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5798032 Method and apparatus for automated carbohydrate mapping and sequencing  
Methods and apparatus are disclosed for improved mapping and sequencing of carbohydrate polymers. In one aspect, the improvement includes a means for coupling two capillary electrophoresis (CE)...
5785831 Mixing liquids using electroosmotic flow  
A method and apparatus for mixing liquids using electroosmotic flow. Multiple capillaries (100, 104, 106) or microchip channels meet at a common junction (102). One capillary (100) is used for...
5766435 Concentration of biological samples on a microliter scale and analysis by capillary electrophoresis  
The present invention provides new methods for the concentration of ionic solutes, particularly ampholytes, such as, for example, peptides, proteins and nucleic acids. The methods are based on the...
5759369 Viscous electrophoresis polymer medium and method  
An electrophoresis separation medium is disclosed comprising a matrix of a copolymer composed of a linear hydrophilic polymer segment having a selected substantially uniform segment length and...
5759370 Method and device for isoelectric focusing without carrier ampholytes  
A device and method for isoelectric focusing of ampholytes in a buffer uses a cone-shaped capillary with a positive electrode connected at a narrow end and a negative electrode connected at the...
5753094 Borate storage buffer and sample diluent  
A composition, which has utility as a storage buffer and as a sample diluent before analysis by capillary zone electrophoresis (CZE), is comprised of water, a borate compound, a buffer compound...
5750074 Reagent segment  
A reagent segment including a body and trough formed therein with the floor of the trough sloped towards a drainage zone. The reagent segment is adapted for transporting reagents within an...
5728282 Denaturing separation matrix having hydroxyethyl cellulose for nucleic acid electrophoresis  
A capillary electrophoresis separation matrix for single-stranded nucleic acids, along with methods for using and preparing the matrix, are disclosed. The separation matrix provides denaturing...
5723031 Method for the analytical separation of viruses  
The method permits the non-destructive analytical detection and/or the quantification of viruses or viral particles (analytes) in a liquid sample matrix containing organic or inorganic minor...
5695626 Capillaries for use in a multiplexed capillary electrophoresis system  
The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the...
5685965 Capillary electrophoresis technique  
To detect bands in an electrophoresis capillary tube having a liquid separating medium, a light source and a light detector of a monitor are positioned on opposite sides of the capillary tube with...
5662787 Device for profiling oligosaccharides released from glycoproteins  
Methods for profiling oligosaccharides released from glycoproteins and methods for the electrophoretic separation of high mannose, complex and hybrid oligosaccharides are disclosed. The disclosed...
5660703 Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump  
Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump. Following a conventional capillary electrophoresis system having a single power supply, a separation capillary, and...
5658446 Preparative capillary electrophoresis with wide-bore capillary  
A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary...
5645702 Low voltage miniaturized column analytical apparatus and method  
A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are...
5646048 Microcolumnar analytical apparatus with microcolumnar flow gating interface and method of using the apparatus  
A microcolumnar analytical apparatus having a flow gating interface system for interfacing a first microcolumn and a second microcolumn is provided. The apparatus includes a flow gating interface,...
5641400 Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems  
Miniaturized planar column devices and miniaturized total analysis systems for liquid phase analysis are disclosed. The systems include a temperature control device for regulating temperature,...
5633129 Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices  
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique...
5630925 Capillary electrophoresis using a conductive capillary tube  
An electrophoretic system employing a capillary with at least one end having an electrically conductive coating or layer directly thereon. In order to introduce a plug of sample from a small...
5624539 Real time monitoring of electroosmotic flow in capillary electrophoresis  
An electrophoretic separation apparatus includes a capillary tube having a length, a cross section, an inlet and an outlet. A first reservoir containing a solvent and, upon injection, a solute is...
5614361 Method for identifying and characterizing organisms  
A method of characterizing an unknown organism species which comprises, determining the position of part or whole of evolutionarily conserved DNA sequences in DNA of the organism, relative to the...
5611903 Capillary electrophoresis method using initialized capillary and polyanion-containing buffer and chemical kit therefor  
A capillary electrophoresis detection and/or analysis method comprising the following steps: rinsing a ready-to-use capillary with an initiator to create an initialized capillary, adding a...
5605662 Active programmable electronic devices for molecular biological analysis and diagnostics  
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
5605613 Polyvinylalcohol coated capillary electrophoresis columns  
Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface...
5599432 Device and a method for the electrophoretic separation of fluid substance mixtures  
A device for the electrophoretic separation of complex fluid substance mixtures comprises a channel system (21, 2, 22) for a carrier medium (C), an injection device (3) for the injection into the...
5597468 Capillary electrophoresis  
An apparatus is disclosed for providing capillary electrophoresis, which includes an electronically controlled valve system for automatically introducing a sample into the capillary by means of a...
