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6964735 |
Method for moving charged particles
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
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6953520 |
Capillary electrophoresis probes and method
A novel class of capillary electrophoresis probes and a method of employing the same are described. The novel class of capillary electrophoresis probes are comprised of one or more vinylogous...
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6942773 |
Particle sizer and DNA sequencer
An electrophoretic device separates and detects particles such as DNA fragments, proteins, and the like. The device has a capillary which is coated with a coating with a low refractive index such...
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6932940 |
Optical detection in bio-separation device using axial radiation input
In a bio-separation system, incident radiation (e.g., from a laser or LED source) for detection of separated analytes is directed at the detection zone axially along the separation medium, instead...
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6925612 |
Device and method for selecting electrophoresis band
The present invention aims at easy and efficient selection of bands present on a lane. A region 502 is set on a display of a lane 503 having a plurality of bands 504 to 508, based on an...
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6908594 |
Efficient microfluidic sealing
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
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6905586 |
DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
An apparatus and method for performing nucleic acid (DNA and/or RNA) sequencing on a single molecule. The genetic sequence information is obtained by probing through a DNA or RNA molecule base by...
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6906797 |
Side light activated microfluid channels
Devices are provided comprising reflecting channels for directing horizontally a vertical light beam through a multiplicity of streams. The devices provide particular applications in microfluidics,...
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6886576 |
Method of controlling the flow in a flow system
A method and flow system for controlling the flow of a liquid in a flow system, the liquid flow comprising particles and being led into a channel thereof. The method comprises the steps of...
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6887359 |
Chemical micro-sensor
An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by...
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6878255 |
Microfluidic devices with thick-film electrochemical detection
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic...
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6863791 |
Method for in-situ calibration of electrophoretic analysis systems
An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration...
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6863790 |
Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode
A simple and rugged sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry (CE/ESI-MS) was designed using common laboratory tools and chemicals. The interface...
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6864055 |
Method for detecting nucleic acids
A method of detecting nucleic acid fragments in plural samples is performed by the steps of: attaching an electroconductive label to nucleic acid fragments in one sample and attaching a different...
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6843901 |
Potential gradient detector for electrophoresis
An on-column detector for electrophoresis samples based on the principles of potential gradient detection, in which the electrodes for detection are physically isolated from the electrophoretic...
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6841128 |
DNA base sequencing system
The present invention provides a DNA base sequencing system having a compact, simple and convenient structure. In one embodiment of the present invention, a reaction chamber module for...
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6837977 |
Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
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6808609 |
Device and method for moving charged particles
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
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6797139 |
Detection cell for guiding excitation light therein and method for using same
The present invention provides a detection cell that comprises a body having a first end that defines a first opening, a second end that defines a second opening, and an internal surface that...
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6783649 |
High throughput capillary electrophoresis system
The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling arm...
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6764583 |
Using impedance measurements for detecting pathogens trapped in an electric field
Impedance measurements between the electrodes in an electric field is utilized to detect the presence of pathogens trapped in the electric field. Since particles trapped in a field using the...
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6755074 |
Liquid chromatographic method and system
To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by...
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6752914 |
Capillary electrophoresis device
An analyser comprises a substrate ( 20 ) of diamond, sapphire or a polymer material; an array ( 10 ) of elongate capillary channels formed in the substrate; means ( 40 ) for driving a sample to be...
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6726820 |
Method of separating biomolecule-containing samples with a microdevice with integrated memory
The present invention provides microdevices, such as those used in the pharmaceutical and biotechnological fields, including an integrated memory. According to various embodiments, the integrated...
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6680208 |
Rapid protein identification using antibody mixtures
A method and device is disclosed for rapidly identifying a large number of proteins by placing a protein mixture in a sample chamber of an electrophoresis gel, and performing electrophoresis to...
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6676819 |
Methods and apparatus for automatic on-line multi-dimensional electrophoresis
The invention provides a method of performing one- and two-dimensional electrophoresis with or without gel in an automated way. The two dimensional electrophoresis can be performed either...
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6632400 |
Integrated microfluidic and electronic components
A microfluidic component having a microfluidic channel is bonded to an electronics component having a circuit for processing signals related to the microfluidic component. In an embodiment, the...
