Match Document Document Title
7115422 Separation apparatus including porous silicon column  
A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed rough surface of hemispherical...
7108775 Apparatus and method for confining eluted samples in electrophoresis systems  
The present teachings provide a microfluidic apparatus comprising a body defining at least one channel that extends through said body, the channel including an inlet and an outlet; and an...
RE39293 Separation of plasma components  
A method for separating components from plasma, the method comprising (I) separating the plasma into a first and second component, the first component comprising an albumin/α-1-antirypsin pool and...
7101467 Mixed mode microfluidic systems  
Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow...
7090003 Method and apparatus for temperature control of a microfluidic device  
A microfluidic device is provided for regulating the temperature of a sample fluid flowing therethrough, as well as, a method of regulating the temperature of the sample fluid flowing through the...
7081189 Microfluidic pumps and mixers driven by induced-charge electro-osmosis  
A microfluidic device includes one or more microchannels providing a passageway for transmitting an electrolyte fluid. A field source provides a defined field in the one or more microchannels,...
7074310 Method for separating single-wall carbon nanotubes and compositions thereof  
The invention relates to a process for sorting and separating a mixture of (n, m) type single-wall carbon nanotubes according to (n, m) type. A mixture of (n, m) type single-wall carbon nanotubes...
7070681 Electrokinetic instability micromixer  
A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex...
7060171 Methods and systems for reducing background signal in assays  
Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction...
7056659 Characterizing nucleic acids  
A method for characterizing DNA, which comprises: (i) providing a population of DNA fragments, each fragment having cleavably attached thereto a mass label for identifying a feature of that...
7056427 Electrophoresis apparatus using capillary array and sample plate assembly used therefor  
A sample plate assembly for an electrophoresis apparatus including a tray at a sample supply portion of a capillary array, an adapter for the tray, a sample plate mounted on the adapter, a septer...
7052589 Method for electrophoretic separations using dynamically generated opposite mobilities  
Method and materials to carry out preparative-scale electrophoretic separations based on the principle of dynamically created non-co-directional effective electrophoretic mobilities are disclosed....
7045048 Polymers for separation of biomolecules by capillary electrophoresis  
The invention provides uncharged water-soluble silica-adsorbing polymers for suppressing electroendoosmotic flow and to reduce analyte-wall interactions in capillary electrophoresis. In one aspect...
7037417 Mechanical control of fluids in micro-analytical devices  
An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a...
7037416 Method for monitoring flow rate using fluorescent markers  
Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of...
7033474 Microfluidic devices incorporating improved channel geometries  
The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation,...
7029561 Fluidic temperature gradient focusing  
A method and device are provided for concentrating and separating ionic species in solution within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is...
7011970 Automatic bio-manipulation factory system for manipulating a single cell  
This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of...
7007709 Microfluidic device and manufacture thereof  
The present invention relates to microfluidic devices and to their method of manufacture. The microfluidic devices are original by their specific structure (of sandwich type) and by the materials...
7010391 Methods and systems for control of microfluidic devices  
The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined...
6994826 Method and apparatus for controlling cross contamination of microfluid channels  
A method for controlling fluid flow at junctions in microchannel systems. Control of fluid flow is accomplished generally by providing increased resistance to electric-field and pressure-driven...
6991712 Spectral calibration of fluorescent polynucleotide separation apparatus  
The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards...
6991713 Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device  
A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of...
6989089 Method for making contact to cells present in a liquid environment above a substrate  
A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment....
6984525 Method for automated isolation of fractions in multichannel separation systems  
A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a...
6982028 Surface charge modification within preformed polymer microchannels with multiple applications including modulating electroosmotic flow and creating microarrays  
A method is described for modifying performed channels fabricated in a variety of substrate materials including PMMA. The method involves exposing a portion of a fluid flow channel to light at a...
6979390 Method and apparatus for separating biological molecules  
A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing...
6974526 Plastic microfluidics enabling two-dimensional protein separations in proteome analysis  
The invention provides a microfluidic apparatus for performing 2-D biomolecular separations. The microfluidic 2-D device may include first and second planar substrates which include at least a...
6974528 High performance wide bore electrophoresis  
Methods, apparatus and systems are provided for efficient separation of various small and large molecules, especially biomolecules such as proteins, nucleic acids and polysaccharides. In...
6969452 Two-dimensional protein separations using chromatofocusing and multiplexed capillary gel electrophoresis  
Disclosed is a two-dimensional protein separation method. It makes separating a protein sample by chromatofocusing into a plurality of aliquots, and then loading each aliquot into a separate...
6960286 Method for controlling sample introduction in microcolumn separation techniques and sampling device  
In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a...
6949176 Microfluidic control using dielectric pumping  
Devices and methods utilizing dielectric pumping and variable dielectric pumping to move fluids through microchannels. Two fluids having dissimilar dielectric constants form an interface that is...
6942777 Sample analysis system with chip-based electrophoresis device  
The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device...
6939451 Microfluidic chip having integrated electrodes  
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities,...
6939453 Electrophoresis process using ionic liquids  
Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid...
6939452 Parallel sample loading and injection device for multichannel microfluidic devices  
A sample load and injection device (10) includes sample introduction capillaries (11) attached to a microfluidic device (12). Sample introduction capillaries (11) are connected to sample...
6932940 Optical detection in bio-separation device using axial radiation input  
In a bio-separation system, incident radiation (e.g., from a laser or LED source) for detection of separated analytes is directed at the detection zone axially along the separation medium, instead...
6929730 Two dimensional microfluidic gene scanner  
One embodiment of the invention relates to a microfluidic apparatus for performing two dimensional biomolecular separations. According to one aspect of the invention, after a first dimension...
6929729 Method for conducting capillary zone electrophoresis  
A method for conducting capillary zone electrophoresis in which a lubricating detergent is added to help prevent sample buildup on the inner walls of the capillary. In a preferred embodiment the...
6923895 Coated capillary electrophoresis tubes and system  
The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to...
6919045 Supply element for a laboratory microchip  
A supply element for a microfluid microchip that can be used for chemical analysis has supply lines or reservoirs that serve to supply the microchip with substances or reagents. Both ends of the...
6913679 Apparatus and methods for high resolution separation of sample components on microfabricated channel devices  
Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce...
6908594 Efficient microfluidic sealing  
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
6905583 Closed-loop control of electrokinetic processes in microfluidic devices based on optical readings  
A method for performing an electrophoretic separation on a microfluidic device includes applying an electric field to electrokinetically move a sample along a channel towards a location. The...
6906797 Side light activated microfluid channels  
Devices are provided comprising reflecting channels for directing horizontally a vertical light beam through a multiplicity of streams. The devices provide particular applications in...
6902657 Electrophoresis separation media and methods  
A low molecular weight non-entangled polyvinylpyrrolidone for use as a separation media for microchannel electrophoretic separation. The separation media may be used in a system in which multiple...
6890411 Control of flow and materials for micro devices  
The present invention generally relates to methods and devices for the control of the movement of fluids and electrically charged sample components within those fluids. More particularly, the...
6887668 Nucleic acid separation and detection by electrophoresis with a counter-migrating high-affinity intercalating dye  
The invention provides novel electrophoretic methods for high-resolution separation and high-sensitivity detection of nucleic acids. The methods involve the use of a high-resolution buffer and a...
6881317 Fractionation of macro-molecules using asymmetric pulsed field electrophoresis  
A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field...
6878255 Microfluidic devices with thick-film electrochemical detection  
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic...