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US20150010593 METHODS AND CELLS FOR THE PRODUCTION OF VIRAL VACCINES  
The present invention provides genetically modified cells useful for viral replication and the production of viral vaccines.
US20140298503 Glycosylation in Avians  
Transgenic avians which produce proteins in their oviduct tissue having modified oligosaccharide structures and methods of making such avians are disclosed herein. The invention also includes the...
US20150082471 METHOD FOR CULTURING AVIAN GONOCYTES  
A sustained culture of isolated avian gonocytes is provided, as well as a method of making and using the same. A chimeric avian containing an isolated gonocyte and a transgenic avian produced...
US20110296541 PRODUCTION OF PROTEINS IN EGGS  
Methods for preparing recombinant proteins, such as antibodies, in eggs are described. The method offers advantages over existing systems for preparing recombinant proteins including high yield,...
US20120266265 Transgenic avians and protein production  
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the...
US20130276156 Multiple Inducible Gene Regulation System  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20140082759 Transgenic Chicken Comprising an Inactivated Immunoglobulin Gene  
A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immuno -well as globulin gene is provided, as we cells and targeting vectors for making the...
US20140201858 METHODS FOR SITE-SPECIFIC GENETIC MODIFICATION IN STEM CELLS USING XANTHOMONAS TAL NUCLEASES (XTN) FOR THE CREATION OF MODEL ORGANISMS  
The invention relates to organisms and compositions comprising one or more stem cells or one or more embryos, wherein the one or more stem cells or one or more embryos comprise one or more of the...
US20120331576 Pathogen Restriction Factors  
The use of interferon induced transmembrane protein 1, 2, or 3 (IFITM1, 2, or 3) as a viral restriction factor, and methods of using the same to produce virus, transgenic animals expressing...
US20140189898 RESISTANCE TO BACTERIAL INFECTION  
The present invention provides a method of identifying an animal having a genotype associated with resistance to bacterial infection comprising the steps of: (a) providing a sample from said...
US20110023160 Functional Disruption Of Avian Immunoglobulin Genes  
A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous...
US20130219533 PLA2G16 AS A TARGET FOR ANTIVIRAL COMPOUNDS  
In some aspects, the invention provides compositions and methods for inhibiting viral infection. In some aspects, the invention provides compositions and methods useful for identifying antiviral...
US20140255383 RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF  
The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased...
US20100306869 MODULATING PRODUCTION TRAITS IN AVIANS  
The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA...
US20140245465 TRANSGENIC BIRD EXPRESSING FOREIGN GENE USING ENDOPLASMIC RETICULUM CHAPERONE PROMOTER  
An aim is to produce a suitable foreign protein in egg white in transgenic birds at levels equivalent to or higher than the expression levels achieved using an ovalbumin promoter or an actin...
US20140123330 CONTROL OF SEXUAL MATURATION IN ANIMALS  
A genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the...
US20100077491 Modulators of RNF5 and Uses Thereof  
Provided herein are compositions and methods relating to the involvement of RNF5 in muscle wasting.
US20140289880 TRANSGENIC CHICKENS  
The present invention is transgenic chickens obtained from long-term cultures of avian PGCs and techniques to produce and transgenic birds derived from prolonged PGC cultures. In some embodiments,...
US20110162096 Gene Therapy Using Transposon-Based Vectors  
Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human
US20110247091 Transgenic Cells and Chickens Expressing RIG-I  
The present disclosure provides a transgenic cell or chicken having increased resistance to RNA viral infection, wherein the chicken cell expresses a foreign RIG-I gene. Also provided are methods...
US20140298504 TRANSGENIC CHICKENS WITH AN INACTIVATED ENDOGENOUS GENE LOCUS  
The present invention is transgenic chickens obtained from long-term cultures of avian PGCs and techniques to produce and transgenic birds derived from prolonged PGC cultures. In some embodiments,...
US20120185954 Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to...
US20110119782 CONSTRUCT CAPABLE OF RELEASE IN CLOSED CIRCULAR FORM FROM A LARGER NUCLEOTIDE SEQUENCE PERMITTING SITE SPECIFIC EXPRESSION AND/OR DEVELOPMENTALLY REGULATED EXPRESSION OF SELECTED GENETIC SEQUENCES  
The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger...
US20130273021 NPP1 FUSION PROTEINS  
The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the...
