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9034161 Sperm separation devices and associated methods  
The present invention provides methods, devices, and kits for separating and selecting top sperm from a sperm sample of a subject. In one aspect, for example, such a method can include removing a...
9017536 Hemoglobin measurement method and electrophoresis apparatus  
An object of the present invention is to provide a method for measuring hemoglobin that enables short-time, high-accuracy measurement of hemoglobin, in particular stable hemoglobin A1c, which is...
8999665 Trapping molecular segments in nano-gaps  
A molecule trapping method includes forming a fluid bridge between a first reservoir and a second reservoir, translocating a molecule from the first reservoir to the second reservoir through the...
8974650 Microfluidic system  
A method for forming a microfluidic channel with improved flow characteristics for one or more analytes is disclosed. A microfluidic channel having modified surfaces is formed in a glass layer or...
8969090 DNA sequencing methods and detectors and systems for carrying out the same  
In some embodiments, an analyte detection system is provided that includes a nanochannel, an electrode arrangement, and a plurality of nanoFET devices disposed in the nanochannel. A plurality of...
8968539 Methods for voltage-induced protein incorporation into planar lipid bilayers  
Disclosed here are methods useful for incorporating protein into lipid bilayers using voltage induced insertion. The methods presented herein can decrease time and costs associated with...
8961763 Dual-pore device  
Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle...
8916375 Integrated microfluidic analysis systems  
The present invention provides an integrated microfluidic analysis system. The system contains at least a first (pre-reaction treatment) domain for treating a sample prior to subjecting the sample...
8906322 Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields  
The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the...
8888980 Electrophoresis apparatus and control method thereof  
An electrophoresis apparatus that applies voltage from electrodes that are provided in a capillary flow channel and causes component separation by performing electrophoresis on a specimen that is...
8871072 Flow step focusing  
Flow step focusing isolates and concentrates a molecule of interest by flowing a liquid comprising a molecule of interest through a main channel having an inlet and an outlet with application of a...
8859211 Immunodisplacement electrophoresis  
The disclosure teaches a method for the analysis of a sample by electrophoresis, making use of a binding partner for a target compound or group of target compounds which may be present in the...
8841116 Inline-injection microdevice and microfabricated integrated DNA analysis system using same  
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including...
8835362 Modifying single proteins (GPCR), ligands, and nanopore surfaces to create binding-induced molecular changes of protein-ligand complexes detected in nanochannel translocation  
A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution....
8834694 Dry compositions and methods for gel electrophoresis  
The invention provides dry compositions for preparing and loading a sample on a gel for electrophoretic separation. The dry compositions preferably include a tracking dye and a sedimenting agent...
8828209 Massively parallel 2-dimensional capillary electrophoresis  
This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is...
8821702 Devices and methods for electroosmotic transport of non-polar solvents  
A microdevice for supporting a flowing nonpolar fluid is disclosed. The microdevice includes a substrate that is at least partially coated by one or more amphiphilic layers. Methods for using the...
8784626 Bio-analysis using ball-ended incident and output optical fibers  
A detection optics configuration for bio-analysis, in which the direction of incident radiation, the axis of the separation channel, and the direction of collection of the output radiation are...
8784630 Sample stacking method using on-line automatic solid phase extraction coupled to nonaqueous capillary electrophoresis and interface structure between solid-phase preconcentration cartridge and capillary therefor  
A sample stacking method using on-line automatic solid phase extraction coupled to nonaqueous capillary electrophoresis, and an interface structure between a solid-phase preconcentration cartridge...
8779333 Column heater  
A direct contact segmented column heater is described. The heater is capable of a broad heating and cooling range, and exhibits a very rapid response, with heating and cooling rates better than...
8778155 Disposible bio-analysis cartridge and instrument for conducting bio-analysis using same  
A cartridge-based bio-separation system configured to utilize a pen shaped bio-separation cartridge that is easy to assemble and use with no moving parts and that has an integrated reagent...
8768517 Methods and systems for control of microfluidic devices  
The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined...
