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7497934 |
System and method
An analysis system for and method of enabling determination of the velocities of migrating objects and also classifying migrating objects into groups having a common constraint. In one aspect the...
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7425254 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Fractionation of macro-molecules using asymmetric pulsed field electrophoresis
A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field...
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7384527 |
Electrophoresis apparatus and a plate therefor
The invention provides an electrophoresis apparatus comprising an electrophoretic chamber containing at least on two-plate housing for a sieving matrix, each said at least one two-plate housing...
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7309409 |
Multi-channel bio-separation cartridge
A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir....
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7217352 |
Capillary electrophoresis device
An electrophoresis device is disclosed that is capable of reducing waves occurring in a fluid in which the capillary tips of a capillary assay are immersed. A plurality of partition plate members...
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7208072 |
Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
A bio-separation instrument using a multi-segment cartridge. The cartridge includes a plurality of efficient, compact, portable, interchangeable, reusable, recyclable, modular, multi-channel...
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7147762 |
Method of electrophoresis
The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the...
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7118662 |
Electrophoresis apparatus
The windows 5 a, 5 b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An...
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7074311 |
Biosensor electrophoresis
The invention provides methods of detecting, purifying, quantifying, and separating molecules using an electrophoresis adapted biosensor.
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RE38817 |
Method and system for velocity-normalized position-based scanning
A data collection method for scanning a scan window comprising one or more channels is described. In the method of the invention an integrated signal (S) is measured across a scan window including...
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6932895 |
Automated electrophoresis gel manipulation apparatus
An automated, computer controlled assembly is provided for continuously processing a large number of electrophoresis gels. The assembly includes a loading assembly for loading a gel onto a carrier,...
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6852206 |
Measurement of fluorescence using capillary isoelectric focusing
Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation...
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6837977 |
Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
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6811663 |
Microelectrode system
A microelectrode system suitable for use in preparative and analytical chemistry having a laminated structure with one or more apertures. In one embodiment a microelectrode system ( 1 ) comprises...
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6793790 |
Sample collection system for gel electrophoresis
An automatic sample collection system for use with an electrophoretic slab gel system is presented. The collection system can be used with a slab gel have one or more lanes. A detector is used to...
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6613210 |
Molecular imaging
A method of imaging molecules of interest within a biological sample includes shining a UV light onto the sample and detecting the molecular UV absorption. Where the molecules of interest are...
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6596140 |
Multi-channel capillary electrophoresis device and method
Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein...
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6576104 |
Apparatus and method for reading gel electrophoresis pattern
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
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6554987 |
Method and apparatus for alignment of signals for use in DNA base-calling
Data traces from four channels of an automated electrophoresis detection apparatus are aligned by identifying peaks in each of the four data traces; optionally normalizing the data traces to...
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6540897 |
Direct detection of histidine tagged biomolecules on electrophoretic gel
A method is disclosed for the detection of a His-tagged target biomolecule while said molecule remains in the gel in which it has been separated from other constituents by electrophoresis. The...
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6524866 |
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
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6491805 |
Sample-analysis system with antisynchronously driven contactless conductivity detector
In a differential condition, an electrophoresis system antisynchronously drives a longitudinally-separated pair of contactless drive electrodes, both of which are coupled to a detection electrode...
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6488832 |
Array based electrophoretic system for the analysis of multiple biological samples
The present invention relates to an electrophoretic method to effect differential net migration, the extent of said migration being dependent on molecular size, of electrically charged...
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6468409 |
Method and apparatus for detecting substances
An apparatus for detecting fluorophore labelled substances in an electrophoretic separation medium comprises illuminating means ( 1 ) for illuminating the fluorophore labelled substances ( 8 ),...
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6454925 |
Device for electrophoresis and component therefor
A device for electrophoresis includes a component formed with a pair of planar members such as glass substrates joined together one on top of the other such that a capillary is formed by a groove...
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6440664 |
Apparatus for sequencing of nucleic acids using multiple dyes
An instrument for sequencing oligonucleotides is loaded with the products of four sequencing reaction mixtures. These products are a combination of A, C, G and T reaction products for several...
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6290831 |
Electrophoretic system for real time detection of multiple electrophoresed biopolymers
An electrophoretic system for real time analysis of a plurality of samples each containing at least one biopolymer is disclosed. The system includes (a) a holder for holding a plurality of...
