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6261430 Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules  
A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a...
6258263 Liquid chromatograph on a chip  
A chromatograph fabricated using microelectromechanical techniques. The chromatograph includes a first layer superimposed over a second layer. At least one micro-channel is etched into the second...
6258238 Method of producing a capillary, a capillary for an electrophoresis device and an electrophoresis device including such a capillary  
A method for producing a capillary comprises the steps of providing first a capillary having a uniform inner width throughout its length, introducing then an etchant into the capillary, and...
6251247 Detection of degradation of RNA using microchannel electrophoresis  
Degradation of RNA present in a sample is detected by using, as an indicator, rRNA included in the RNA. The steps include: (a) introducing the sample onto a microchannel, at an introducing point,...
6231737 Material transport method and apparatus  
An electrospray apparatus uses a microchannel formed in a microchip. Fluid is pumped through the channel to an outlet orifice using either hydraulic or electrokinetic means. An electrospray is...
6221223 Method of quantitative analysis for thuringiensin by capillary electrophoresis  
Quantitative analysis for thuringiensin by capillary electrophoresis ("CE`) was demonstrated. CE is a suitable separation technique for thuringiensin because of its high resolution, great...
6217731 Method and apparatus for monitoring and displaying the status of a parallel capillary electrophoresis device  
An automated parallel electrophoresis system including a plurality of capillaries configured to accommodate samples during an electrophoresis run which includes a plurality of phases. The system...
6210986 Microfluidic channel fabrication method  
A new channel structure for microfluidic systems and process for fabricating this structure. In contrast to the conventional practice of fabricating fluid channels as trenches or grooves in a...
6176962 Methods for fabricating enclosed microchannel structures  
Methods are provided for the fabrication of polymeric microchannel structures having enclosed microchannels of capillary dimension. The microchannel structures are constructed of a base plate and...
6176991 Serpentine channel with self-correcting bends  
A serpentine electrophoresis channel, e.g., for a microchip format, is disclosed. The channel includes pairs of linear segments, e.g., parallel or right-angle segments, each joined by an angled...
6156576 Fast controllable laser lysis of cells for analysis  
Fast lysis of a single cell or cellular component thereof is performed by generating a shock wave in a medium in which the cell or cellular component thereof is positioned. The cell or cellular...
6148508 Method of making a capillary for electrokinetic transport of materials  
A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed...
6149815 Precise electrokinetic delivery of minute volumes of liquid(s)  
Femtoliter to milliliter volumes of one or a plurality of different liquids are accurately dispensed electrokinetically without any direct electrical contact with such liquid(s). This is...
6143153 DNA sequencing  
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
6132578 Method and apparatus for electrophoresis separation and detection  
An electrophoresis separation and detection apparatus for separating and detecting fluorophore-labeled samples by electrophoresis, which comprises a migrating and separating means for...
6132419 Electroporetic gene and drug therapy  
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into...
6132579 Liquid separation  
A liquid is separated into its constituent species by electrophoresis along a capillary channel. A plurality of the channels is provided in the thickness of an injection molded plastics disc. The...
6126804 Integrated polymerase chain reaction/electrophoresis instrument  
A new approach and instrument for field identification of micro-organisms and DNA fragments using a small and disposable device containing integrated polymerase chain reaction (PCR) enzymatic...
6120666 Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same  
A microfabricated device and method for electrokinetic transport of a liquid phase biological or chemical material is described. In accordance with one aspect of the present invention there is...
6117326 Capillary electrochromatography separation media  
The present invention provides for the convenient preparation, purification, use and re-use of capillary electrochromatography columns that employ polymer gel materials as the separation media....
6110339 Nanofabricated separation matrix for analysis of biopolymers and methods of making and using same  
Separation matrices useful in the formation of solid-state mm- to cm-scale devices for the rapid, high-resolution separation of single-stranded DNA ladder bands generated by the Sanger dideoxy- or...
6103081 Heat sink for capillary electrophoresis  
A cooling means for a capillary electrophoresis system is described. The cooling means is designed for efficient heat dissipation and operates without arcing at voltages higher than 30 kV.
6103537 Capillary assays involving separation of free and bound species  
The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member...
6093300 Sample plate and multi-capillary electrophoresis apparatus  
A base plate is made of an insulating material, and comprised of a flat surface and a connector part connected therewith. A plurality of wells are vertically and transversely arranged on the...
