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6054032 Capillary electrophoresis array  
A capillary electrophoresis array that includes: (a) a plurality of capillary tubes arranged adjacent each other in a generally longitudinal orientation, each of the tubes having an inlet end, and...
6051636 Entrapment of nucleic acid sequencing template in sample mixtures by entangled polymer networks  
A capillary electrophoresis system and method of electrokinetically loading a capillary electrophoresis sample into a separation medium in a capillary tube in which an entangled polymer matrix is...
6048444 Capillary electrophoresis apparatus  
A capillary electrophoresis apparatus of the invention has: a plurality of capillaries which are filled with a migration medium and have first ends into which samples are injected and second ends...
6045676 Electrochemical detector integrated on microfabricated capilliary electrophoresis chips  
A microfabricated capillary electrophoresis chip which includes an integral thin film electrochemical detector for detecting molecules separated in the capillary.
6042709 Microfluidic sampling system and methods  
The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions...
6027627 Automated parallel capillary electrophoretic system  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6013168 Microchip electrophoresis apparatus  
When a microchip is set on a tray and operation of an apparatus is begun, the microchip moves to feed position in order to be filled up with a buffer solution, where upon a sample is injected into...
6007690 Integrated microfluidic devices  
Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main...
6004443 Chromatography-format fluid electrophoresis  
A novel free-fluid electrophoresis system applicable to both "analytical" and "preparative" separations combines the advantages of electrophoresis with those of automated liquid chromatography....
6001230 Automated capillary electrophoresis apparatus  
An integrated apparatus for capillary electrophoresis which is automated using conveyors which carry vials containing electrolytes and samples, a capillary contained in a modular, portable, and...
5997708 Multilayer integrated assembly having specialized intermediary substrate  
A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The...
5993633 Capillary electrophoresis electrospray ionization mass spectrometry interface  
The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an...
5992820 Flow control in microfluidics devices by controlled bubble formation  
Provided is a fluid control device comprising: (a) a channel of capillary dimensions for conveying a liquid, (b) a bubble-forming device for forming a channel-blocking bubble in the channel,...
5993626 Capillary electrophoresis of transferrin glycoforms  
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is...
5985121 Fast sampling device and sampling method for capillary electrophoresis  
An improved apparatus and method for the capillary electrophoretic separation of chemical compounds comprises carrying out on-line sample preparation by means of semipermeable membranes connected...
5980719 Electrohydrodynamic receptor  
An electrohydrodynamic (EHD) receptor that incorporates microchannels and reservoir(s) for selectively dispensing fluid from the reservoir(s) to a specific location, e.g., onto the surface of the...
RE36350 Fully integrated miniaturized planar liquid sample handling and analysis device  
A miniaturized total analysis system ("μ-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The μ-TAS comprises microstructures fabricated by laser...
5964997 Balanced asymmetric electronic pulse patterns for operating electrode-based pumps  
Provided is a method of operating an electrode-based pump to pump a liquid, the method comprising periodically reversing the voltage polarity applied to the electrodes of the pump while...
5963456 Method and apparatus for displaying capillary electrophoresis data  
A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected...
5961800 Indirect electrode-based pumps  
Provided is an electrode-based pump having source of a pumped fluid, a conduit channel of capillary dimensions connected via a first end to the pumped fluid source and having an outlet at a second...
5958202 Capillary electrophoresis enzyme immunoassay  
Disclosed are methods and apparatus for performing highly sensitive enzyme-amplified assays using channel electrophoresis of an enzyme having a biorecognition moiety. Combining a binding reaction...
5954931 Electrophoresis apparatus and method involving parallel channels  
An electrophoresis apparatus includes a substrate (34) which supports a filling region (22) and a plurality of electrophoresis lanes (20). The filling region (22) communicates a sample to the...
5948231 Compositions, methods and apparatus for ultrafast electroseparation analysis  
Compositions, methods, and apparatus for performing ultrafast binding assays by capillary electrophoresis or other electroseparation techniques are disclosed. In one embodiment, a first binding...
5942093 Electro-osmotically driven liquid delivery method and apparatus  
Method and apparatus for controlling precisely the composition and delivery of liquid at sub-μL/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient...
5938905 High-pressure electrophoresis apparatus and method  
A high-pressure electrophoresis apparatus is formed by a high-pressure tubing (101) in which at least one column-shaped cell is arranged, said cell comprising two cell portions being arranged in...
