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7586091 |
Mass spectrometric system and mass spectrometry
After a sample is previously separated into plural components in a channel formed in a microchip ( 353 ), the channel is irradiated along a separation direction with a laser beam from a laser...
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7459070 |
Automated parallel capillary electrophoresis system with hydrodynamic sample injection
An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends...
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7439075 |
Method and device for withdrawing suspended microparticles from a fluidic microsystem
A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem ( 10 ) is described, whereby the fluid flow converges with at least one output flow to form a discharge...
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7422672 |
Capillary array apparatus, method of manufacturing the same, and electrophoresis analysis method
An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids,...
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7419577 |
Removal method for coating of polymer coated glass capillary tubing and polymer coated glass capillary tubing
The present invention provides a method for producing a high-quality capillary tube used in an electrophoresis apparatus in a safe and inexpensive manner. A polymer coating on a capillary tube is...
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7410559 |
Electrophoresis methods
A separation carrier comprising β-1,3-glucan and/or methyl cellulose; a running buffer comprising the separation carrier; a method of capillary electrophoresis or microchip electrophoresis,...
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7396444 |
Device to operate a laboratory microchip
In a device to operate and handle a laboratory microchip to chemically process or analyze substances, the microchip is on a chip holder ( 41 ) that is part of a first assembly ( 42 ). The first...
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7344628 |
Capillary electrophoresis-electrochemical detection microchip device and supporting circuits
The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate...
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7341652 |
Stationary capillary electrophoresis system
A system and method for capillary electrophoresis are provided for analyzing a macromolecule prepared from a complex liquid mixture. In particular applications, methods and apparatus are provided...
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7264702 |
Total analyte quantitation
Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and...
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7258776 |
Capillary array assembly for loading samples from a device, and method
A capillary array assembly is provided that can be used to inject samples into an electrophoresis device. The capillary array assembly can include an injection end that can be arranged to interface...
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7244961 |
Integrated system with modular microfluidic components
Modular fluidic microchips, systems integrating such microchips, and associated preparative and analytical methods are presented.
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7235163 |
Loading features for channel array
Apparatus and method for loading a channel device for electrophoretic separation including cilia which can be deflected into wells of a multi-well tray.
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7229540 |
Biochip and a manufacturing method of biochip
To provide a biochip, a biochip manufacturing method, an electrophoresis method, and an electrophoresis apparatus, by which the detection accuracy may improve, there is a biochip introducing a...
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7223325 |
Method for orthogonal analyte stacking/injection systems in electrophoresis
In the present capillary electrokinetic chromatograpy method, analytes are injected by electroosmotic flow directly from a sample matrix into a separation buffer containing an electrokinetic vector...
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7211184 |
Capillary electrophoresis devices
A capillary electrophoresis device as well as a process for fabrication of the device is disclosed. The capillary electrophoresis device comprises a device body structure having a plurality of...
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7195699 |
Electrophoresis member, production thereof and capillary electrophoresis apparatus
An electrophoresis member is produced by laying a plurality of capillaries on an adhesive layer born on a support layer to form a capillary layer, laminating thereon a second support layer, and...
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7179357 |
Serial sample injection in capillary electrophoresis
The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is...
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7169279 |
Sample handling system for a multi-channel capillary electrophoresis device
A sample handling system in a multi-channel capillary electrophoresis apparatus is disclosed. The sample handling system includes a work surface for supporting a plurality of samples located at a...
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7169277 |
High throughput separations based analysis systems
Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample...
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7160423 |
Mixed mode microfluidic systems
Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow...
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7101467 |
Mixed mode microfluidic systems
Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow...
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7090003 |
Method and apparatus for temperature control of a microfluidic device
A microfluidic device is provided for regulating the temperature of a sample fluid flowing therethrough, as well as, a method of regulating the temperature of the sample fluid flowing through the...
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7081191 |
Capillary electrophoresis device
The capillary electrophoresis device using one pressure-resistant syringe ( 125 ) is capable of automatically suctioning in polymer solution and injecting polymer solution into a capillary array (...
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7037417 |
Mechanical control of fluids in micro-analytical devices
An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a...
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7033474 |
Microfluidic devices incorporating improved channel geometries
The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or...
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7018520 |
Concentration and cleanup of nucleic acid samples
Methods and devices are described for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, PNA). Various embodiments provide for...
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7005050 |
Electrophoresis in microfabricated devices using photopolymerized polyacrylamide gels and electrode-defined sample injection
The present invention relates to a novel, small-scale, electrophoretic separation system based on photodefined polymers and electrode-defined sample injection. Diffusion and displacement...
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6994778 |
Microfluidic device and analyzing method using the same
A microfluidic device includes a base member, a separating channel, and a sample quantity control channel branching from the separating channel. The separating channel has one end projecting from...
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6991713 |
Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of...
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6989085 |
Method for separation of compounds using cycling denaturing conditions
A method for electrophoretic separation in separation channels in which the temperature of the channel is repeatedly cycled during the course of the separation.
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6960286 |
Method for controlling sample introduction in microcolumn separation techniques and sampling device
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
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6942777 |
Sample analysis system with chip-based electrophoresis device
The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device...
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6933098 |
Process for roll-to-roll manufacture of a display by synchronized photolithographic exposure on a substrate web
This invention relates to an electrophoretic display or a liquid crystal display and novel processes for its manufacture. The electrophoretic display (EPD) of the present invention comprises...
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6929729 |
Method for conducting capillary zone electrophoresis
A method for conducting capillary zone electrophoresis in which a lubricating detergent is added to help prevent sample buildup on the inner walls of the capillary. In a preferred embodiment the...
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6919045 |
Supply element for a laboratory microchip
A supply element for a microfluid microchip that can be used for chemical analysis has supply lines or reservoirs that serve to supply the microchip with substances or reagents. Both ends of the...
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6908594 |
Efficient microfluidic sealing
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
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6905586 |
DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
An apparatus and method for performing nucleic acid (DNA and/or RNA) sequencing on a single molecule. The genetic sequence information is obtained by probing through a DNA or RNA molecule base by...
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6905583 |
Closed-loop control of electrokinetic processes in microfluidic devices based on optical readings
A method for performing an electrophoretic separation on a microfluidic device includes applying an electric field to electrokinetically move a sample along a channel towards a location. The sample...
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6890411 |
Control of flow and materials for micro devices
The present invention generally relates to methods and devices for the control of the movement of fluids and electrically charged sample components within those fluids. More particularly, the...
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6881312 |
Ultra high throughput microfluidic analytical systems and methods
Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a...
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6870662 |
Methods of surface modification for improving electrophoretic display performance
The present invention is directed to methods for improving the performance of an electrophoretic display by modifying the display cell surface. More specifically, the methods are directed to...
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6846398 |
Device and method for miniaturized, highly parallel electrophoretic separation
In an electrophoresis device with numerous separation channels S loadable with samples, samples are loaded by applying samples in a shared injection channel I intersecting the separation channels S...
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6837977 |
Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
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6827831 |
Controller/detector interfaces for microfluidic systems
The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices....
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6818113 |
Microfluidic device with sample injector and method of using
A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having...
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6783649 |
High throughput capillary electrophoresis system
The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling arm...
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6773567 |
High-throughput analytical microfluidic systems and methods of making same
A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through...
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6770182 |
Method for producing a thin sample band in a microchannel device
The present invention improves the performance of microchannel systems for chemical and biological synthesis and analysis by providing a method and apparatus for producing a thin band of a species...
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6755074 |
Liquid chromatographic method and system
To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by...
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