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7601251 |
Methods and apparatus for low resistance electrophoresis of prior-cast, hydratable separation media
Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of...
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7569130 |
Fluorescent detection of proteins in polyacrylamide gels
The mechanism of the UV light-induced reaction between the indole moiety of tryptophan and chloroform, and the structure of the modified tryptophan and polypeptides including such modified...
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7566544 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7517442 |
Facile method and apparatus for the analysis of biological macromolecules in two dimensions using common and familiar electrophoresis formats
An ensemble of components and methods are disclosed for utilizing two-dimensional electrophoresis in polyacrylamide or related polymer gels using common, existing and familiar electrophoresis...
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7459069 |
Electrophoresis device and the use thereof
The invention relates to a device for electrophoretically separating molecules. The inventive device comprises: at least one plate having a top side and an underside; a first separating channel...
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7435322 |
Device and method for automatically analysing the constituents of an analyte
The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing,...
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7416902 |
Method and apparatus for airborne particle sorting
An apparatus for airborne particle sorting is provided comprising a charging system adapted for applying an electrostatic charge to the particles, such that particles of at least a first group are...
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7316771 |
Medium for analytic and preparative electrophoresis
The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the...
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7247224 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Medium for analytic and preparative electrophoresis
The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the...
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7238269 |
Sample processing device with unvented channel
A device includes a substrate having first and second major surfaces and a hub that defines an axis of rotation for the substrate, and an unvented channel having a plurality of connected...
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7198703 |
Chamber-forming electrophoresis cassette cover
A multielevational cover for assembling a fluid retaining chamber on a face of an electrophoresis cassette is presented. The cover comprises a cassette-containing member, at least one...
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7166202 |
Matrixes, arrays, systems and methods
The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The...
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7022214 |
Carrier ampholytes of high pH range
Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH...
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6979390 |
Method and apparatus for separating biological molecules
A system for separating biological molecules includes a chip ( 10 ) on which there is an electrophoresis separation microchannel ( 16 ). At the start of the channel there is an isoelectric focusing...
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6942774 |
Electrophoresis apparatus and a method of using the same
An apparatus for rehydrating and for performing electrophoresis on a gel strip includes a tray defining a plurality of parallel troughs configured to receive gel strips. Each trough defines a...
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6905584 |
Electrophoresis system and method therefor
A method for separating a sample into components by two-dimensional electrophoresis uses an IPG strip, and a gel slab which are spaced apart and carried on a single generally planar support means....
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6875849 |
Methods of recovering chaperone proteins and complexes thereof
The present invention provides methods for efficient and concomitant recovery of multiple chaperone proteins and/or chaperone protein complexes from a limited sample source. Disclosed are methods...
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6833061 |
Methods for isoelectric particle separation
In order to isoelectrically separate particles with a pH-dependent net charge, the particles are exposed in a guiding liquid to electric field forces. The pH value of the guiding liquid is set in...
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6793791 |
Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing
An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the...
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6783648 |
Method and apparatus for unloading gels from isoelectric gel tubes
An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for...
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6767443 |
Method and apparatus for electrophoretic focusing
An apparatus and method is described for obtaining a preparative-scale, free-fluid electrophoretic separator with high resolution as well as an analytical capability commensurate with capillary...
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6761810 |
Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation
An automated assembly for performing first dimension electrophoresis is described herein that includes a supply magazine, an electrophoresis tank and an automated transferring device that...
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6685811 |
Method for separation of macromolecules
The invention relates to a method and a system, suitable for automation, for the, preferably preparative, separation of amphoteric macromolecules, e.g. proteins or peptides, wherein said method...
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6638408 |
Method and device for separation of charged molecules by solution isoelectric focusing
The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures...
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6558522 |
Apparatus for electrophoresis
An electrophoresis apparatus for the simultaneous electrophoretic separation of a plurality of component mixtures using a disposable tray having a plurality of parallel troughs shaped to retain an...
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6537434 |
First dimension electrophoresis separation method and apparatus
An automated apparatus for carrying out a first dimension electrophoresis separation of proteins and other macromolecules includes a supply magazine, an automated transferring device and an...
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6537799 |
Electrical current for controlling fluid parameters in microchannels
A novel method and device for transporting and/or monitoring a fluid in a multi-port device 400, 800, 1000 used in a microfluidic system is provided. The multi-port device includes a substrate...
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6379970 |
Analysis of differential protein expression
A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that...
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6294667 |
Analysis of carbohydrates
The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive...
