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7384527 |
Electrophoresis apparatus and a plate therefor
The invention provides an electrophoresis apparatus comprising an electrophoretic chamber containing at least on two-plate housing for a sieving matrix, each said at least one two-plate housing...
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7361259 |
Capillary array and electrophoresis apparatus, and method
A capillary electrophoresis device including a capillary array, and a method of manufacturing the capillary array, are provided. During the manufacture of the capillary array, a plurality of...
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7344628 |
Capillary electrophoresis-electrochemical detection microchip device and supporting circuits
The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate...
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7329333 |
Uniform laser excitation and detection in capillary array electrophoresis system and method
A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is...
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7315021 |
Charged droplet spray probe
An improved sample introduction probe is disclosed for the production of ions from liquid sample solutions in an electrospray ion source. Nebulization of a liquid sample emerging from the end of an...
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7309409 |
Multi-channel bio-separation cartridge
A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir....
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7307802 |
Optical lens system and method for microfluidic devices
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic...
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7258775 |
Method and device for the qualitative and/or quantitative analysis of a protein and/or peptide pattern of a liquid sample that is derived from the human or animal body
The invention relates to a method for the qualitative and/or quantitative analysis of a protein and/or peptide pattern of a liquid sample that is derived from the human or animal body. The proteins...
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7250099 |
Optical detection alignment coupling apparatus
An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical blocks...
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7250098 |
Multi-capillary array electrophoresis device
An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than...
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7223326 |
Capillary electrophoresis system
A capillary electrophoresis system includes a plurality of capillaries arranged in parallel on a vertical plane at an identical distance from each other, each of which has a sample injection end...
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7217352 |
Capillary electrophoresis device
An electrophoresis device is disclosed that is capable of reducing waves occurring in a fluid in which the capillary tips of a capillary assay are immersed. A plurality of partition plate members...
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7217350 |
Mobility and effects arising from surface charge
A method of, and apparatus for, automatically determining an electric charge—related characteristic or derived parameter of particles in a dispersion or of a cell wall, comprises having a...
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7208072 |
Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
A bio-separation instrument using a multi-segment cartridge. The cartridge includes a plurality of efficient, compact, portable, interchangeable, reusable, recyclable, modular, multi-channel...
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7195699 |
Electrophoresis member, production thereof and capillary electrophoresis apparatus
An electrophoresis member is produced by laying a plurality of capillaries on an adhesive layer born on a support layer to form a capillary layer, laminating thereon a second support layer, and...
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7161356 |
Voltage/current testing equipment for microfluidic devices
The present invention provides novel methods and devices for testing/verifying the configuration of one or more microfluidic elements in a microfluidic device. In particular the methods and devices...
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7125478 |
Microscale electrophoresis devices for biomolecule separation and detection
The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis...
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7118711 |
Microcolumn reactor
The invention relates to a microcolumn reactor for carrying out reactions on solid phases and/or with biological cells. The aim of the invention is to provide a microcolumn reactor for processes of...
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7118662 |
Electrophoresis apparatus
The windows 5 a, 5 b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An...
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7118660 |
Method and apparatus for analyzing a mixture of sample substances
An apparatus for analyzing a mixture of sample substances comprises a fluid-guiding structure wherein the sample substances are moving essentially in one dimension along the structure and are...
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7112266 |
Multi channel capillary electrophoresis device and method
Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein...
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7108775 |
Apparatus and method for confining eluted samples in electrophoresis systems
The present teachings provide a microfluidic apparatus comprising a body defining at least one channel that extends through said body, the channel including an inlet and an outlet; and an electrode...
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7090758 |
Capillary array electrophoresis scanner
An improved rotary confocal fluorescence scanner capable of detecting analytes separated on over a 1,000 capillaries simultaneously. This system uses a confocal microscope objective and mirror...
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7056427 |
Electrophoresis apparatus using capillary array and sample plate assembly used therefor
A sample plate assembly for an electrophoresis apparatus including a tray at a sample supply portion of a capillary array, an adapter for the tray, a sample plate mounted on the adapter, a septer...
