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6033544 |
Liquid distribution system
The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The...
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6027623 |
Device and method for electrophoretic fraction
A device for fractionating macromolecules in a fluid medium includes a plurality of individual obstacles which are arranged on a substrate in rows and columns. An electric field is provided and...
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6013164 |
Electokinetic high pressure hydraulic system
A compact high pressure hydraulic system having no moving parts for converting electric potential to hydraulic force and for manipulating fluids. Electro-osmotic flow is used to provide a valve and...
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6007690 |
Integrated microfluidic devices
Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main...
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5993633 |
Capillary electrophoresis electrospray ionization mass spectrometry interface
The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an...
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5985119 |
Electrokinetic pumping
The invention provides methods of performing a synthetic process in a liquid distribution system having reaction cells, by pumping at least one reagent into a reaction cell.
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5968331 |
Sample holding device for electrophoresis apparatus and sample injection method
A sample holding device for electrophoresis apparatus according to the present invention wherein a plurality of sample holding capillaries are laid out in an array and are immobilized to the...
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5964997 |
Balanced asymmetric electronic pulse patterns for operating electrode-based pumps
Provided is a method of operating an electrode-based pump to pump a liquid, the method comprising periodically reversing the voltage polarity applied to the electrodes of the pump while maintaining...
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5961800 |
Indirect electrode-based pumps
Provided is an electrode-based pump having source of a pumped fluid, a conduit channel of capillary dimensions connected via a first end to the pumped fluid source and having an outlet at a second...
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5961804 |
Microencapsulated electrophoretic display
An application-ready electrophoresis material includes a carrier and a dispersion of microcapsules therein, the microcapsules each containing a plurality of phases therein. At least some of the...
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5948278 |
System and method for enrichment of rare cell population from whole blood samples
A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole blood sample according to the relative charge density and/or the relative binding...
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5942093 |
Electro-osmotically driven liquid delivery method and apparatus
Method and apparatus for controlling precisely the composition and delivery of liquid at sub-μL/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient...
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5914025 |
Ion chromatographic method and apparatus using ion reflux
A method and apparatus for generating an acid or base eluent in an aqueous stream solely from an ion exchange bed for liquid chromatography of anions or cations and for simultaneously suppressing...
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5906724 |
Apparatus for separation of nucleated blood cells from a blood sample
A charge-flow separation apparatus (CFS) for enriching rare cell populations, particularly fetal cells, from a whole blood sample by separating the rare cell fractions from whole fractions...
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5879632 |
Apportioning system
The invention provides an apportioning system comprising a first apportioning chamber having a first outlet and fillable with liquid to a first defined level such that if liquid is added to fill...
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5858644 |
Analysis of analytes in biological fluids
A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1)...
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5856100 |
Method for purification and transfer to separation/detection systems of DNA sequencing samples and plates used therefor
Disclosed are: a part for assembling reaction vessels comprising a base plate with holes passing through said plate in the direction of thickness; a method for preparation of reaction vessels...
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5853668 |
Apparatus allowing sequential chemical reactions
A first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile...
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5851370 |
Automated electrophoresis system and method
Automated electrophoresis is performed by applying a cover plate to a substrate having a plurality of electrophoresis lanes, applying at least one sample to the plurality of electrophoresis lanes,...
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5849166 |
Electrophoresis of nucleic acid fragments
A method for electrophoresis of nucleic acid fragments present in the solution which contains an amount, e.g., 0.2% or more, of a reagent, e.g., glycerol, dithiolthreitol (DTT) and trehalose or...
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5846702 |
Reagent including an osmium-containing redox mediator
A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the...
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5846393 |
Electrochemically-aided biodigestion of organic materials
An integrated electrochemical soil remediation method and apparatus for treating contaminated soils, especially those contaminated with mixtures of nonvolatile organic contaminants, ionic...
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5837115 |
Microlithographic array for macromolecule and cell fractionation
A sorting apparatus and method for fractionating and simultaneously viewing individual microstructures, such as free cells, viruses, macromolecules, or minute particles in a fluid medium. The...
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5798032 |
Method and apparatus for automated carbohydrate mapping and sequencing
Methods and apparatus are disclosed for improved mapping and sequencing of carbohydrate polymers. In one aspect, the improvement includes a means for coupling two capillary electrophoresis (CE)...
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5795976 |
Detection of nucleic acid heteroduplex molecules by denaturing high-performance liquid chromatography and methods for comparative sequencing
The present invention describes a method for separating heteroduplex and homoduplex DNA molecules in a mixture. In the method, such a mixture is applied to a stationary reverse phase support. The...
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5759369 |
Viscous electrophoresis polymer medium and method
An electrophoresis separation medium is disclosed comprising a matrix of a copolymer composed of a linear hydrophilic polymer segment having a selected substantially uniform segment length and...
