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US20110173706 |
NOVEL GPR101 TRANSGENIC MICE AND METHODS OF USE THEREOF
The invention provides transgenic animals comprising a disruption in the endogenous GPR101 gene and methods of producing such transgenic animals. The invention further provides methods of...
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US20100115636 |
PIG MODEL FOR BREAST CANCER, MITOCHONDRIA RELATED PROTEIN FOLDING DISORDERS AND/OR EPIDERMOLYSIS BULLOSA SIMPLEX
The present invention relates to a genetically modified pig as a model for studying breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex. The modified...
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US20110107445 |
Efficient Insertion of DNA Into Embryonic Stem Cells
The present invention relates, in general, to a method for introducing a heterologous replacement gene sequence into a host embryonic stem cell to replace an endogenous host gene target sequence....
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US20080222745 |
Colcemid-Treatment of Oocytes to enhance Nuclear Transfer Cloning
Disclosed herein are methods of generating a recipient cytoplast for nuclear cloning with improved developmental capacity. These methods involve the in vitro maturation of an oocyte from a...
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US20110010783 |
METHOD FOR REPROGRAMMING IN VITRO STEM CELLS AND SOMATIC CELLS INTO GERMINAL CELLS
The present invention is related to a method for inducing in vitro the differentiation of stem cells or somatic cells towards germinal cells, comprising the following steps: cultivating said stem...
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US20100024047 |
Prion-free transgenic ungulates
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion...
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US20090241206 |
METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES
The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to...
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US20100115641 |
GFP-TRANSFECTED CLON PIG, GT KNOCK-OUT CLON PIG AND METHODS FOR PRODUCTIONS THEREOF
Disclosed are a cloned pig expressing green fluorescent protein (GFP) and a cloned pig having a 1,3-galactosyltransferase (GT) gene knocked out. Also, the present invention discloses methods of...
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US20080134352 |
Method for producing transgenic rats
The present invention relates to methods for producing transgenic animals, particularly transgenic rats, using retroviral constructs engineered to carry the transgene(s) of interest.
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US20100287635 |
Cloned Canines and Method for Producing Thereof
Disclosed herein are a cloned canine and a production method thereof. The method comprises the steps of enucleating the oocyte of a canine to prepare an enucleated recipient oocyte, conducting...
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US20100218264 |
Genome editing in rats using zinc-finger nucleases
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain....
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US20090055945 |
Method for Producing Nuclear-Transplanted Egg
It is intended to provide a method for improving a development rate in a somatic nuclear transplantation technique or an artificial insemination technique using a spermatid. The method is a method...
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US20090019560 |
CLONED RAT BY NUCLEAR TRANSFER USING ENUCLEATED RAT OOCYTES
The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the...
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US20100281554 |
TWO STEP CLUSTER DELETION AND HUMANISATION
This invention relates to a method for humanising a mouse. In particular, the invention relates to a method for replacing a cluster of mouse genes with single or multiple genes from the...
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US20070245424 |
METHOD FOR PRODUCING GERM-LINE CHIMERIC ANIMAL
The present invention provides a method for efficiently producing a germ-line chimeric animal and a method for conveniently producing a heterozygous animal and a homozygous animal. Specifically, a...
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US20100107265 |
Double-muscling in mammals
The invention relates to a gene (cDNA) encoding a bovine myostatin protein. The nucleic acid coding sequence is identified as SEQ ID NO:1 and the protein sequence is identified as SEQ ID NO:2. A...
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US20080295191 |
METHOD FOR PRODUCING CLONED DOG
Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out...
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US20100122364 |
METHOD OF CONSTRUCTING NUCLEUS-IMPLANTED EGG, PARTHENOGENETIC EMBRYO AND PARTHENOGENETIC MAMMAL
Disclosed is a method for constructing a nucleus-implanted egg, a parthenogenetic embryo and for producing a parthenogenetic mammal each having 2 haploid genome sets originating in mammalian ova,...
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US20060263829 |
Efficient haploid cell sorting flow cytometer systems
A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21)...
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US20100235937 |
PRODUCTION OF TRANSGENIC AVIAN ORGANISMS EMPLOYING EMBRYONIC STEM CELLS
Method of culturing embryonic stem (ES) cells of avian origin includes the steps of: a) suspending ES cells originating from the blastoderm disk of fertilized un-incubated avian egg(s) in a basal...
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US20080044392 |
Isolation of Stem Cell-Like Cells and Use Thereof
The present invention relates to isolated stem cell-like cells and a method of isolation. The invention also relates to a media composition for producing primary cell cultures comprising...
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US20090133140 |
Injecting Drosophila Embryos
The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of...
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US20100281553 |
PRODUCTION METHOD OF CYST EXPRESSED TRANSGENIC ANIMAL USING PKD2 GENE
Disclosed herein is a method for producing a cyst-expressed transgenic animal using a PDK2 gene. The production method comprises preparing a PKD2 protein expression vector, inserting the expression...
