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7482583 |
Time of flight mass spectrometer
In a time of flight mass spectrometer (TOFMS) having a flight space in which ions fly in a loop orbit formed by a plurality of electric sector fields, the present invention provides a simple...
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7482582 |
Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording
The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow...
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7479629 |
Multichannel rapid sampling of chromatographic peaks by tandem mass spectrometer
Systems and methods for optimizing the analysis of co-eluting compounds during a cycle of a tandem mass spectrometer system are provided. The tandem mass spectrometer system switches fast from...
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7479630 |
Method and apparatus for flow cytometry linked with elemental analysis
An apparatus ( 100 ) for sequentially analyzing particles such as single cells or single beads, by spectrometry. The apparatus, an elemental flow cytometer, includes means ( 102 ) for sequential...
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7476853 |
Ion fragmentation by reaction with neutral particles
The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral...
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7476850 |
Method and its apparatus for mass spectrometry
The present invention relates to a data processing device for mass spectrometry, in which measurements are performed in a high dynamic range without causing an overrange in an A/D converter in any...
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7470898 |
Monitoring drinking water quality using differential mobility spectrometry
Continuous monitoring of fluid composition, e.g. drinking water supply, with improved detection sensitivity and selectivity to varying degrees of contamination at and below the predetermined...
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7462824 |
Combined ambient desorption and ionization source for mass spectrometry
Combined desorption and ionization sources are provided to generate molecular ions form a sample disposed on a substrate surface. A heated gas-jet probe or heated solvent stream probe desorbs...
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7462819 |
Statistical methods applied to surface chemistry in minerals flotation
The present invention provides a method of analysis which couples principle component analysis (PCA) with ToF-SIMS for obtaining surface chemical information from minerals. Statistical methods,...
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7456394 |
Compact sample analysis systems and related methods of using combined chromatography and mobility spectrometry techniques
The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems and methods, and...
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7456393 |
Device for testing surfaces of articles for traces of explosives and/or drugs
A device is provided for testing surfaces of a card for the presence of explosives, drugs or other substances of interest. The device includes a slot for receiving the card. Thin metallic wiper...
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7456391 |
Gating device and driver for modulation of charged particle beams
By connecting the Bradbury-Nielson gate (BNG) directly to a driver without a transmission line, distortion of the voltage waveform experienced a the BNG are much reduced. Because the magnitude of...
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7456388 |
Ion guide for mass spectrometer
An ion guide 24 for a mass spectrometer 30 including means for ejecting ions of different mass-to-charge ratios from the ion guide towards a detector or other object or device. The ejecting...
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7453059 |
Technique for monitoring and controlling a plasma process
A time-of-flight ion sensor for monitoring ion species in a plasma includes a housing. A drift tube is positioned in the housing. An extractor electrode is positioned in the housing at a first end...
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7453060 |
Solid-state flow generator and related systems, applications, and methods
The invention, in various embodiments, is directed to an analyzer using a solid-state flow generator to provide effluent flow along a flow path and deliver a sample to an ion mobility based filter...
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7449685 |
Gas monitoring apparatus
A gas monitoring apparatus includes a sample introducing portion, a measurement portion, an ionization portion, a mass analysis portion, a data processing portion and a display. The sample...
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7448131 |
Method of making gate for charged particle motion
A Bradbury-Nielson gate (BNG) includes a set of evenly spaced, co-planar, and parallel wires. The wires alternate in a repeating ABAB pattern, where all of the A wires are electrically connected to...
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7449150 |
Probe and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7449683 |
Method and apparatus for high-order differential mobility separations
The present invention relates generally to separation of ions based on their transport properties. More particularly, the invention relates to separation of ionic mixtures and characterization of...
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7445907 |
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells)...
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7442921 |
Protein profiles with atmospheric pressure ionization
The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to...
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7439497 |
Control system and apparatus for use with laser excitation and ionization
A control system and apparatus for use with laser ionization is provided. In another aspect of the present invention, the apparatus includes a laser, pulse shaper, detection device and control...
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7435951 |
Ion source sample plate illumination system
The invention provides a mass spectrometry system ion source containing a sample plate and an illumination device that is configured to produce a light beam that contacts the sample plate surface...
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7429728 |
Distance of flight spectrometer for MS and simultaneous scanless MS/MS
A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each...
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7429730 |
SIFT-MS instruments
A SIFT or SIFDT apparatus in which the upstream quadrupole and the downstream quadrupole are housed within a single evacuated chamber with the upstream quadrupole being connected to the downstream...
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7429729 |
Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods...
