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9034161 Sperm separation devices and associated methods  
The present invention provides methods, devices, and kits for separating and selecting top sperm from a sperm sample of a subject. In one aspect, for example, such a method can include removing a...
8968678 Microfluidic detection of analytes  
An apparatus and methods for concentrating samples for application to microfluidic devices are disclosed. The methods involve electrophoresing charged molecules from a high volume sample into a...
8871072 Flow step focusing  
Flow step focusing isolates and concentrates a molecule of interest by flowing a liquid comprising a molecule of interest through a main channel having an inlet and an outlet with application of a...
8841116 Inline-injection microdevice and microfabricated integrated DNA analysis system using same  
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including...
8834697 Electrophoresis apparatus and a method for electrophoresis  
A channel (12) is formed inside a transparent substrate (11), and the two ends are respectively connected to a sample inlet (13) and a separation medium filling port (14) both open to outside, and...
8828209 Massively parallel 2-dimensional capillary electrophoresis  
This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is...
8784626 Bio-analysis using ball-ended incident and output optical fibers  
A detection optics configuration for bio-analysis, in which the direction of incident radiation, the axis of the separation channel, and the direction of collection of the output radiation are...
8778155 Disposible bio-analysis cartridge and instrument for conducting bio-analysis using same  
A cartridge-based bio-separation system configured to utilize a pen shaped bio-separation cartridge that is easy to assemble and use with no moving parts and that has an integrated reagent...
8685343 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Microfluidic detection of analytes
 
An apparatus and methods for concentrating samples for application to microfluidic devices are disclosed. The methods involve electrophoresing charged molecules from a high volume sample into a...
8585973 Nano-sensor array  
In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of...
8470149 Electrowetting dispensing devices and related methods  
A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality...
8377277 System and method for performing microfluidic manipulation  
Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel...
8366897 Gradient elution electrophoresis and detectorless electrophoresis apparatus  
A microfluidic apparatus and method for performing electrophoretic separation of compounds. The method comprises the steps of: a) providing a separation buffer; b) providing a sample solution in...
8287707 Device for controlling particle distribution in an evaporating droplet using radial electroosmotic flow  
Provided is a device for controlling a particle distribution in a droplet including particles. The device includes: a first electrode for developing an electric field in the vicinity of the...
8263022 Microfluidic detection of analytes  
An apparatus and methods for concentrating samples for application to microfluidic devices are disclosed. The methods involve electrophoresing charged molecules from a high volume sample into a...
8237117 Methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry  
The present invention relates a use of the electrocapture-based separation technology combined with mass spectrometrical fragmentation methods, e.g. sequence of polypeptides by collision-induce...
8182746 Electrophoresis process using a valve system  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
8163150 Electrowetting dispensing devices and related methods  
A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality...
8123925 Electrophoretic apparatus  
An electrophoretic apparatus that allows bubbles to be readily removed out of an electrophoretic passage. The passage for electrophoretic medium, at a connecting section where capillaries filled...
8101137 Analysis instrument  
An analysis instrument for processing a microfluidic device, having sample storage means, a microfluidic device holder, sample loading means for loading sample into a microfluidic device disposed...
RE43122 Apparatus and method for trapping bead based reagents within microfluidic analysis systems  
The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends...
8101057 Concentration and cleanup of nucleic acid samples  
Methods and devices are described for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, PNA). Various embodiments provide for...
8043492 Method for pretreatment of electrophoresis, substrate for analysis, and pretreatment apparatus for electrophoresis  
A sample (14) is supplied into a sample reservoir (8) (see (A)). A voltage is applied by an electrode (20) to introduce the sample into a capillary (6) filled with a separation medium (see (B)). A...
8030092 Controlled electrophoresis method  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
8007725 Electrophoresis apparatus having valve system  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
7993507 Separation method for multi channel electrophoresis device having no individual sample wells  
The present invention is related to a method of separation of compounds by electrophoresis in which the compounds such as genes, proteins, etc. may be analyzed very precisely as samples are...
