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7074331 |
Separation system, components of a separation system and methods of making and using them
Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston...
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7074334 |
Method for determining the binding behavior of ligands which specifically bind to target molecules
The invention relates to a method for determining the binding behavior of ligands which specifically bind to target molecules at at least one binding site, whereby the markers are present in a...
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7067059 |
Generation of ion exchanger media
The present invention relates to a method of generating a separation medium comprising mixed mode cation-exchanger ligands coupled to a base matrix, which method comprises to provide a scaffold...
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7066011 |
Liquid chromatograph and analysis system
The present invention aims to provide a liquid chromatograph, an analysis system, and a gradient elution method, which are designed to permit a gradient change of eluent with higher precision and...
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7063784 |
Processing of chemicals in flow-through device with porous media
A method of processing a sample comprising introducing a sample into a flow-through device containing a porous solid media therein, and thereafter subjecting the device to microwave energy.
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7063785 |
Pump for liquid chromatography
The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup. At startup, a...
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7060187 |
Post-modification of a porous support
The present invention relates to a method for post-modification of a macroporous polymeric support comprising one or more unreacted double bonds, which method includes the steps of contacting the...
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7060188 |
Separation system and process
The invention relates to a system and a process for fractionating a solution into two or more fractions. The system of the invention comprises at least two compartments having a diameter of at...
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7056434 |
Method and system for identifying and quantifying chemical components of a mixture
Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality...
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7052609 |
Method for regeneration of adsorbent matrices
The present invention relates to the regeneration of adsorbent matrices that are used for the purification of substances from aqueous liquid samples derived from biological material. The method is...
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7052608 |
Cast-to-shape electrokinetic trapping medium
A three-dimensional microporous polymer network material, or monolith, cast-to-shape in a microchannel. The polymer monolith, produced by a phase separation process, is capable of trapping and...
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7052603 |
Single-use manifold for automated, aseptic transfer of soulutions in bioprocessing applications
Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These...
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7051758 |
Scalable inlet liquid distribution system for large scale chromatography columns
A uniform fluid distribution system ( 2 ) for use with a liquid transfer system ( 100 ) for maintaining an interface between liquid phases within a large scale separator system including a cell of...
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7048858 |
Post-modification of a porous support
The present invention relates to a method for post-modification of a porous polymeric polysaccharide support comprising one or more unreacted double bonds, which method includes to contact the...
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7045059 |
Universal bonded phase material for chromatographic separation
The invention provides a new universal bonded phase material used for separation of a wide variety of organic and inorganic substances by liquid chromatography. The material is produced by bonding...
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7041216 |
Chromatography column
The present invention relates to a chromatography column that removes the longitudinal load from the column tube altogether and transfers it to a yoke and stanchion arrangement situated around but...
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7041623 |
Porous silica microsphere scavengers
Highly purified, porous silica microspheres contain functional groups which are capable of selectively binding to reaction impurities, such as excess reactant or reaction by-products, which are...
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7033505 |
Packings for liquid chromatography, process for preparing and usage
The present invention provides packings for high performance liquid chromatography whose residual silanol groups are extremely reduced and which remarkably prevent tailing of basic compounds....
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7025886 |
Material
The present invention provides porous monoliths with high flow permeability that can be produced by polymerising and divinylbenzene in the presence of an initiator, a carboxy-functionalized...
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7025876 |
Sample processing device and sample processing method
A solution such as a washing liquid can be passed through a separation column such as a nozzle tip having a solid phase quickly and reliably, thereby achieving improvements in throughput. A sample...
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7022239 |
Method for fractionating liquid mixtures
The present invention relates to a method of fractionating liquid mixtures or solutions, comprising the steps of subjecting a feed in the form of a liquid mixture or solution to a first...
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7018540 |
Multi column chromatography system
The present invention relates to a method and apparatus for chromatographically analyzing each of a plurality of samples in detector, comprising an autosampler to contain a plurality of samples for...
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7018538 |
Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers
Use of a composite sorbent having an at least partial coating on a support, which coating comprises essentially polyanilines or derivatives of polyanilines for the separation, isolation,...
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7018537 |
Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid
The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the...
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7015465 |
Parallel concentration, desalting and deposition onto MALDI targets
A method and apparatus for the continuous deposition of RP HPLC eluent, from isocratic or gradient elutions, on to a MALDI target using a parallel sample desalting method, allows increased...