US20140237633 GERMLINE TRANSMISSION OF AVIAN PRIMORDIAL GERM CELLS (PGCS)  
The present invention is long-term cultures of avian PGCs and techniques to produce germline chimeric and transgenic birds derived from prolonged PGC cultures. In some embodiments, these PGCs can...
US20070011756 Method of constructing offspring originating from frozen sperm stem cell  
The present invention provides a method of producing offspring originating in a spermatogonial stem cell of a donor animal which comprises generating spermatozoa in the reproductive organ of a...
US20080051328 Novel Muscle Growth Regulator  
A muscle growth regulating factor includes polynucleotide and polypeptide sequences, promoter sequences, constructs comprising the sequences, and compositions for regulating muscle growth and...
US20060166260 Visualization of avian eggs  
The invention includes methods of visualizing and manipulating avian eggs employing TPLSM.
US20140363467 AVIAN INDUCED PLURIPOTENT STEM CELLS AND THEIR USE  
The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method,...
US20100192241 Production of Proteins in Eggs  
Methods for preparing recombinant proteins, such as antibodies, in eggs are described. The method offers advantages over existing systems for preparing recombinant proteins including high yield,...
US20150072064 Cell Transfection Method  
The present invention relates to methods for transfecting cells. In particular, the present invention relates to methods of transfecting primordial germ cells in avians, and to methods of breeding...
US20070214511 Transgenic Bird And Method Of Constructing The Same  
The present invention provides a G1 transgenic bird or an offspring thereof by: incubating a fertilized avian egg, microinjecting, into the early embryo thereof at a stage except for and after the...
US20120084873 SEX-DETERMINATION AND METHODS OF SPECIFYING SAME  
The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as...
US20070101453 Invention Process - Refined Cloned Super Adipose Tissue - Bio Fuel  
Disclosed is a method of making oil byproducts off of cloned and processed fats separated into lines for different byproducts. Process can be done on a scaleable design such as a fuel tank or an...
US20150232878 Construct  
A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1...
US20140289881 DOUBLE-STRANDED RNA  
The present disclosure provides methods and compositions relating to a polynucleotide comprising a dsRNA region that is complementary to a particular region of the NS1 gene segment in the...
US20120222143 GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME  
Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs...
US20110088106 COMPOSITIONS AND METHODS FOR MEDIATING CELL CYCLE PROGRESSION  
Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size...
US20130209436 LYSOSOMAL STORAGE DISEASE ENZYMES  
The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the...
US20140068797 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION  
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a...
US20090064351 TRANSGENIC BIRD PRODUCING ERYTHROPOIETIN AND METHOD OF CONSTRUCTING THE SAME  
The present invention has its object to provide a transgenic bird producing erythropoietin at high concentration levels as well as a method for constructing the same. The present invention...
US20140317765 TRANSGENIC BIRDS THAT PRODUCE CHIMERIC HUMAN IMMUNOGLOBULINS  
The invention relates to transgenic birds capable of producing chimeric immunoglobulins, with a combination of human and avian sequence, in their B cells. In some embodiments, the birds are...
US20090210953 Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release  
The present invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals and based thereon high-throughput mammalian...
US20140053287 Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them  
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these...
US20070061910 Method for culturing avian spermatogonial stem cells and avian spermatogonial stem cells prepared thereby  
The present invention relates to a method for long-term culturing of avian spermatogonial stem cells, which comprises the steps of: (a) preparing an avian testis; (b) isolating a population of...
US20120073005 TRANSGENIC ANIMAL CARRYING AT LEAST TWO TYPES OF FOREIGN FUNCTIONAL RNA  
The present invention relates to a transgenic animal which intracellularly expresses at least two types of foreign functional RNA and has resistance to a pathogen such as a virus. In the animal...
US20140359796 GENETICALLY STERILE ANIMALS  
A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis,...
US20060259997 Method of constructing transgenic bird using lentivirus vector and transgenic bird obtained thereby  
The present invention provides a lentivirus vector which comprises a coat protein containing VSV-G; a recombinant bird host which is constructed by infecting a bird host with the lentivirus...
US20140329996 TISSUE SPECIFIC EXPRESSION OF ANTIBODIES IN CHICKENS  
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are...
US20130023653 Tissue Specific Expression Of Antibodies In Chickens  
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are...

Matches 1 - 50 out of 114 1 2 3 >