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US20090280183 |
MULTIPARTICULATE FORM OF ADMINISTRATION, COMPRISING NUCLEIC ACID-CONTAINING MUCOADHESIVE ACTIVE INGREDIENTS, AND METHOD FOR PRODUCING SAID FORM OF ADMINISTRATION
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix...
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US20090275526 |
Mucoadhesive nanoparticles for cancer treatment
The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a...
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US20090269397 |
TARGETED AND HIGH DENSITY DRUG LOADED POLYMERIC MATERIALS
Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to...
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US20090269373 |
Saposin C-DOPS: A Novel Anti-Tumor Agent
Compositions and methods for treating subjects with disorders characterized by hyper-proliferating cells such as tumors and cancers are provided. The compositions comprise agents that are...
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US20090263495 |
BACTERIOSTATIC OR BACTERIOCIDAL COMPOSITIONS AND METHODS
Particular aspects provide compositions and methods for treating or preventing bacterial infection or at least one symptom related to bacterial infection, and the like in a subject in need thereof...
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US20090263491 |
Polylactide Nanoparticles
A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises...
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US20090258073 |
MAGNETIC CARRIER AND MEDICAL PREPARATION FOR CONTROLLABLE DELIVERY AND RELEASE OF ACTIVE SUBSTANCES, METHODS OF THEIR PRODUCTION AND METHODS OF TREATMENT USING THEREOF
The present invention relates to magnetic carriers and medical preparations for controllable delivery and release of active substances. The carrier for active substances comprises material A, which...
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US20090258071 |
COMPOSITIONS AND METHODS FOR PH TARGETED DRUG DELIVERY
The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock...
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US20090252796 |
NUTRITIONAL SUPPLEMENT FOR THE PREVENTION OF CARDIOVASCULAR DISEASE, ALZHEIMER'S DISEASE, DIABETES, AND REGULATION AND REDUCTION OF BLOOD SUGAR AND INSULIN RESISTANCE
A mixture (which may be utilized as a food or a drink or a supplement or a drug or a cosmetic or a hygienic product) that is formulated and is capable of improving a person's well being, lowering...
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US20090246269 |
IDENTIFICATION AND USE OF GPRC VARIANTS IN THE TREATMENT AND DIAGNOSIS OF PARKINSON'S DISEASE
The invention relates genes that are deregulated in Parkinson's disease tissues and the corresponding proteins are identified. These genes and the corresponding proteins are suitable targets for...
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US20090232870 |
APPARATUS AND METHOD OF RETAINING AND RELEASING MOLECULES FROM NANOSTRUCTURES BY AN EXTERNAL STIMULUS
An apparatus and method for using nanostructures, such as nanopores, nanofibers, nanowells, or nanocones as carriers for drugs, biomarkers and/or biomolecules. The apparatus and method for use on...
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US20090232855 |
Percutaneous controlled releasing material using nano-sized polymer particles and external application agent containing the same
A percutaneous releasing material and agent having characteristics that include a high stability of an active agent in the formulation, a high topical absorption rate, decreased irritation on the...
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US20090226521 |
Active nanoparticles and method of using
Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological...
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US20090226495 |
NANODIAMOND ENHANCED EFFICACY
The present invention is directed to attaching drugs and other functional groups to surfaces of nano-sized diamonds (NDs) to enhance the efficacy of drugs and other substances. The method involved...
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US20090209629 |
Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications
Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
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US20090208567 |
SUBSTANCE-CONTAINING CARBON NANOHORN COMPOSITE HAVING POLYAMINE PLUG AND PROCESS FOR PRODUCING THE SAME
The present invention provides: a carbon nanohorn composite including a carbon nanohorn, a substance encapsulated in the carbon nanohorn, and a polyamine adsorbed by chemical reaction firmly to a...
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US20090202644 |
FUNCTIONAL NANOPARTICLE FILLED CARBON NANOTUBES AND METHODS OF THEIR PRODUCTION
Carbon nanotubes filled with a suspension or colloidal solution of functional nanoparticles and methods for production of carbon nanotubes loaded with functional nanoparticles are provided.
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US20090202628 |
Nanoparticles for protein drug delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced...
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US20090196937 |
TEMPERATURE-SENSITIVE NANO-CARRIERS
The present invention relates to a process of preparing a biocompatible temperature-sensitive nano-carrier, which comprises the steps of (a) preparing a polymer dispersion comprising a...
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US20090196936 |
Hydrogel wound dressing and biomaterials formed in situ and their uses
The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which...
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US20090196827 |
Drug Loaded Contrast Agents: Combining Diagnosis and Therapy
This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the...
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US20090191277 |
PROTEIN NANOPARTICLES
It is an object of the present invention to provide a highly safe composition comprising minoxidil and having high transparency due to the small particle size and high permeability into scalp and...
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US20090186013 |
INORGANIC MATERIALS FOR HEMOSTATIC MODULATION AND THERAPEUTIC WOUND HEALING
The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the...
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US20090181090 |
Protein-Based Carrier System for Overcoming Resistance in Tumour Cells
Nanoparticles, the particle matrix of which is based on at least one protein and has at least one active agent embedded therein and methods of producing the nanoparticles with at least one active...
