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5928906 Process for direct sequencing during template amplification  
Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and perfonning high throughput DNA sequencing are described.
5916428 Automated system for multi-capillary electrophoresis having a two-dimensional array of capillary ends  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
5903348 System and method for molecular sample measurements  
A system for aligning the optical components of a chemical analysis system in which capillaries or optical fibers are supported by a micromechanied substrate. The system provides for alignment of...
5900132 Capillary holder  
A holder (10) is provided for securing a capillary (30) having a window section (28) including first and second edges (46) (48) to a mount (80). The holder (10) comprises a retaining surface (14)...
5890745 Micromachined fluidic coupler  
A method for producing a microfluidic coupler includes the step of producing a first mask on a top surface of a wafer. The first mask defines an insertion channel pattern selected to correspond to...
5888366 Capillary made of polymer material having a modified inside surface and process for its production  
A capillary made of plastics material that is suited for use in capillary electrophoresis. The capillary has its inner surface chemically modified for the generation of properties different from...
5888390 Multilayer integrated assembly for effecting fluid handling functions  
A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The...
5885430 Capillary tube holder for an electrophoretic apparatus  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
5872010 Microscale fluid handling system  
A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip...
5863401 Simultaneous analysis of analytes by immunoassay using capillary electophoresis with laser induced fluorescence  
Homogeneous competitive immunoassay methods for simultaneously detecting analytes using capillary electrophoresis and fluorescent detection systems are described. The methods are useful for...
5858187 Apparatus and method for performing electrodynamic focusing on a microchip  
A microchip device includes a focusing channel, in which an electric field strength established in the focusing channel is controlled relative to an electric field strength established in a...
5858644 Analysis of analytes in biological fluids  
A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1)...
5856100 Method for purification and transfer to separation/detection systems of DNA sequencing samples and plates used therefor  
Disclosed are: a part for assembling reaction vessels comprising a base plate with holes passing through said plate in the direction of thickness; a method for preparation of reaction vessels...
5853668 Apparatus allowing sequential chemical reactions  
A first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile...
RE36011 Protein separations by capillary electrophoresis using amino acid-containing buffers  
Protein mixtures are separated by capillary electrophoresis in a buffer containing one or more amino acids in an amount sufficient to prevent or substantially reduce the degree of protein binding...
5851370 Automated electrophoresis system and method  
Automated electrophoresis is performed by applying a cover plate to a substrate having a plurality of electrophoresis lanes, applying at least one sample to the plurality of electrophoresis lanes,...
5846396 Liquid distribution system  
The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The...
5846727 Microsystem for rapid DNA sequencing  
A system is disclosed for the rapid and cost-effective sequencing of DNA. There are three principal components of the system: (1) a microreactor, which prepares DNA sequencing "ladders" using...
5840388 Polyvinyl alcohol (PVA) based covalently bonded stable hydrophilic coating for capillary electrophoresis  
A coated microcapillary column for high performance electrophoresis is disclosed. A preferred microcapillary includes a fused silica capillary column, the inner surface of the column having an...
5833826 Method and apparatus for reducing the distortion of a sample zone eluting from a capillary electrophoresis capillary  
An electrophoresis system including means for reducing the distortion of a sample zone eluting from a capillary electrophoresis separation capillary is disclosed. The system includes one or more...
5824204 Micromachined capillary electrophoresis device  
A micromachined structure for handling fluids with an applied high voltage, i.e. for electrophoresis, includes a glass or other highly insulative substrate on which are formed very small diameter...
5810985 Electrophoretically mediated chemical analysis  
Disclosed are methods of electrochemical analysis of an analyte in a sample. The methods include providing a sample comprising an analyte, and introducing the sample into a capillary tube...
5800692 Preseparation processor for use in capillary electrophoresis  
A preseparation processor for use in capillary electrophoresis is described. The preseparation processor contains sample processing material, preferably in the form of a membrane, for use in...
5798032 Method and apparatus for automated carbohydrate mapping and sequencing  
Methods and apparatus are disclosed for improved mapping and sequencing of carbohydrate polymers. In one aspect, the improvement includes a means for coupling two capillary electrophoresis (CE)...
5792330 Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis  
The present invention provides a method for direct detection concurrently with separation in capillary electrophoresis using a lanthanide cation selected from the group consisting of Tb(III),...
5785831 Mixing liquids using electroosmotic flow  
A method and apparatus for mixing liquids using electroosmotic flow. Multiple capillaries (100, 104, 106) or microchip channels meet at a common junction (102). One capillary (100) is used for...