6093296 Method and device for moving molecules by the application of a plurality of electrical fields  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6090250 Chiral surfactants and methods for their use in chiral separations  
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having...
6083372 Reagents and methods for performing electrokinetic chromatography  
The invention is in the field of electrokinetic chromatography. In particular, the invention is directed to reagents and methods of performing electrokinetic chromatography. The reagents and...
6074541 Preformed polymer coating process and product  
A method of coating a solid support (e.g. a capillary or chromatography packing) to alter the properties of the support surface for separating components in a fluid stream. The method comprises...
6074542 Compounds for molecular separations  
The present invention describes a method and apparatus utilizing a capillary coating of linear and crosslinked polymers and copolymers of acrylamidomonomers or methacrylamides bearing two...
6068749 Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications  
A subatmospheric, variable pressure sample delivery chamber, useful as an electrospray ionization device for introducing a sample into a mass spectrometer or as a sample delivery device for...
6056859 Method and apparatus for staining immobilized nucleic acids  
A method for staining immobilized nucleic acids includes the steps of affixing DNA probes to a solid substrate, moving target DNA material into proximity with the DNA probes, whereby the target...
6056860 Surface modified electrophoretic chambers  
Electrophoretic chambers having at least a region of surface modification, and methods for their fabrication, are provided. In some embodiments the subject chambers include in the region of...
6054034 Acrylic microchannels and their use in electrophoretic applications  
Microchannels having at least an acrylic inner surface and methods of their use in electrophoretic applications are provided. The subject microchannels may be in the form of a variety of...
6054032 Capillary electrophoresis array  
A capillary electrophoresis array that includes: (a) a plurality of capillary tubes arranged adjacent each other in a generally longitudinal orientation, each of the tubes having an inlet end, and...
6051636 Entrapment of nucleic acid sequencing template in sample mixtures by entangled polymer networks  
A capillary electrophoresis system and method of electrokinetically loading a capillary electrophoresis sample into a separation medium in a capillary tube in which an entangled polymer matrix is...
6048444 Capillary electrophoresis apparatus  
A capillary electrophoresis apparatus of the invention has: a plurality of capillaries which are filled with a migration medium and have first ends into which samples are injected and second ends...
6033544 Liquid distribution system  
The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The...
6027627 Automated parallel capillary electrophoretic system  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6020126 Rapid genetic screening method  
A rapid and sensitive detection method capable of reliably distinguishing fragments identical to a defined sequence from fragments containing a single base pair mismatch relative to the defined...
6007690 Integrated microfluidic devices  
Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main...
6001230 Automated capillary electrophoresis apparatus  
An integrated apparatus for capillary electrophoresis which is automated using conveyors which carry vials containing electrolytes and samples, a capillary contained in a modular, portable, and...
5993626 Capillary electrophoresis of transferrin glycoforms  
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is...
RE36350 Fully integrated miniaturized planar liquid sample handling and analysis device  
A miniaturized total analysis system ("μ-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The μ-TAS comprises microstructures fabricated by laser...
5964997 Balanced asymmetric electronic pulse patterns for operating electrode-based pumps  
Provided is a method of operating an electrode-based pump to pump a liquid, the method comprising periodically reversing the voltage polarity applied to the electrodes of the pump while...
5963456 Method and apparatus for displaying capillary electrophoresis data  
A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected...
5961800 Indirect electrode-based pumps  
Provided is an electrode-based pump having source of a pumped fluid, a conduit channel of capillary dimensions connected via a first end to the pumped fluid source and having an outlet at a second...
5958202 Capillary electrophoresis enzyme immunoassay  
Disclosed are methods and apparatus for performing highly sensitive enzyme-amplified assays using channel electrophoresis of an enzyme having a biorecognition moiety. Combining a binding reaction...
5954931 Electrophoresis apparatus and method involving parallel channels  
An electrophoresis apparatus includes a substrate (34) which supports a filling region (22) and a plurality of electrophoresis lanes (20). The filling region (22) communicates a sample to the...
5935430 Structure for capturing express transient liquid phase during diffusion bonding of planar devices  
A miniaturized planar device formed of first and second planar substrates that may be superimposed and diffusion bonded to form a single, planar integrated assembly. Each of the first and second...
5932080 Mobility-based and normalized capillary electrophoresis  
Identification and quantification of constituents of a sample is achieved by mobility-based electropherograms obtained from capillary electrophoresis, the mobilities being normalized by zero...