS of the present invention is based on the use of quadrupole lenses with angular gradient of the electrostatic field. On the entrance side, the TOF MS contains an ion-optic system...
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7148474 |
Device for two-dimensional gas-phase separation and characterization of ion mixtures
The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS)...
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7145134 |
Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisitions
A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is...
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7141785 |
Ion detector
An ion detector for a mass spectrometer is disclosed comprising a microchannel plate 8 which receives ions 12 at an input surface and releases electrons 16 from an output surface. A detecting...
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