5593564 Microcolumn-microcolumn flow interface and method  
A flow gating interface system including a first microcolumnar section, a second microcolumnar section, and a channel for interfacing a first fluid conduit and a second fluid conduit is provided....
5593565 Devices for separating particles contained in a fluid  
In order to separate, within a fluid (1), certain particles (2) contained therein, this fluid is arranged in a corridor (C) partly defined by two faces which are close together and substantially...
5580435 System for detecting components of a sample in electrophoretic separation  
A substrate defines a group therein having three sections: a first and third sections having dimensions larger than the outside dimensions of two capillaries and a second section separating the...
5580434 Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer  
An apparatus for collecting samples from capillary electrophoresis (CE) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is disclosed. The apparatus has a capillary,...
5578460 Electrophoretic method for the isolation and separation of microorganisms and cell populations  
The present invention sorts microorganism populations from a mixture which contains more than one microorganism population. Microorganisms of different types vary in size, shape, and surface...
5573651 Apparatus and method for flow injection analysis  
Method and apparatus for flow injection analysis (FIA) using an electroosmotic pump. The apparatus includes: an electroosmotic pump having a grounding joint; a sample injection valve for...
5571398 Precise capillary electrophoretic interface for sample collection or analysis  
A capillary electrophoretic system and method for accurate and precise post-column manipulation of molecules separated by capillary electrophoresis is disclosed. The system of the invention...
5569366 Fluorescent labelled carbohydrates and their analysis  
Processes for the electrophoretic analysis of monosaccharides and/or polysaccharides are disclosed. The processes generally first include providing a composition having derivatized mono and/or...
5567282 On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins  
A method for classifying and typing M-proteins present in a sample of serum, etc. of an individual is disclosed. The method employs an on-capillary electrophoretic immunosubtractive method to...
5560811 Capillary electrophoresis apparatus and method  
This invention involves method and apparatus for multiplexing electrophoresis analysis. An array of samples in multi well plates are simultaneously transferred to an array of electrophoresis...
5545302 Suppression of electroendosmosis during electrophoresis in gel-free polymer media by use of charged polymers  
The phenomenon of electroendosmosis which occurs in electrophoretic separations and interferes with the efficiency, accuracy and reproducibility of the separations, is suppressed by the inclusion...
5545304 Ion current detector for high pressure ion sources for monitoring separations  
The present invention relates generally to any application involving the monitoring of signal arising from ions produced by electrospray or other high pressure (>100 torr) ion sources. The present...
5545303 System for analyzing the concentration of a number of different ions in a watery solution  
System for analyzing the concentration of a number of different ions in a watery solution, using a capillary zone electrophoresis apparatus comprising a capillary tube extending between an input...
5502169 Deactivation of the inner surfaces of capillaries  
The invention relates to a process for deactivating the inner surfaces of capillaries for capillary zone electrophoresis and capillary gel electrophoresis. The deactivation is effected by coating...
5492834 Method of sample preparation for urine protein analysis with capillary electrophoresis  
Processes are provided for pretreating body fluid compositions and subsequently analyzing the pretreated body fluid compositions for analytes of interest. Processes for pretreating the...
5472584 Method and apparatus for improved detection of ionic species by capillary electrophoresis  
Apparatus and methods are provided for increasing the sensitivity of detection of ionic species separated by capillary electrophoresis. The apparatus includes capillary electrophoretic separating...
5462646 Coated capillary columns and electrophoretic separation methods for their use  
Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface...
5424037 Apparatus for handling liquid vials in an analytical device  
An apparatus for handling liquid vials in an analytical device comprises a single movable tray for accommodating a plurality of vials, and lifting devices arranged in the proximity of the tray for...
5332480 Capillary bed electrophoresis  
A capillary bed electrophoresis device for separating and collecting large-scale electrophoretic samples is disclosed. The invention relates to an improvement in the anticonvective packing and...
5322608 Siloxandediol coating for capillary electrophoresis and for general surface modification  
A coated microcapillary column for high performance electrophoresis is disclosed. A preferred microcapillary includes a column; a universal sub-layer of coating material that has been highly...
5316630 Methods for chromatography analysis  
A method is described for the normalization and standardization of variabilities of electropherograms obtained with conductometric capillary electrophoresis. The variabilities may be associated...
5314593 Capillary tube with reversible protein interaction and method  
A method for treating capillary walls exposable to protein solutes is provided that promotes reversible interactions between the protein solutes and the wall. Thus a small bore capillary tube,...
5310463 On-column junction for capillary columns  
An electrophoretic or chromatographic separation capillary containing a fluid defines a bore therein through which a sample travels and separates into components. The tube has a side wall defining...
5302264 Capillary eletrophoresis method and apparatus  
A capillary electrophoresis method and apparatus (10) are disclosed in which pressure or vacuum is selectively applied to an outlet end (16) of the capillary tube (12) during sample loading,...