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6878254 Size separation of analytes using monomeric surfactants  
A sieving medium for use in the separation of analytes in a sample containing at least one such analyte comprises a monomeric non-ionic surfactant of the of the general formula, B-A, wherein A is...
6878253 Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis  
A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of...
6866759 Stepped electrophoresis for movement and concentration of DNA  
A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative...
6849722 Polymerized oligopeptide-surfactant chiral micelles  
Chiral separations can be enhanced through the use of polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles. Because polymerized micelles eliminate much of the complex...
6846645 Multiplexed enzymatic assays  
A mutiplexed enzyme assay method and substrate set for performing the method are disclosed. The method includes performing a plurality of enzyme reactions in the presence of a plurality of enzymes...
6843272 Conductance valve and pressure-to-conductance transducer method and apparatus  
A device for interrupting or throttling undesired ionic transport through a fluid network is disclosed. The device acts as a fluid valve by reversibly generating a fixed “bubble” in the conducting...
6837977 Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand  
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug...
6835537 Method for equalizing band intensities on sequencing gels  
A method for normalizing the intensity of G bands in sequencing methods which utilize dITP is presented. The use of dITP normally results in decreased intensities of G bands which occur after A...
6827831 Controller/detector interfaces for microfluidic systems  
The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices....
6824663 Efficient compound distribution in microfluidic devices  
Microfluidic devices are provided having units of 8-fold symmetry comprising 8 assay units, where a reservoir provides a common component to 8 assay units. The units can be compactly formed in a...
6818112 Protein separation via multidimensional electrophoresis  
The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve...
6813009 Detection of metabolic dysfunctions using fluorescence emission from serum  
Serum emission can be used as the first test to detect metabolic disorders in mammals. When changes in emission of the serum from patients with different pathological conditions were...
6808609 Device and method for moving charged particles  
Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of...
6805783 Method for manipulating a solution using a ferroelectric electro-osmotic pump  
A device and method for pumping an electrolyte solution includes a conduit having a first end, a second end and a lumen for containing the electrolyte solution. An opening at each end of the...
6787015 Methods for conducting electrophoretic analysis  
Capillary electrophoresis is performed under conventional conditions in microchannels having a norbornene based polymer surface. The norbornene based polymers can be used as a solid substrate for...
6787088 Controlled fluid transport in microfabricated polymeric substrates  
Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with...
6787018 Dielectrophoretic concentration of particles under electrokinetic flow  
The use of dielectrophoresis to collect particles under the conditions of electrokinetically-driven flow. Dielectrophortic concentration of particles under electrokinetic flow is accomplished by...
6787111 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis  
An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet...
6783649 High throughput capillary electrophoresis system  
The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling...
6776911 Methods for surface modification of silica for use in capillary zone electrophoresis and chromatography  
The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When...
6773567 High-throughput analytical microfluidic systems and methods of making same  
A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed...
6770182 Method for producing a thin sample band in a microchannel device  
The present invention improves the performance of microchannel systems for chemical and biological synthesis and analysis by providing a method and apparatus for producing a thin band of a species...
6764648 Robotic microchannel bioanalytical instrument  
A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the...
6759013 Modular apparatus for chemical microanalysis  
A modular microchannel apparatus for analysis of an analyte. The apparatus includes a separation unit and a reservoir unit. The separation unit has a microchannel. The analyte can be driven to...
6755074 Liquid chromatographic method and system  
To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by...
6752914 Capillary electrophoresis device  
An analyser comprises a substrate (20) of diamond, sapphire or a polymer material; an array (10) of elongate capillary channels formed in the substrate; means (40) for driving a sample to be...
6749735 Electromobility focusing controlled channel electrophoresis system  
An electromobility focusing controlled channel electrophoresis system includes a first separation channel including an electric field intensity gradient profile in which the intensity is a...
6726820 Method of separating biomolecule-containing samples with a microdevice with integrated memory  
The present invention provides microdevices, such as those used in the pharmaceutical and biotechnological fields, including an integrated memory. According to various embodiments, the integrated...
6696020 Electrochemiluminescence cell with floating reaction electrodes  
An electrochemiluminescence apparatus comprises a reaction vessel; means for generating an electric field (140, 160) within at least a region (120) of the reaction vessel; and one or more reaction...
