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6821418 |
Surface modification of a porous polymer monolith and products therefrom
A process is provided for modifying a porous polystyrene monolith to render its internal pore surfaces grafted with alkyl groups, preferably of at least four carbon atoms, which includes the step...
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6822231 |
Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device comprises a substrate defining a channel between an entrance orifice on...
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6821417 |
Chromatographic and electrophoretic separation of chemicals using electrically conductive polymers
A separation system comprising a stationary phase, a double stranded conductive polymer system contacting the stationary phase and means to place a mobile phase carrying a component to be separated...
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6818134 |
Systems and methods for screening and optimization of solid oxide fuel cell materials
Systems and methods for high-throughput fabrication and evaluation of electrode and electrolyte material performance for solid oxide fuel cells. A system comprising a substrate, an auto-sampler...
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6814870 |
Microchip electrospray device and column with affinity adsorbents and use of the same
A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination....
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6814859 |
Frit material and bonding method for microfluidic separation devices
A frit for use in multi-layer microfluidic separation devices is provided. The frit comprises a polymeric membrane that may be securely bonded within the device and minimizes lateral wicking. A...
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6811688 |
Chromatography columns
A chromatography column suitable for small-scale laboratory use as a column tube resembling that of a syringe and a movable plunger which slides in the column tube. End filter arrangements are...
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6812458 |
Systems and methods for high-throughput microfluidic sample analysis
Systems and methods for collecting the output of multiple simultaneously operated chromatography columns and providing the outputs to a single mass spectrometer are provided. Such systems utilize...
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6805799 |
Simulated moving bed chromatographic focusing
A continuous simulated moving bed chromatographic focusing process is disclosed for separating and concentrating multiple components from a complex mixture. Said process comprises a number of zones...
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6805793 |
Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material
A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or...
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6802968 |
Chromatography apparatus
An apparatus for use in liquid chromatography involves a column filled with media bounded axially by first and second porous plates. The column has an inlet end with an inflow region between the...
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6802969 |
Preparative chromatography system and separation/purification method using same
A prepartive chromatography system, and a separation and purification method using the system, are provided for small scale, low cost, efficient multicomponent separation and purification without...
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6802967 |
Multi-dimension liquid chromatography separation system
Liquid chromatography based on the difference of two or more kinds of separation modes, (e.g., chemical or physical properties of analytes) may improve separations when samples contain complex...
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6803200 |
Compositions and methods for the release of nucleic acid molecules from solid matrices
The present invention relates to compositions and methods for releasing nucleic acid molecules from solid matrices. The invention further relates to compositions and methods for purifying and...
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6800202 |
Integrated monolithic microfabricated electrospray and liquid chromatography system and method
An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an...
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6797175 |
Device for injecting a diverted fluid into a simulated moving bed separation process
A device and process for injecting a diverted fluid into a simulated moving bed comprises a vessel containing beds of adsorbant Ai separated by plates Pi for distributing and extracting fluids,...
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6797174 |
Connecting system for plastic columns
The invention relates to a plastic cartridge system including a cartridge having a plastic-covered column, said column including a monolithic sorbent and at least one closing cap which is applied...
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6797523 |
Methods for systematic identification of protein—protein interactions
The present invention relates to a method for identifying protein—protein interactions. The interacting proteins are isolated by affinity chromatography and identified by mass spectrometry. The...
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6793815 |
Pumping arrangement
A pumping arrangement, for example for liquid chromatography, includes a first liquid reservoir at a first height level, connected via a first hydraulic path to a pumping device; a second liquid...
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6790361 |
Mobile phase dilution scheme for enhanced chromatography
A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a...
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6787030 |
Effluent collection apparatus and method
The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is...
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6783680 |
Sample preconcentration tubes with sol-gel surface coatings and/or sol-gel monolithic beds
A method of preconcentrating trace analytes is accomplished by extracting polar and non-polar analytes through a sol-gel coating. The sol-gel coating is either disposed on the inner surface of a...
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6783988 |
Methods for quantitative and qualitative analyses of phospholipids using one-dimensional thin layer chromatography
A highly sensitive and specific method for the detection and quantification of lipids is provided. Specifically, methods for the simultaneous detection and quantification of phospholipids extracted...
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6783673 |
Composite chromatography column
Apparatus for chromatography, featuring a composite chromatography column including a tubular member having an inlet end and an outlet end, where the tubular member includes an innermost first...
