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6364516 Electrophoretic sample excitation light assembly  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6349740 Monolithic high performance miniature flow control unit  
A monolithic flow controller for controlling the rate at which a medicinal liquid is administered to a patient. The monolithic flow controller includes one or more virtual valves that, because of...
6322683 Alignment of multicomponent microfabricated structures  
Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on...
6322682 Method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds  
A method of capillary electrophoresis utilizing a capillary tube made up of hydrophobic plastics, charactarized in that the inner surface of said capillary is coated with a hydrophilic polymer...
6319705 Microchip device for electrophoresis  
A microchip device for electrophoresis includes not only a microchip having a separation flow route for separating a sample electrophoretically and an electrical power source for applying a...
6306273 Methods and compositions for conducting processes in microfluidic devices  
A method is disclosed for controlling the direction and transport of a material on a microfluidic device formed from an acrylic polymer, by electrokinetic flow of a fluid containing the material....
6306272 Method and device for performing chemical reactions  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6301931 Vacuum fusion bonded glass plates having microstructures thereon  
An improved apparatus and method for vacuum fusion bonding of large, patterned glass plates. One or both glass plates are patterned with etched features such as microstructure capillaries and a...
6296768 Separating materials for chromatography and electrophoresis applications comprising regiodefined functionalised cyclodextrins chemically bonded to a support via urethane functionalities  
Novel and improved chiral stationary phases (CSP) materials comprising a support and completely regiodefined derivitised cyclodextrin chemically bonded via single or double urethane linkage(s)...
6287440 Method for eliminating gas blocking in electrokinetic pumping systems  
A method for eliminating gas bubble blockage of current flow during operation of an electrokinetic pump. By making use of the ability to modify the surface charge on the porous dielectric medium...
6284113 Apparatus and method for transferring liquids  
The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements....
6284525 Miniature reaction chamber and devices incorporating same  
The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have...
6264892 Miniaturized planar columns for use in a liquid phase separation apparatus  
Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of...
6261431 Process for microfabrication of an integrated PCR-CE device and products produced by the same  
A fully integrated monolithic small volume PCR-CE device in glass, or the like materials, is fabricated using thin film metal heaters and thermocouples to thermally cycle sub-microliter PCR...
6261430 Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules  
A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a...
6258263 Liquid chromatograph on a chip  
A chromatograph fabricated using microelectromechanical techniques. The chromatograph includes a first layer superimposed over a second layer. At least one micro-channel is etched into the second...
6258238 Method of producing a capillary, a capillary for an electrophoresis device and an electrophoresis device including such a capillary  
A method for producing a capillary comprises the steps of providing first a capillary having a uniform inner width throughout its length, introducing then an etchant into the capillary, and...
6251247 Detection of degradation of RNA using microchannel electrophoresis  
Degradation of RNA present in a sample is detected by using, as an indicator, rRNA included in the RNA. The steps include: (a) introducing the sample onto a microchannel, at an introducing point,...
6231737 Material transport method and apparatus  
An electrospray apparatus uses a microchannel formed in a microchip. Fluid is pumped through the channel to an outlet orifice using either hydraulic or electrokinetic means. An electrospray is...
6210986 Microfluidic channel fabrication method  
A new channel structure for microfluidic systems and process for fabricating this structure. In contrast to the conventional practice of fabricating fluid channels as trenches or grooves in a...
6184029 Mesoscale sample preparation device and systems for determination and processing of analytes  
A mesoscale sample preparation device capable of providing microvolume test samples, separated into a cell-enriched fraction and a fraction of reduced cell content, for performing various...
6176962 Methods for fabricating enclosed microchannel structures  
Methods are provided for the fabrication of polymeric microchannel structures having enclosed microchannels of capillary dimension. The microchannel structures are constructed of a base plate and...
6176991 Serpentine channel with self-correcting bends  
A serpentine electrophoresis channel, e.g., for a microchip format, is disclosed. The channel includes pairs of linear segments, e.g., parallel or right-angle segments, each joined by an angled...
6159353 Capillary electrophoretic separation system  
The present invention provides an electrophoretic separation system on a planar chip of glass or plastic material with on-chip FIA (flow injection analysis) injection and one or multiple sets of...
