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US20130254909 SYNTHETIC REGULATION OF GENE EXPRESSION  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
US20130150465 PIG MODEL FOR BREAST CANCER, MITOCHONDRIA RELATED PROTEIN FOLDING DISORDERS AND/OR EPIDERMOLYSIS BULLOSA SIMPLEX  
The present invention relates to a genetically modified pig as a model for studying breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex. The modified...
US20110126305 Mutant blue fluorescent protein and method of using the same for fluorescence resonance energy transfer and blue fluorescent fish  
The present invention discloses a mutant blue fluorescent protein (BFP) exhibiting, at an aerobic or anaerobic system, larger fluorescent intensity than a BFPvv D7 of SEQ ID NO:2 derived from a...
US20130061343 IN VIVO GENE REGULATION BY THE COMBINATION OF KNOCK-IN-TETO SEQUENCE INTO THE GENOME AND TETRACYCLINE-CONTROLLED TRANS-SUPPRESSOR (TTS) PROTEIN  
Disclosed is a FAST (Flexible Accelerated STOP TetO-knockin) system, an efficient method for manipulating gene expression in vivo to rapidly screen animal models of disease. This invention further...
US20120066783 AAV CAPSID LIBRARY AND AAV CAPSID PROTEINS  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20150106961 Humanized IL-15 Animals  
Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or...
US20110055936 TRANSGENIC MAMALS MODIFIELD IN BRI PROTEIN EXPRESSION  
Provided are non-human mammals comprising a transgenic nucleic acid sequence capable of causing an alteration of expression of Bri2 or Bri3 in the mammal. Also provided are non-human mammals...
US20110004952 METHOD FOR THE SEPARATION OF CELLS  
The invention relates to a cell containing a gene encoding a conditional transgenic surface marker that is detectable upon expression on the surface of the cell, wherein the gene encoding a...
US20110179510 METHOD FOR CULTURING AVIAN GONOCYTES  
A sustained culture of isolated avian gonocytes is provided, as well as a method of making and using the same. A chimeric avian containing an isolated gonocyte and a transgenic avian produced...
US20150143552 BIOCONTROL  
Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system comprises a first expression unit...
US20110061119 METHOD OF PRODUCING NON-HUMAN MAMMALS  
A method of producing mutant/targeted non-human mammals, such as mutant mice that does not require production of chimera and permits the introduction of multiple mutations in embryos and, thus,...
US20130247233 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20110185439 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20120278910 Transgenic Pig in which HO-1 and TNFR1-Fc are Simultaneously Expressed, and Method for Producing Same  
The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously...
US20150173330 MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS AND/OR FRONTOTEMPORAL LOBAR DEGENERATION  
To generate an animal model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration. An animal model exhibiting symptoms similar...
US20120151614 VECTOR UTILIZING BORNA DISEASE VIRUS AND USE THEREOF  
Disclosed is a viral vector comprising (a) a cDNA of a recombinant viral RNA having at least the N gene, the X gene, the P gene, and the L gene of a Borna disease virus genome in the same order as...
US20140033333 TRANSGENIC PIG FOR MUTANT GUCY2D AS CONE DYSTROPHY MODEL  
The present invention relates to a transgenic pig as a model for studying a cone affecting disease, in particular a cone dystrophy or cone-rod-dystrophy, wherein the pig model expresses a dominant...
US20130340104 Humanized IL-7 Rodents  
Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that...
US20120266265 Transgenic avians and protein production  
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the...
US20110239318 METHODS FOR PRODUCING FISH WITH HIGH LIPID CONTENT  
The invention provides methods for producing biofuel from algae, that use fish which have a high capacity of producing and/or accumulating lipids to harvest algae from an algal culture. The...
US20110239319 Use of Endonucleases for Inserting Transgenes Into Safe Harbor Loci  
The present invention concerns the endonucleases capable of cleaving a target sequence located in a “safe harbor loci”, i.e. a loci allowing safe expression of a transgene. The present invention...
US20120174245 TRANSPOSITION OF MAIZE AC/DS ELEMENTS IN VERTEBRATES  
The present invention is directed to the use of the maize Ac/Ds transposable elements in vertebrates.
US20120017290 Genome editing of a Rosa locus using zinc-finger nucleases  
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain....
US20100333222 KNOCKOUT MICE FOR A P450 GENE CLUSTER  
The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and...
US20120047589 METHOD OF DELIVERY OF NUCLEIC ACIDS TO A DEVELOPING EMBRYO  
Methods to introduce genetic material, such as DNA, to embryos, are disclosed. In some embodiments, the method involves preparing the pregnant mother to receive the genetic material into a blood...
US20150013023 HUMANIZED IL-6 AND IL-6 RECEPTOR  
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα...
