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7495231 |
MALDI sample plate imaging workstation
The invention provides an apparatus for producing an image of a global surface of an ion source sample plate that is exterior to an ion source. In general terms, the apparatus contains a sample...
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7435322 |
Device and method for automatically analysing the constituents of an analyte
The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing,...
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7332268 |
Layered support sheet for high-yield spot cutting from gels or membranes
The excision of sample spots from a gel or membrane by pressing a cutting tool terminating in a hollow cylinder against the gel or membrane supported on a rigid surface is made more reliable by...
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7250097 |
Device for sequential protein transfer from a gel
An apparatus and method for the sequential electroelution of biomolecules is described, the apparatus comprising a separation medium having an outlet, and a collector having at least a first...
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7153405 |
Cassette, system, and 2-D gel electrophoresis method for separating molecules
A gel electrophoresis cassette ( 33 ) is disclosed which includes two plates ( 34, 35 ) and at least one seal ( 36 ) which separates these plates. The seal ( 36 ) is annular; it may be positioned...
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7153404 |
Gel spot picker
The present invention relates to a gel sheet ( 1 ) for use in a spot picker device wherein said gel sheet is provide with reference marks ( 5′–5 ′″) which can be used to determine if the...
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7147762 |
Method of electrophoresis
The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the...
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7077940 |
Strip holder, chamber, cassette, and 2-D gel electrophoresis method and system for performing this method for separating molecules
A strip holder ( 1 ) is disclosed for accommodating a gel strip ( 3 ) for separating molecules using gel electrophoresis. The strip holder ( 1 ) disclosed is distinguished by including a baseplate...
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7070682 |
Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
The invention relates to an apparatus for performing gel protein extractions and methods of using the apparatus.
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7025864 |
Method and apparatus for recovering target molecules from a gel containing said target molecules
A preparative electrophoresis apparatus suitable for recovery of molecules from gels comprises two spaced apart electrode compartments connected by a conduit that descends from the bottom of the...
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6991714 |
Apparatus and method for taking samples from polymer support material
A sample taking apparatus comprises a plurality of separation tools ( 10 ) (for example, punching capillaries) on a holding device ( 20 ), wherein the separation tools ( 10 ) are each provided with...
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6916423 |
Device and methods for subdividing and filtering gel material and extracting molecules therefrom
An apparatus and method for mincing a gel includes a gel mincing tube and a mesh material. The mesh material extends across the end of the tube. To subdivide a gel using the mincing apparatus, a...
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6793790 |
Sample collection system for gel electrophoresis
An automatic sample collection system for use with an electrophoretic slab gel system is presented. The collection system can be used with a slab gel have one or more lanes. A detector is used to...
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6783648 |
Method and apparatus for unloading gels from isoelectric gel tubes
An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for...
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6699986 |
Electrophoretic separation of nucleic acids from proteins at low ph
The present invention relates to methods for separating nucleic acids from other cellular debris, especially substances that carry a net positive charge at low pH, by electrophoresis under acid...
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6652724 |
Automated apparatus for separating a biological sample from a two dimensional electrophoresis gel
An automated high-throughput system for excising spots or samples from an electrophoresis slab gel includes a computer controlled robotic arm assembly and a sample plate handling assembly for...
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6632339 |
Method of identifying polypeptides
Polypeptides which have been separated by gel electrophoresis can be identified by electroblotting them through a “sandwich” comprising in order: a) the separation gel; b) at least one...
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6579378 |
De-staining composition and apparatus
The present invention is drawn to a method for de-staining a substrate that is stained with a dye by bringing the substrate into contact with a de-staining composition and absorbing the dye from...
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6540897 |
Direct detection of histidine tagged biomolecules on electrophoretic gel
A method is disclosed for the detection of a His-tagged target biomolecule while said molecule remains in the gel in which it has been separated from other constituents by electrophoresis. The...
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6482303 |
Automated system for two-dimensional electrophoresis
The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions...
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6342143 |
Cutting tool for multiple sample retrieval from gelatinous material
The invention relates to a sample retrieval apparatus of particular benefit in the field of molecular biology. The apparatus permits the rapid collection of numerous specified fractions of samples:...
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6203680 |
Electrophoresis gels
The present invention provides electrophoresis apparatus and electrophoresis methods employing gellan gum based gels employing divalent metal cation and diamine cross-linking agents. The gels are...
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6136551 |
Assay for detecting the presence of botulinum toxin neutralizing antibodies in a patient serum sample
An assay for the identification of neutralizing botulinum antibodies in sera is provided which includes the steps of separating non-sodium dodecyl sulfate, non-trypsinized complex botulinum toxin...
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6068754 |
Multi-tank gel developing apparatus and method
The claimed multi-tank gel developing apparatus and method comprises of two inner tanks within one outer tank to develop multiple electrophoresis gels simultaneously. The two inner tanks have...
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5922186 |
Staining, de-staining and quantification of proteins by coomassie-blue and related dyes
The present invention presents a novel method for both staining electrophoresis gels, as well as removing the background dye during de-staining. This novel and simple pad-based technique minimizes...
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5882495 |
Electrophoresis system
The present invention provides electrophoresis systems and methods for forming at least one gel therein and for conducting electrophoresis on the gel without removing the gel from the...
