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7566544 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7497934 |
System and method
An analysis system for and method of enabling determination of the velocities of migrating objects and also classifying migrating objects into groups having a common constraint. In one aspect the...
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7347922 |
Multi-dimensional proteomic analysis method
A multi-dimensional proteomic analysis method utilizing cationic electrophoresis is described. The method includes separating proteins in one direction using cationic electrophoresis and separating...
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7338808 |
Method and apparatus for determining zeta potential using alternating current electric field and T channel
Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel,...
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7312087 |
Devices and methods for biochip multiplexing
The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a...
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7198754 |
Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
A biological material detection apparatus which detects a charged biological material such as a gene or protein contained in a sample liquid is disclosed. A biological material detection element...
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7147762 |
Method of electrophoresis
The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the...
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7118662 |
Electrophoresis apparatus
The windows 5 a, 5 b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An...
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7070949 |
Protein mixture analysis by mass spectrometry
The invention relates to the analysis of complex protein mixtures such as entire proteomes, and in particular the rapid detection of previously unknown or unusually expressed proteins by common...
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7037416 |
Method for monitoring flow rate using fluorescent markers
Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of...
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6982029 |
Electrophoretic method and system having internal lane standards for color calibration
An electrophoretic system having a plurality of separation lanes is provided with an automatic color calibration feature in which each lane is separately calibrated. For each lane, a dye matrix...
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6872530 |
Method for determining the presence of DNA variants using peptide nucleic acid probes
The present invention relates to a peptide nucleic acid probe-based method for generating data indicative of the presence of a nucleotide polymorphism, mutation, or methylated cytosine in a...
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6863791 |
Method for in-situ calibration of electrophoretic analysis systems
An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration...
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6855554 |
Methods and compositions for detection of breast cancer
Systematic comparisons of breast ductal fluid samples obtained by nipple aspiration from women with unilateral breast cancer revealed significant differences in ductal fluid protein expression...
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6818402 |
Method and kit for the detection of schistosomiasis through the polymerase chain reaction
The present invention provides a method of detection of Schistosoma sp. in biological samples through PCR, as well as a method for the diagnosis of Schistosomiasis through the amplification by...
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6793790 |
Sample collection system for gel electrophoresis
An automatic sample collection system for use with an electrophoretic slab gel system is presented. The collection system can be used with a slab gel have one or more lanes. A detector is used to...
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6764583 |
Using impedance measurements for detecting pathogens trapped in an electric field
Impedance measurements between the electrodes in an electric field is utilized to detect the presence of pathogens trapped in the electric field. Since particles trapped in a field using the...
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6613210 |
Molecular imaging
A method of imaging molecules of interest within a biological sample includes shining a UV light onto the sample and detecting the molecular UV absorption. Where the molecules of interest are...
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6605434 |
Direct bacterial lysate sequencing
The present invention relates to novel methods for sequencing nucleic acid molecules. More specifically, methods are provided for sequencing nucleic acid molecules present in bacterial lysates...
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6596140 |
Multi-channel capillary electrophoresis device and method
Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein...
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6582574 |
pK-matched running buffers for gel electrophoresis
pK-matched buffers, each containing two effective buffering components: one weak base and one weak acid which have similar pK a at 25° C. (within 0.3 pK units On agarose gels, the buffers in...
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6576106 |
Method for separating and assaying lipoprotein, an assembly for performing such a method, and a system including such an assembly
A method for separating and assaying lipoprotain to determine a degree of modification of a predetermined component in a specimen of lipoprotein, comprising the step of: determining a distance...
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6576104 |
Apparatus and method for reading gel electrophoresis pattern
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
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6555392 |
Antisera tray
An improvement in the immunofixation electrophoresis procedure for detecting proteins in serum, urine or cerebral spinal fluids. Multiple samples from a single patient are placed on a gel and...
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6554987 |
Method and apparatus for alignment of signals for use in DNA base-calling
Data traces from four channels of an automated electrophoresis detection apparatus are aligned by identifying peaks in each of the four data traces; optionally normalizing the data traces to...
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6540897 |
Direct detection of histidine tagged biomolecules on electrophoretic gel
A method is disclosed for the detection of a His-tagged target biomolecule while said molecule remains in the gel in which it has been separated from other constituents by electrophoresis. The...