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7054004 |
Capillary array and capillary array photodetector
A multi-focus capillary array that can reduce crosstalk and a capillary array photodetector are provided. On a substrate 20 on which a plurality of capillaries are aligned, a perforation 72 is...
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7037417 |
Mechanical control of fluids in micro-analytical devices
An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a...
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7037416 |
Method for monitoring flow rate using fluorescent markers
Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of...
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7033476 |
Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection
An apparatus for carrying out the separation, detection, and/or counting of single molecules at nanometer scale. Molecular separation is achieved by driving single molecules through a microfluidic...
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7033475 |
Electrophoretic apparatus
An electrophoretic apparatus which can analyze multiple tests specimens and being comprised of an electrophoretic member having a relatively simple configuration of passages, such that one or a...
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7018519 |
Multicapillary electrophoresis systems
A multicapillary electrophoresis system includes juxtaposed capillaries, at least one source configured for the emission of a light beam intended to excite molecules lying in its path and inside...
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7015466 |
Electrosonic spray ionization method and device for the atmospheric ionization of molecules
There is described a device and method for generating gaseous ions of a sample material such as molecules in solution at atmospheric pressure. The device includes a conduit for receiving a solution...
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7014746 |
Capillary electrophoretic instrument and capillary array assembly
The troublesomeness during the setting of a plurality of capillaries is eliminated by composing pairs of electrodes, which are electrically connected to the common electrode, and capillaries. By...
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7010391 |
Methods and systems for control of microfluidic devices
The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined...
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7005052 |
Capillary array
A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis,...
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7002144 |
Transfer line for measurement systems
An enhanced transfer system that increases the accuracy and sensitivity of a measurement system is disclosed. In one embodiment, the transfer system includes transfer tubing that transports samples...
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6989085 |
Method for separation of compounds using cycling denaturing conditions
A method for electrophoretic separation in separation channels in which the temperature of the channel is repeatedly cycled during the course of the separation.
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6986837 |
Microfluidic controller and detector system with self-calibration
A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at...
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6984525 |
Method for automated isolation of fractions in multichannel separation systems
A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a microfabricated...
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6977034 |
Capillary array and electrophoresis apparatus
A capillary array comprising multiple capillaries and two holding substrates for arranging the aforementioned multiple capillaries in a substantially plane surface by sandwiching at least some of...
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6974527 |
Multidimensional separations employing an array of electrophoresis channels
The present invention relates to a method for separating components of a sample. The method includes obtaining a first separation of the sample components along a first dimension wherein the sample...
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6964736 |
Method and apparatus for analysis and sorting of polynucleotides based on size
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
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6953520 |
Capillary electrophoresis probes and method
A novel class of capillary electrophoresis probes and a method of employing the same are described. The novel class of capillary electrophoresis probes are comprised of one or more vinylogous...
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6942778 |
Microstructure apparatus and method for separating differently charged molecules using an applied electric field
The field of the present invention relates generally to a microstructure apparatus which may be used in a high-throughput screening context to monitor the rate of reaction of an enzyme with its...
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6942773 |
Particle sizer and DNA sequencer
An electrophoretic device separates and detects particles such as DNA fragments, proteins, and the like. The device has a capillary which is coated with a coating with a low refractive index such...
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6942771 |
Microfluidic systems in the electrochemical detection of target analytes
The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
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6936152 |
Capillary array electrophoresis apparatus and method of separating and analyzing specimen
At a wall constituting a space for a thermostatic oven in an electrophoresis apparatus, a capillary array attachment portion is formed which permits attachment of a plurality of capillary arrays...
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6925612 |
Device and method for selecting electrophoresis band
The present invention aims at easy and efficient selection of bands present on a lane. A region 502 is set on a display of a lane 503 having a plurality of bands 504 to 508, based on an...
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6908594 |
Efficient microfluidic sealing
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
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6905586 |
DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
An apparatus and method for performing nucleic acid (DNA and/or RNA) sequencing on a single molecule. The genetic sequence information is obtained by probing through a DNA or RNA molecule base by...
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6887359 |
Chemical micro-sensor
An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by...
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