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7597790 |
Flow control systems
A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid ( 1204 ) whose flow rate is dependent on both hydrostatic...
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7439075 |
Method and device for withdrawing suspended microparticles from a fluidic microsystem
A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem ( 10 ) is described, whereby the fluid flow converges with at least one output flow to form a discharge...
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7431888 |
Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices
A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a...
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7316543 |
Electroosmotic micropump with planar features
An electroosmotic micropump having a plurality of thin, closely-spaced, approximately planar, transversel aligned partitions formed in or on a substrate, among which electroosmotic flow (EOF) is...
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7285421 |
Apparatus for capillary electrophoresis and associated method
An apparatus and method for capillary zone electrophoresis includes a polyelectrolyte multilayer positioned in a capillary tube for analytical separations of macromolecules. The capillary comprises...
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7282127 |
Microcapillary devices using high dielectric constant materials and related methods
A microcapillary device includes a microcapillary tube. An anode is positioned at a first end of the microcapillary tube. A cathode is positioned at a second end of said microcapillary tube. A...
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7252928 |
Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size...
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7243670 |
Microfluidic system
A microfluidic system, particularly a microfluidic chip, with at least one operational channel, in which a fluid and/or the constituents contained therein are moveable in the direction of the...
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7201834 |
Methods and compositions for modifying the surface of a polymeric substrate
Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a...
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7081190 |
Methods and compositions for performing molecular separations
The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods...
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7070681 |
Electrokinetic instability micromixer
A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex...
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7060171 |
Methods and systems for reducing background signal in assays
Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction...
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7060170 |
Bridges, elements and junctions for electroosmotic flow systems
In accordance with the present invention, stable electroosmotic flow systems and methods for designing the same are disclosed. The invention provides electroosmotic flow systems comprising...
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7052589 |
Method for electrophoretic separations using dynamically generated opposite mobilities
Method and materials to carry out preparative-scale electrophoretic separations based on the principle of dynamically created non-co-directional effective electrophoretic mobilities are disclosed....
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7037416 |
Method for monitoring flow rate using fluorescent markers
Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of...
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7018520 |
Concentration and cleanup of nucleic acid samples
Methods and devices are described for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, PNA). Various embodiments provide for...
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7011970 |
Automatic bio-manipulation factory system for manipulating a single cell
This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of...
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6982028 |
Surface charge modification within preformed polymer microchannels with multiple applications including modulating electroosmotic flow and creating microarrays
A method is described for modifying performed channels fabricated in a variety of substrate materials including PMMA. The method involves exposing a portion of a fluid flow channel to light at a...
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6960285 |
Electrokinetically pumped high pressure sprays
An electrokinetic pump capable of producing high pressure is combined with a nozzle having a submicron orifice to provide a high pressure spray device. Because of its small size, the device can be...
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6939451 |
Microfluidic chip having integrated electrodes
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities,...
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6923895 |
Coated capillary electrophoresis tubes and system
The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to...
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6902657 |
Electrophoresis separation media and methods
A low molecular weight non-entangled polyvinylpyrrolidone for use as a separation media for microchannel electrophoretic separation. The separation media may be used in a system in which multiple...
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6890411 |
Control of flow and materials for micro devices
The present invention generally relates to methods and devices for the control of the movement of fluids and electrically charged sample components within those fluids. More particularly, the...
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6863790 |
Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode
A simple and rugged sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry (CE/ESI-MS) was designed using common laboratory tools and chemicals. The interface...
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6805783 |
Method for manipulating a solution using a ferroelectric electro-osmotic pump
A device and method for pumping an electrolyte solution includes a conduit having a first end, a second end and a lumen for containing the electrolyte solution. An opening at each end of the...
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6787015 |
Methods for conducting electrophoretic analysis
Capillary electrophoresis is performed under conventional conditions in microchannels having a norbornene based polymer surface. The norbornene based polymers can be used as a solid substrate for...
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6770182 |
Method for producing a thin sample band in a microchannel device
The present invention improves the performance of microchannel systems for chemical and biological synthesis and analysis by providing a method and apparatus for producing a thin band of a species...
