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6800489 |
Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening
Tandem mass spectrometry (MS/MS) has been used extensively for solving various biological problems, such as structure identification of oligopeptides, nucleic acids, and nucleotides. One of the...
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6800862 |
Ion implanting apparatus and ion implanting method
The ion implanting apparatus is provided with a control device which controls the operating state thereof in a period during which ion implantation is not carried out for a substrate in the state...
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6800847 |
Fast variable gain detector system and method of controlling the same
A micro-channel plate (MCP) detector system ( 30 ) comprising a MCP detector, a data acquisition unit ( 20 ), wherein the detector comprises a first and a second MCP electron multiplier ( 12, 14 ),...
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6797947 |
Internal introduction of lock masses in mass spectrometer systems
An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions...
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6799121 |
Sequencing of peptides by mass spectrometry
A strategy for semiautomatic sequencing of argentinated (silver-containing) oligopeptides is described. The method of sequencing described is based on a search algorithm that identifies a triplet...
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6797516 |
Mass spectrometric screening of catalysts
Screening methods to identify catalysts or to identify improved catalysts using mass spectrometric analysis of products of catalysis, particularly catalyst-bound intermediate products in the...
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6794645 |
Proton-transfer-reaction/ion-mobility-spectrometer and method of using the same
A high-pressure hollow cathode ionizer is combined with an ion-mobility-spectrometer (IMS) for the detection of trace amounts of organic compounds in gas. The ionizer uses H 3 0 + , ions which do...
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6794646 |
Method and apparatus for atmospheric pressure chemical ionization
An apparatus for use as an ion source for mass analysis includes a nebulizing device, a vaporizing device, a chamber, an ion sampling structure, and an ionizing device. The vaporizing device...
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6794644 |
Method and apparatus for automating an atmospheric pressure ionization (API) source for mass spectrometry
The present invention provides an apparatus and method for automated and rapid loading of a large number of samples for mass spectrometric analysis using various ionization methods (e.g. matrix...
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6787764 |
Method and apparatus for automating a matrix-assisted laser desorption/ionization (MALDI) mass spectrometer
The present invention provides an apparatus and method for automated and rapid loading of a large number of samples for mass spectrometric analysis using various ionization methods (e.g. matrix...
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6787762 |
Time dispersive spectrometer using digital switching means
Methods and apparatus are described for time dispersive spectroscopy. In particular, a modulated flow of ionized molecules of a sample are introduced into a drift region of an ion spectrometer. The...
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6784421 |
Method and apparatus for fourier transform mass spectrometry (FTMS) in a linear multipole ion trap
An apparatus and method whereby ions from an ion source can be selected and transferred via a multipole analyzer by inductive detection. Ions generated at an elevated pressure are transferred by a...
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6785433 |
Waveguide grid array and optical measurement arrangement
A (bio)chemo-functional waveguide grating structure consisting of at least one (bio)chemo-functional waveguide grating structure unit or at least one (bio)chemo-functional sensor location with beam...
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6784422 |
Parallel sample introduction electrospray mass spectrometer with electronic indexing through multiple ion entrance orifices
An interface apparatus, for coupling a plurality of ion source to a mass spectrometer has a plurality of ion sources for generating a plurality of ion beams. An inlet device for passing ion beams...
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6784439 |
Thin-channel electrospray emitter
An electrospray device includes a high voltage electrode chamber. The high voltage electrode chamber includes an inlet for receiving a fluid to be ionized and for directing the fluid into the...
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6781117 |
Efficient direct current collision and reaction cell
An improved collison or reaction cell for collecting and focusing gas-phase ions in a mixture from an ion source or a mass analyzer into a gas-filled collision cell, inducing fragmentation or...
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6781118 |
Particle charge spectrometer
An airflow through a tube is used to guide a charged particle through the tube. A detector may be used to detect charge passing through the tube on the particle. The movement of the particle...
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6782323 |
Method and program for evaluating molecular similarity
A molecular similarity evaluation method has steps of: (a) obtaining an upper threshold and a lower threshold from one of a value specific to an atom included in a first molecule, a value specific...
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6781121 |
Time-of-flight mass spectrometer
A time-of-flight mass spectrometer, for example, a MALDI-TOF spectrometer, measures the characteristics of the charge to mass ratio of ionized particles by measuring the time taken for the...
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6777673 |
Ion trap mass spectrometer
A mass spectrometer that includes an ion source, an ion trap, and a light detection module. The ion trap has two end-cap electrodes and a ring electrode. The ring electrode is positioned relative...
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6777670 |
Mass analyzer capable of parallel processing one or more analytes
An improved mass analyzer capable of parallel processing one or more analytes is set forth. The mass analyzer comprises a mass filter unit having a plurality of ion selection chambers disposed in...
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6777671 |
Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
A mass spectrometer includes an ion source, an extraction device, a TOF mass analyzer, an ion trap mass analyzer, and an ion guiding optical element which guides at least one of extracted ions from...
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6774360 |
FAIMS apparatus and method using carrier gas of mixed composition
A method and an apparatus is disclosed for selectively transmitting ions with a FAIMS analyzer in which a flow of carrier gas of a mixed composition is provided. Ions that are transmitted at a same...
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6770870 |
Tandem time-of-flight mass spectrometer with delayed extraction and method for use
A tandem time-of-flight mass spectrometry including a pulsed ion generator, a timed ion selector in communication with the pulsed ion generator, an ion fragmentor in communication with the ion...