6156576 Fast controllable laser lysis of cells for analysis  
Fast lysis of a single cell or cellular component thereof is performed by generating a shock wave in a medium in which the cell or cellular component thereof is positioned. The cell or cellular...
6153076 Extended length microchannels for high density high throughput electrophoresis systems  
High throughput electrophoresis systems which provide extended well-to-read distances on smaller substrates, thus compacting the overall systems. The electrophoresis systems utilize a high density...
6149815 Precise electrokinetic delivery of minute volumes of liquid(s)  
Femtoliter to milliliter volumes of one or a plurality of different liquids are accurately dispensed electrokinetically without any direct electrical contact with such liquid(s). This is...
6143153 DNA sequencing  
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
6132419 Electroporetic gene and drug therapy  
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into...
6132579 Liquid separation  
A liquid is separated into its constituent species by electrophoresis along a capillary channel. A plurality of the channels is provided in the thickness of an injection molded plastics disc. The...
6126804 Integrated polymerase chain reaction/electrophoresis instrument  
A new approach and instrument for field identification of micro-organisms and DNA fragments using a small and disposable device containing integrated polymerase chain reaction (PCR) enzymatic...
6120666 Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same  
A microfabricated device and method for electrokinetic transport of a liquid phase biological or chemical material is described. In accordance with one aspect of the present invention there is...
6111096 Nucleic acid isolation and purification  
The invention is based on the discovery that hyperbaric, hydrostatic pressure reversibly alters the partitioning of nucleic acids between certain adsorbed and solvated phases relative to...
6110339 Nanofabricated separation matrix for analysis of biopolymers and methods of making and using same  
Separation matrices useful in the formation of solid-state mm- to cm-scale devices for the rapid, high-resolution separation of single-stranded DNA ladder bands generated by the Sanger dideoxy- or...
6103081 Heat sink for capillary electrophoresis  
A cooling means for a capillary electrophoresis system is described. The cooling means is designed for efficient heat dissipation and operates without arcing at voltages higher than 30 kV.
6103537 Capillary assays involving separation of free and bound species  
The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member...
6093300 Sample plate and multi-capillary electrophoresis apparatus  
A base plate is made of an insulating material, and comprised of a flat surface and a connector part connected therewith. A plurality of wells are vertically and transversely arranged on the...
6093296 Method and device for moving molecules by the application of a plurality of electrical fields  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6090250 Chiral surfactants and methods for their use in chiral separations  
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having...
6086740 Multiplexed microfluidic devices and systems  
Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input...
6083372 Reagents and methods for performing electrokinetic chromatography  
The invention is in the field of electrokinetic chromatography. In particular, the invention is directed to reagents and methods of performing electrokinetic chromatography. The reagents and...
6074541 Preformed polymer coating process and product  
A method of coating a solid support (e.g. a capillary or chromatography packing) to alter the properties of the support surface for separating components in a fluid stream. The method comprises...
6074542 Compounds for molecular separations  
The present invention describes a method and apparatus utilizing a capillary coating of linear and crosslinked polymers and copolymers of acrylamidomonomers or methacrylamides bearing two...
6068749 Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications  
A subatmospheric, variable pressure sample delivery chamber, useful as an electrospray ionization device for introducing a sample into a mass spectrometer or as a sample delivery device for...
6068751 Microfluidic valve and integrated microfluidic system  
A microfluidic delivery system (20) and microfluidic system (100) control flows of a liquid or a gas through elongated capillaries (62, 126) that are enclosed along at least one surface by a layer...
6062261 MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs  
A microfabricated device and method for proportioning and mixing electrokinetically manipulated biological or chemical materials is disclosed. The microfabricated device mixes a plurality of...
6063251 Electrically insulated capillary arrays for electrophoretic applications  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6056859 Method and apparatus for staining immobilized nucleic acids  
A method for staining immobilized nucleic acids includes the steps of affixing DNA probes to a solid substrate, moving target DNA material into proximity with the DNA probes, whereby the target...
6056860 Surface modified electrophoretic chambers  
Electrophoretic chambers having at least a region of surface modification, and methods for their fabrication, are provided. In some embodiments the subject chambers include in the region of...
6054034 Acrylic microchannels and their use in electrophoretic applications  
Microchannels having at least an acrylic inner surface and methods of their use in electrophoretic applications are provided. The subject microchannels may be in the form of a variety of...