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7070681 Electrokinetic instability micromixer  
A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex...
7069943 Microfluidic system including a bubble valve for regulating fluid flow through a microchannel  
A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for...
7059352 Triggerable passive valve for use in controlling the flow of fluid  
The present invention is directed to valves for use in controlling the flow of fluid and, more particularly, to a triggerable passive valve for use in controlling the flow of fluid. In one...
7055540 Method of moving fluid in capillary chip  
The present invention is a method of moving a fluid in a capillary using a capillary chip having a layer including a polymer composition and a capillary formed on the surface or inside of the...
7056427 Electrophoresis apparatus using capillary array and sample plate assembly used therefor  
A sample plate assembly for an electrophoresis apparatus including a tray at a sample supply portion of a capillary array, an adapter for the tray, a sample plate mounted on the adapter, a septer...
7045048 Polymers for separation of biomolecules by capillary electrophoresis  
The invention provides uncharged water-soluble silica-adsorbing polymers for suppressing electroendoosmotic flow and to reduce analyte-wall interactions in capillary electrophoresis. In one aspect...
7037082 Corbino disc electroosmotic flow pump  
The present invention provides a pump for generating an Electroosmotic Flow (EOF) in a solution in a canal, guide, pipe or equivalent. Electroosmotic flow is generated by application of an...
7037417 Mechanical control of fluids in micro-analytical devices  
An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a...
7037416 Method for monitoring flow rate using fluorescent markers  
Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of...
7033476 Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection  
An apparatus for carrying out the separation, detection, and/or counting of single molecules at nanometer scale. Molecular separation is achieved by driving single molecules through a microfluidic...
7033474 Microfluidic devices incorporating improved channel geometries  
The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation,...
7029561 Fluidic temperature gradient focusing  
A method and device are provided for concentrating and separating ionic species in solution within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is...
7018519 Multicapillary electrophoresis systems  
A multicapillary electrophoresis system includes juxtaposed capillaries, at least one source configured for the emission of a light beam intended to excite molecules lying in its path and inside...
7007710 Microfluidic devices and methods  
Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an...
7007709 Microfluidic device and manufacture thereof  
The present invention relates to microfluidic devices and to their method of manufacture. The microfluidic devices are original by their specific structure (of sandwich type) and by the materials...
7005052 Capillary array  
A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis,...
7004198 Micro-fluidic interconnect  
An apparatus for simultaneously aligning and interconnecting microfluidic ports is presented. Such interconnections are required to utilize microfluidic devices fabricated in...
7001496 Electropipettor and compensation means for electrophoretic bias  
A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically...
6994826 Method and apparatus for controlling cross contamination of microfluid channels  
A method for controlling fluid flow at junctions in microchannel systems. Control of fluid flow is accomplished generally by providing increased resistance to electric-field and pressure-driven...
6991713 Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device  
A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of...
6989128 Apparatus for continuous liquid flow in microscale channels using wicking  
Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an...
6984525 Method for automated isolation of fractions in multichannel separation systems  
A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a...
6981522 Microfluidic devices with distributing inputs  
Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple...
6982028 Surface charge modification within preformed polymer microchannels with multiple applications including modulating electroosmotic flow and creating microarrays  
A method is described for modifying performed channels fabricated in a variety of substrate materials including PMMA. The method involves exposing a portion of a fluid flow channel to light at a...
6979390 Method and apparatus for separating biological molecules  
A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing...
6974526 Plastic microfluidics enabling two-dimensional protein separations in proteome analysis  
The invention provides a microfluidic apparatus for performing 2-D biomolecular separations. The microfluidic 2-D device may include first and second planar substrates which include at least a...
6974528 High performance wide bore electrophoresis  
Methods, apparatus and systems are provided for efficient separation of various small and large molecules, especially biomolecules such as proteins, nucleic acids and polysaccharides. In...
6974529 Hand-held electrophoresis detection device and support thereof  
A hand-held electrophoresis detection device and support thereof. The hand-held electrophoresis detection device includes a support and a cartridge. The cartridge attaches a sample, and is...
6969454 Apparatus for the location and concentration of polar analytes using an alternating electric field  
A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric...
6969452 Two-dimensional protein separations using chromatofocusing and multiplexed capillary gel electrophoresis  
Disclosed is a two-dimensional protein separation method. It makes separating a protein sample by chromatofocusing into a plurality of aliquots, and then loading each aliquot into a separate...
6960286 Method for controlling sample introduction in microcolumn separation techniques and sampling device  
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
6960285 Electrokinetically pumped high pressure sprays  
An electrokinetic pump capable of producing high pressure is combined with a nozzle having a submicron orifice to provide a high pressure spray device. Because of its small size, the device can be...
6949176 Microfluidic control using dielectric pumping  
Devices and methods utilizing dielectric pumping and variable dielectric pumping to move fluids through microchannels. Two fluids having dissimilar dielectric constants form an interface that is...
6942778 Microstructure apparatus and method for separating differently charged molecules using an applied electric field  
The field of the present invention relates generally to a microstructure apparatus which may be used in a high-throughput screening context to monitor the rate of reaction of an enzyme with its...
6942777 Sample analysis system with chip-based electrophoresis device  
The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device...
6939451 Microfluidic chip having integrated electrodes  
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities,...
6939453 Electrophoresis process using ionic liquids  
Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid...
6939452 Parallel sample loading and injection device for multichannel microfluidic devices  
A sample load and injection device (10) includes sample introduction capillaries (11) attached to a microfluidic device (12). Sample introduction capillaries (11) are connected to sample...
6939454 Chip type electrophoresis device  
An electrophoresis chip is formed of a pair of transparent base plates. A sample introduction flow path and a separation flow path crossing each other are formed on a surface of one of the base...
6929730 Two dimensional microfluidic gene scanner  
One embodiment of the invention relates to a microfluidic apparatus for performing two dimensional biomolecular separations. According to one aspect of the invention, after a first dimension...
6929729 Method for conducting capillary zone electrophoresis  
A method for conducting capillary zone electrophoresis in which a lubricating detergent is added to help prevent sample buildup on the inner walls of the capillary. In a preferred embodiment the...
6929731 Parallel array of independent thermostats for column separations  
A thermostat array including an array of two or more capillary columns (10) or two or more channels in a microfabricated device is disclosed. A heat conductive material (12) surrounded each...
6923895 Coated capillary electrophoresis tubes and system  
The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to...
6919045 Supply element for a laboratory microchip  
A supply element for a microfluid microchip that can be used for chemical analysis has supply lines or reservoirs that serve to supply the microchip with substances or reagents. Both ends of the...
6913679 Apparatus and methods for high resolution separation of sample components on microfabricated channel devices  
Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce...
6908594 Efficient microfluidic sealing  
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
6890411 Control of flow and materials for micro devices  
The present invention generally relates to methods and devices for the control of the movement of fluids and electrically charged sample components within those fluids. More particularly, the...
6881316 Capillary array device  
The present invention easies a connection between electrodes of a capillary array device and a connection plate for supplying a high voltage to the electrodes. According to the present invention,...
6881317 Fractionation of macro-molecules using asymmetric pulsed field electrophoresis  
A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field...
6880576 Microfluidic devices for methods development  
Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to...