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5739946 |
Display device
A novel display device suitable as a portable display device is disclosed. The device includes a pair of substrates and a light modulation layer sandwiched between the substrates. A functional gel...
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5736050 |
Currents in narrow pores
Current fluctuations typical of those observed with biological channels which are ion selective and inhibited by divalent cations and protons have been observed in synthetic membranes, and a...
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5702588 |
Soap fiber extraction process
A method of separating soap fibers from the liquid phase component of grease to prepare the fibers for microscopic analysis includes the steps of admixing a sample of the grease with a solvent to...
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5681751 |
Method allowing sequential chemical reactions
A first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile...
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5676849 |
Method for enrichment of fetal cell population from maternal whole blood samples
A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole according to the relative charge density and/or the relative binding affinity for...
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5662813 |
Method for separation of nucleated fetal erythrocytes from maternal blood samples
A charge-flow separation apparatus (CFS) and method for enriching rare cell populations, particularly fetal cells, from a whole blood sample by separating the rare cell fractions from whole...
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5650055 |
Electrophoresis separation method and apparatus using barrier separation and polarity reversing
The method and apparatus for preparative electrophoresis is especially useful for proteins. An electrophoretic potential with an initial polarity is applied across an electrophoretic medium (13) to...
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5641390 |
Labelled sugars immobilized on a solid support
An immobilized complex of one or more labeled carbohydrates wherein the labeled carbohydrates have been derivatized in a substantially hydrophobic solvent system and components other then the...
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5633129 |
Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting...
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5616235 |
Electrochemical stabilization of soils and other porous media
Suitable electrolyte conditioning at the electrodes greatly facilitates the transport of desired ions through soil, enhancing the ability of electrokinetic processes to stabilize the soil through...
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5614072 |
Increased efficiency of electrophoretic separations by mobility matching
The invention concerns electrophoresis and methods and electrolyte compositions for decoupling or isolating the dual functions of the electrolyte composition in order to increase separation...
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5611904 |
Electrochromatography apparatus
The invention provides fittings for the ends of electrochromatography cols. Each fitting includes an annular electrode surrounding one end of the passage electrical fields to be applied. The...
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5589047 |
Methods for the selection, separation and fusion of cells
Methods are described for the separation of cells of different types using dielectrophoresis; for the electrochemical selection of cells by the dielectrophoretic attraction of ligand bearing cells...
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5585069 |
Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
A system for processing a plurality of tests or syntheses in parallel comprising a sample channel for moving samples into a microlaboratory array of a plurality of wells connected by one or more...
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5582700 |
Electrophoretic display utilizing phase separation of liquids
An electrophoretic display is provided which includes first and second plates spaced apart to define a volume of space therebetween. The display also includes a first electrode positioned on the...
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5580654 |
Insulated electrical conductor
An improved electrical conductor is provided which includes an electrical conductor having an insulating layer which electrically insulates the electrical conductor. The insulating layer is...
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5569368 |
Electrophoretic apparatus and method for applying therapeutic, cosmetic and dyeing solutions to hair
A method of introducing therapeutic, cosmetic, and dyeing agents in buffer medium created by the electrophoretic flow of these solutions into the hair. The result is to increase the therapeutic...
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5569367 |
Apparatus for separating a mixture
Apparatus for separating a mixture of particles comprising a chamber with an inlet and an outlet, means for providing an eluant flow between said inlet and said outlet, within the chamber an...
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5569365 |
Intermittent electrolytic membrane suppressor regeneration for ion chromatography
A method and apparatus using suppression of eluents for the analysis of anions or cations in ion chromatography. The invention relates to the intermittent use of the electric field during...
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5567282 |
On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins
A method for classifying and typing M-proteins present in a sample of serum, etc. of an individual is disclosed. The method employs an on-capillary electrophoretic immunosubtractive method to...
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5556528 |
Structures with field responsive permeation control
Devices are useful to capture or dispense target molecules and include an electric field-responsive valve unit. The valve unit includes an active control structure having at least one monomolecular...
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5547581 |
Method of separating ionic fluids with a flow through capacitor
A flow-through capacitor and a controlled charge chromatography column system using the capacitor for the purification of a fluid-containing material, which column comprises an inlet for a fluid to...
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5529678 |
Lens decontamination system
A system by which contaminants from and below the surface of contact lenses may be electrokinetically removed. The system includes a protective encasement packet in which a lens is safely protected...
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5520793 |
Methods of producing hydrogen iodide electrochemically
Improved electrochemical processes for producing high purity grades of hydrogen iodide without developing cell fouling iodine solids through oxidation of iodide at the anode back migrating through...
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