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6881312 |
Ultra high throughput microfluidic analytical systems and methods
Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a...
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6878255 |
Microfluidic devices with thick-film electrochemical detection
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic...
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6864055 |
Method for detecting nucleic acids
A method of detecting nucleic acid fragments in plural samples is performed by the steps of: attaching an electroconductive label to nucleic acid fragments in one sample and attaching a different...
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6863790 |
Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode
A simple and rugged sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry (CE/ESI-MS) was designed using common laboratory tools and chemicals. The interface...
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6852206 |
Measurement of fluorescence using capillary isoelectric focusing
Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation...
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6843901 |
Potential gradient detector for electrophoresis
An on-column detector for electrophoresis samples based on the principles of potential gradient detection, in which the electrodes for detection are physically isolated from the electrophoretic...
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6837977 |
Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
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6827906 |
Continuous form microstructure assay array
A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially lengthwise...
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6808610 |
Capillary array electrophoresis apparatus
When irradiating laser beam from the side face of the capillary array, an optical axis of the laser beam is inclined in vertical direction with respect to a plane face formed by the capillary...
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6808609 |
Device and method for moving charged particles
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
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6790671 |
Optically characterizing polymers
The invention relates to new systems, methods and products for analyzing polymers and in particular new systems, methods and products useful for obtaining sequence information from polymers. The...
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6787017 |
Capillary electrophoretis system, sample analyzer and liquid sample cassette for electrophoretic separation
The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to removably...
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6783650 |
Capillary electrophoretic apparatus
A capillary cassette is made up of two separated holders, an array of capillaries and a tube. The capillaries that make up the array are inserted into the first holder, extend through second holder...
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6783649 |
High throughput capillary electrophoresis system
The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling arm...
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6767731 |
Electron induced fluorescent method for nucleic acid sequencing
An apparatus, compositions and related methods for sequencing a target nucleic acid are described. In certain embodiments, the apparatus is a microfluidic apparatus comprising an input chamber,...
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6755952 |
Device for electrophoresis
The present invention allows detection in short time while maintaining the level of the resolving power as high as when a capillary is utilized. The entire surface of an electrophoresis board 10...
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6755074 |
Liquid chromatographic method and system
To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by...
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6752914 |
Capillary electrophoresis device
An analyser comprises a substrate ( 20 ) of diamond, sapphire or a polymer material; an array ( 10 ) of elongate capillary channels formed in the substrate; means ( 40 ) for driving a sample to be...
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6740219 |
Electrophoresis analysis apparatus and sample vessel used therefor
A multi-capillary type electrophoresis analysis apparatus has a sample tray for containing a plurality of samples, wherein part of the sample tray is made from a conductive material. Samples are...
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6706164 |
Method for controlling sample introduction in microcolumn separation techniques and sampling device
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
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6699378 |
Method for controlling sample introduction in microcolumn separation techniques and sampling device
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
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6699377 |
Method for controlling sample introduction in microcolumn separation techniques and sampling device
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
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6660149 |
Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis
A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or...
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6635164 |
Capillary electrophoresis system
A capillary electrophoresis system includes a plurality of capillaries arranged in parallel on a vertical plane at an identical distance from each other, each of which has a sample injection end...
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6632400 |
Integrated microfluidic and electronic components
A microfluidic component having a microfluidic channel is bonded to an electronics component having a circuit for processing signals related to the microfluidic component. In an embodiment, the...
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6630063 |
Uniform laser excitation and detection in capillary array electrophoresis system and method
A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is...
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6616824 |
Apparatus for electrophoresis
An apparatus for electrophoresis includes not only a transparent device for electrophoresis such as a microchip or a capillary having a flow route, a power source for applying a voltage difference...
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6613212 |
Multiple capillary electrophoresis systems
The invention concerns a multiple capillary electrophoresis system including many juxtaposed capillaries, at least one source for transmitting a beam designed to excite the molecules present in its...