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6613210 |
Molecular imaging
A method of imaging molecules of interest within a biological sample includes shining a UV light onto the sample and detecting the molecular UV absorption. Where the molecules of interest are...
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6613212 |
Multiple capillary electrophoresis systems
The invention concerns a multiple capillary electrophoresis system including many juxtaposed capillaries, at least one source for transmitting a beam designed to excite the molecules present in its...
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6596140 |
Multi-channel capillary electrophoresis device and method
Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein...
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6592733 |
Capillary electrophoresis devices incorporating optical waveguides
A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that...
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6576108 |
DNA detector and DNA detection method
An electrophoresis apparatus includes an optical cell having an outlet for fluid and filled with a buffer solution, and a plurality of electrophoresis lanes, each including a separation medium,...
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6576104 |
Apparatus and method for reading gel electrophoresis pattern
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
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6554986 |
Capillary array electrophoresis scanner
An improved rotary confocal fluorescence scanner capable of detecting analytes separated on over a 1,000 capillaries simultaneously. This system uses a confocal microscope objective and mirror...
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6552784 |
Disposable optical cuvette cartridge
A cuvette cartridge for optical measurements is disclosed herein, the cartridge comprising a flat, adhesive sheet having a selected thickness that defines an optical path length perpendicular to...
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6533914 |
Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
The present invention concerns methods and apparatus for the high resolution, high output electrophoretic separation of molecules. In preferred embodiments, the methods and apparatus are of use for...
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6531041 |
Multiplexed capillary electrophoresis system with rotatable photodetector
A parallel capillary electrophoresis system for separating and analyzing the components of multiple chemical samples. The system comprises a bundle of capillary tubes arrayed to have at least...
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6524866 |
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
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6511850 |
Pneumatic nebulizing interface to convert an analyte-containing fluid stream into an aerosol, method for using same and instruments including same
A self-adjusting, free-flowing pneumatic nebulizer interface is described for coupling fluid phase separation apparatus such as capillary electrophoresis apparatus or fluid-phase analyte delivery...
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6508923 |
Multi-capillary electrophoretic apparatus
A data processing part comprises a time-series data production part for producing time-series data as to each capillary column from a scan waveform obtained by an optical measuring part, further...
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6488832 |
Array based electrophoretic system for the analysis of multiple biological samples
The present invention relates to an electrophoretic method to effect differential net migration, the extent of said migration being dependent on molecular size, of electrically charged...
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6468409 |
Method and apparatus for detecting substances
An apparatus for detecting fluorophore labelled substances in an electrophoretic separation medium comprises illuminating means ( 1 ) for illuminating the fluorophore labelled substances ( 8 ),...
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6464852 |
Multicapillary bundle for electrophoresis and detection for DNA
A multichannel electrophoretic cassette structure is disclosed comprising distinct regions for loading and detection with different spacing between channels. A method and an apparatus are further...
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6416643 |
Method for measuring cellular chemical profiles
A method for spectrographically providing a chemical profile of mammalian cells in vitro using capillary ( 10 ) electrophoresis is described. The method enables rapid determination of the...
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6413398 |
Method for electrochemical detection
A method for electrochemical detection (ECD) is disclosed. The illustrated embodiments are particularly adapted to use in detection of analytes separated by capillary electrophoresis. The method is...
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6406605 |
Electroosmotic flow controlled microfluidic devices
In one embodiment, a fluidic module, such as a microfluidic module, has a fluid-flow channel, an electroosmotic flow membrane positioned in the channel, and a cathode located on one side and an...
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6384411 |
Ion source and mass spectrometer instrument using the same
An ion source includes a gas supplier which supplies a gas through a gas inlet into a gas passage defined in a body to form a gas flow through the gas passage along a capillary inserted into the...
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6375819 |
Fluid delivery system for capillary electrophoretic applications
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
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6361672 |
Multiple laser diode electromagnetic radiation source in multiple electrophoresis channel systems
The present invention is a multiple channel electrophoresis system which includes a multiple laser diode illumination source. The multiple laser diode illumination source has a plurality of...
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6361671 |
Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels
This invention relates to a microfabricated capillary electrophoresis chip for detecting multiple redox-active labels simultaneously using a matrix coding scheme and to a method of selectively...
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