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5840169 |
Apparatus and process for electroelution of a gel containing charged macromolecules
A process for electroelution of a gel containing charged macromolecules, such as proteins or polynucleotides, comprising the steps of providing a plurality of adjacent parallel chambers having a...
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5654149 |
Non-radioactive DNA sequencing
A new process and kit are described that combines methods for generating the nucleotide base sequence of a DNA molecule with an ultra-sensitive silver staining protocol. This new combination of...
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5635045 |
Apparatus for, and a method of, electroelution isolation of biomolecules and recovering biomolecules after elution
An apparatus for electroelution isolation of biomolecules and recovering biomolecules after elution including a tubular enclosure for engaging a piece of separating gel having a band of...
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5635046 |
Method for drying polyacrylamide gel after electrophoresis
A polyacrylamide gel which has undergone electrophoresis is dried in the presence of pressure applied via a semipermeable film placed on the gel. Before applying the semipermeable film onto the...
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5595636 |
Method for mass spectrometric analysis of samples from electrophoresis plates
The invention relates to the mass spectrometric analysis of separated substance samples on so-called 2-D-gel electrophoresis plates, used particularly for protein determination, with ionization of...
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5593561 |
Multiple electrophoresis method and apparatus for migration and transfer of macromolecules
A multiple electrophoresis method and apparatus for migrating and transferring macromolecules in a vessel (10) containing a plurality of parallel elongate electrodes (14), membranes (22) disposed...
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5587062 |
Sample collecting apparatus by gel electrophoresis
An apparatus for collecting samples by gel electrophoresis has a base table, a cutting tool or an extractor disposed above the base table, a moving mechanism, a pattern detector and a control...
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5587061 |
Device and method for biomolecule purification
A novel device and method for biomolecule purification is provided as a handy tool for routine applications when both a high resolution and an easy manipulation are required. A sample is applied...
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5569364 |
Separation media for electrophoresis
Separation media for electrophoresis, and methods of filling and flushing of electrophoretic devices such as capillaries are described. By preparing submicron to above-micron sized cross-linked gel...
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5567585 |
Method and kit for silver staining, developing an image and visualizing biological materials
A silver staining method is provided for staining an organic molecule capable of binding silver. An improved image is developed and visualized. A kit useful in practicing the method is described. A...
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5543054 |
Method and apparatus for covalent immobilization of charge- conjugated carbohydrate molecules
A method for covalent immobilization of a carbohydrate molecule with an oppositely charged surface, comprising the steps of adsorbing the carbohydrate molecule to the oppositely charged surface in...
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5538614 |
Macromolecule recovery cassette
An elution cassette is invented for macromolecule recovery from electrophoresis gels. The cassette comprises a frame (10), a front barrier (20), a back barrier (30), and a space inside the cassette...
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5534121 |
Preparative two dimensional gel electrophoresis system
A preparative two dimensional gel electrophoresis system which serves as a single procedure for separation and isolation of preparative amounts of proteins from complex biological preparations. The...
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5527680 |
Method for extracting solutes from gel plugs
A flow-through receptacle is disclosed, one end of which is designed to hold multiple plugs of gel material, containing solutes such as macromolecules, excised from electrophoretic separations, and...
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5492810 |
DNA silver staining
A method for visualizing nucleic acids in a polyacrylamide gel. The method comprises fixing the nucleic acids with 10% acetic acid for about 20 minutes, washing the gel multiple times with water...
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5480803 |
Apparatus for treating analytes
An apparatus includes an enclosed chamber in which a motor-driven cylinder is mounted for rotation about a horizontal axis. The lower half of the cylinder is disposed in a trough. A blot can be...
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5458749 |
Device and process for staining electrophoretic gels
A process and apparatus are described herein which provide for the automated processing of electrophoresed gels having biological material thereon within a single processing chamber. The described...
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5440822 |
Method and apparatus for drying electrophoresis gels
A method and apparatus for drying electrophoresis gels. The apparatus includes a base unit and gel drying frame assembly. The base unit serves as a both a support for the frame when placing the gel...
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5427664 |
Free solution electrophoresis-membrane filters trapping assay apparatus and method
A free solution electrophones-membrane filter trapping assay apparatus includes a container and at least one porous membrane. The porous membrane and container define a chamber capable of holding...
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5415758 |
Method and apparatus for electro-elution of biological molecules
The invention includes methods for electro-elution of a biological molecule from a biological sample matrix, the methods including electro-eluting a negatively charged molecule from each of plural...
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5407546 |
Method for high-resolution two-dimensional electrophoresis and device for carrying out the same
For high-resolution two-dimensional electrophoresis comprising the steps of carrying out, on a gel base, at first a first separation process in a first direction and then a second separation...
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5316908 |
Size markers for electrophoretic analysis of DNA
The present invention discloses a DNA marker ladder useful in Southern blot hybridizations. The ladder is made up of pooled DNA restriction endonuclease digests, where each restriction digest...
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5308460 |
Rapid synthesis and analysis of carbohydrates
The subject invention provides novel methods and apparatus for synthesizing carbohydrates of a desired structure. The subject synthesis methods include using carbohydrage-modifying enzymes to...
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5292665 |
Catalyst for preparing polyacrylamide gel which improves the detection of biomaterials by silver staining
A polyacrylamide gel comprising acrylamide and diacrylylpiperazine. A method for providing a polyacrylamide gel comprising employing a catalyst system which comprises dimethylpiperazine, sodium...
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