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8431390 Systems of sample processing having a macro-micro interface  
Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various...
8431340 Methods for processing and analyzing nucleic acid samples  
Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various...
8420318 Microfabricated integrated DNA analysis system  
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of...
8388822 Method and apparatus for analysis and sorting of polynucleotides based on size  
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
8366896 Capillary electrophoresis device  
Provided is a capillary electrophoresis device including a holder preventing a septum from coming off when a capillary is pulled out, and also allowing containers to be taken out in any order. In...
8366897 Gradient elution electrophoresis and detectorless electrophoresis apparatus  
A microfluidic apparatus and method for performing electrophoretic separation of compounds. The method comprises the steps of: a) providing a separation buffer; b) providing a sample solution in...
8361292 Method for analyzing hemoglobin by capillary electrophoresis and additive used therein  
The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and...
8357277 Enhanced method for detecting and/or quantifying an analyte in a sample  
The invention relates to an enhanced method of detecting and/or quantifying at least one analyte in a sample.
8349159 Microfluidic device for detection of charged analytes contained in an electrolyte and a method for detecting charged analytes contained in an electrolyte  
A device for selective preconcentration/detection of charged analytes contained in an electrolyte having at least two reservoirs separated by at least one rectilinear microchannel with no...
8350243 Optically induced dielectrophoresis chip for control and analysis of bio-molecules  
An optically-induced dielectrophoresis chip including a substrate, a first electrode layer disposed on the substrate, and an interface modification layer disposed on the first electrode layer. A...
8337685 Serum components that bind to threat agents  
Low molecular weight serum components (less than 10,000 m.w.), in vaccinated animals and a human subject who has been exposed to a threat agent inadvertently, bound to purified O-polysaccharide...
8329115 Nanofluidic preconcentration device in an open environment  
This invention provides a device and methods for increasing the concentration of a charged species in solution, wherein the solution containing the concentrated species is exposed to the...
8298392 Microfluidic devices and methods of using same  
The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided...
8282799 Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields  
The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the...
8283157 System and method for increasing polymer/nanopore interactions  
An electrolytic system includes an analyte chamber having an access port for introducing a sample containing a molecules of interest, such as DNA. Electrodes create an electric field along a...
8262881 Method for finger-printing heparins  
Methods to generate a distinctive fingerprint (pattern of migration) for a sample of complex, polydisperse heparins are provided. The methods involve adding resolving agents such as polyamines to...
8257567 Hemoglobin determination method  
An object of the present invention is to provide a method for measuring hemoglobin using electrophoresis, in particular a method for measuring hemoglobin that enables high accuracy measurement of...
8246805 Micro-fluidic chip and flow sending method in micro-fluidic chip  
Disclosed herein is a micro-fluidic chip including a hollow area into which a charged droplet is introduced, and an electrode configured to be provided toward the hollow area. Movement direction...
8232074 Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells  
The present invention relates to methods of measuring electrical properties of a cell using electrode devices comprising tapered nanotips having submicrometer dimensions (“nanoelectrodes”) for...
8221604 Method for controlling substance transfer  
Transfer of fluid substances, and/or substances comprised in fluid substances, is controlled by introducing a separation medium, which prevents transfer of the fluid substances, and/or the...
8182746 Electrophoresis process using a valve system  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
8173001 Method and apparatus for analysis and sorting of polynucleotides based on size  
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
8163154 Method for voltage-gated protein fractionation  
We report unique findings on the voltage dependence of protein exclusion from the pores of nanoporous polymer exclusion membranes. The pores are small enough that proteins are excluded from...
8163150 Electrowetting dispensing devices and related methods  
A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality...
8142631 Particle focusing apparatus and method for focusing particles by using the same  
In a particle focusing apparatus and a method for focusing particles, the particle focusing apparatus includes a channel, a fixing member, a fluid feeding portion and a power supply. The channel...