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7008532 |
Chromatographic device having an elongate rod and method of forming and chromatographic device
A chromatographic device comprises a chromatographic tube, a chromatographic medium, a piston assembly, an elongate rod, and a threaded member. The piston assembly is within the tube and is...
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7008533 |
Macrocyclic antibiotics as separation agents
Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic...
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7005071 |
Method of generating metal chelating affinity ligands
The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of
a) providing at least one cyclic scaffold...
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7001513 |
Automated processing of a biological component
A biological fluid processing device includes a multiple biological fraction container enclosing a liquid biological fraction. A rigid cassette contains at least one biological fluid processing...
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7001522 |
Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components
The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a...
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6998040 |
Sol-gel open tubular ODS columns with charged inner surface for capillary electrochromatography
The present invention provides for a column for use in capillary electrochromatography including a tube, wherein the tube includes an inner surface having a positively or negatively charged,...
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6998041 |
Device and system for reversibly trapping and isolating carbohydrates
A device and system for reversibly trapping and isolating carbohydrate moieties. The apparatus includes an aldehyde-containing trapping material, a trapping means into which the aldehyde-containing...
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6994791 |
Adsorbent material and method of preparing an adsorbent material
The present invention relates to an adsorbent material for chromatography comprising a polymer immobilized onto a support, wherein the polymer backbone is attached to the support by one or more...
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6991729 |
Optical isomer separating filler, production method therefor and application method therefor
The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, a process for producing...
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6989129 |
Automated capillary liquid chromatography small volume analysis system
A system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration...
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6989098 |
Methods for the isolation, recovery and purification of non-polar compounds using novel hydrophobically-modified polysaccharide gels
A process is described for the preparation f electrostatically-linked, aliphatic- or alicyclic-substituted anionic or cationic polysaccharide gels from readily available macroporous ionic...
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6989100 |
Methods for time-alignment of liquid chromatography-mass spectrometry data
Nonlinear retention time variations in chromatography-mass spectrometry data sets are adjusted by time-alignment methods, enabling automated comparison of spectra for differential phenotyping and...
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6986841 |
Fused-silica capillaries with photopolymer components
A separation column is provided with a photopolymer component which, when irradiated, causes controlled porosity polymerization. A particularly preferred embodiment is wherein the separation medium...
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6986847 |
Method and apparatus for isolation and purification of biomolecules
An apparatus and method for recovering bioproducts from a feed solution. In one embodiment, the apparatus includes a module housing, a membrane means disposed in the housing for filtering the...
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6984318 |
Chromatographic column seal
A seal on a movable top or bottom plate for use in a chromatography column. The plate is formed of a flow distributor connected to one or more movement rods that control the movement of the top...
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6984525 |
Method for automated isolation of fractions in multichannel separation systems
A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a microfabricated...
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6979402 |
Miniature actual moving bed assembly
An apparatus is presented for separating chemicals using adsorption separation methods. The apparatus uses a plurality of adsorption units holding adsorbent, where the adsorption units positioned...
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6977369 |
Cold spray mass spectrometric device
The instrument cold sprays a solution sample at a low temperature and desolvates the sample. Under this condition, a mass analysis is performed. The instrument comprises a needle pipe ( 8 ) through...
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6972090 |
Composite chromatographic sorbent of mineral oxide beads with hydroxyapatite-filled pores
A new adsorbent of a porous mineral oxide material with apatite crystals, preferably hydroxyapatite crystals, in the pores of the mineral oxide material is disclosed. The adsorbent is useful for...
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6969605 |
Miniature immuno-optical rapid analyte sensor platform
A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an...
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6966991 |
Methods and apparatus for packing chromatography columns and chromatography column
Ultrasound transceivers ( 20 ) are distributed up the side wall of a chromatography column ( 1 ) and enable tracking of the progress of a rising bed front ( 5 ) during packing. Comparison with a...
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6966992 |
Method of purification of molecules using unbranched terminal alkyldiols
The current invention provides methods for molecule purification by RP-LC and RP-HPLC that uses unbranched terminal alkyldiols as eluting solvents. In particular, the present invention purifies...
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6962658 |
Variable flow rate injector
A variable flow rate injector provides accurate, precise, and reproducible injection volumes that have low dispersion. The invention is particularly well-suited for HPLC injection volumes <500...
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6958119 |
Mobile phase gradient generation microfluidic device
The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a...
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6949194 |
Disposable chromatographic columns
To make an inexpensive chromatographic column and perform chromatography with it, column walls and a column end with an inlet port are molded integrally from plastic and a snap-on end is molded...
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