Match Document Document Title
6540895 Microfabricated cell sorter for chemical and biological materials  
The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the...
6541274 Integrated devices and method of use for performing temperature controlled reactions and analyses  
Reactor systems that include a reaction receptacle that includes a plurality of reservoirs disposed in the surface of a substrate. The reactor system also typically includes a temperature control...
6533914 Microfabricated injector and capillary array assembly for high-resolution and high throughput separation  
The present invention concerns methods and apparatus for the high resolution, high output electrophoretic separation of molecules. In preferred embodiments, the methods and apparatus are of use...
6524866 Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities  
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
6503757 Analytical system and method  
An analytical or preparatory microfluidic system is disclosed which generally comprises a base unit comprising a first adapter interface array; a first adapter plate selected from a set of a...
6488895 Multiplexed microfluidic devices, systems, and methods  
Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input...
6485625 Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments  
This invention is an integrated instrument for the high-capacity electrophoretic analysis of biopolymer samples. It comprises a specialized high-voltage, electrophoretic module in which the...
6485626 Multiple capillary electrophoresis devices with detection in capillary output  
The invention concerns a multiple capillary electrophoresis device comprising a plurality of juxtaposed capillaries, means for generating inside the capillaries an electric field ensuring...
6482364 Microfluidic systems including pipettor elements  
The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions...
6479299 Pre-disposed assay components in microfluidic devices and methods  
Microfluidic devices having predisposed assay components for increased throughput and prolonged shelf life are provided.
6475361 Capillary electrophoresis apparatus having filling/refilling system and methods for use thereof  
The present invention relates to an electrophoresis apparatus having a filling/refilling system and methods of using the same. The electrophoresis apparatus comprises a first buffer chamber...
6475364 Methods, devices and systems for characterizing proteins  
A method of characterizing a polypeptide, comprising providing a first capillary channel having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked...
6475722 Surface treatments for DNA processing devices  
The present invention discloses methodologies for the treatment of the surface(s) of DNA processing devices so as to greatly reduce DNA adsorption to the surface(s) exposed to the DNA-containing...
6476118 Polymer mixtures for high performance/high temperature separation in capillary electrophoresis, especially for long read DNA sequencing  
A method of separating a mixture of biopolymers of various lengths using a blend of two linear hydrophilic polymers, particularly polyacrylamides (LPA) or substituted polyacrylamides, one with...
6475363 Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis  
A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using...
6475362 Method and apparatus for compression of DNA samples for DNA sequencing  
A novel method of spatial compression of a DNA sample inside the capillary for the gel capillary electrophoresis and an article for operating the method are disclosed. In this method, after the...
6465692 Reagents for preparing a sample containing biomolecular analytes for capillary electrophoretic separation and methods for making the reagents  
Formamide with low conductivity and a neutral or slightly basic pH is provided. Such formamide may be used in a sample loading solution for capillary electrophoretic separation of biomolecular...
6465257 Microfluidic systems  
The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials...
6451264 Fluid flow control in curved capillary channels  
A capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of groups of microstructures are...
6444461 Microfluidic devices and methods for separation  
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
6444106 Method of moving fluid in a microfluidic device  
A microfluidic device has a layer that has a capillary break formed by a capillary sluice. The capillary sluice has a lower surface and an upper surface. An input channel is coupled to the...
6428666 Electrokinetic concentration of charged molecules  
A method for separating and concentrating charged species from uncharged or neutral species regardless of size differential. The method uses reversible electric field induced retention of charged...
6428670 Gel charger for capillary column  
A holder for a capillary cassette closes a chamber, and is fixed to a detection side holder fixing member. An acidic solution container, an alkaline solution container, a pure water container and...
6416642 Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection  
Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an...
6413400 Polycarbonate electrophoretic devices  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6413782 Methods of manufacturing high-throughput screening systems  
Microfluidic devices for analyzing a plurality of compounds are manufactured for performing high throughput screening assays. The methods are used to manufacture devices that screen large numbers...