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6613210 |
Molecular imaging
A method of imaging molecules of interest within a biological sample includes shining a UV light onto the sample and detecting the molecular UV absorption. Where the molecules of interest are...
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6596140 |
Multi-channel capillary electrophoresis device and method
Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein...
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6592733 |
Capillary electrophoresis devices incorporating optical waveguides
A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that...
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6576108 |
DNA detector and DNA detection method
An electrophoresis apparatus includes an optical cell having an outlet for fluid and filled with a buffer solution, and a plurality of electrophoresis lanes, each including a separation medium,...
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6576104 |
Apparatus and method for reading gel electrophoresis pattern
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
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6554986 |
Capillary array electrophoresis scanner
An improved rotary confocal fluorescence scanner capable of detecting analytes separated on over a 1,000 capillaries simultaneously. This system uses a confocal microscope objective and mirror...
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6547941 |
Ultra high throughput microfluidic analytical systems and methods
Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a...
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6534013 |
Microfluidic devices and systems
The present invention is generally directed to improved microfluidic devices and systems, and particularly to a microfluidic device which comprises a planar body structure, at least a first channel...
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6533914 |
Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
The present invention concerns methods and apparatus for the high resolution, high output electrophoretic separation of molecules. In preferred embodiments, the methods and apparatus are of use for...
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6531044 |
Capillary array electrophoresis apparatus
The electrophoresis apparatus includes plural capillaries for separating fluorephore-labeled samples by electrophoresis, fluorescence detecting parts provided in a part of these capillaries...
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6531041 |
Multiplexed capillary electrophoresis system with rotatable photodetector
A parallel capillary electrophoresis system for separating and analyzing the components of multiple chemical samples. The system comprises a bundle of capillary tubes arrayed to have at least...
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6529275 |
Optical detection in bio-separation device using a widened detection zone
In a bio-separation system, the detection zone for optical detection of sample analytes is located at a widened zone along the separation channel. In one embodiment of the present invention, the...
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6527933 |
DNA sample preparation and electrophoresis analysis apparatus
The DNA sample preparation apparatus of the present invention comprises a base plate having a plurality of first grooves for fixing two or more kinds of DNA samples or primers to the inner surfaces...
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6524866 |
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
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6509085 |
Fabrication of microfluidic circuits by printing techniques
Laminates having microfluidic structures disposed between sheets of the laminate are provided. The microfluidic structures are raised on a sheet of laminate, typically by printing the structure on...
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6508923 |
Multi-capillary electrophoretic apparatus
A data processing part comprises a time-series data production part for producing time-series data as to each capillary column from a scan waveform obtained by an optical measuring part, further...
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6497804 |
Method and apparatus for DNA sequencing
The development of the network structure and the basic modules of an automated 4-color DNA sequencing apparatus comprising more than one thousand capillary electrophoresis lanes is disclosed. The...
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6491805 |
Sample-analysis system with antisynchronously driven contactless conductivity detector
In a differential condition, an electrophoresis system antisynchronously drives a longitudinally-separated pair of contactless drive electrodes, both of which are coupled to a detection electrode...
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6488832 |
Array based electrophoretic system for the analysis of multiple biological samples
The present invention relates to an electrophoretic method to effect differential net migration, the extent of said migration being dependent on molecular size, of electrically charged...
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6485626 |
Multiple capillary electrophoresis devices with detection in capillary output
The invention concerns a multiple capillary electrophoresis device comprising a plurality of juxtaposed capillaries, means for generating inside the capillaries an electric field ensuring...
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6468409 |
Method and apparatus for detecting substances
An apparatus for detecting fluorophore labelled substances in an electrophoretic separation medium comprises illuminating means ( 1 ) for illuminating the fluorophore labelled substances ( 8 ),...
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6464852 |
Multicapillary bundle for electrophoresis and detection for DNA
A multichannel electrophoretic cassette structure is disclosed comprising distinct regions for loading and detection with different spacing between channels. A method and an apparatus are further...
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