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7537679 |
Materials classifier, method of using, and method of making
The present invention relates to a method of classifying charged molecules such as proteins for quantitative analysis. An analyte solution of the molecules is subjected to separational forces may...
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7527720 |
Device for electrophoresis, electrophoresis equipment, electrophoretic method, and specimen detection method
An electrophoretic device in the form of a casing having inside sealed spaces isolated by an electrophoretic carrier. The device includes at least one liquid injection/discharge opening,...
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7517441 |
Electrophoretic buffer
By using an electrophoretic buffer comprising a polymerized polymer micelle formed by the steps comprising dispersing into an aqueous medium a block copolymer represented by HPLS-HPBS-PLZA, wherein...
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7473341 |
Denaturant-free electrophoresis of biological molecules under high temperature conditions
The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to electrophoresis using a matrix that is...
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7459069 |
Electrophoresis device and the use thereof
The invention relates to a device for electrophoretically separating molecules. The inventive device comprises: at least one plate having a top side and an underside; a first separating channel...
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7459068 |
Multi-capillary electrophoresis apparatus
A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The...
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7439075 |
Method and device for withdrawing suspended microparticles from a fluidic microsystem
A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem ( 10 ) is described, whereby the fluid flow converges with at least one output flow to form a discharge...
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7419578 |
Capillary electrophoresis apparatus
A capillary array electrophoresis which can measure fluorescence of a number of capillaries at a time with high sensitivity and can automatically analyze a sample sequentially. An end edge as a...
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7407568 |
Method of using sol-gel coatings for on-line preconcentration of amino acids in capillary electrophoresis
A novel on-line method is presented for the extraction and preconcentration of amino acids using a sol-gel coated column coupled to a conventional UV/vis detector. Extraction, stacking and focusing...
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7381317 |
Methods and compositions for capillary electrophoresis (CE)
This invention relates to improved methods and compositions for conducting Capillary Electrophoresis (CE) to separate molecules on the basis of their respective size or charge.
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7316770 |
Method of electrophoresis, electrophoresis apparatus and capillary array
A method of electrophoresis, an electrophoresis apparatus and a capillary array in which a fluorescently labelled sample is supplied into capillaries in a capillary array constituted by a plurality...
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7314550 |
Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers
Polymeric surfactants (molecular micelles) are disclosed for use in open tubular capillary electrochromatography or in high performance liquid chromatography. For example, fused silica capillaries...
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7294247 |
Electrophoretic separating device and method for using the device
The invention concerns to an electrophoretic separation device comprising a separation channel having at least one in- and outlet opening at the beginning and at the end of the channel and one...
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7285421 |
Apparatus for capillary electrophoresis and associated method
An apparatus and method for capillary zone electrophoresis includes a polyelectrolyte multilayer positioned in a capillary tube for analytical separations of macromolecules. The capillary comprises...
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7214299 |
Method for separation, identification and evaluation of microbes and cells
The method entails using capillary electrophoresis or capillary isoelectric focusing to separate intact microbes. The capillary system can be a conventional capillary tube or a microfluidic device....
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7198701 |
Nucleic acid analyzing method
To provide a method for analyzing a nucleic acid according to high throughput microcapillary electrophoresis during microchip electrophoresis under non-steady electric field, the method being...
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7195698 |
Capillary electrophoretic apparatus, sample plate and sample injection method
An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension...
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7179357 |
Serial sample injection in capillary electrophoresis
The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is...
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7169277 |
High throughput separations based analysis systems
Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample...
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7169276 |
Capillary electrophoresis method and apparatus for reducing peak broadening associated with the establishment of an electric field
Methods for reducing peak broadening associated with the establishment of a run field in a capillary electrophoresis process, and apparatus useful for carrying out such methods, are described. Such...
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7163610 |
Conductive media for electrophoresis
A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate...
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7156969 |
Microfluidic matrix localization apparatus and methods
Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided.
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7135144 |
Method for the manipulation of a fluid sample
The invention provides a device and method for the manipulation of materials (e.g., particles, cells, macromolecules, such as proteins, nucleic acids or other moieties) in a fluid sample. The...
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7081191 |
Capillary electrophoresis device
The capillary electrophoresis device using one pressure-resistant syringe ( 125 ) is capable of automatically suctioning in polymer solution and injecting polymer solution into a capillary array (...