6680208 Rapid protein identification using antibody mixtures  
A method and device is disclosed for rapidly identifying a large number of proteins by placing a protein mixture in a sample chamber of an electrophoresis gel, and performing electrophoresis to...
6676819 Methods and apparatus for automatic on-line multi-dimensional electrophoresis  
The invention provides a method of performing one- and two-dimensional electrophoresis with or without gel in an automated way. The two dimensional electrophoresis can be performed either...
6677593 Planar flow-by electrode capacitive electrospray ion source  
An electrospray ion source includes a chamber including a channel region therein, the channel including at least one inlet for directing a solution into the channel and at least a first and a...
6673593 Integrated device for microfluid thermoregulation, and manufacturing process thereof  
The integrated device for microfluid thermoregulation comprises a semiconductor material body having a surface; a plurality of buried channels extending in the semiconductor material body at a...
6662830 Sample processing device with integral electrophoresis channels  
Sample processing devices with electrophoresis channels and methods of loading the electrophoresis channels with electrophoresis sieving polymer while rotating the sample processing device are...
6637463 Multi-channel microfluidic system design with balanced fluid flow distribution  
Methods and apparatus are presented for controlling fluid flow through flow paths with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing...
6620625 Ultra high throughput sampling and analysis systems and methods  
Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods...
6613512 Apparatus and method for correcting for variable velocity in microfluidic systems  
Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and...
6613525 Microfluidic apparatus and method for purification and processing  
Integrated microfluidic devices comprising at least an enrichment channel (10) and a main electrophoretic flowpath (12) are provided. In the subject integrated devices, the enrichment channel and...
6610186 Method and device for separating particles or molecules by migration through a ferrofluid  
The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said...
6607644 Microanalytical device containing a membrane for molecular identification  
The invention provides a microanalytical device for analyzing a fluid sample containing at least one analyte molecule. The device is constructed from a substrate and a cover plate each having a...
6602391 Apparatus and method for combined capillary separation and blotting of biological macromolecules  
An apparatus and method are described for capillary separation of macromolecules and precise post-separation blotting. Apparatus include disposable separating element (capillary), which contains a...
6596238 Coatings with cross-linked hydrophilic polymers  
The present invention relates to a process for permanently coating the inner surface of columns, capillaries and microchannel systems with hydroxylic polymers, such as polyvinyl alcohol, and to...
6576104 Apparatus and method for reading gel electrophoresis pattern  
An apparatus and a method for reading a gel electrophoresis pattern can read the gel electrophoresis pattern of a sample, such as a nucleic acid and a protein, with high sensitivity and without...
6576105 Pteridine analysis by capillary electrophoresis using laser-induced fluorescence detection  
The present invention provides a unique method and means for detecting pteridines in biological samples using the novel combination of capillary electrophoresis (CE) and laser-induced fluorescence...
6572750 Hydrodynamic injector  
A hydrodynamic injector for substantially concurrently loading fluid samples to be analyzed into multiple capillary tubes of a capillary electrophoresis system. The injector includes an enclosure...
6569305 Method for injection and stacking of analytes in high-conductivity samples  
The present invention is a method for injection and stacking of analytes in high salt samples. This stacking method works with both pressure injection or electrokinetic injection. The ability to...
6560859 Capillary cassette and method of producing the same  
Capillary columns (102) pass through and are inserted in a rubber plate (14), held and fixed by elastic force of rubber, and two-dimensionally arranged on a sample injection side. It fixes the...
6554985 Methods and formulations for the separation of biological macromolecules  
This invention relates to methods and formulations for the separation of biological macromolecules according to their size using capillary electrophoresis with improved polyacrylamide matrixes...
6551836 Microfluidic devices, systems and methods for performing integrated reactions and separations  
Microfluidic devices for performing integrated reaction and separation operations. The devices have a planar substrate having a first surface with an integrated channel network disposed therein....
6542691 Glass capillary array for fluorescence analysis and manufacturing method thereof  
A glass capillary array for fluorescence analysis is provided which is capable of preventing reduction of the transmittance of a laser beam through the glass capillaries during electrophoretic DNA...