8142630 Electrophoresis devices and methods for focusing charged analytes  
Devices are provided for separating and focusing charged analytes, comprising a separation chamber and two or more electrodes, for example, an electrode array. A membrane separates the separation...
8118986 Determination of the hydrodynamic radii of the constituents of an admixture by means of analysis of a taylor dispersion carried out following a separation by means of capillary electrophoresis  
A method for determining the hydrodynamic radius for the constituents of an admixture, includes: (A) by separating capillary electrophoresis, the constituents of the admixture, leaving them within...
8114349 Bio-analysis cartridge tracking and protection mechanism  
A reusable bio-analysis cartridge that includes a built-in mechanism to track various parameters and usage data. The tracking mechanism includes a non-volatile rewritable memory “smart-key” that...
8105471 Nanofluidics for bioseparation and analysis  
The invention includes nanochannel devices and methods for using such nanochannel devices for separating molecules, ions and biomolecules. The nanochannel devices have at least one nanochannel...
RE43122 Apparatus and method for trapping bead based reagents within microfluidic analysis systems  
The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends...
8097470 Microchip analysis method and apparatus  
The analysis apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips...
8083821 System for modifying the atmosphere within an enclosed space and incubator system including the same  
System for modifying the chemical composition of atmosphere within an enclosed space and incubator system including such a system. The concentration of oxygen within the enclosed space may be...
8083915 Methods for forming small-volume electrical contacts and material manipulations with fluid microchannels  
A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging...
8083917 Methods and apparatus for the location and concentration of polar analytes using an alternating electric field  
A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric...
8080144 Gradient elution electrophoresis  
A method for performing electrophoretic separation of ionic compounds which involves varying a bulk fluid flow though a separation path into which ionic species are continuously introduced and...
8057191 Electrokinetic micropump having ion-exchange membranes  
The invention is directed to the elimination of changes of the chemical composition of a pumped liquid caused by introduction of strange components or by modification of original components....
8057724 Portable water quality sensor fabrication method  
A disposable microsensor is designed, fabricated and tested for standard BOD (Biochemical Oxygen Demand) measurements. A transparent Cyclic Olefin Copolymer (COC) substrate is used for sensor...
8053239 Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures  
A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the...
8030092 Controlled electrophoresis method  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
8021531 Method for modifying the concentration of reactants in a microfluidic device  
A method of carrying out a chemical reaction on a microfluidic device in which a first reactant at a first concentration is delivered into a reaction channel; within the reaction channel the...
8007725 Electrophoresis apparatus having valve system  
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus...
7993507 Separation method for multi channel electrophoresis device having no individual sample wells  
The present invention is related to a method of separation of compounds by electrophoresis in which the compounds such as genes, proteins, etc. may be analyzed very precisely as samples are...
7988839 Capillary electrophoresis systems and methods  
An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the...
7988840 Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields  
The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the...
7955575 Microfluidic surfaces  
A microfluidic device comprising a set of one or more, preferably more than 5, covered microchannel structures manufactured in the surface of a planar substrate. The device is characterized in...
7931792 System for concentrating and analyzing particles suspended in a fluid  
Disclosed is a device for separating and concentrating particles suspended in a fluid stream by using dielectrophoresis (DEP) to trap and/or deflect those particles as they migrate through a fluid...
7909973 Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels  
A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging...
7906001 Method for separating proteins by capillary electrophoresis and buffer compositions for capillary electrophoresis  
The invention concerns a free solution capillary electrophoresis method at alkaline pH for the analysis of samples comprising protein constituents including a lipoprotein constituent or...
7902500 Methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry  
The present invention relates a use of the electrocapture-based separation technology combined with mass spectrometry (e.g. sequence of polypeptides by collision-induce dissociation mass...
7887686 Method for analyzing haemoglobin by capillary electrophoresis, a kit for capillary electrophoresis, and use of a flow inhibitor in said method  
The invention concerns a method for free solution capillary electrophoresis at an alkaline pH to analyze samples comprising haemoglobin, in which the sample is passed through a capillary...