US20150013022 HUMANIZED IL-6 AND IL-6 RECEPTOR  
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα...
US20130117873 HUMANIZED IL-6 AND IL-6 RECEPTOR  
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα...
US20120204282 METHODS AND COMPOSITIONS FOR TREATING OCCULAR DISORDERS  
Disclosed herein are methods and compositions for treating ocular disorders.
US20130061342 Identification and Enrichment of Cell Subpopulations  
Markers useful for the identification, characterization and, optionally, the enrichment or isolation of tumorigenic cells or cell subpopulations are disclosed.
US20120054880 METHOD FOR ENHANCING PRODUCTION OF PATHOGEN-RESISTANT PROTEINS USING BIOREACTOR  
A method for enhancing production of pathogen-resistant proteins using bioreactor comprising: (a) constructing a plasmid which comprises a nucleic acid sequence of exogenous pathogen-resistant...
US20120066779 HEPATITIS C RECEPTOR PROTEIN CD81  
The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for...
US20140082757 TRANSFORMED CAENORHABDITIS ELEGANS AND METHOD FOR SCREENING FOR SUBSTANCES REGULATING GLUCOSE METABOLISM USING SAME  
The present invention relates to a method for preparing a transformed Caenorhabditis elegans (C. elegans) which reacts to glucose by exhibiting fluorescence, and to a method for screening for a...
US20110258715 ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION  
It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (iPS cell) into a...
US20110099644 MIG-6 KNOCKOUT MICE AND ELUCIDATION OF ASSOCIATION OF MIG-6 WITH EARLY ONSET DEGENERATIVE JOINT DISEASE AND ROLE AS A TUMOR SUPPRESSOR  
The molecular mechanism underlying degenerative joint disease, also known as osteoarthritis (OA), is not fully understood. Disruption of mitogen inducible gene 6 (Mig-6) in mice by homologous...
US20140096275 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS  
The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically...
US20130198878 ORGANISMS HOMOZYGOUS FOR TARGETED MODIFICATION  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20110247089 Organisms homozygous for targeted modification  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20110307967 TetO-p16 Transgenic Mice  
Mice comprising a human p16 transgene operably linked to an inducible promoter and capable of controlled expression of p16 are provided. Also provided are cells, tissues, and organs obtainable...
US20150257373 MOUSE MODEL AND TREATMENT OF HEREDITARY INCLUSION BODY MYOPATHY  
Disclosed herein are methods of treating HIBM in a subject comprising identifying subject in need thereof; and administering to the subject a compound, or a pharmaceutically acceptable salt,...
US20100319079 ISOLATED PROLIFERATING CELLS WITH STEM CELL PROPERTIES FROM ADULT TISSUE OF POIKILOTHERMIC VERTEBRATES, STABLE CELL CULTURES THEREOF, AND METHODS FOR THEIR PREPARATION  
A method of preparing adult proliferating cells with stem cell properties includes removing tissue from pronephros or pyloric appendates of an intestine of poikilothermic vertebrates, comminuting...
US20120094312 BOOSTING HUMAN DENDRITIC CELL DEVELOPMENT, HOMEOSTASIS AND FUNCTION IN XENOGRAFTED IMMUNODEFICIENT MICE  
The present invention relates to a transgenic animal mode system based on the development of transgenic mice bearing components of the human immune system. Specifically, the Invention relates to a...
US20150047061 Humanized M-CSF Mice  
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a...
US20150089678 NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE  
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous...
US20150128300 METHODS AND COMPOSITIONS FOR GENERATING CONDITIONAL KNOCK-OUT ALLELES  
The disclosure provides methods and compositions for generating conditional knock-out alleles using donor constructs together with sequence-specific nucleases to generate conditional knock-out...
US20150135346 MATERIALS AND METHODS FOR MAKING A RECESSIVE GENE DOMINANT  
The subject invention provides materials and method for making a recessive gene dominant. This is accomplished by interfering with the natural mechanisms that inhibit expression of the recessive...
US20110145940 TAL EFFECTOR-MEDIATED DNA MODIFICATION  
Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
US20140033338 GREEN TRANSGENIC FLUORESCENT ORNAMENTAL FISH  
The present invention relates to transgenic green ornamental fish, as well as methods of making such fish by in vitro fertilization techniques. Also disclosed are methods of establishing a...
US20130333060 GREEN TRANSGENIC FLUORESCENT ORNAMENTAL FISH  
The present invention relates to transgenic green ornamental fish, as well as methods of making such fish by in vitro fertilization techniques. Also disclosed are methods of establishing a...
US20100319078 Stem Cells Modified to Facilitate Threonine Catabolism  
A mammalian cell comprising a recombinant, functional L-threonine 3-dehydrogenase (EC 1.1.1.103; TDH) gene, methods of making, and methods of use.