5935430 Structure for capturing express transient liquid phase during diffusion bonding of planar devices  
A miniaturized planar device formed of first and second planar substrates that may be superimposed and diffusion bonded to form a single, planar integrated assembly. Each of the first and second...
5935522 On-line DNA analysis system with rapid thermal cycling  
An apparatus particularly suited for subjecting biological samples to any necessary sample preparation tasks, subjecting the sample to rapid thermal cycling, and then subjecting the sample to...
5928906 Process for direct sequencing during template amplification  
Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and perfonning high throughput DNA sequencing are described.
5916428 Automated system for multi-capillary electrophoresis having a two-dimensional array of capillary ends  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
5908552 Column for capillary chromatographic separations  
A column for capillary chromatographic separations, for example high performance liquid chromatography, capillary electrochromatography, or supercritical chromatography, includes a column bed of...
5906723 Electrochemical detector integrated on microfabricated capillary electrophoresis chips  
A microfabricated capillary electrophoresis chip which includes an integral thin film electrochemical detector for detecting molecules separated in the capillary.
5904824 Microfluidic electrophoresis device  
A microfluidic device having opposed spaced apart sheets of siliceous material, such as glass, the opposed facing sides of each of the sheets having hydrophilic and hydrophobic areas which form...
5900132 Capillary holder  
A holder (10) is provided for securing a capillary (30) having a window section (28) including first and second edges (46) (48) to a mount (80). The holder (10) comprises a retaining surface (14)...
5890745 Micromachined fluidic coupler  
A method for producing a microfluidic coupler includes the step of producing a first mask on a top surface of a wafer. The first mask defines an insertion channel pattern selected to correspond to...
5888366 Capillary made of polymer material having a modified inside surface and process for its production  
A capillary made of plastics material that is suited for use in capillary electrophoresis. The capillary has its inner surface chemically modified for the generation of properties different from...
5888390 Multilayer integrated assembly for effecting fluid handling functions  
A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The...
5885430 Capillary tube holder for an electrophoretic apparatus  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
5882496 Porous silicon structures with high surface area/specific pore size  
Fabrication and use of porous silicon structures to increase surface area of heated reaction chambers, electrophoresis devices, and thermopneumatic sensor-actuators, chemical preconcentrates, and...
5872010 Microscale fluid handling system  
A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip...
5858187 Apparatus and method for performing electrodynamic focusing on a microchip  
A microchip device includes a focusing channel, in which an electric field strength established in the focusing channel is controlled relative to an electric field strength established in a...
5858194 Capillary, interface and holder  
A capillary, interface and holder for a capillary electrophoresis system are provided herein. The capillary is disposed in a substantially planar housing having side surfaces. The capillary...
5856100 Method for purification and transfer to separation/detection systems of DNA sequencing samples and plates used therefor  
Disclosed are: a part for assembling reaction vessels comprising a base plate with holes passing through said plate in the direction of thickness; a method for preparation of reaction vessels...
RE36011 Protein separations by capillary electrophoresis using amino acid-containing buffers  
Protein mixtures are separated by capillary electrophoresis in a buffer containing one or more amino acids in an amount sufficient to prevent or substantially reduce the degree of protein binding...
5846396 Liquid distribution system  
The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The...
5846727 Microsystem for rapid DNA sequencing  
A system is disclosed for the rapid and cost-effective sequencing of DNA. There are three principal components of the system: (1) a microreactor, which prepares DNA sequencing "ladders" using...
5840388 Polyvinyl alcohol (PVA) based covalently bonded stable hydrophilic coating for capillary electrophoresis  
A coated microcapillary column for high performance electrophoresis is disclosed. A preferred microcapillary includes a fused silica capillary column, the inner surface of the column having an...
5833826 Method and apparatus for reducing the distortion of a sample zone eluting from a capillary electrophoresis capillary  
An electrophoresis system including means for reducing the distortion of a sample zone eluting from a capillary electrophoresis separation capillary is disclosed. The system includes one or more...
5824204 Micromachined capillary electrophoresis device  
A micromachined structure for handling fluids with an applied high voltage, i.e. for electrophoresis, includes a glass or other highly insulative substrate on which are formed very small diameter...
5810985 Electrophoretically mediated chemical analysis  
Disclosed are methods of electrochemical analysis of an analyte in a sample. The methods include providing a sample comprising an analyte, and introducing the sample into a capillary tube...
5800692 Preseparation processor for use in capillary electrophoresis  
A preseparation processor for use in capillary electrophoresis is described. The preseparation processor contains sample processing material, preferably in the form of a membrane, for use in...