5770084 Polymerized chiral micelles for chiral separations  
Chiral separations can be enhanced through the use of polymerized chiral micelles. Because polymerized micelles eliminate much of the complex dynamic behavior associated with conventional...
5766435 Concentration of biological samples on a microliter scale and analysis by capillary electrophoresis  
The present invention provides new methods for the concentration of ionic solutes, particularly ampholytes, such as, for example, peptides, proteins and nucleic acids. The methods are based on the...
5763162 Multichromophore fluorescent DNA intercalation complexes  
Novel fluorescent labeling techniques and fluorescent labels are provided, employing high affinity non-covalently binding and intercalating fluorescent dyes and dsDNA. The dyes find application to...
5759370 Method and device for isoelectric focusing without carrier ampholytes  
A device and method for isoelectric focusing of ampholytes in a buffer uses a cone-shaped capillary with a positive electrode connected at a narrow end and a negative electrode connected at the...
5753094 Borate storage buffer and sample diluent  
A composition, which has utility as a storage buffer and as a sample diluent before analysis by capillary zone electrophoresis (CZE), is comprised of water, a borate compound, a buffer compound...
5728282 Denaturing separation matrix having hydroxyethyl cellulose for nucleic acid electrophoresis  
A capillary electrophoresis separation matrix for single-stranded nucleic acids, along with methods for using and preparing the matrix, are disclosed. The separation matrix provides denaturing...
5723031 Method for the analytical separation of viruses  
The method permits the non-destructive analytical detection and/or the quantification of viruses or viral particles (analytes) in a liquid sample matrix containing organic or inorganic minor...
5695626 Capillaries for use in a multiplexed capillary electrophoresis system  
The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the...
5685965 Capillary electrophoresis technique  
To detect bands in an electrophoresis capillary tube having a liquid separating medium, a light source and a light detector of a monitor are positioned on opposite sides of the capillary tube with...
5681751 Method allowing sequential chemical reactions  
A first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile...
5662787 Device for profiling oligosaccharides released from glycoproteins  
Methods for profiling oligosaccharides released from glycoproteins and methods for the electrophoretic separation of high mannose, complex and hybrid oligosaccharides are disclosed. The disclosed...
5658446 Preparative capillary electrophoresis with wide-bore capillary  
A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary...
5641400 Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems  
Miniaturized planar column devices and miniaturized total analysis systems for liquid phase analysis are disclosed. The systems include a temperature control device for regulating temperature,...
5633129 Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices  
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique...
5630925 Capillary electrophoresis using a conductive capillary tube  
An electrophoretic system employing a capillary with at least one end having an electrically conductive coating or layer directly thereon. In order to introduce a plug of sample from a small...
5624539 Real time monitoring of electroosmotic flow in capillary electrophoresis  
An electrophoretic separation apparatus includes a capillary tube having a length, a cross section, an inlet and an outlet. A first reservoir containing a solvent and, upon injection, a solute is...
5605613 Polyvinylalcohol coated capillary electrophoresis columns  
Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface...
5599433 Capillary electrophoresis of glycosylated proteins  
A buffer and method useful for the analysis of glycoproteins by capillary zone electrophoresis. The buffer comprises water, a sugar complexing compound, a base compound for adjusting the pH, and a...
5599432 Device and a method for the electrophoretic separation of fluid substance mixtures  
A device for the electrophoretic separation of complex fluid substance mixtures comprises a channel system (21, 2, 22) for a carrier medium (C), an injection device (3) for the injection into the...
5593564 Microcolumn-microcolumn flow interface and method  
A flow gating interface system including a first microcolumnar section, a second microcolumnar section, and a channel for interfacing a first fluid conduit and a second fluid conduit is provided....
5582701 Ionic liquid-channel charge-coupled device  
An ionic liquid-channel charge-coupled device that separates ions in a liquid sample according to ion mobility characteristics includes a channel having an inner wall that has a matrix liquid...
5580435 System for detecting components of a sample in electrophoretic separation  
A substrate defines a group therein having three sections: a first and third sections having dimensions larger than the outside dimensions of two capillaries and a second section separating the...
5580434 Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer  
An apparatus for collecting samples from capillary electrophoresis (CE) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is disclosed. The apparatus has a capillary,...
5578460 Electrophoretic method for the isolation and separation of microorganisms and cell populations  
The present invention sorts microorganism populations from a mixture which contains more than one microorganism population. Microorganisms of different types vary in size, shape, and surface...