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6533913 |
Electrophoresis method, electrophoresis device, and marker sample used for the same
An electrophoresis method, comprising simultaneously electrophoresing a test sample containing a plurality of molecules labeled with a plurality of luminescent reagents and a marker sample...
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6524866 |
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
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6511831 |
Electrical integrated nucleic acid isolation, purification and detection
The invention relates to a method and a device for the isolation and purification of nucleic acids. According to the invention, after decomposition of a sample the nucleic acids present in said...
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6500648 |
Methods for recombinant peptide production
The present invention provides improved methods for the production of recombinant peptides from bacterial cells.
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6495812 |
Apparatus and method for analyzing an object of interest having a pivotably movable source and detector
The preferred embodiments described herein provide an apparatus and method for intersecting a light beam and a focal point of a detector at an object of interest. In one preferred embodiment, an...
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6488832 |
Array based electrophoretic system for the analysis of multiple biological samples
The present invention relates to an electrophoretic method to effect differential net migration, the extent of said migration being dependent on molecular size, of electrically charged...
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6468409 |
Method and apparatus for detecting substances
An apparatus for detecting fluorophore labelled substances in an electrophoretic separation medium comprises illuminating means ( 1 ) for illuminating the fluorophore labelled substances ( 8 ),...
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6376193 |
Method for detecting mutations in nucleic acids
A denaturation fingerprinting method (dnF) involves subjecting a nucleic acid segment of interest to bidirectional cycle sequencing using oppositely oriented primers and incorporating two different...
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6294667 |
Analysis of carbohydrates
The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive...
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6287441 |
Multi-conditional SSCP (SSCP5): a rapid method for mutation scanning with virtually 100% sensitivity
Experiments were performed to test for a set of SSCP conditions that would detect virtually all mutations in a nucleic acid being analyzed. The effects of buffer, gel matrix, temperature, and...
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6277259 |
High performance multidimensional proteome analyzer
A proteome analyzer includes a separation cassette having a first dimension separation compartment for separation of protein samples by isoelectric focusing and a second dimension separation...
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6274317 |
Automated allele caller
An auto allele caller executed in a computer system for identifying alleles from a trace is described. The auto allele caller applies a typical shape of an allele for a marker to the trace to...
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6245507 |
In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
The present invention provides a hyperspectral imaging apparatus and methods for employing such an apparatus for multi-dye/base detection of a nucleic acid molecule coupled to a solid surface.
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6190522 |
Analysis of carbohydrates derivatized with visible dye by high-resolution polyacrylamide gel electrophoresis
The present invention is related to the field of carbohydrate analysis. More particularly, this invention relates to a simple and inexpensive method for analyzing carbohydrates which can be used to...
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6156179 |
Computer directed identification of paraproteins
The present invention is generally directed to the analysis of biological samples. More particularly, the present invention is directed to automated sample analysis for paraproteins using...
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6143153 |
DNA sequencing
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
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6131072 |
Lane tracking system and method
A system and method for identifying lanes in images generated from DNA sequencing and fragment analysis is described. One example method includes a computer implemented method of determining the...
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RE36826 |
Electrophoresis pattern reading system of fluorescence type
An electrophoresis pattern reading system of fluorescent type is comprised of a detachable migration unit comprising a gel functioning as a base for electrophoresis and a gel-supporting body for...
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6086737 |
Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or...
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6066245 |
Method and apparatus for scanning fluorescently labeled particles
A system and method for illuminating an optically active sample and collecting scattered light emitted by the sample. Preferably, the sample is a fluorescently labeled and fluoresces light. The...
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6027628 |
Gel cassette for electrophoresis
A gel cassette for electrophoresis includes opposed plastic plates holding a gel therebetween. An upper buffer tank can be adhered to one of the plates by double backed tape that is sandwiched...
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6014213 |
High dynamic range apparatus for separation and detection of polynucleotide fragments
A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with...
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6007691 |
Fluorophore assisted carbohydrate electrophoresis diagnosis
The subject invention provides methods and kits for conveniently diagnosing various physiological conditions that produce altered levels of specific carbohydrates, known as diagnostic...
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6005663 |
Automated electrophoresis and fluorescence detection apparatus and method
Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short...
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