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5667656 |
DNA detector and DNA detection method
An electrophoresis apparatus for detecting samples migrating in migration portions includes a plurality of gel separation portions separate from one another and having respective ends disposed...
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5663790 |
Method and apparatus for determination of refractive index
In a method of determining the refractive index of a gaseous, liquid or solid sample, preferably a gaseous or liquid sample, there is used a waveguide resonator (1) which includes an open waveguide...
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5660703 |
Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump
Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump. Following a conventional capillary electrophoresis system having a single power supply, a separation capillary, and...
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5650846 |
Microcolumnar analytical system with optical fiber sensor
An analytical system for analyzing a fluid sample is disclosed. The analytical system includes a microcolumn for conducting the fluid sample, a light source for delivering light through the...
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5630924 |
Compositions, methods and apparatus for ultrafast electroseparation analysis
Compositions, methods, and apparatus for performing ultrafast binding assays by capillary electrophoresis or other electroseparation techniques are disclosed. In one embodiment, a first binding...
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5627643 |
Method and detector for separation processes
The present invention comprises a method Of detecting and quantifying components separated by capillary electrophoresis or other techniques using thin capillaries in the separation. The method of...
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5616228 |
Capillary electrophoresis apparatus for detecting emitted fluorescence from a sample without employing an external light source device
The electrophoresis apparatus has a capillary filled with gel for use in electrophoresis. A first buffer solution container is provided for storing a buffer solution and introducing a sample...
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5614726 |
Automated optical alignment system and method using Raman scattering of capillary tube contents
A system and method are disclosed for optically aligning a capillary tube and an excitation laser beam for fluorescence detection applications by utilizing the Raman scatter signals of the...
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5614073 |
Method and apparatus for detection of underivatized amines and amino acids utilizing end column addition of Ru(bpy).sub.3.sup.2+
Disclosed is a method for and an apparatus for detecing amines or amino acids, which apparatus generally includes a capillary electrophoresis separation tube with a post-capillary reactor...
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5607568 |
Assembly suitable for identifying a code sequence of a biomolecule in a free-solution embodiment
An assembly suitable for identifying a code sequence of at least a portion of a biomolecule in a free-solution embodiment. The assembly comprises first means for migrating and separating a portion...
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5605666 |
Capillary retaining system
A capillary and capillary retaining system including a capillary assembly having first and second end holders. The first and second end holders are adapted to be received by first and second...
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5600444 |
Detecting analyte light absorption utilizing degenerate four wave mixing
A method and apparatus using either two or three input laser beams in a nonlinear degenerate four-wave mixing arrangement for ultrasensative analytical measurements of an analyte. In accordance...
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5600433 |
Optical fiber waist refractometer
The present invention relates to a refractive index detector for a dynamic liquid sample having a fiber optic filament of a predetermined diameter with an unclad sensor region, wherein the sensor...
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5599503 |
Detector cell
A miniaturized detector cell (4) having a measuring chamber volume of 25 fl-1 μl is described. In spite of its miniaturized construction, the detector cell has an optical path length of about...
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5597467 |
System for interfacing capillary zone electrophoresis and inductively coupled plasma-mass spectrometer sample analysis systems, and method of use
A system for interfacing Capillary Zone Electrophoresis (CZE) systems to Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) sample analysis systems is disclosed. The interface system includes a...
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5594545 |
Microflow cell
A microflow cell comprising an outer cylinder disposed on the outer periphery of a cylindrical flow cell and having a flat surface on at least a light-entering surface, and a filling material...
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5587582 |
Self-aligning liquid junction
An interface for connecting an electrophoresis capillary to a mass spectrometer sprayer tube includes a first length of support tubing having an axial bore receiving and aligning the capillary and...
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5584982 |
Multiple capillary biochemical analyzer
A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being...
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5582705 |
Multiplexed capillary electrophoresis system
The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array...
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5580435 |
System for detecting components of a sample in electrophoretic separation
A substrate defines a group therein having three sections: a first and third sections having dimensions larger than the outside dimensions of two capillaries and a second section separating the...
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5580434 |
Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer
An apparatus for collecting samples from capillary electrophoresis (CE) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is disclosed. The apparatus has a capillary, a...
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5573651 |
Apparatus and method for flow injection analysis
Method and apparatus for flow injection analysis (FIA) using an electroosmotic pump. The apparatus includes: an electroosmotic pump having a grounding joint; a sample injection valve for...
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5571398 |
Precise capillary electrophoretic interface for sample collection or analysis
A capillary electrophoretic system and method for accurate and precise post-column manipulation of molecules separated by capillary electrophoresis is disclosed. The system of the invention...
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5569366 |
Fluorescent labelled carbohydrates and their analysis
Processes for the electrophoretic analysis of monosaccharides and/or polysaccharides are disclosed. The processes generally first include providing a composition having derivatized mono and/or...
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5567294 |
Multiple capillary biochemical analyzer with barrier member
A multiple capillary biochemical analyzer for sequencing DNA and performing other analyses, in which a set of capillaries extends from wells in a microtiter plate into a cuvette. In the cuvette the...
