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6878255 Microfluidic devices with thick-film electrochemical detection  
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic...
6878254 Size separation of analytes using monomeric surfactants  
A sieving medium for use in the separation of analytes in a sample containing at least one such analyte comprises a monomeric non-ionic surfactant of the of the general formula, B-A, wherein A is...
6866759 Stepped electrophoresis for movement and concentration of DNA  
A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative...
6860980 Polyelectrolyte derivatization of microfluidic devices  
A microchannel device is provided with a plastic substrate having a microchannel formed therein. Polyelectrolyte multilayers are disposed along selected surfaces of the microchannel. The...
6857449 Multi-layer microfluidic devices  
The present invention provides multi-layer microfluidic systems, by providing additional substrate layers, e.g., third, fourth, fifth and more substrate layers, mated with the typically described...
6852206 Measurement of fluorescence using capillary isoelectric focusing  
Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation...
6848462 Adhesiveless microfluidic device fabrication  
A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device...
6845787 Microfluidic multi-splitter  
A splitter for multi-layer microfluidic devices is provided. The splitter includes multiple forked channels defined in two or more device layers. The forked channels communicate fluidically at...
6843272 Conductance valve and pressure-to-conductance transducer method and apparatus  
A device for interrupting or throttling undesired ionic transport through a fluid network is disclosed. The device acts as a fluid valve by reversibly generating a fixed “bubble” in the conducting...
6837977 Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand  
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
6835293 Analysis system  
The invention relates to an analysis system comprising a main body (1) with a surface, at least one analysis unit (6) consisting of at least two reservoirs (10) placed in flow connection by at...
6833068 Passive injection control for microfluidic systems  
Apparatus for eliminating siphoning, “dead” regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive...
6827906 Continuous form microstructure assay array  
A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially...
6824663 Efficient compound distribution in microfluidic devices  
Microfluidic devices are provided having units of 8-fold symmetry comprising 8 assay units, where a reservoir provides a common component to 8 assay units. The units can be compactly formed in a...
6818113 Microfluidic device with sample injector and method of using  
A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having...
6818112 Protein separation via multidimensional electrophoresis  
The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve...
6808609 Device and method for moving charged particles  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6805784 Capillary array  
The structure of a capillary head section is made such that the liquid contacting surfaces of a capillary holder, a capillary, and an adhesive form a plane surface, and this shared liquid...
6787015 Methods for conducting electrophoretic analysis  
Capillary electrophoresis is performed under conventional conditions in microchannels having a norbornene based polymer surface. The norbornene based polymers can be used as a solid substrate for...
6787018 Dielectrophoretic concentration of particles under electrokinetic flow  
The use of dielectrophoresis to collect particles under the conditions of electrokinetically-driven flow. Dielectrophortic concentration of particles under electrokinetic flow is accomplished by...
6787017 Capillary electrophoretis system, sample analyzer and liquid sample cassette for electrophoretic separation  
The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to...
6787111 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis  
An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet...
6783650 Capillary electrophoretic apparatus  
A capillary cassette is made up of two separated holders, an array of capillaries and a tube. The capillaries that make up the array are inserted into the first holder, extend through second...
6783649 High throughput capillary electrophoresis system  
The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling...
6779559 Non-mechanical valves for fluidic systems  
Methods devices and systems that employ non-mechanical valve modules for controlling directing fluid and other material movement through integrated microscale channel network. These non-mechanical...
6780300 Device for analyzing samples by multi-capillary electrophoresis with solid/solid temperature regulation  
A device for analyzing samples by electrophoresis comprises a plurality of capillaries, receiver means comprising a multiplicity of independent units each made of a material that is thermally...
6773567 High-throughput analytical microfluidic systems and methods of making same  
A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed...
6767194 Valves and pumps for microfluidic systems and method for making microfluidic systems  
The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap...
6764648 Robotic microchannel bioanalytical instrument  
A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the...
6755074 Liquid chromatographic method and system  
To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by...
6755952 Device for electrophoresis  
The present invention allows detection in short time while maintaining the level of the resolving power as high as when a capillary is utilized. The entire surface of an electrophoresis board 10,...
6752914 Capillary electrophoresis device  
An analyser comprises a substrate (20) of diamond, sapphire or a polymer material; an array (10) of elongate capillary channels formed in the substrate; means (40) for driving a sample to be...
6748978 Microfluidic devices with porous regions  
Microfluidic devices having porous materials that restrict fluid flow rate for a given pressure are provided. Multiple porous regions can be constructed in a single device so that they have...
6749735 Electromobility focusing controlled channel electrophoresis system  
An electromobility focusing controlled channel electrophoresis system includes a first separation channel including an electric field intensity gradient profile in which the intensity is a...
6733730 Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems  
What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses...
6730206 Microfluidic device and system with improved sample handling  
An improved microfluidics device and system for sample loading and injection are disclosed. The device includes three main channels—a separation channel, supply channel, and drain channel—for use...
6729352 Microfluidic synthesis devices and methods  
A microfluidic reactor for performing chemical and biological synthesis reactions, including chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein,...
6725882 Configurable micro flowguide device  
Disclosed is a micro flowguide device comprising: a micro channel comprising at least one bubble trap to retard bubbles positioned in said bubble trap; an electrolytic bubble generating device to...
6716328 Microchannel cross load array with dense parallel input  
An architecture or layout for microchannel arrays using T or Cross (+) loading for electrophoresis or other injection and separation chemistry that are performed in microfluidic configurations....
6695009 Microfluidic methods, devices and systems for in situ material concentration  
Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the...
6677593 Planar flow-by electrode capacitive electrospray ion source  
An electrospray ion source includes a chamber including a channel region therein, the channel including at least one inlet for directing a solution into the channel and at least a first and a...
6662830 Sample processing device with integral electrophoresis channels  
Sample processing devices with electrophoresis channels and methods of loading the electrophoresis channels with electrophoresis sieving polymer while rotating the sample processing device are...
6663757 Method and device for the convective movement of liquids in microsystems  
The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial...
6637463 Multi-channel microfluidic system design with balanced fluid flow distribution  
Methods and apparatus are presented for controlling fluid flow through flow paths with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing...
6632400 Integrated microfluidic and electronic components  
A microfluidic component having a microfluidic channel is bonded to an electronics component having a circuit for processing signals related to the microfluidic component. In an embodiment, the...
6627076 Compact microchannel system  
The present invention provides compact geometries for the layout of microchannel columns through the use of turns and straight channel segments. These compact geometries permit the use of long...
6613512 Apparatus and method for correcting for variable velocity in microfluidic systems  
Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and...
6613525 Microfluidic apparatus and method for purification and processing  
Integrated microfluidic devices comprising at least an enrichment channel (10) and a main electrophoretic flowpath (12) are provided. In the subject integrated devices, the enrichment channel and...
6613212 Multiple capillary electrophoresis systems  
The invention concerns a multiple capillary electrophoresis system including many juxtaposed capillaries, at least one source for transmitting a beam designed to excite the molecules present in...
6613211 Capillary electrokinesis based cellular assays  
Cell based assays are performed in a microfluidic device, where the cells are introduced into a reservoir and are contacted with one or more agents prior to or during their residence in the...