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US20100122356 |
PIG MODEL FOR PSORIASIS
The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a...
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US20100154069 |
PIG MODEL
The present invention relates to a genetically modified pig comprising at least one site for integration of at least one transgene. The invention also pertains to a porcine embryo, blastocyst,...
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US20070204357 |
Process for producing normal parenchymal cells, tissues or organs by bioincubator
Methods of producing cells, tissues and organs as close as possible to homoplasy have been developed to provide nonhuman mammals having normal parenchymal cells of a foreign mammal, a tissue made...
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US20100293623 |
Rabbit nuclear cloning method and uses thereof
The invention concerns a method for producing non-human mammal embryos, in particular rabbit by nuclear cloning. The invention also concerns the mammals obtained and their uses.
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US20100212032 |
Compositions and Methods for the Efficient and Reproducible Generation of Clone Animals of All Developmental Stages and Methods of Use Thereof
Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and...
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US20100083393 |
METHOD OF CONSTRUCTING CLONE MAMMAL
The present invention provides a method of producing a cloned mammal, which uses a mammalian natural killer T cell as a donor cell, a cloned mammal obtained by the method, a method of obtaining an...
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US20100138940 |
TRANSGENIC PIG AS A MODEL OF ALZHEIMER'S DISEASE
The present invention relates to a modified pig as a model for studying Alzheimer's disease. The modified pig model displays one or more phenotypes associated with Alzheimer's disease. Disclosed is...
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US20100293627 |
METHOD FOR CLONING ANIMALS WITH TARGETTED GENETIC ALTERATIONS BY TRANSFER OF LONG-TERM CULTURED MALE OR FEMALE SOMATIC CELL NUCLEI, COMPRISING ARTIFICIALLY-INDUCED GENETIC ALTERATIONS, TO ENUCLEATED RECIPIENT CELLS
An improved method of nuclear transfer employing long-term cultured somatic cells as the donor cells and enucleated oocytes as the recipient cells to produce dividing cybrids. Such cybrids are...
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US20100064380 |
PLURIPOTENT CELLS FROM THE MAMMALIAN LATE EPIBLAST LAYER
This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range...
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US20090075380 |
Methods and Compositions To Enhance Efficiency Of Nuclear Transfer/Cloning
The present invention provides compositions and methods for increasing the success of assisted reproductive technology (ART). Specifically, the inventions described herein increase the survival...
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US20090126032 |
Method to produce cloned embryos and adults from cultured cells
A nuclear transfer method is provided wherein nuclear DNA in whole or part is injected into enucleated oocytes. The method is suitable for different donor cells, and preferably ES cells.
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US20090255005 |
Method for Preparing Fish Embryo
An object of the invention is to effectively prepare a fish embryo with a correct chromosomal ploidy by nuclear transplantation in which an exogenous fish nucleus is transplanted in a cytoplasmic...
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US20090328241 |
MITOCHONDRIAL-NUCLEAR EXCHANGED CELLS, TISSUES, ORGANS AND ANIMALS
Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a...
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US20090138979 |
MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONING
The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The...
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US20100242125 |
METHODS FOR CORRECTING MITOTIC SPINDLE DEFECTS AND OPTIMIZING PREIMPLANTATION EMBRYONIC DEVELOPMENTAL RATES ASSOCIATED WITH SOMATIC CELL NUCLEAR TRANSFER IN ANIMALS
The present invention is directed to various methodologies to make NT a practical procedure for animals, specifically, primates including human and non-human primates. Furthermore, the methods and...
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US20080120733 |
Rnai-Based Method for Selecting Transfected Eukaryotic Cells
The invention relates to a method for the production of a eukaryotic cell selectable by inactivation or reduction of an endogenous gene function, comprising the steps of (a) introduction of one or...
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US20070250943 |
Construction of Chimera Using En Cells
It is intended to provide a chimeric animal producing a protein or tissue of an animal of the same or a different species or comprising a desired pluripotent cell transmitted to the germ line and...
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US20100011452 |
CHIMERIC NON-HUMAN ANIMAL
The present invention relates to a method for producing a chimeric non-human animal expressing a desired protein, and a chimeric non-human animal or an offspring thereof expressing a desired...
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US20100205678 |
OOCYTE SPINDLE-ASSOCIATED FACTORS IMPROVE SOMATIC CELL CLONING
The invention pertains to the discovery that the presence of oocyte spindle associated factors in an enucleated oocyte improves oocyte quality and subsequently nuclear transfer. In particular, it...
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US20110041197 |
Promoter-Regulated Differentiation-Dependent Self-Deleting Cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a...
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US20080066197 |
PLURIPOTENT CELLS FROM RAT AND OTHER SPECIES
Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.
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US20080051334 |
Diagnostic and Therapeutic Use of Kcnc1 for Neurodegenerative Diseases
The present invention provides a novel protein encoded by the KCNC1 gene and discloses the differential expression of the gene KCNC1 coding for KCNC1 proteins in specific brain regions of...
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