6406605 Electroosmotic flow controlled microfluidic devices  
In one embodiment, a fluidic module, such as a microfluidic module, has a fluid-flow channel, an electroosmotic flow membrane positioned in the channel, and a cathode located on one side and an...
6403338 Microfluidic systems and methods of genotyping  
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
6391622 Closed-loop biochemical analyzers  
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
6387234 Integrated multiplexed capillary electrophoresis system  
The present invention provides an integrated multiplexed capillary electrophoresis system for the analysis of sample analytes. The system integrates and automates multiple components, such as...
6379970 Analysis of differential protein expression  
A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that...
6379515 Process for separating mixtures of substances using capillary affinity gel electrophoresis  
Process for the selective separation of electrically charged target molecules in an analytical mixture by means of capillary affinity gel electrophoresis, using a capillary tube which is at least...
6375819 Fluid delivery system for capillary electrophoretic applications  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6365024 Motorized positioning apparatus having coaxial carrousels  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6364516 Electrophoretic sample excitation light assembly  
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from...
6344120 Method for controlling liquid movement in a chemical device  
A method of controlling liquid movement in a chemical device comprising a porous structure involved applying an electrical potential to generate an electroosmotic force in the porous structure so...
6322682 Method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds  
A method of capillary electrophoresis utilizing a capillary tube made up of hydrophobic plastics, charactarized in that the inner surface of said capillary is coated with a hydrophilic polymer...
6319379 Modified electrokinetic sample injection method in chromatography and electrophoresis analysis  
A sample injection method for horizontal configured multiple chromatography or electrophoresis units, each containing a number of separation/analysis channels, that enables efficient introduction...
6319705 Microchip device for electrophoresis  
A microchip device for electrophoresis includes not only a microchip having a separation flow route for separating a sample electrophoretically and an electrical power source for applying a...
6306273 Methods and compositions for conducting processes in microfluidic devices  
A method is disclosed for controlling the direction and transport of a material on a microfluidic device formed from an acrylic polymer, by electrokinetic flow of a fluid containing the material....
6306272 Method and device for performing chemical reactions  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6301931 Vacuum fusion bonded glass plates having microstructures thereon  
An improved apparatus and method for vacuum fusion bonding of large, patterned glass plates. One or both glass plates are patterned with etched features such as microstructure capillaries and a...
6299747 Capillary electrophoretic methods to detect new biologically active compounds in complex biological material  
This invention relates to a competitive-binding, capillary electrophoretic method of detecting new therapeutic regulatory (modulating) and diagnostic compounds in natural samples and other complex...
6297009 Method and silicate composition for conditioning silica surfaces  
Disclosed is a method for increasing the electroosmotic flow rate available for a silica surface. In the method, there is provided an electrophoretic channel which is defined by one or more silica...
6294064 Method and reagent for suppressing the injection of nucleic acid sequencing template into micro-bore capillary during DNA separation with capillary electrophoresis  
Reagents and methods for preparing samples containing both biomolecule analytes and macrobiomolecules for capillary electrophoresis separation are provided. The reagents comprise a branched...
6284113 Apparatus and method for transferring liquids  
The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements....
6274017 Buffer for analyzing small inorganic cations by capillary electrophoresis  
Disclosed herein is electrophoresis buffer and a buffer kit useful in the analysis of small cations in samples containing simple or complex mixture of ions and/or neutral organic compounds in a...
6271038 Methods for high throughout determination and ranking of formulations and solubility  
The invention provides apparatus and methods for formulation mixing and measurement to produce rank orders of solubility of chemicals in a variety of formulations. One such method includes mixing...
6264892 Miniaturized planar columns for use in a liquid phase separation apparatus  
Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of...
6261431 Process for microfabrication of an integrated PCR-CE device and products produced by the same  
A fully integrated monolithic small volume PCR-CE device in glass, or the like materials, is fabricated using thin film metal heaters and thermocouples to thermally cycle sub-microliter PCR...