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5556790 |
Method for Automated DNA sequencing
An automated DNA sequencing apparatus and method is disclosed in which a laser beam having a predetermined wavelength is sequentially focused on a plurality of lanes of DNA fragments migrating in a...
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5545304 |
Ion current detector for high pressure ion sources for monitoring separations
The present invention relates generally to any application involving the monitoring of signal arising from ions produced by electrospray or other high pressure (>100 torr) ion sources. The...
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5545303 |
System for analyzing the concentration of a number of different ions in a watery solution
System for analyzing the concentration of a number of different ions in a watery solution, using a capillary zone electrophoresis apparatus comprising a capillary tube extending between an input...
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5543618 |
Capillary zone electrophoresis-mass spectrometer interface
A device for providing equal electrical potential between two loci unconnected by solid or liquid electrical conducts is provided. The device comprises a first electrical conducting terminal, a...
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5541420 |
Multi-sample fraction collector by electrophoresis
The fraction collector according to the present invention comprises a separating means composed of electrophoresis tracks to separate samples by electrophoresis, and a transferring means to...
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5540825 |
Noise suppressing capillary separation system
A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through...
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5534707 |
Apparatus and method for aligning capillary column and detection optics
An apparatus and method of aligning a capillary with respect to a radiation source. More particularly, the capillary is aligned with a laser beam for laser induced fluorescence detection. The...
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5529679 |
DNA detector and DNA detection method
An electrophoresis apparatus includes a plurality of first capillaries containing a separation medium, such as a gel, and an optical cell in which one end of each of the first capillaries is...
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5516409 |
DNA detector and DNA detection method
An electrophoresis apparatus for detecting samples migrating in migration portions includes a plurality of gel separation portions separate from one another and having respective ends disposed...
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5505832 |
Device and method for mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI)
The invention relates to a device and a method for mass-spectrometric analysis of substance samples which have been separated by capillary electrophoresis, particularly proteins, proteoglycanes or...
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5498324 |
Multiplexed fluorescence detector system for capillary electrophoresis
A fluorescence detection system for capillary electrophoresis is provided wherein the detection system can simultaneously excite fluorescence and substantially simultaneously monitor separations in...
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RE35157 |
Means and method for capillary zone electrophoresis with laser-induced indirect fluorescence detection
A means and method for capillary zone electrphoresis with laser-induced indirect fluorescence detection. A detector is positioned on the capillary tube of a capillary zone electrophoresis system....
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5484571 |
Enhanced fluorescence detection of samples in capillary column
A simple device for collecting a greater amount of fluorescent emission from a minute sample in a capillary column. An axially symmetrical paraboloid reflector is implemented to collect fluorescent...
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5482608 |
Capillary electrophoresis flow control system
A system for controlling the bulk flow rate in capillary electrophoresis employs pressure to increase velocity without unacceptably increasing plate height. Thus, the system controls bulk flow over...
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5480614 |
Micro-reactor device for minute sample analysis
A minute sample analysis system includes a micro-reactor device, a quantitative measuring device, an analyzing device and a controller, whereby, when a very small amount of sample is handled, its...
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5480525 |
Machine-accessible electrochemical detector for capillary electrophoresis
End-column detectors are provided in which either a sensing microelectrode or optical fiber is placed at the end of the separation capillary. Additionally, an alignment apparatus is provided to...
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5468364 |
Base sequencing apparatus
Disclosed herein is an on-line base sequencing apparatus, which is provided with electrophoresis tubes having a sheath flow part in each lower end thereof, which a sulfuric acid solution of pH 1.0...
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5459325 |
High-speed fluorescence scanner
A high-speed fluorescence scanner for scanning a sample at equal angles is disclosed. The scanner has most of its optical components, including a light beam source, a detector, and various filters,...
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5453170 |
Off-column detector for ion separation techniques
An off-column conductivity detector for ion electrophoresis measurements is formed from a first connector having a body carrying the discharge end of a separation capillary and a second connector...
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5449064 |
On-line interface and valve for capillary electophoresis system
An interface is provided for use with a multiple sample acquisition device and a capillary electrophoresis separation device. The interface includes a body member having a base and an upstanding...
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5444807 |
Micro chemical analysis employing flow through detectors
The chemical properties of a flowing liquid analyte, the analyte comprising a solvent having an index of refraction which is the same as or closely approaches that of water, are determined by...
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5439578 |
Multiple capillary biochemical analyzer
A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being...
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5433838 |
Electrophoresis with chemically suppressed detection
Improved capillary electrophoresis apparatus of the type that generally includes a capillary tube, the capillary tube having a sample inlet end and an outlet end, a first electrode in electrical...
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5430541 |
High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis
A fluorescence flow cell having a capillary through which a sample fluid is moved, an optical source that directs an exposing beam of light through the sample fluid, a collector that collects...
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5429734 |
Monolithic capillary electrophoretic device
A method and apparatus for separating ions in a liquid sample based on electrophoretic mobility. The device includes a buried channel formed upon a semiconductor wafer and surrounded by an...
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