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US20090181076 |
Drug Release From Nanoparticle-Coated Capsules
Methods of producing a controlled release formulation for an active substance are disclosed, wherein the methods involve dispersing a discontinuous phase comprising an active substance into a...
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US20090170768 |
WATER-SOLUBLE CARBON NANOTUBE COMPOSITIONS FOR DRUG DELIVERY AND MEDICINAL APPLICATIONS
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some...
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US20090169637 |
NANOCOMPOSITE PARTICLES
Nanocomposite particles having good solubility and redispersibility in water are provided. The nanocomposite particles include a sugar material and nanoparticles containing a drug to be delivered...
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US20090162407 |
PROCESS FOR PREPARING MICROPARTICLES HAVING A LOW RESIDUAL SOLVENT VOLUME
The disclosed processes for forming microparticles utilize low volumes of processing water while still providing microparticles having low residual solvent levels. The processes are adaptable to...
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US20090155375 |
Compositions comprising a lipid and copolymer of styrene and maleic acid
A composition comprising a lipid and copolymer of styrene and maleic acid, wherein the copolymer of styrene and maleic acid is non-alternating, and wherein the polymer and lipid are in the form of...
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US20090155331 |
INJECTABLE NANOPARTICULATE OLANZAPINE FORMULATIONS
Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable...
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US20090148384 |
FUNCTIONALIZED, SOLID POLYMER NANOPARTICLES COMPRISING EPOTHILONES
The present invention describes polymer nanoparticles with a cationic surface potential, in which both hydrophobic and hydrophilic pharmaceutically active substances can be encapsulated. The...
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US20090136585 |
SURFACE-MODIFIED NANOPARTICLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS AND COMPOSITION FOR MAKING SAME
Surface-modified polymeric nanoparticles (NPs), compositions for making them, and their use in drug delivery are disclosed.
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US20090136583 |
Sol-Gel phase-reversible hydrogel templates and uses thereof
Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a...
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US20090136582 |
COLLOIDAL MAGNETIC NANOBIOPARTICLES FOR CYTOTOXICITY AND DRUG DELIVERY
The present invention provides systems that include magnetic colloidal particles of differing elemental compositions with differing morphologies. The colloidal particles comprise a magnetic...
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US20090130216 |
MULTIMODAL PARTICULATE FORMULATIONS
Multimodal particulate formulations of medicaments and methods for their use, e.g. by nasal or pulmonary administration for the treatment of various medical conditions, are provided.
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US20090130214 |
Gemcitabine derivatives nanoparticles
The invention concerns a 2′,2′-difluoro-2′-deoxycytidine derivative of general formula (I), wherein: R 1 , R 2 and R 3 , identical or different, represent independently of one another, a...
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US20090117195 |
Hydrophilic Particles Based on Cationic Chitosan Derivatives
The present invention provides new nanoparticles and microparticles of hydrophilic character, prepared out of a cationic chitosan derivative and a polyanionic polymer.
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US20090105738 |
DEVICE FOR TRANSFECTING CELLS USING SHOCK WAVES GENERATED BY THE IGNITION OF NANOENERGETIC MATERIALS
A miniature device for generating shock waves using the energy of combustion of a nanoenergetic material and directing the shock waves into biological tissues is described.
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US20090098044 |
SOLID PARTICLES FROM CONTROLLED DESTABILISATION OF MICROEMULSIONS
The present invention relates to a process for making a particulate substance. The process comprises providing an emulsion, optionally a microemulsion, comprising droplets dispersed in a continuous...
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US20090074819 |
POLYMERIC NANO-SHELLS
The present invention provides a method for manufacturing polymeric nano-structures (nano-shells), wherein the nano-structures are hollow and respond to a temperature change by reversibly changing...
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US20090022655 |
Nanotubes for Cancer Therapy and Diagnostics
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
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US20090011040 |
Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
The present invention is a method of using compacted nucleic acid (such as DNA) nanoparticles for non-viral gene transfer to various tissues of the human eye or eyes of other mammals. These...
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US20090004278 |
Enzymatically Crosslinked Protein Nanoparticles
It is an object of the present invention to provide highly safe nanoparticles made from highly biocompatible materials without the use of a surfactant or synthetic polymer. The present invention...
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US20090004118 |
Multifunctional Nanoparticle Conjugates And Their Use
Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods...
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US20080311214 |
Polymerized solid lipid nanoparticles for oral or mucosal delivery of therapeutic proteins and peptides
The present invention encompasses lipid nano/micro particles, which have been modified, preferably on their surface, to contain a molecule or ligand, which targets the nano/micro particles to a...
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US20080311172 |
Programmed-release, nanostructured biological construct
A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery...
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US20080311045 |
Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
Targeted therapeutic delivery systems comprising specially designed nanocarriers for intracellular therapeutic delivery, mediated by acoustic energy, for use either in vivo or in vitro, are...
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US20080300669 |
In situ trapping and delivery of agent by a stent having trans-strut depots
A method of delivering an agent into a bodily lumen, the method comprising: implanting an implantable medical device into a treatment site of a lumen, the device having an abluminal face and a...
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US20080279950 |
NANO-PARTICLES COMPRISING CUCURBITURIL DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND PROCESS FOR THE PREPARATION THEREOF
Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active...
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US20080274195 |
Compositions and Methods for Making and Using Nanoemulsions
The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of...
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