7927476 Injection method for microfluidic chips  
Methods and systems for injecting a sample during electrophoresis, that generally comprise: loading a sieving matrix through a first end of a separation channel; having the an end of the sieving...
7837848 Bidimensional separation by means of capillary electrophoresis carried out in a single capillary  
A method for separating the constituents of a mixture M by electrophoresis in a single capillary includes (A) separating compounds of the mixture M in a single capillary according to the capillary...
7820023 Preconcentration interface coupling liquid chromatography to capillary electrophoresis  
An arrangement for two-dimensional separation of a complex analyte mixture is provided comprising a first separation device for the separation in a first dimension and a second device for the...
7749365 Optimized sample injection structures in microfluidic separations  
The invention herein provides improved sample injection systems and related methods to create microfluidic devices with symmetrical channel configurations that can produce relatively large sample...
7740748 Electrophoresis system and method  
Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis device comprises a loading channel, an injection channel, and a separation channel. The loading...
7740747 Injection method for microfluidic chips  
A microchip for capillary electrophoresis is provided. The microchip comprises an injection channel and a separation channel configured to receive a sample through a sample well disposed on a...
7736482 Electrophoresis member, production thereof and capillary electrophoresis apparatus  
An electrophoresis member is produced by laying a plurality of capillaries on an adhesive layer born on a support layer to form a capillary layer, laminating thereon a second support layer, and...
7713394 Electrophoresis apparatus using capillary array and sample plate assembly used therefor  
A sample plate assembly for an electrophoresis apparatus including a tray at a sample supply portion of a capillary array, an adapter for the tray, a sample plate mounted on the adapter, a septer...
7704727 Device and method for processing biological material  
Disclosed is a device for processing biological material which at least comprises a chamber at least closable to the outside and having an inner space for receiving the biological material. The...
7691245 Microfluidic device for controlling sample introduction in microcolumn separation techniques and sampling device  
A microfluidic device for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug...
7651599 High density fluidic chip design and method of sample injection  
The present invention discloses a high-density parallel channel design for a microfabricated capillary array electrophoresis chip, with vertical T or double T design for sample injection. An...
7586091 Mass spectrometric system and mass spectrometry  
After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser...
7459070 Automated parallel capillary electrophoresis system with hydrodynamic sample injection  
An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends...
7439075 Method and device for withdrawing suspended microparticles from a fluidic microsystem  
A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge...
7422672 Capillary array apparatus, method of manufacturing the same, and electrophoresis analysis method  
An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids,...
7419577 Removal method for coating of polymer coated glass capillary tubing and polymer coated glass capillary tubing  
The present invention provides a method for producing a high-quality capillary tube used in an electrophoresis apparatus in a safe and inexpensive manner. A polymer coating on a capillary tube is...
7410559 Electrophoresis methods  
A separation carrier comprising β-1,3-glucan and/or methyl cellulose; a running buffer comprising the separation carrier; a method of capillary electrophoresis or microchip electrophoresis,...
7396444 Device to operate a laboratory microchip  
In a device to operate and handle a laboratory microchip to chemically process or analyze substances, the microchip is on a chip holder (41) that is part of a first assembly (42). The first...
7344628 Capillary electrophoresis-electrochemical detection microchip device and supporting circuits  
The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the...
7341652 Stationary capillary electrophoresis system  
A system and method for capillary electrophoresis are provided for analyzing a macromolecule prepared from a complex liquid mixture. In particular applications, methods and apparatus are provided...
7264702 Total analyte quantitation  
Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and...
7258776 Capillary array assembly for loading samples from a device, and method  
A capillary array assembly is provided that can be used to inject samples into an electrophoresis device. The capillary array assembly can include an injection end that can be arranged to...
7244961 Integrated system with modular microfluidic components  
Modular fluidic microchips, systems integrating such microchips, and associated preparative and analytical methods are presented.
7235163 Loading features for channel array  
Apparatus and method for loading a channel device for electrophoretic separation including cilia which can be deflected into wells of a multi-well tray.

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