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6749735 |
Electromobility focusing controlled channel electrophoresis system
An electromobility focusing controlled channel electrophoresis system includes a first separation channel including an electric field intensity gradient profile in which the intensity is a...
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6586065 |
Capillary having coated inner wall
It is to provide a capillary having adsorbed a polymer. A capillary having absorbed on an inner wall of the capillary, an ionic polymer having positive electric charge and an ionic polymer having...
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6569305 |
Method for injection and stacking of analytes in high-conductivity samples
The present invention is a method for injection and stacking of analytes in high salt samples. This stacking method works with both pressure injection or electrokinetic injection. The ability to...
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6508273 |
Device and method for controlling a liquid flow
The present invention relates to a device for controlling a liquid flow in a liquid channel, comprising: an elongate liquid holder in which a liquid channel is provided in longitudinal direction;...
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6488831 |
Chemical surface for control of electroosmosis by an applied external voltage field
The present invention is directed to a method for controlling electroosmotic flow by treating a surface with an organosilane having a single leaving group and optionally a ceramic oxide. This...
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6475722 |
Surface treatments for DNA processing devices
The present invention discloses methodologies for the treatment of the surface(s) of DNA processing devices so as to greatly reduce DNA adsorption to the surface(s) exposed to the DNA-containing...
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6471841 |
Methods and systems for enhanced fluid transport
The present invention generally provides methods for enhancing transport and direction of materials in fluidic systems, which systems utilize electroosmotic (E/O) flow systems, to affect that...
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6458259 |
Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
Methods and apparatus for reducing adsorption in microscale devices are provided. In the methods and apparatus, an electrical current such as an alternating current is applied to materials under...
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6451264 |
Fluid flow control in curved capillary channels
A capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of groups of microstructures are...
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6413782 |
Methods of manufacturing high-throughput screening systems
Microfluidic devices for analyzing a plurality of compounds are manufactured for performing high throughput screening assays. The methods are used to manufacture devices that screen large numbers...
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6406605 |
Electroosmotic flow controlled microfluidic devices
In one embodiment, a fluidic module, such as a microfluidic module, has a fluid-flow channel, an electroosmotic flow membrane positioned in the channel, and a cathode located on one side and an...
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6375818 |
Surfaces with reduced electroosmotic flow
An article of manufacture is provided that is useful in differentiating between solutes, such as during electrophoretic separations. An embodiment of the article is a capillary tube, that carries a...
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6344120 |
Method for controlling liquid movement in a chemical device
A method of controlling liquid movement in a chemical device comprising a porous structure involved applying an electrical potential to generate an electroosmotic force in the porous structure so...
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6322682 |
Method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds
A method of capillary electrophoresis utilizing a capillary tube made up of hydrophobic plastics, charactarized in that the inner surface of said capillary is coated with a hydrophilic polymer...
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6306273 |
Methods and compositions for conducting processes in microfluidic devices
A method is disclosed for controlling the direction and transport of a material on a microfluidic device formed from an acrylic polymer, by electrokinetic flow of a fluid containing the material....
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6221226 |
Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates...
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6120665 |
Electrokinetic pumping
The invention provides a method of changing the electrode-based pumping parameters of a liquid, the method comprising (a) selecting a pumping additive based on the pumping pressure, pumping flow...
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6074542 |
Compounds for molecular separations
The present invention describes a method and apparatus utilizing a capillary coating of linear and crosslinked polymers and copolymers of acrylamidomonomers or methacrylamides bearing two...
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6074541 |
Preformed polymer coating process and product
A method of coating a solid support (e.g. a capillary or chromatography packing) to alter the properties of the support surface for separating components in a fluid stream. The method comprises (a)...
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6056860 |
Surface modified electrophoretic chambers
Electrophoretic chambers having at least a region of surface modification, and methods for their fabrication, are provided. In some embodiments the subject chambers include in the region of surface...
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6033544 |
Liquid distribution system
The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The...
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6004443 |
Chromatography-format fluid electrophoresis
A novel free-fluid electrophoresis system applicable to both "analytical" and "preparative" separations combines the advantages of electrophoresis with those of automated liquid chromatography. The...
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5993626 |
Capillary electrophoresis of transferrin glycoforms
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is...
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