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6284119 |
DNA base sequencer
A DNA base sequencer including a gel electrophoretic means having tracks for electrophoresing fluorophore-labelled DNA fragments, a laser diode as a light source for illuminating said tracks with...
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6277259 |
High performance multidimensional proteome analyzer
A proteome analyzer includes a separation cassette having a first dimension separation compartment for separation of protein samples by isoelectric focusing and a second dimension separation...
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6274317 |
Automated allele caller
An auto allele caller executed in a computer system for identifying alleles from a trace is described. The auto allele caller applies a typical shape of an allele for a marker to the trace to...
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6224830 |
Absorbance cell for microfluid devices
An improved absorbance or detection cell for a microfluid device, and in accordance with an aspect of the invention, the absorbance cell comprises a bottom plate having a channel bearing surface in...
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6203990 |
Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products
A system and corresponding method analyzes data for patterns, such as data produced from DNA sequencers. An ASCII text file, generated by DNA sequencer software, is used as the input source for the...
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6143153 |
DNA sequencing
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
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6132578 |
Method and apparatus for electrophoresis separation and detection
An electrophoresis separation and detection apparatus for separating and detecting fluorophore-labeled samples by electrophoresis, which comprises a migrating and separating means for...
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RE36826 |
Electrophoresis pattern reading system of fluorescence type
An electrophoresis pattern reading system of fluorescent type is comprised of a detachable migration unit comprising a gel functioning as a base for electrophoresis and a gel-supporting body for...
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6103084 |
Apparatus for electroporation
An apparatus for electroporation stores a level of charge, specified by a user, on a capacitor, which is delivered to a cuvette through an optically isolated high voltage switch. The capacitor is...
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6086737 |
Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or...
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6068753 |
Automatic electrophoresis apparatus with fluorescent and visible scanning
An apparatus for electrophoresing a sample and for thereafter either scanning in the visible mode or the fluorescent mode, under control of a central processor, to provide scanning densitometry of...
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6066245 |
Method and apparatus for scanning fluorescently labeled particles
A system and method for illuminating an optically active sample and collecting scattered light emitted by the sample. Preferably, the sample is a fluorescently labeled and fluoresces light. The...
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6027628 |
Gel cassette for electrophoresis
A gel cassette for electrophoresis includes opposed plastic plates holding a gel therebetween. An upper buffer tank can be adhered to one of the plates by double backed tape that is sandwiched...
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6014213 |
High dynamic range apparatus for separation and detection of polynucleotide fragments
A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with...
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6007691 |
Fluorophore assisted carbohydrate electrophoresis diagnosis
The subject invention provides methods and kits for conveniently diagnosing various physiological conditions that produce altered levels of specific carbohydrates, known as diagnostic...
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6005663 |
Automated electrophoresis and fluorescence detection apparatus and method
Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short...
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5951838 |
Method and apparatus for correcting illumination non-uniformities
A method and apparatus for achieving uniform illumination in an electrophoresis apparatus is provided. Uniform illumination allows quantitative measurements of an electrophoresis gel to be made,...
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5949899 |
Apparatus for measuring and analyzing electrophoresis images
A system for measuring and analyzing an image of a gel electrophoresis, includes measuring apparatus and a processor. The measuring apparatus includes a frame mountable in a fixed location relative...
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5904822 |
Methods and apparatus for analyzing electrophoresis gels
This invention relates to a system and methods for the straightening an electrophoresis gel image in the vertical and horizontal directions, and for analyzing a straightened gel image. The system...
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5900131 |
Method and apparatus for automated electrophoresis using light polarization detector
Changes in polarized light incident on a detection zone within a separation matrix are used to detect optically active molecules within the separation matrix. The separation and detection of...
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5897760 |
Method and apparatus for the removal of non-uniformities in an electrophoresis apparatus
A method and apparatus for correcting non-uniformities in the source and the lens assembly of an electrophoresis apparatus is provided. Assuming a detector with a uniform responsivity, correcting...
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5891314 |
Method and apparatus for correcting lens non-uniformities in an electrophoresis apparatus
A method and apparatus for correcting non-uniformities in the lens assembly of an electrophoresis apparatus is provided. Assuming a detector with a uniform responsivity as well as a uniform...
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5863403 |
Digital DNA typing
To sequence DNA automatically, fluorescently marked DNA are electrophoresed in a plurality of channels through a gel electrophoresis slab; wherein the DNA samples are resolved in accordance with...
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