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6277259 |
High performance multidimensional proteome analyzer
A proteome analyzer includes a separation cassette having a first dimension separation compartment for separation of protein samples by isoelectric focusing and a second dimension separation...
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5866683 |
Isoelectric point markers for isoelectric focusing with fluorescence detection
Provided are isoelectric point(pI) markers for isoelectric focusing with fluorescence detection. The markers are fluorescence-labeled oligopeptides which comprise a fluorescence dye bonded...
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5856298 |
Erythropoietin isoforms
Erythropoietin isoforms having a specific number of sialic acids per erythropoietin molecule are disclosed. Also disclosed are mixtures of such isoforms, pharmaceutical compositions containing such...
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5759370 |
Method and device for isoelectric focusing without carrier ampholytes
A device and method for isoelectric focusing of ampholytes in a buffer uses a cone-shaped capillary with a positive electrode connected at a narrow end and a negative electrode connected at the...
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5534121 |
Preparative two dimensional gel electrophoresis system
A preparative two dimensional gel electrophoresis system which serves as a single procedure for separation and isolation of preparative amounts of proteins from complex biological preparations. The...
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5512158 |
Capillary electrophoresis method and apparatus for electric field uniformity and minimal dispersion of sample fractions
A capillary electrophoresis method and apparatus for reducing dispersion of sample fractions are disclosed. The capillary tube in which the electrophoresis is performed has been flared, at least at...
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5472582 |
Analysis of carbohydrates using 2-aminoacridone
The present invention provides for the use of the fluorescent label 2-aminoacridone for use in separating carbohydrate mixtures and analyzing the structure of carbohydrates. Carbohydrates for...
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5466348 |
Methods and devices for enhanced biochemical sensing
A method and application for detecting and measuring the presence of a binding target material employs a semiconductor device having a receptor-covered surface topgate, separated by a dielectric...
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5447612 |
Buffering system and its use in electrophoretic processes
A novel pH buffering system which is functionally stable under electrophoretic conditions employs buffering components in complementary buffer pairs. The buffering components are selected from...
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5407546 |
Method for high-resolution two-dimensional electrophoresis and device for carrying out the same
For high-resolution two-dimensional electrophoresis comprising the steps of carrying out, on a gel base, at first a first separation process in a first direction and then a second separation...
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5320727 |
Electrophoresis
A method of separating or distinguishing proteins by isoelectric focusing (IEF), comprises fluorescently labelling proteins by reacting monobromobimane or monochlorobimane with free sylphydryl...
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5173160 |
Analysis of carrier ampholytes using immobilized pH gradients
New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the...
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5164055 |
High-viscosity polymer matrix and methods
A supported, substantially uniform matrix for use in electric field-induced separation of molecular components in a sample. The matrix is prepared by forming a viscoelastic polymer matrix and...
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5104505 |
Method and apparatus for electrophoretic separations
The present invention relates to electrophoresis. More particularly, the present invention relates to utilization of electrophoresis with controlled cooling. Still more particularly, the invention...
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5068019 |
Electrophoresis film support
An electrophoresis film support particularly useful for the electrophoretic separation of serum proteins. According to one aspect, the electrophoresis film support comprises a microporous polymer...
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4971670 |
Isoelectric focusing process and a means for carrying out said process
Described is an isoelectric focusing electrophoretic process for the separation and purification of an amphoteric or neutral chemical compound from one or more electrically charged chemical...
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4925545 |
Method of generating pH functions in electrophoresis and isoelectric focusing
The present invention provides an improved method for forming pH gradients or other pH functions for use in electrophoresis and isoelectric focusing. It also involves electrophoresis and IEF...
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4911808 |
Mobilization of focused protein zones by ion introduction
Zones of ampholytic substances which have been isoelectrically focused in a separation medium are mobilized for analytical or preparative purposes by either introducing anions other than hydroxyl...
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4900414 |
Commercial separation system and method using electrokinetic techniques
A commercial electrokinetic separation system extracts charged particles from fluids and separates the particles into discrete separation bands. An electrokinetic column of extended length has a...
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4892814 |
Method for distinguishing Creutzfeldt-Jakob disease from other dementias
A method for distinguishing Creutzfeldt-Jakob disease from other causes of human dementia by analyzing the cerebrospinal fluid of patients for proteins 130 and 131. The presence of these proteins...
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4704198 |
Porosity gradient electrophoresis gel
Describes a process for controlling the polymerization and cross-linked density of electrophoretic gel products useful for separation of bioorganic molecules, which process does not use initiators...
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