8758587 Analysis apparatus and analysis method  
An analysis apparatus is provided with a storage tank, an injection nozzle, a syringe, a collection nozzle, a test sample tank, a microchip having two or more separation channels, detectors, a...
8721858 Non-focusing tracers for indirect detection in electrophoretic displacement techniques  
A novel method for visualizing electrokinetic process zones (e.g., for isotachophoresis (ITP)) is provided. We introduce negligibly small concentrations of a fluorophore that is not focused by...
8716025 Drifting two-dimensional separation with adaption of second dimension gradient to actual first dimension condition  
A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and...
8702941 Method of analyzing hemoglobin by electrophoresis  
A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The...
8702949 Capillary electrophoresis apparatus  
The solution reservoir apparatus of the capillary electrophoresis apparatus securely affixes an evaporation-preventing membrane to a container when a capillary is inserted or withdrawn, without...
8697004 Sequencing system with memory  
The present teachings provide a device including a memory. According to various embodiments, the memory is readable, writable, and rewritable. The present teachings further provide processing...
8691067 Charged entities as locomotive to control motion of polymers through a nanochannel  
A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the...
8663990 Measurement method utilizing internal standard substance  
A subject of the present invention is to provide a measurement method using an internal standard substance in an electrophoresis where an analyte is a protein or a compound. The present invention...
8652805 Trapping molecular segments in nano-gaps  
A molecule trapping method includes forming a fluid bridge between a first reservoir and a second reservoir, translocating a molecule from the first reservoir to the second reservoir through the...
8641879 Charged entities as locomotive to control motion of polymers through a nanochannel  
A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the...
8585973 Nano-sensor array  
In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of...
8564760 Lithographic apparatus, device manufacturing method and a control system  
A capillary passage is formed between a substrate holder and an edge structure. Along the capillary passage are arranged a plurality of electrodes which, when charged, become liquidphilic. The...
8545686 Electrophoretic apparatus and electrophoretic method  
The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the...
8535500 Surface acoustic wave sensor device including target biomolecule isolation component  
Provided herein is a surface acoustic wave (“SAW”) sensor device including an isolation component of a target biomolecule. A sample containing the target biomolecule is separated by its size using...
8518226 Microfluidic methods for the separation of supercoiled DNA  
The present invention provides for a novel method of supercoiled DNA isolation using a microfluidic device. In a preferred embodiment, the supercoiled DNA is a plasmid present in combination with...
8518227 Nanopore-based nanoparticle translocation devices  
A nanoparticle translocation device includes a first reservoir having a first reservoir electrode, a second reservoir having a second reservoir electrode, and at least one nanopore providing fluid...
8512538 Capillary electrophoresis device  
This invention provides a capillary electrophoresis device in which capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit...
8476063 Microfluidic devices  
Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various...
8470149 Electrowetting dispensing devices and related methods  
A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality...
8473104 Methods and systems for control of microfluidic devices  
The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined...
8465637 Ion sensor for fluid and method for its manufacture  
The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble...
8460530 Method for modifying the concentration of reactants in a microfluidic device  
A method of modifying the concentration of reactants and carrying out a chemical reaction on a microfluidic device in which first and second reactants are delivered into a reaction channel...
8454811 Microfluidic system  
A method for forming a microfluidic channel with improved flow characteristics for one or more analytes is disclosed. A microfluidic channel having modified surfaces is formed in fused silica. The...
8449880 Chemical modification of proteins for their more accurate molecular-weight determination by electrophoresis  
Disclosed herein is a composition and method for sample preparation of proteins for their size separation by electrophoresis, suitable for molecular-weight determination of proteins in the range...
8445223 Anionic acid-labile surfactants and methods of use  
Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H...
8435396 Method of detecting analyte-biomolecule interactions  
The invention provides methods for detecting an interaction between an analyte and a biomolecule. The method comprises separating at least one biomolecule according to its isoelectric point in the...
8435756 Anionic acid-labile surfactants and methods of use  
Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H...
8435795 Evaluating heparin preparations  
Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is...