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6770875 |
Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing...
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6770871 |
Two-dimensional tandem mass spectrometry
A tandem mass spectrometer is provided including two mass analyzers with an ion fragmentation device interposed between the two mass analyzers. The first mass analyzer is a non-destructive mass...
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6768118 |
Electron beam monitoring sensor and electron beam monitoring method
The present invention provides a beam monitoring sensor which can offer both high beam monitoring precision and high speed monitoring in a multi-electron beam writing system and a monitoring method...
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6765199 |
Time-dependent digital signal scaling process
A method for processing time-dependent signal data is disclosed. The time-dependent signal data are received in a memory, wherein the time-dependent signal data represent a time-dependent signal,...
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6765200 |
Mass spectrometry and mass spetrometer using the same
In order to provide an equipment that permits easy elimination of interference ions even in a low resolution mass spectrometer, the isotope mass number information and the isotope presence ratio...
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6762407 |
Mass spectrometer including a quadrupole mass analyzer arrangement
A mass spectrometer having an ion optics system in a first vacuum region, which diverts ions travelling in a first direction from a source, characterized by an initial pressure, through an angle...
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6756586 |
Methods and apparatus for analyzing biological samples by mass spectrometry
Methods and apparatuses for analyzing proteins and other biological materials and xenobiotics within a sample. A specimen is generated, which may include an energy absorbent matrix. The specimen is...
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6750448 |
Preparative separation of mixtures by mass spectrometry
The present invention provides an instrument and methods for the preparative separation of components of mixtures using mass spectrometric methods. Nondestructive ionization methods are employed to...
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6750449 |
Sampling and analysis of airborne particulate matter by glow discharge atomic emission and mass spectrometries
The apparatus and methods employ momentum separation to implement a particle beam (PB) sampling scheme for the introduction of particulate matter into low pressure (e.g., glow discharge) plasma...
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6750061 |
Method and product for the sequence determination of peptides using a mass spectrometer
Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining...
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6744042 |
Ion trapping
A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors having a common optical axis, the mirrors being arranged...
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6744040 |
Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
A means and method are disclosed whereby ions from an ion source can be selected and transferred to a time-of-flight mass analyzer via an arrangement of multipoles in such a way that fragmented...
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6744045 |
Portable underwater mass spectrometer
A portable mass spectrometer for underwater use includes a watertight case having an inlet and means for transforming an analyte gas molecule from a solution phase into a gas phase positioned...
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6740878 |
System and method for automatically tensioning wires and for retaining tensioned wires under tension
A wire tensioning apparatus and method tensions one or more wires by moving the tensioning function from a wire module to an apparatus external to the wire module. Within the wire module, the wire...
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6740872 |
Space-angle focusing reflector for time-of-flight mass spectrometers
The invention relates to an energy-focusing and space-angle focusing reflector for time-of-flight mass spectrometers. The invention consists in producing an adjustable space-angle focusing system...
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6740873 |
Method for measuring the concentration of nitrogen in argon by means of ion mobility spectrometry
A method for carrying out nitrogen analysis by ionization mobility spectroscopy at concentrations of few parts per billion (ppb) in argon is described. The method involves the addition of hydrogen...
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6740874 |
Ion mobility spectrometer with mechanically stabilized vacuum-tight x-ray window
An ion mobility spectrometer (IMS) has a non-radioactive electron source and an x-ray anode in an evacuated chamber. The impinging of electrons from the source on the anode results in the...
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6737643 |
Detector and method for cluster ion beam diagnostics
A detector apparatus and its use for cluster ion beam diagnostics are described. The detector has a Faraday cup with a conductance path to a gas pressure detector and a conductance to the detector...
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6737642 |
High dynamic range analog-to-digital converter
A high speed analog to digital converter (“ADC”) that can be used in a detector system. The ADC is coupled to a detector and a processor. The detector generates an analog signal in response to...
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6734422 |
Portable outgas detection apparatus
A portable device for detecting surface outgas contaminants of an article includes: (i) a portable housing that has a chamber which is in communication with a port that is adapted to be sealably...
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6734435 |
Photo-ionization detector and method for continuous operation and real-time self-cleaning
A photo-ionization detector (PID) including two detection units controls gas flows through the ionization chambers of the detection units for real-time self-cleaning and measurement. Operation of...
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6727495 |
Ion mobility spectrometer with high ion transmission efficiency
An ion mobility spectrometer comprising a drift tube having a central axis, along which a plurality of ring electrodes are arranged is provided. The plurality of ring electrodes provides a linear...
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6727499 |
Method and device for detecting compounds in a gas stream
In a method and apparatus for detecting compounds in a gas stream, the gas stream with the compounds to be detected is conducted into an ionization chamber of a mass spectrometer where the gas...
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6727494 |
Method and apparatus for detecting contaminating species on a wafer edge
A method and an apparatus for detecting contaminating species such as metal particles on a wafer edge from a semiconductor fabrication process are disclosed. In the method, a wafer is suspended and...
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6723286 |
Chemical monitoring method and apparatus, and incinerator
There was previously no monitoring method and monitoring apparatus which could measure dioxins at ppt levels and dioxin precursors at ppb levels with high sensitivity. According to this invention,...
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6723983 |
High throughput of laser desorption mass spectra in time-of-flight mass spectrometers
The invention relates to a time-of-flight mass spectrometer for acquiring spectra of either primary or daughter ions with high mass precision. All the periodic voltage pulse sequences used in the...
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