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7423259 |
Mass spectrometer and method for enhancing dynamic range
A mass spectrometer comprises an ion detector, a first amplifier, a second amplifier, and a spectra combiner. The ion detector is configured to generate an analog signal indicative of ions detected...
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7423261 |
Curved conduit ion sampling device and method
An ion sampling apparatus for use in a mass spectrometry system. The ion sampling apparatus includes a target support for receiving a sample, an irradiation source for emitting energetic radiation...
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7417225 |
Apparatus and method for adjustment of ion separation resolution in FAIMS
An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is...
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7417224 |
Ion mobility spectrometer with parallel drift gas and ion carrier gas flows
An ion mobility spectrometer is provided with at least one ionization chamber ( 1 ) through which analyte-containing gas can flow. A radiation source ( 2 ) is provided from which ionizing radiation...
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7417223 |
Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences
A first mass spectrum and a second mass spectrum of the same ion sample can be analyzed to determine reaction pairs. These reaction pairs are determined based on a selected neutral difference by...
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7417226 |
Mass spectrometer
An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1 , a reaction chamber 2 and a passage 6 connecting...
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7413909 |
Method and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7411185 |
Atmospheric pressure ionization mass spectrometer system
An atmospheric pressure ionization mass spectrometry system has an atmospheric pressure ionization chamber for ionizing a sample, an evacuated intermediate evacuation chamber into which generated...
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7408151 |
Dynamic biasing of ion optics in a mass spectrometer
A device for dynamically biasing an ion optic element, for example, in a mass spectrometer. The device includes a voltage source, a first ion optical element coupled with the voltage source, a...
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7408152 |
Ion source using matrix-assisted laser desorption/ionization
An ion source generating ions by matrix-assisted laser desorption/ionization (MALDI) comprising a MALDI sample support and a solid-state the laser system generating a pulsed laser beam, which has a...
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7405401 |
Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
There is disclosed a method of selectively extracting ions comprising the steps of: providing a supply of ions in a body of gas; generating a ponderomotive ion trapping potential generally along...
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7405394 |
Gas cluster-ion irradiation apparatus
In a cluster ion beam irradiation apparatus including an apparatus for measuring size and energy distribution of gas cluster ions by using the time of flight (TOF) mass spectrometry, a unit for...
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7405398 |
Mass spectrometer interface
A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion...
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7403867 |
Spectroscopy instrument using broadband modulation and statistical estimation techniques to account for component artifacts
A spectroscopy instrument that uses spectra produced from random binary sequence modulated data. Statistical estimation techniques are used to achieve resolution enhancement, while properly...
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7399959 |
Method and apparatus for enhanced ion based sample filtering and detection
The invention provides, in various embodiments, systems and methods relating to enhancing the filtering and detection capability of ion mobility based systems by various techniques to counteract a...
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7399957 |
Coded mass spectroscopy methods, devices, systems and computer program products
A coded mass spectrometer incorporates a spatial or temporal code to reduce the resolution/sensitivity dichotomy inherent in mass spectrometry. The code is used to code one or more portions of a...
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7399958 |
Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations
A system for analyzing one or more ion species of a sample including a first ion mobility filter associated with a first flow path for passing first ions of the sample, a second ion mobility filter...
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7397027 |
Multi-channel high-field asymmetric waveform ion mobility spectrometry
A multi-channel high field asymmetric waveform ion mobility spectrometer (FAIMS) is provided. The apparatus provides for substantially simultaneous FAIMS analysis of plurality of ions from a single...
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7391017 |
Mass scale alignment of time-of-flight mass spectra
The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption....
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7388195 |
Apparatus and systems for processing samples for analysis via ion mobility spectrometry
The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological...
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7388196 |
Hyperbolic horn helical mass spectrometer
An improved rotating electric field ion mass spectrometer (REFIMS) provides for a smooth transition of the input ion beam from zero rotation to the desired level of field rotation. The REFIMS grid...
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7388193 |
Time-of-flight spectrometer with orthogonal pulsed ion detection
This invention provides an apparatus and method for efficient detection of ions in a time-of-flight mass spectrometer. The apparatus of the invention provides for orthogonal deflection of ions in...
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7385188 |
Linear electric field time-of-flight ion mass spectrometer
A linear electric field ion mass spectrometer having an evacuated enclosure with means for generating a linear electric field located in the evacuated enclosure and means for injecting a sample...
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7385187 |
Multi-reflecting time-of-flight mass spectrometer and method of use
A multiple reflecting time-of-flight mass spectrometer (MR-TOF MS) and method of analysis are disclosed. The flight path of ions is folded along a trajectory by electrostatic mirrors. The longer...
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