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6783668 |
Integrated pressurized liquid extraction and purification system
A system for pressurized liquid extraction and purification of solid samples includes a pressurized liquid extraction (PLE) module including a PLE cell, a heating element, a high-pressure source of...
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6783672 |
Integrated high throughput system for the mass spectrometry of biomolecules
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to...
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6780325 |
Diffusion promoting apparatus for low flow velocity gradient high-speed liquid chromatography
The present invention provides a device for improving detection sensitivity and a method for improving the detection sensitivity for use in a low flow velocity high performance liquid...
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6780315 |
Backflow prevention for high pressure gradient systems
Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with...
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6776902 |
Parallel high-performance liquid chromatography with post-separation treatment
High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves...
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6776911 |
Methods for surface modification of silica for use in capillary zone electrophoresis and chromatography
The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When...
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6773583 |
Water-wettable chromatographic media for solid phase extraction
A method for removing an organic solute from a solution comprises contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic...
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6770195 |
Compact automated radionuclide separator
A method and apparatus are provided for automatically separating radionuclides using a chromatographic separation process. The method includes the steps of displaying a first flow diagram on a...
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6770876 |
Mass spectrometer autosampler
The present invention relates to an autosampler device useful in high pressure liquid chromatography (HPLC), and more particularly to a device useful for the automated introduction of small sample...
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6767467 |
Fraction collection delay calibration for liquid chromatography
A fraction collection system for liquid chromatography includes a conduit, which directs a sample eluent from an LC column through a flow splitter to a destructive analytical detector such as a...
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6761855 |
Column for solid phase processing
The present invention is directed to an improved column for use in solid phase synthesis or purification. In a specific embodiment, the column is a disposable plastic column for use in solid phase...
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6762057 |
Separation apparatus including porous silicon column
A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed from a material such as porous...
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6758967 |
Liquid chromatography apparatus having two stationary phases
An ion exchange chromatography apparatus includes a first stationary phase and a second stationary phase. The first stationary phase has at least one complexing agent functional group capable of...
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6758966 |
Capillary columns employing monodispersed particles
A capillary column comprising monodispersed particles. The capillary is formed using a suitable substrate, wherein two plates are bonded together. At least one of the plates comprises a channel...
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6752929 |
Methods of separating FTC isomers and derivatives thereof
The present invention relates to a method of preparing enantiomers and diastereomers of a 2′,3′-dideoxy-5-fluoro-3′thiocytadine (FTC) or a derivative thereof as represented by the structural...
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6749749 |
Separation system, components of a separation system and methods of making and using them
Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston...
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6746607 |
Use of an adsorbent gel for eliminating and purifying biomolecules
The invention concerns the use of an adsorptive size exclusion chromatography gel, said gel essentially consisting of a polysaccharide matrix whereon is grafted a polymer coupled with an affinity...
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6743364 |
Method and system for identifying and quantifying chemical components of a mixture
Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality...
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6743356 |
High throughput high performance chromatography system
A high throughput high performance chromatography system operating at a high mixing pressure including a plurality of pressurized solvent reservoirs, e.g. pumps, each maintaining an associated...
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6740242 |
Plating apparatus and method of managing plating liquid composition
A plating apparatus comprises a plating unit having a plating bath for holding a plating liquid therein, and a planting monitoring unit having a liquid chromatography device and an arithmetical...
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6740241 |
Chromatography column system and method of packing of a chromatography column
A method of packing a chromatography column ( 101 ) with a chromatography media ( 104 ) from a vessel ( 102 ) in which the chromatography media ( 104 ) is pumped into the chromatography column (...
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6736967 |
Separating agent for enantiomeric isomers
A separating agent for enantiomeric isomers has an enantiomerically active polymer compound supported thereon. The polymer compound has an exothermic peak before a decomposition temperature of the...
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6736975 |
Method of separating compound(s) from mixture(s)
The invention relates to methods of separating compounds of interest from mixtures using high performance liquid chromatography (HPLC). An initial separation of a sample of a mixture is performed...
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6736973 |
Chromatographic device
A porous self-supporting structure comprising at least two porous components A and B and the porous component B embraces the porous component A, wherein (i) surfaces of pores of the at least two...
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6733731 |
Device for storing and/or treating chemicals
A device for storing and/or treating chemicals is described. The device includes a glass casing provided with a receiving cavity for storing chemicals therein, and further includes a transponder...
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6730216 |
Carrier for a chromatographic column
An assembly consisting of a winding structure 1 around which a chromatographic column 6 can be wound, and an information carrier 7 which can be connected to said winding structure 1 . This...
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