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7081190 |
Methods and compositions for performing molecular separations
The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods...
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7052608 |
Cast-to-shape electrokinetic trapping medium
A three-dimensional microporous polymer network material, or monolith, cast-to-shape in a microchannel. The polymer monolith, produced by a phase separation process, is capable of trapping and...
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7041208 |
Microfluidic devices and methods for two-dimensional separations
A microfluidic device includes first and second substrates and a microfluidic cavity formed in one of the first and second substrates. The microfluidic cavity has a width (W) and a depth (D),...
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6998251 |
Nanoporous membrane reactor for miniaturized reactions and enhanced reaction kinetics
Reactors and methods for miniaturized reactions having enhanced reaction kinetics. In particular the subject matter is directed to chemical and biological reactions conducted in a nanoporous...
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6991713 |
Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of...
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6991712 |
Spectral calibration of fluorescent polynucleotide separation apparatus
The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards...
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6984525 |
Method for automated isolation of fractions in multichannel separation systems
A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a microfabricated...
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6943031 |
Simultaneous chemical separation and surface-enhanced Raman spectral detection using metal-doped sol-gels
Sol-gel beds and deposits are utilized for SERS analysis of liquid analytes. The use of the same medium to both separate the chemicals and also for SERS greatly reduces the complexity of such...
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6926815 |
Copolymers for capillary gel electrophoresis
This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer,...
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6908594 |
Efficient microfluidic sealing
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
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6878255 |
Microfluidic devices with thick-film electrochemical detection
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic...
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6878254 |
Size separation of analytes using monomeric surfactants
A sieving medium for use in the separation of analytes in a sample containing at least one such analyte comprises a monomeric non-ionic surfactant of the of the general formula, B-A, wherein A is a...
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6849722 |
Polymerized oligopeptide-surfactant chiral micelles
Chiral separations can be enhanced through the use of polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles. Because polymerized micelles eliminate much of the complex dynamic...
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6841055 |
Method of preparing electrophoretic support, electrophoretic matrix, and method of electrophoresis
A method of preparing an electrophoretic support comprising washing of at least a portion of the surface of a silicon-containing support member supporting an electrophoretic matrix with a weak...
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6837977 |
Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
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6830670 |
Heat-sensitive medium for separating species in a separating channel and use thereof
A medium comprises an electrolyte wherein is dissolved at least an assembly of block copolymers characterized in that the block copolymers: are present in the electrolyte at a concentration level...
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6787016 |
Dynamic coating with linear polymer mixture for electrophoresis
Compositions and methods are provided for performing capillary electrophoresis using a composition comprising in combination in an aqueous buffered medium a coating polymer and a sieving polymer,...
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6783992 |
Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
Methods for selectively separating at least one component from a multi-component componant fluidic sample are provided. In the subject methods, the fluidic sample is introduced into a micro-fluidic...
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6706162 |
High speed, high resolution compositions, methods, and kits for capillary electrophoresis
The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a...
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6680208 |
Rapid protein identification using antibody mixtures
A method and device is disclosed for rapidly identifying a large number of proteins by placing a protein mixture in a sample chamber of an electrophoresis gel, and performing electrophoresis to...
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6660148 |
Electrophoretic method and electrophoretic instrument therefor
An injection syringe 14 for injecting a gel into a capillary 111, a charging syringe 15 for charging the injection syringe 14 with the gel 10 are attached to a block 17. A check valve 16 is...
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6613512 |
Apparatus and method for correcting for variable velocity in microfluidic systems
Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and...
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6610186 |
Method and device for separating particles or molecules by migration through a ferrofluid
The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said...
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6602391 |
Apparatus and method for combined capillary separation and blotting of biological macromolecules
An apparatus and method are described for capillary separation of macromolecules and precise post-separation blotting. Apparatus include disposable separating element (capillary), which contains a...
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6576104 |
Apparatus and method for reading gel electrophoresis pattern
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
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6542691 |
Glass capillary array for fluorescence analysis and manufacturing method thereof
A glass capillary array for fluorescence analysis is provided which is capable of preventing reduction of the transmittance of a laser beam through the glass capillaries during electrophoretic DNA...
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